Cancers, Vol. 12, Pages 1413: Prognostic Implications of CD10 and CD15 Expression in Papillary Thyroid Carcinoma Cancers doi: 10.3390/cancers12061413 Authors: Eun Ji Oh Andrey Bychkov Haejin Cho Tae-Min Kim Ja Seong Bae Dong-Jun Lim Chan Kwon Jung Patients with papillary thyroid carcinoma (PTC) have excellent survival, but recurrence remains a major problem in the management of PTC. We aimed to determine the prognostic impact of the expression of CD10 and CD15 in patients...
Sat May 30, 2020 03:00
Cancers, Vol. 12, Pages 1412: A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants Cancers doi: 10.3390/cancers12061412 Authors: Chang Woo Han Mi Suk Jeong Sung Chul Ha Se Bok Jang Kirsten-RAS (KRAS) has been the target of drugs because it is the most mutated gene in human cancers. Because of the low affinity of drugs for KRAS mutations, it was difficult to target these tumor genes directly. We found a direct interaction between KRAS G12V...
Sat May 30, 2020 03:00
Cancers, Vol. 12, Pages 1414: Inflammatory Cytokines and ctDNA Are Biomarkers for Progression in Advanced-Stage Melanoma Patients Receiving Checkpoint Inhibitors Cancers doi: 10.3390/cancers12061414 Authors: Jesper Geert Pedersen Anne Tranberg Madsen Kristine Raaby Gammelgaard Ninna Aggerholm-Pedersen Boe Sandahl Sørensen Trine Heide Øllegaard Martin Roelsgaard Jakobsen Purpose: Checkpoint inhibitors have significantly improved treatment of metastatic melanoma. However,...
Sat May 30, 2020 03:00
Cancers, Vol. 12, Pages 1411: Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages Cancers doi: 10.3390/cancers12061411 Authors: Irina Larionova Elena Kazakova Marina Patysheva Julia Kzhyshkowska Macrophages are key innate immune cells in the tumor microenvironment (TME) that regulate primary tumor growth, vascularization, metastatic spread and tumor response to various types of therapies. The present review highlights the mechanisms of macrophage...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1410: The Pivotal Role of the Dysregulation of Cholesterol Homeostasis in Cancer: Implications for Therapeutic Targets Cancers doi: 10.3390/cancers12061410 Authors: Mok Lee Cholesterol plays an important role in cellular homeostasis by maintaining the rigidity of cell membranes, providing a medium for signaling transduction, and being converted into other vital macromolecules, such as sterol hormones and bile acids. Epidemiological studies have shown the...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1409: Utilisation of Colorectal Cancer Screening Tests in European Countries by Type of Screening Offer: Results from the European Health Interview Survey Cancers doi: 10.3390/cancers12061409 Authors: Cardoso Guo Heisser Hoffmeister Brenner In the past two decades, an extensive rollout of colorectal cancer (CRC) screening programmes has been initiated in European countries with a large heterogeneity of screening offers. Using data from a population-based...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1408: Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights Cancers doi: 10.3390/cancers12061408 Authors: Ye Xi Huang Xu The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades. More than 650 million obese and 2 billion overweight individuals are currently living in the world. CRC is the third most common cancer. Obesity is regarded as one of the key environmental risk factors for the pathogenesis...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1407: Exercise Attenuates the Transition from Fatty Liver to Steatohepatitis and Reduces Tumor Formation in Mice Cancers doi: 10.3390/cancers12061407 Authors: Guarino Kumar Felser Terracciano Guixé-Muntet Humar Foti Nuoffer St-Pierre Dufour Non-alcoholic fatty liver disease (NAFLD) leads to steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. For sedentary patients, lifestyle interventions combining exercise and...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1406: The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response Cancers doi: 10.3390/cancers12061406 Authors: Sánchez-Alcoholado Ramos-Molina Otero Laborda-Illanes Ordóñez Medina Gómez-Millán Queipo-Ortuño Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota can alter CRC susceptibility...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1405: Neuronal Repressor REST Controls Ewing Sarcoma Growth and Metastasis by Affecting Vascular Pericyte Coverage and Vessel Perfusion Cancers doi: 10.3390/cancers12061405 Authors: Zhichao Zhou Yuanzheng Yang Fei Wang Eugenie S. Kleinerman Survival rates for Ewing sarcoma (ES) patients with metastatic disease have not improved in over 20 years. Tumor growth and metastasis are dependent on tumor vasculature expansion; therefore, identifying the regulators...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1404: Neoadjuvant Treatment for Triple Negative Breast Cancer: Recent Progresses and Challenges Cancers doi: 10.3390/cancers12061404 Authors: Jin Sun Lee Susan E. Yost Yuan Yuan Triple negative breast cancer (TNBC) is an aggressive breast cancer with historically poor outcomes, primarily due to the lack of effective targeted therapies. The tumor molecular heterogeneity of TNBC has been well recognized, yet molecular subtype driven therapy remains lacking....
