Biomolecules, Vol. 10, Pages 834: Significance of STAT3 in Immune Infiltration and Drug Response in Cancer Biomolecules doi: 10.3390/biom10060834 Authors: Wei Chen Xiaoshuo Dai Yihuan Chen Fang Tian Yanyan Zhang Qiushuang Zhang Jing Lu Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and regulates tumorigenesis. However, the functions of STAT3 in immune and drug response in cancer remain elusive. Hence, we aim to reveal the impact...
Fri May 29, 2020 03:00
Biomolecules, Vol. 10, Pages 831: The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin Biomolecules doi: 10.3390/biom10060831 Authors: Ching-Shu Lai Chi-Tang Ho Min-Hsiung Pan In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research....
Fri May 29, 2020 03:00
Biomolecules, Vol. 10, Pages 832: Naturally Occurring and Artificial N9-Cytokinin Conjugates: From Synthesis to Biological Activity and Back Biomolecules doi: 10.3390/biom10060832 Authors: Hana Vylíčilová Magdaléna Bryksová Vlasta Matušková Karel Doležal Lucie Plíhalová Miroslav Strnad Cytokinins and their sugar or non-sugar conjugates are very active growth-promoting factors in plants, although they occur at very low concentrations. These compounds have been identified...
Fri May 29, 2020 03:00
Biomolecules, Vol. 10, Pages 830: Novel Intact Polar and Core Lipid Compositions in the Pyrococcus Model Species, P. furiosus and P. yayanosii, Reveal the Largest Lipid Diversity Amongst Thermococcales Biomolecules doi: 10.3390/biom10060830 Authors: Maxime Tourte Vanessa Kuentz Philippe Schaeffer Vincent Grossi Anais Cario Philippe M. Oger Elucidating the lipidome of Archaea is essential to understand their tolerance to extreme environmental conditions. Previous characterizations...
Fri May 29, 2020 03:00
Biomolecules, Vol. 10, Pages 829: Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113–122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice Biomolecules doi: 10.3390/biom10060829 Authors: Andrea Rivas-Urbina Anna Rull Joile Aldana-Ramos David Santos Nuria Puig Nuria Farre-Cabrerizo Sonia Benitez Antonio Perez David de Gonzalo-Calvo Joan Carles Escola-Gil Josep Julve Jordi Ordoñez-Llanos Jose Luis Sanchez-Quesada...
Fri May 29, 2020 03:00
Biosensors, Vol. 10, Pages 59: Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging Biosensors doi: 10.3390/bios10060059 Authors: Lina D. Ardila-Diaz Taíla V. de Oliveira Nilda de F. F. Soares Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development...
Sun May 31, 2020 03:00
Biosensors, Vol. 10, Pages 58: Application of Biosensors for Detection of Pathogenic Food Bacteria: A Review Biosensors doi: 10.3390/bios10060058 Authors: Athmar A. Ali Ammar B. Altemimi Nawfal Alhelfi Salam A. Ibrahim The use of biosensors is considered a novel approach for the rapid detection of foodborne pathogens in food products. Biosensors, which can convert biological, chemical, or biochemical signals into measurable electrical signals, are systems containing a biological...
Sat May 30, 2020 03:00
Biosensors, Vol. 10, Pages 57: Characteristics of an Extended Gate Field-Effect Transistor for Glucose Sensing Using an Enzyme-Containing Silk Fibroin Membrane as the Bio-Chemical Component Biosensors doi: 10.3390/bios10060057 Authors: Kazuto Koike Taihou Sasaki Kenta Hiraki Kodai Ike Yuichi Hirofuji Mitsuaki Yano The characteristics of a glucose sensor based on an ion-sensitive TiO2/Ti extended gate electrode field-effect transistor (EGFET) are reported. A glucose oxidase-containing...
Fri May 29, 2020 03:00
Brain Sciences, Vol. 10, Pages 336: Sensory Profiles of Children with Autism Spectrum Disorder with and without Feeding Problems: A Comparative Study in Sicilian Subjects Brain Sciences doi: 10.3390/brainsci10060336 Authors: Simonetta Panerai Raffaele Ferri Valentina Catania Marinella Zingale Daniela Ruccella Donatella Gelardi Daniela Fasciana Maurizio Elia The aim of this study is to better understand the relationship between sensory and feeding problems in Autism...
Sun May 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 335: The Bilateral Ovariectomy in a Female Animal Exacerbates the Pathogenesis of an Intracranial Aneurysm Brain Sciences doi: 10.3390/brainsci10060335 Authors: Oka Ono Shimizu Kushamae Miyata Kawamata Aoki Considering the poor outcome of subarachnoid hemorrhage (SAH) due to the rupture of intracranial aneurysms (IA), mechanisms underlying the pathogenesis of IAs, especially the rupture of lesions, should be clarified. In the present...
