IJMS, Vol. 21, Pages 3909: License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity International Journal of Molecular Sciences doi: 10.3390/ijms21113909 Authors: Angélica Díaz-Basabe Francesco Strati Federica Facciotti Invariant Natural Killer T (iNKT) cells are a non-conventional, innate-like, T cell population that recognize lipid antigens presented by the cluster of differentiation (CD)1d molecule. Although iNKT cells are mostly known for mediating several...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3933: The Role of Pro-Inflammatory and Regulatory Signaling by IL-33 in the Brain and Liver: A Focused Systematic Review of Mouse and Human Data and Risk of Bias Assessment of the Literature International Journal of Molecular Sciences doi: 10.3390/ijms21113933 Authors: Zharichenko Njoku Interleukin (IL)-33 is a member of the IL-1 family of proteins that have multiple roles in organ-specific inflammation. Many studies suggest diagnostic and therapeutic implications...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3936: Insight into the Genome of Diverse Penicillium chrysogenum Strains: Specific Genes, Cluster Duplications and DNA Fragment Translocations International Journal of Molecular Sciences doi: 10.3390/ijms21113936 Authors: Martín Background: There are eighteen species within the Penicillium genus section chrysogena, including the original penicillin producers Penicillium notatum (Fleming strain) and Penicillium chrysogenum NRRL 1951. Other wild type isolates of the...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3931: Differentiation of Human Cardiac Atrial Appendage Stem Cells into Adult Cardiomyocytes: A Role for the Wnt Pathway? International Journal of Molecular Sciences doi: 10.3390/ijms21113931 Authors: Willems Daniëls Fanton Linsen Evens Bito Declercq Rummens Hensen Hendrikx Human cardiac stem cells isolated from atrial appendages based on aldehyde dehydrogenase activity (CASCs) can be expanded in vitro and differentiate into mature...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3930: Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications International Journal of Molecular Sciences doi: 10.3390/ijms21113930 Authors: Del Prete Sozio Barbazza Salvi Tiberio Laffranchi Gismondi Bosisio Schioppa Sozzani Dendritic cells (DCs) constitute a complex network of cell subsets with common functions but also with many divergent aspects. All dendritic cell subsets share the ability...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3926: Evaluation of the Effect of Selected Brominated Flame Retardants on Human Serum Albumin and Human Erythrocyte Membrane Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21113926 Authors: Monika Jarosiewicz Katarzyna Miłowska Anita Krokosz Bożena Bukowska Brominated flame retardants (BFRs) have been using to reduce the flammability of plastics contained in many products, such as household articles, furniture, mattresses, textiles...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3929: Hypersensitivity of Airway Reflexes Induced by Hydrogen Sulfide: Role of TRPA1 Receptors International Journal of Molecular Sciences doi: 10.3390/ijms21113929 Authors: Chung Lin Chan Chen Hsu The activation of capsaicin-sensitive lung vagal (CSLV) afferents can elicit airway reflexes. Hypersensitivity of these afferents is known to contribute to the airway hypersensitivity during airway inflammation. Hydrogen sulfide (H2S) has been suggested...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3932: Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization International Journal of Molecular Sciences doi: 10.3390/ijms21113932 Authors: Chaudhary Kim Jee Lee Park Kim Platelet G protein-coupled receptors (GPCRs) regulate platelet function by mediating the response to various agonists, including adenosine diphosphate (ADP), thromboxane A2, and thrombin. Although GPCR kinases...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3927: Targeting Wnt Signaling for the Treatment of Gastric Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21113927 Authors: Koushyar G. Powell Vincan J. Phesse The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeostasis. Wnt signaling controls several fundamental cell functions, including proliferation, differentiation, migration, and stemness. It therefore...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3925: Functional Heterologous Expression of Mature Lipase LipA from Pseudomonas aeruginosa PSA01 in Escherichia coli SHuffle and BL21 (DE3): Effect of the Expression Host on Thermal Stability and Solvent Tolerance of the Enzyme Produced International Journal of Molecular Sciences doi: 10.3390/ijms21113925 Authors: Pulido Prieto Pieffet Méndez Jiménez-Junca This study aimed to express heterologously the lipase LipA from Pseudomonas aeruginosa PSA01...