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1403: Spectrum-Wide Exploration of Human Adenoviruses for Breast Cancer Therapy Cancers doi: 10.3390/cancers12061403 Authors: Nicolas Mach Jian Gao Lukas Schaffarczyk Sebastian Janz Eric Ehrke-Schulz Thomas Dittmar Anja Ehrhardt Wenli Zhang Oncolytic adenoviruses (Ads) are promising tools for cancer therapeutics. However, most Ad-based therapies utilize Ad type 5 (Ad5), which displays unsatisfying efficiency in clinical trials, partly due...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1402: Gastric Cancer Staging: Is It Time for Magnetic Resonance Imaging? Cancers doi: 10.3390/cancers12061402 Authors: Matteo Renzulli Alfredo Clemente Daniele Spinelli Anna Maria Ierardi Giovanni Marasco Davide Farina Stefano Brocchi Matteo Ravaioli Irene Pettinari Matteo Cescon Alfonso Reginelli Salvatore Cappabianca Gianpaolo Carrafiello Rita Golfieri Gastric cancer (GC) is a common cancer worldwide. Its incidence and...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1398: Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord–Stromal Tumors: A Contemporary Review Cancers doi: 10.3390/cancers12061398 Authors: Asaf Maoz Koji Matsuo Marcia A. Ciccone Shinya Matsuzaki Maximilian Klar Lynda D. Roman Anil K. Sood David M. Gershenson Non-epithelial ovarian tumors are heterogeneous and account for approximately 10% of ovarian malignancies. The most common subtypes of non-epithelial...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1400: Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles Cancers doi: 10.3390/cancers12061400 Authors: Manuel Castanheira de Oliveira Hugo R. Caires Maria J. Oliveira Avelino Fraga M. Helena Vasconcelos Ricardo Ribeiro Extracellular vesicles (EVs) are small membrane vesicles released by all cells and involved in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipids, and...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1399: ABL Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo Cancers doi: 10.3390/cancers12061399 Authors: Shu-Huey Chen Yao-Yu Hsieh Huey-En Tzeng Chun-Yu Lin Kai-Wen Hsu Yun-Shan Chiang Su-Mei Lin Ming-Jang Su Wen-Shyang Hsieh Chia-Hwa Lee Chronic myelogenous leukemia (CML) is the most common type of leukemia in adults, and more than 90% of CML patients harbor the abnormal...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1397: Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells Cancers doi: 10.3390/cancers12061397 Authors: Ana Lazaro-Carrillo Macarena Calero Antonio Aires Aitziber L. Cortajarena Bruno M. Simões Alfonso Latorre Álvaro Somoza Robert B. Clarke Rodolfo Miranda Angeles Villanueva Nanotechnology-based approaches hold substantial potential to avoid chemoresistance and minimize side effects....
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1401: Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors Cancers doi: 10.3390/cancers12061401 Authors: Mans Broekgaarden Ahmed Alkhateeb Shazia Bano Anne-Laure Bulin Girgis Obaid Imran Rizvi Tayyaba Hasan Extensive desmoplasia is a hallmark of pancreatic ductal adenocarcinoma (PDAC), which frequently associates with treatment resistance. Recent findings indicate that a combination...
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1362: Epigenetic Analysis of Circulating Tumor DNA in Localized and Metastatic Prostate Cancer: Evaluation of Clinical Biomarker Potential Cells doi: 10.3390/cells9061362 Authors: Marianne Trier Bjerre Maibritt Nørgaard Ole Halfdan Larsen Sarah Østrup Jensen Siri H. Strand Peter Østergren Mikkel Fode Jacob Fredsøe Benedicte Parm Ulhøi Martin Mørck Mortensen Jørgen Bjerggaard Jensen Michael Borre Karina D. Sørensen Novel and minimally-invasive...
Sun May 31, 2020 03:00
Cells, Vol. 9, Pages 1361: Current View on EpCAM Structural Biology Cells doi: 10.3390/cells9061361 Authors: Aljaž Gaber Brigita Lenarčič Miha Pavšič EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been primarily addressed as a cell adhesion molecule. With regard to recent discoveries of its role in signaling with implications in cell proliferation and differentiation, and findings contradicting a direct role in mediating adhesion contacts, we provide...