Sun May 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 334: Endovascular Temporary Balloon Occlusion for Microsurgical Clipping of Posterior Circulation Aneurysms Brain Sciences doi: 10.3390/brainsci10060334 Authors: Kienzler Diepers Marbacher Remonda Fandino Based on the relationship between the posterior clinoid process and the basilar artery (BA) apex it may be difficult to obtain proximal control of the BA using temporary clips. Endovascular BA temporary balloon occlusion (TBO) can reduce...
Sat May 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 331: Infants’ Gaze Patterns for Same-Race and Other-Race Faces, and the Other-Race Effect Brain Sciences doi: 10.3390/brainsci10060331 Authors: Anna Krasotkina Antonia Götz Barbara Höhle Gudrun Schwarzer The other-race effect (ORE) can be described as difficulties in discriminating between faces of ethnicities other than one’s own, and can already be observed at approximately 9 months of age. Recent studies also showed that infants visually...
Fri May 29, 2020 03:00
Brain Sciences, Vol. 10, Pages 332: Increased Time Difference between Imagined and Physical Walking in Older Adults at a High Risk of Falling Brain Sciences doi: 10.3390/brainsci10060332 Authors: Hideki Nakano Shin Murata Kayoko Shiraiwa Koji Nonaka Walking motor imagery ability is thought to be associated with a fear of falling; however, no studies have compared fall risk and motor imagery ability. This study aimed to ascertain the time difference between imagined and physical...
Fri May 29, 2020 03:00
Brain Sciences, Vol. 10, Pages 333: Recent Advances in Antigen-Specific Immunotherapies for the Treatment of Multiple Sclerosis Brain Sciences doi: 10.3390/brainsci10060333 Authors: Olga Kammona Costas Kiparissides Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is considered to be the leading non-traumatic cause of neurological disability in young adults. Current treatments for MS comprise long-term immunosuppressant drugs and disease-modifying...
Fri May 29, 2020 03:00
Brain Sciences, Vol. 10, Pages 330: VEGF Upregulates EGFR Expression to Stimulate Chemotactic Behaviors in the rMC-1 Model of Müller Glia Brain Sciences doi: 10.3390/brainsci10060330 Authors: Juan S. Peña Maribel Vazquez Progressive vision loss in adults has become increasingly prevalent worldwide due to retinopathies associated with aging, genetics, and epigenetic factors that damage the retinal microvasculature. Insufficient supply of oxygen and/or nutrients upregulates factors...
Fri May 29, 2020 03:00
Cancers, Vol. 12, Pages 1438: Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study Cancers doi: 10.3390/cancers12061438 Authors: Roman Kocian Jiri Slama Daniela Fischerova Anna Germanova Andrea Burgetova Ladislav Dusek Pavel Dundr Kristyna Nemejcova Jiri Jarkovsky Silvie Sebestova Filip Fruhauf Lukas Dostalek Tereza Ballaschova David...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1436: Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities Cancers doi: 10.3390/cancers12061436 Authors: Turdo Porcelli D’Accardo Franco Verona Forte Giuffrida Memeo Todaro Stassi Although improvement in early diagnosis and treatment ameliorated life expectancy of cancer patients, metastatic disease still lacks effective therapeutic approaches. Resistance to anticancer therapies stems from the refractoriness...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1434: Combined Targeting of Glioblastoma Stem-Like Cells by Neutralizing RNA-Bio-Drugs for STAT3 Cancers doi: 10.3390/cancers12061434 Authors: Carla Lucia Esposito Silvia Nuzzo Maria Luigia Ibba Lucia Ricci-Vitiani Roberto Pallini Gerolama Condorelli Silvia Catuogno Vittorio de Franciscis An important drawback in the management of glioblastoma (GBM) patients is the frequent relapse upon surgery and therapy. A likely explanation is that conventional...