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3923: Age Dependent Modification of the Metabolic Profile of the Tibialis Anterior Muscle Fibers in C57BL/6J Mice International Journal of Molecular Sciences doi: 10.3390/ijms21113923 Authors: Emiliana Giacomello Emanuela Crea Lucio Torelli Alberta Bergamo Carlo Reggiani Gianni Sava Luana Toniolo Skeletal muscle aging is accompanied by mass reduction and functional decline, as a result of multiple factors, such as protein expression, morphology...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3922: Investigation of Some Antiviral N-Heterocycles as COVID 19 Drug: Molecular Docking and DFT Calculations International Journal of Molecular Sciences doi: 10.3390/ijms21113922 Authors: Mohamed Hagar Hoda A. Ahmed Ghadah Aljohani Omaima A. Alhaddad The novel coronavirus, COVID-19, caused by SARS-CoV-2, is a global health pandemic that started in December 2019. The effective drug target among coronaviruses is the main protease Mpro, because of its essential...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3928: Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe International Journal of Molecular Sciences doi: 10.3390/ijms21113928 Authors: Panuzzo Jovanovski Pergolizzi Pironi Stanga Fava Cilloni Mitochondria are the main fascinating energetic source into the cells. Their number, shape, and dynamism are controlled by the cell’s type and current behavior. The perturbation of the mitochondrial inward system via...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3920: Impact of the Hereditary P301L Mutation on the Correlated Conformational Dynamics of Human Tau Protein Revealed by the Paramagnetic Relaxation Enhancement NMR Experiments International Journal of Molecular Sciences doi: 10.3390/ijms21113920 Authors: Kawasaki Tate Tau forms intracellular insoluble aggregates as a neuropathological hallmark of Alzheimer’s disease. Tau is largely unstructured, which complicates the characterization of the tau aggregation...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3914: Pilot Scale Study: First Demonstration of Hydrophobic Membranes for the Removal of Ammonia Molecules from Rendering Condensate Wastewater International Journal of Molecular Sciences doi: 10.3390/ijms21113914 Authors: Brian Brennan Ciprian Briciu-Burghina Sean Hickey Thomas Abadie Sultan M. al Ma Awali Yan Delaure John Durkan Linda Holland Brid Quilty Mohammad Tajparast Casper Pulit Lorna Fitzsimons Kieran Nolan Fiona Regan Jenny...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3919: Combined Optimization of Codon Usage and Glycine Supplementation Enhances the Extracellular Production of a β-Cyclodextrin Glycosyltransferase from Bacillus sp. NR5 UPM in Escherichia coli International Journal of Molecular Sciences doi: 10.3390/ijms21113919 Authors: Nik Ida Mardiana Nik-Pa Mohamad Farhan Mohamad Sobri Suraini Abd-Aziz Mohamad Faizal Ibrahim Ezyana Kamal Bahrin Noorjahan Banu Mohammed Alitheen Norhayati Ramli Two optimization...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3921: The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function International Journal of Molecular Sciences doi: 10.3390/ijms21113921 Authors: Takumi Okamoto Kazunori Imaizumi Masayuki Kaneko Ubiquitylation plays multiple roles not only in proteasome-mediated protein degradation but also in various other cellular processes including DNA repair, signal transduction, and endocytosis. Ubiquitylation is...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3918: Salt Stress Signals on Demand: Cellular Events in the Right Context International Journal of Molecular Sciences doi: 10.3390/ijms21113918 Authors: Ahmed Ismail Islam El-Sharkawy Sherif Sherif Plant stress is a real dilemma; it puzzles plant biologists and is a global problem that negatively affects people’s daily lives. Of particular interest is salinity, because it represents one of the major water-related stress types. We aimed to determine...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3916: Cerebrovascular and Neurological Dysfunction under the Threat of COVID-19: Is There a Comorbid Role for Smoking and Vaping? International Journal of Molecular Sciences doi: 10.3390/ijms21113916 Authors: Sabrina Rahman Archie Luca Cucullo The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3917: SRC Tyrosine Kinase Inhibitor and X-rays Combined Effect on Glioblastoma Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21113917 Authors: Filippo Torrisi Luigi Minafra Francesco P. Cammarata Gaetano Savoca Marco Calvaruso Nunzio Vicario Laura Maccari Elodie A. Pérès Hayriye Özçelik Myriam Bernaudin Lorenzo Botta Giorgio Russo Rosalba Parenti Samuel Valable Glioblastoma (GBM) is one of the most...