Sun May 31, 2020 03:00
Cells, Vol. 9, Pages 1360: TERC Variants Associated with Short Leukocyte Telomeres: Implication of Higher Early Life Leukocyte Telomere Attrition as Assessed by the Blood-and-Muscle Model Cells doi: 10.3390/cells9061360 Authors: Simon Toupance Maria G. Stathopoulou Alexandros M. Petrelis Vesna Gorenjak Carlos Labat Tsung-Po Lai Sophie Visvikis-Siest Athanase Benetos Short leukocyte telomere length (LTL) is associated with atherosclerotic cardiovascular disease (ASCVD)....
Sun May 31, 2020 03:00
Cells, Vol. 9, Pages 1359: DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers Cells doi: 10.3390/cells9061359 Authors: Ekanayake Weeramange Tang Vasani Langton-Lockton Kenny Punyadeera Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins...
Sun May 31, 2020 03:00
Cells, Vol. 9, Pages 1358: [68Ga]-NODAGA-RGD Positron Emission Tomography (PET) for Assessment of Post Myocardial Infarction Angiogenesis as a Predictor for Left Ventricular Remodeling in Mice after Cardiac Stem Cell Therapy Cells doi: 10.3390/cells9061358 Authors: Cajetan Immanuel Lang Piet Döring Ralf Gäbel Praveen Vasudevan Heiko Lemcke Paula Müller Jan Stenzel Tobias Lindner Markus Joksch Jens Kurth Carina Bergner Hans-Jürgen Wester Hüseyin Ince Gustav...
Sat May 30, 2020 03:00
Cells, Vol. 9, Pages 1357: Human Liver-Derived Extracellular Matrix for the Culture of Distinct Human Primary Liver Cells Cells doi: 10.3390/cells9061357 Authors: Alevra Sarika Payen Fléron Ravau Brusa Najimi Pauw Eppe Mazzucchelli Sokal Rieux Taghdouini The lack of robust methods to preserve, purify and in vitro maintain the phenotype of the human liver’s highly specialized parenchymal and non-parenchymal cell types importantly...
Sat May 30, 2020 03:00
Cells, Vol. 9, Pages 1353: Algae-Bacteria Consortia as a Strategy to Enhance H2 Production Cells doi: 10.3390/cells9061353 Authors: Neda Fakhimi David Gonzalez-Ballester Emilio Fernández Aurora Galván Alexandra Dubini Biological hydrogen production by microalgae is a potential sustainable, renewable and clean source of energy. However, many barriers limiting photohydrogen production in these microorganisms remain unsolved. In order to explore this potential and make biohydrogen...
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1355: Molecular Dissection of Neurodevelopmental Disorder-Causing Mutations in CYFIP2 Cells doi: 10.3390/cells9061355 Authors: Matthias Schaks Michael Reinke Walter Witke Klemens Rottner Actin remodeling is frequently regulated by antagonistic activities driving protrusion and contraction downstream of Rac and Rho small GTPases, respectively. WAVE regulatory complex (WRC), which primarily operates downstream of Rac, plays pivotal roles in neuronal morphogenesis....
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1354: The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation Cells doi: 10.3390/cells9061354 Authors: Marianna Ranieri Maria Venneri Tommaso Pellegrino Mariangela Centrone Annarita Di Mise Susanna Cotecchia Grazia Tamma Giovanna Valenti NSIAD is a rare X-linked condition,...
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1352: Blocking the Bromodomains Function Contributes to Disturbances in Alga Chara vulgaris Spermatids Differentiation Cells doi: 10.3390/cells9061352 Authors: Agnieszka Wojtczak Bromodomain containing (BRD) proteins play an essential role in many cellular processes. The aim of this study was to estimate activity of bromodomains during alga Chara vulgaris spermatids differentiation. The effect of a bromodomain inhibitor, JQ1 (100 µM), on the distribution...
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1356: PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes Cells doi: 10.3390/cells9061356 Authors: Minjie Tan Helena T.A. van Tol David Rosenkranz Elke F. Roovers Mirjam J. Damen Tom A.E. Stout Wei Wu Bernard A.J. Roelen P-element induced wimpy testis (PIWIs) are crucial guardians of genome integrity, particularly in germ cells. While mammalian PIWIs have been primarily studied in mouse and rat, a homologue for the human PIWIL3 gene is absent...
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1351: Centering and Shifting of Centrosomes in Cells Cells doi: 10.3390/cells9061351 Authors: Anton V. Burakov Elena S. Nadezhdina Centrosomes have a nonrandom localization in the cells: either they occupy the centroid of the zone free of the actomyosin cortex or they are shifted to the edge of the cell, where their presence is justified from a functional point of view, for example, to organize additional microtubules or primary cilia. This review discusses centrosome...