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1437: BAX Redistribution Induces Apoptosis Resistance and Selective Stress Sensitivity in Human HCC Cancers doi: 10.3390/cancers12061437 Authors: Kathrin Funk Carolin Czauderna Ramona Klesse Diana Becker Jovana Hajduk Aline Oelgeklaus Frank Reichenbach Franziska Fimm-Todt Joachim Lauterwasser Peter R. Galle Jens U. Marquardt Frank Edlich Cancer therapies induce differential cell responses, ranging from efficient cell death to complete...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1433: A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12061433 Authors: Rocio I. R. Macias Luis Muñoz-Bellvís Anabel Sánchez-Martín Enara Arretxe Ibon Martínez-Arranz Ainhoa Lapitz M. Laura Gutiérrez Adelaida La La Casta Cristina Alonso Luis M. González Matias A. Avila Maria L. Martinez-Chantar Rui E. Castro Luis Bujanda...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1432: Association of a CT-Based Clinical and Radiomics Score of Non-Small Cell Lung Cancer (NSCLC) with Lymph Node Status and Overall Survival Cancers doi: 10.3390/cancers12061432 Authors: Francesca Botta Sara Raimondi Lisa Rinaldi Federica Bellerba Federica Corso Vincenzo Bagnardi Daniela Origgi Rocco Minelli Giovanna Pitoni Francesco Petrella Lorenzo Spaggiari Alessio G. Morganti Filippo Del Del Grande Massimo Bellomi Stefania...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1431: Characterization of a Myeloid Activation Signature that Correlates with Survival in Melanoma Patients Cancers doi: 10.3390/cancers12061431 Authors: Kremenovic Rombini Chan Gruber Bäriswyl Lee Schenk Understanding the cellular interactions within the tumor microenvironment (TME) of melanoma paved the way for novel therapeutic modalities, such as T cell-targeted immune checkpoint inhibitors (ICI). However, only a limited fraction of...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1430: Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer Cancers doi: 10.3390/cancers12061430 Authors: Marlène Deschuyter Florian Pennarubia Emilie Pinault Sébastien Legardinier Abderrahman Maftah Background: Protein O-fucosyltransferase 1 (POFUT1) overexpression, which is observed in many cancers such as colorectal cancer (CRC), leads to a NOTCH signaling dysregulation associated with the tumoral process. In rare CRC...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1435: The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling Cancers doi: 10.3390/cancers12061435 Authors: Bang Manh Tran Dustin James Flanagan Gregor Ebert Nadia Warner Hoanh Tran Theodora Fifis Georgios Kastrappis Christopher Christophi Marc Pellegrini Joseph Torresi Toby James Phesse Elizabeth Vincan An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms....
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1427: The Recombinant Fragment of Human κ-Casein Induces Cell Death by Targeting the Proteins of Mitochondrial Import in Breast Cancer Cells Cancers doi: 10.3390/cancers12061427 Authors: Max Richter Fabian Wohlfromm Thilo Kähne Hannes Bongartz Kamil Seyrek Yuriy Kit Olga Chinak Vladimir A. Richter Olga A. Koval Inna N. Lavrik Breast cancer is still one of the most common cancers for women. Specified therapeutics are indispensable for...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1425: A Phase 1 Study of mTORC1/2 Inhibitor BI 860585 as a Single Agent or with Exemestane or Paclitaxel in Patients with Advanced Solid Tumors Cancers doi: 10.3390/cancers12061425 Authors: Filippo de Braud Jean-Pascal H. Machiels Daniela Boggiani Sylvie W.H. Rottey Matteo Duca Marie Laruelle Stefania Salvagni Silvia Damian Lore D.F. Lapeire Marcello Tiseo Alexandre Dermine Mahmoud Ould-Kaci Juergen Braunger Juliane Rascher Daniela...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1428: Benefits of Conversion Surgery after Multimodal Treatment for Unresectable Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12061428 Authors: Yanagimoto Satoi Yamamoto Yamaki Hirooka Kotsuka Ryota Ishida Matsui Sekimoto Background: Traditionally, the treatment options for unresectable locally advanced (UR-LA) and metastatic (UR-M) pancreatic ductal adenocarcinoma (PDAC) are palliative chemotherapy or chemoradiotherapy....