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3912: Functional and Structural Leaf Plasticity Determine Photosynthetic Performances during Drought Stress and Recovery in Two Platanus orientalis Populations from Contrasting Habitats International Journal of Molecular Sciences doi: 10.3390/ijms21113912 Authors: Velikova Arena Izzo Tsonev Koleva Tattini Roeva De Maio Loreto In the context of climatic change, more severe and long-lasting droughts will modify the fitness of plants,...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3911: A New Method for Collecting Large Amounts of Symbiotic Gastrodermal Cells from Octocorals International Journal of Molecular Sciences doi: 10.3390/ijms21113911 Authors: Hsiang-Yi Chiu Li-Yi Lin Ying Chen En-Ru Liu Hsing-Hui Li The study of cnidarian-dinoflagellate endosymbiosis in octocorals is becoming increasingly important. As symbiotic gastrodermal cells (SGCs) are the key cells in a symbiotic relationship, obtaining SGCs and studying their...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3908: Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril International Journal of Molecular Sciences doi: 10.3390/ijms21113908 Authors: Meetha Medhora Tracy Gasperetti Ashley Schamerhorn Feng Gao Jayashree Narayanan Zelmira Lazarova Elizabeth R. Jacobs Sergey Tarima Brian L. Fish The goal of this study is to understand and mitigate the effects of wounds on acute radiation syndrome (ARS)...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3905: Extracellular Matrix Analysis of Human Renal Arteries in Both Quiescent and Active Vascular State International Journal of Molecular Sciences doi: 10.3390/ijms21113905 Authors: Christian G.M. van Dijk Laura Louzao-Martinez Elise van Mulligen Bart Boermans Jeroen A.A. Demmers Thierry P.P. van den Bosch Marie-José Goumans Dirk J. Duncker Marianne C. Verhaar Caroline Cheng In vascular tissue engineering strategies, the addition of vascular-specific...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3915: How TRPC Channels Modulate Hippocampal Function International Journal of Molecular Sciences doi: 10.3390/ijms21113915 Authors: Gualdani Gailly Transient receptor potential canonical (TRPC) proteins constitute a group of receptor-operated calcium-permeable nonselective cationic membrane channels of the TRP superfamily. They are largely expressed in the hippocampus and are able to modulate neuronal functions. Accordingly, they have been involved in different...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3902: Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice International Journal of Molecular Sciences doi: 10.3390/ijms21113902 Authors: Julia A. Taylor Maren Bell Jones Cynthia L. Besch-Williford Ashley F. Berendzen William A. Ricke Frederick S. vom S. vom Saal Obstructive voiding disorder (OVD) occurs during aging in men and...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3904: Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers International Journal of Molecular Sciences doi: 10.3390/ijms21113904 Authors: Park Kim Baek The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes. Dysregulation of Wnt signaling is associated with...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3906: CAR-T Cell Therapies: An Overview of Clinical Studies Supporting Their Approved Use against Acute Lymphoblastic Leukemia and Large B-Cell Lymphomas International Journal of Molecular Sciences doi: 10.3390/ijms21113906 Authors: Aamir Ahmad Shahab Uddin Martin Steinhoff Chimeric Antigen Receptor (CAR)-T cell therapy is an exciting development in the field of cancer immunology, wherein immune T-cells from patients are collected, engineered to create ‘CAR’-T...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3907: Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression International Journal of Molecular Sciences doi: 10.3390/ijms21113907 Authors: Liang-Jun Wang Li-Ren Liou Yi-Jun Shi Jing-Ting Chiou Yuan-Chin Lee Chia-Hui Huang Po-Wei Huang Long-Sen Chang Previous studies have shown that MCL1 stabilization confers cancer cells resistance to microtubule targeting agents (MTAs) and functionally...