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1350: Generation of Multipotent Stem Cells from Adult Human Peripheral Blood Following the Treatment with Platelet-Derived Mitochondria Cells doi: 10.3390/cells9061350 Authors: Haibo Yu Wei Hu Xiang Song Yong Zhao Autologous stem cells are highly preferred for cellular therapy to treat human diseases. Mitochondria are organelles normally located in cytoplasm. Our recent studies demonstrated the differentiation of adult peripheral blood-derived insulin-producing...
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1349: Non-Human Primate iPSC Generation, Cultivation, and Cardiac Differentiation under Chemically Defined Conditions Cells doi: 10.3390/cells9061349 Authors: Michael Stauske Ignacio Rodriguez Polo Wadim Haas Debbra Yasemin Knorr Thomas Borchert Katrin Streckfuss-Bömeke Ralf Dressel Iris Bartels Malte Tiburcy Wolfram-Hubertus Zimmermann Rüdiger Behr Non-human primates (NHP) are important surrogate models for late preclinical development...
Fri May 29, 2020 03:00
Cells, Vol. 9, Pages 1348: NF-κB and tPA Signaling in Kidney and Other Diseases Cells doi: 10.3390/cells9061348 Authors: Samantha White Ling Lin Kebin Hu The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating...
Fri May 29, 2020 03:00
Climate, Vol. 8, Pages 68: Surface Temperature Trend Estimation over 12 Sites in Guinea Using 57 Years of Ground-Based Data Climate doi: 10.3390/cli8060068 Authors: René Tato Loua Hassan Bencherif Nelson Bègue Nkanyiso Mbatha Thierry Portafaix Alain Hauchecorne Venkataraman Sivakumar Zoumana Bamba Trend-Run model was performed to estimate the trend in surface temperatures recorded at 12 sites in Guinea from 1960 to 2016 and to examine the contribution of each climate...
Sun May 31, 2020 03:00
Climate, Vol. 8, Pages 67: An Investigation into the Future Changes in Onset and Cessation of Rain and their Variability over the Aswa Catchment, Uganda Climate doi: 10.3390/cli8060067 Authors: Michael Iwadra P.T. Odirile B.P. Parida D.B. Moalafhi Future global warming may result in extreme precipitation events leading to crop, environment and infrastructure damage. Rainfall is a major input for the livelihood of peasant farmers in the Aswa catchment where the future rainfall...
Fri May 29, 2020 03:00
Clocks & Sleep, Vol. 2, Pages 225-245: Can Special Light Glasses Reduce Sleepiness and Improve Sleep of Nightshift Workers? A Placebo-Controlled Explorative Field Study Clocks & Sleep doi: 10.3390/clockssleep2020018 Authors: Mariëlle P. J. Aarts Steffen L. Hartmeyer Kars Morsink Helianthe S. M. Kort Yvonne A. W. de Kort Nightshift workers go against the natural sleep–wake rhythm. Light can shift the circadian clock but can also induce acute alertness. This...
Fri May 29, 2020 03:00
Clocks & Sleep, Vol. 2, Pages 208-224: Auditory Countermeasures for Sleep Inertia: Exploring the Effect of Melody and Rhythm in an Ecological Context Clocks & Sleep doi: 10.3390/clockssleep2020017 Authors: Stuart J. McFarlane Jair E. Garcia Darrin S. Verhagen Adrian G. Dyer Sleep inertia is a decline in cognition one may experience upon and following awakening. A recent study revealed that an alarm sound perceived as melodic by participants displayed a significant relationship...
Fri May 29, 2020 03:00
Diagnostics, Vol. 10, Pages 361: Analyzing 24-Hour Blood Pressure Measurements with a Novel Cuffless Pulse Transit Time Device in Clinical Practice—Does the Software for Heartbeat Detection Matter? Diagnostics doi: 10.3390/diagnostics10060361 Authors: Kilian Krisai Socrates Arranto Pfister Meienberg Mayr Vischer Burkard : Background: The Somnotouch-Non-Invasive-Blood-Pressure (NIBP) device delivers raw data consisting of electrocardiography and photoplethysmography...
Sun May 31, 2020 03:00
Diagnostics, Vol. 10, Pages 360: Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model—An Experimental and Computational Approach Diagnostics doi: 10.3390/diagnostics10060360 Authors: Johana M. Guevara-Morales Michael Frohbergh Hector Castro-Abril Juan J. Vaca-González Luis A. Barrera Diego A. Garzón-Alvarado Edward Schuchman Calogera Simonaro Background: Mucopolysaccharidoses (MPS) are a group of inherited metabolic diseases caused by impaired function...
Sun May 31, 2020 03:00
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