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1426: Retrospective Multicentric Study on Non-Optic CNS Tumors in Children and Adolescents with Neurofibromatosis Type 1 Cancers doi: 10.3390/cancers12061426 Authors: Santoro Picariello Palladino Spennato Melis Roth Cirillo Quaglietta D’Amico Gaudino Meucci Ferrara Constantini Perrotta Cinalli s: The natural history of non-optic central nervous system (CNS) tumors in neurofibromatosis type 1 (NF1) is largely...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1424: Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer Cancers doi: 10.3390/cancers12061424 Authors: Toshihiko Takeiwa Kazuhiro Ikeda Yuichi Mitobe Kuniko Horie-Inoue Satoshi Inoue Long noncoding RNAs (lncRNAs) are defined as RNAs longer than 200 nucleotides that do not encode proteins. Recent studies have demonstrated that numerous lncRNAs are expressed in humans and play key roles in the development of various types...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1423: Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma Cancers doi: 10.3390/cancers12061423 Authors: Ramzy Koessler Ducrey McKee Ris Buchs Rubbia-Brandt Dietrich Nowak-Sliwinska Lack of relevant preclinical models that reliably recapitulate the complexity and heterogeneity of human cancer has slowed down the development and approval of new anti-cancer therapies. Even though two-dimensional in vitro culture...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1429: Baseline Splenic Volume as a Prognostic Biomarker of FOLFIRI Efficacy and a Surrogate Marker of MDSC Accumulation in Metastatic Colorectal Carcinoma Cancers doi: 10.3390/cancers12061429 Authors: Julie Niogret Emeric Limagne Marion Thibaudin Julie Blanc Aurelie Bertaut Karine Le Malicot Yves Rinaldi François-Xavier Caroli-Bosc Franck Audemar Suzanne Nguyen Corinne Sarda Catherine Lombard-Bohas Christophe Locher Miguel Carreiro...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1422: Surveillance for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: Universal or Selective? Cancers doi: 10.3390/cancers12061422 Authors: Plaz Torres Bodini Furnari Marabotto Zentilin Strazzabosco Giannini Hepatocellular carcinoma (HCC), the most frequent primary liver cancer, is the sixth most common cancer, the fourth leading cause of cancer-related deaths worldwide, and accounts globally for about 800,000...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1419: Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12061419 Authors: Sangineto Villani Cavallone Romano Loizzi Serviddio : Metabolic reprogramming is critically involved in the development and progression of cancer. In particular, lipid metabolism has been investigated as a source of energy, micro-environmental adaptation, and cell signalling in neoplastic cells. However, the specific...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1420: Targeted Osmotic Lysis of Highly Invasive Breast Carcinomas Using Pulsed Magnetic Field Stimulation of Voltage-Gated Sodium Channels and Pharmacological Blockade of Sodium Pumps Cancers doi: 10.3390/cancers12061420 Authors: Paul Maggi Piero Scahill Sherman Edenfield Gould Abstract: Concurrent activation of voltage-gated sodium channels (VGSCs) and blockade of Na+ pumps causes a targeted osmotic lysis (TOL) of carcinomas that over-express...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1421: Galectins and Ovarian Cancer Cancers doi: 10.3390/cancers12061421 Authors: Chisa Shimada Rui Xu Linah Al-Alem Marina Stasenko David R. Spriggs Bo R. Rueda Ovarian cancer is known for its aggressive pathological features, including the capacity to undergo epithelial to mesenchymal transition, promoting angiogenesis, metastatic potential, chemoresistance, inhibiting apoptosis, immunosuppression and promoting stem-like features. Galectins, a...
Sun May 31, 2020 03:00
Cancers, Vol. 12, Pages 1418: Pharmacogenomic Analysis Reveals CCNA2 as a Predictive Biomarker of Sensitivity to Polo-Like Kinase I Inhibitor in Gastric Cancer Cancers doi: 10.3390/cancers12061418 Authors: Yunji Lee Chae Eun Lee Sejin Oh Hakhyun Kim Jooyoung Lee Sang Bum Kim Hyun Seok Kim Despite recent innovations and advances in early diagnosis, the prognosis of advanced gastric cancer remains poor due to a limited number of available therapeutics. Here, we employed...
Sat May 30, 2020 03:00
Cancers, Vol. 12, Pages 1415: Current Therapies and New Targets to Fight Melanoma: A Promising Role for the β3-Adrenoreceptor Cancers doi: 10.3390/cancers12061415 Authors: Luca Filippi Gennaro Bruno Vladana Domazetovic Claudio Favre Maura Calvani Melanoma is one of the most aggressive types of cancer and the most deadly skin cancer. According to World Health Organization, about 132,000 melanoma skin cancers occur globally each year. Thanks to the efficacy of new therapies,...
Sat May 30, 2020 03:00
Cancers, Vol. 12, Pages 1416: Efficacy and Safety of Oncolytic Viruses in Randomized Controlled Trials: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers12061416 Authors: Zengbin Li Zeju Jiang Yingxuan Zhang Xiaotian Huang Qiong Liu Oncolytic virotherapy is a promising antitumor therapeutic strategy. It is based on the ability of viruses to selectively kill cancer cells and induce host antitumor immune responses. However, the clinical outcomes of oncolytic...
Sat May 30, 2020 03:00
Cancers, Vol. 12, Pages 1417: Fanconi Anemia Pathway Activation by FOXM1 Is Critical to Bladder Cancer Recurrence and Anticancer Drug Resistance Cancers doi: 10.3390/cancers12061417 Authors: Yun-Gil Roh Jeong-Yeon Mun Seon-Kyu Kim Wonyoung Park Mi-So Jeong Tae Nam Kim Won-Tae Kim Yung Hyun Choi In-Sun Chu Sun-Hee Leem Although the 5-year survival rate of patients diagnosed with nonmuscle invasive bladder cancer (NMIBC) has reached 85%, more than 50% of patients...
Sat May 30, 2020 03:00
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