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3901: Shoot Tip Cryopreservation of Lamprocapnos spectabilis (L.) Fukuhara Using Different Approaches and Evaluation of Stability on the Molecular, Biochemical, and Plant Architecture Levels International Journal of Molecular Sciences doi: 10.3390/ijms21113901 Authors: Kulus The aim of this study is to optimize and evaluate the effectiveness of vitrification, droplet-vitrification, and encapsulation-vitrification techniques in the cryopreservation of Lamprocapnos...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3903: Gene Therapy for Cystic Fibrosis: Progress and Challenges of Genome Editing International Journal of Molecular Sciences doi: 10.3390/ijms21113903 Authors: Giulia Maule Daniele Arosio Anna Cereseto Since the early days of its conceptualization and application, human gene transfer held the promise of a permanent solution to genetic diseases including cystic fibrosis (CF). This field went through alternated periods of enthusiasm and distrust. The development...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3899: Fatty Acid Profile and Desaturase Activities in 7–10-Year-Old Children Attending Primary School in Verona South District: Association between Palmitoleic Acid, SCD-16, Indices of Adiposity, and Blood Pressure International Journal of Molecular Sciences doi: 10.3390/ijms21113899 Authors: Bonafini Giontella Tagetti Bresadola Gaudino Cavarzere Ramaroli Branz Marcon Pietrobelli Minuz Antoniazzi Maffeis Fava In...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3900: Drug-Related Cutaneous Adverse Events in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms: A Literature Review International Journal of Molecular Sciences doi: 10.3390/ijms21113900 Authors: Malato Rossi Palumbo Guglielmelli Pugliese Since myeloproliferative neoplasms (MPN) pose a significant risk for vascular and thrombotic complications, cytoreductive therapies, such as hydroxyurea (HU), interferon (IFN) inhibitors, and Janus...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3898: Testing the Effectiveness of Curcuma longa Leaf Extract on a Skin Equivalent Using a Pumpless Skin-on-a-Chip Model International Journal of Molecular Sciences doi: 10.3390/ijms21113898 Authors: Kyunghee Kim Hye Mi Jeon Kyung Chan Choi Gun Yong Sung The in vitro tests in current research employ simple culture methods that fail to mimic the real human tissue. In this study, we report drug testing with a ‘pumpless skin-on-a-chip’ that...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3897: TLR2, TLR4 and TLR10 Shape the Cytokine and Chemokine Release of H. pylori-Infected Human DCs International Journal of Molecular Sciences doi: 10.3390/ijms21113897 Authors: Theresa Neuper Tobias Frauenlob Muamera Sarajlic Gernot Posselt Silja Wessler Jutta Horejs-Hoeck Helicobacter pylori (H. pylori) is a stomach pathogen that persistently colonizes the gastric mucosa, often leading to chronic inflammation and gastric pathologies. Although infection...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3896: Expression and Role of Response Regulating, Biosynthetic and Degrading Genes for Cytokinin Signaling during Clubroot Disease Development International Journal of Molecular Sciences doi: 10.3390/ijms21113896 Authors: Rawnak Laila Arif Hasan Khan Robin Jong-In Park Gopal Saha Hoy-Taek Kim Md. Abdul Kayum Ill-Sup Nou The obligate biotroph Plasmodiophora brassicae causes clubroot disease in oilseeds and vegetables of the Brassicaceae family, and...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3894: Correction: Zhang, Z.; et al. Roles of MicroRNAs in Establishing and Modulating Stem Cell Potential. Int. J. Mol. Sci. 2019, 20, 3643 International Journal of Molecular Sciences doi: 10.3390/ijms21113894 Authors: Zhenwu Zhang Lili Zhuang Chao-Po Lin The authors wish to make the following correction to this paper [...]
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3895: Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide International Journal of Molecular Sciences doi: 10.3390/ijms21113895 Authors: Yosuke Hirotsu Udo Schmidt-Edelkraut Hiroshi Nakagomi Ikuko Sakamoto Markus Hartenfeller Ram Narang Theodoros G. Soldatos Sajo Kaduthanam Xiaoyue Wang Stephan Hettich Stephan Brock David B. Jackson Masao Omata BRCA1/2...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3893: Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models International Journal of Molecular Sciences doi: 10.3390/ijms21113893 Authors: Gabriele Di Rosa Giovanni Brunetti Maria Scuto Angela Trovato Salinaro Edward J. Calabrese Roberto Crea Christian Schmitz-Linneweber Vittorio Calabrese Nadine Saul Parkinson’s disease (PD) is the second most prevalent late-age onset neurodegenerative disorder,...
Fri May 29, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου