Biomolecules, Vol. 10, Pages 1074: Identification of a Biosynthetic Gene Cluster Responsible for the Production of a New Pyrrolopyrimidine Natural Product—Huimycin Biomolecules doi: 10.3390/biom10071074 Authors: Hui Shuai Maksym Myronovskyi Suvd Nadmid Andriy Luzhetskyy Pyrrolopyrimidines are an important class of natural products with a broad spectrum of biological activities, including antibacterial, antifungal, antiviral, anticancer or anti-inflammatory. Here, we present...
Sat Jul 18, 2020 03:00
Biomolecules, Vol. 10, Pages 1073: Isoprostanoid Profiling of Marine Microalgae Biomolecules doi: 10.3390/biom10071073 Authors: Claire Vigor Camille Oger Guillaume Reversat Amandine Rocher Bingqing Zhou Amandyne Linares-Maurizi Alexandre Guy Valérie Bultel-Poncé Jean-Marie Galano Joseph Vercauteren Thierry Durand Philippe Potin Thierry Tonon Catherine Leblanc Algae result from a complex evolutionary history that shapes their metabolic network. For...
Sat Jul 18, 2020 03:00
Biomolecules, Vol. 10, Pages 1072: Regulated Iron Siderophore Production of the Halophilic Archaeon Haloferax volcanii Biomolecules doi: 10.3390/biom10071072 Authors: Natalie Niessen Jörg Soppa Iron is part of many redox and other enzymes and, thus, it is essential for all living beings. Many oxic environments have extremely low concentrations of free iron. Therefore, many prokaryotic species evolved siderophores, i.e., small organic molecules that complex Fe3+ with very high affinity....
Fri Jul 17, 2020 03:00
Biomolecules, Vol. 10, Pages 1071: Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection Biomolecules doi: 10.3390/biom10071071 Authors: Ken Asada Amina Bolatkan Ken Takasawa Masaaki Komatsu Syuzo Kaneko Ryuji Hamamoto Studies have shown that epigenetic abnormalities are involved in various diseases, including cancer. In particular, in order to realize precision medicine, the integrated analysis of genetics and epigenetics is considered to be important;...
Fri Jul 17, 2020 03:00
Biomolecules, Vol. 10, Pages 1070: Adipose Tissue-Derived Stem Cells Retain Their Adipocyte Differentiation Potential in Three-Dimensional Hydrogels and Bioreactors † Biomolecules doi: 10.3390/biom10071070 Authors: Benjamen T. O'Donnell Sara Al-Ghadban Clara J. Ives Michael P. L'Ecuyer Tia A. Monjure Monica Romero-Lopez Zhong Li Stuart B. Goodman Hang Lin Rocky S. Tuan Bruce A. Bunnell Osteoarthritis (OA) is a common joint disorder with a significant economic...
Fri Jul 17, 2020 03:00
Biomolecules, Vol. 10, Pages 1069: The Droserasin 1 PSI: A Membrane-Interacting Antimicrobial Peptide from the Carnivorous Plant Drosera capensis Biomolecules doi: 10.3390/biom10071069 Authors: Marc A. Sprague-Piercy Jan C. Bierma Marquise G. Crosby Brooke P. Carpenter Gemma R. Takahashi Joana Paulino Ivan Hung Rongfu Zhang John E. Kelly Natalia Kozlyuk Xi Chen Carter T. Butts Rachel W. Martin The Droserasins, aspartic proteases from the carnivorous...
Fri Jul 17, 2020 03:00
Biomolecules, Vol. 10, Pages 1068: The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier Biomolecules doi: 10.3390/biom10071068 Authors: Joséphine Zangari Francesco Petrelli Benoît Maillot Jean-Claude Martinou Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria...
Fri Jul 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 463: Domain Mapping and Deep Learning from Multiple MRI Clinical Datasets for Prediction of Molecular Subtypes in Low Grade Gliomas Brain Sciences doi: 10.3390/brainsci10070463 Authors: Muhaddisa Barat Ali Irene Yu-Hua Gu Mitchel S. Berger Johan Pallud Derek Southwell Georg Widhalm Alexandre Roux Tomás Gomez Vecchio Asgeir Store Jakola Brain tumors, such as low grade gliomas (LGG), are molecularly classified which require the surgical...
Sat Jul 18, 2020 03:00
Brain Sciences, Vol. 10, Pages 462: Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity Brain Sciences doi: 10.3390/brainsci10070462 Authors: Ulyana Lalo Alexander Bogdanov Guy W. Moss Yuriy Pankratov Experience- and diet-dependent regulation of synaptic plasticity can underlie beneficial effects of active lifestyle on the aging brain. Our previous results demonstrate a key role for brain-derived neurotrophic factor (BDNF) and MSK1 kinase...
Sat Jul 18, 2020 03:00
Brain Sciences, Vol. 10, Pages 461: The Disengagement of Visual Attention: An Eye-Tracking Study of Cognitive Impairment, Ethnicity and Age Brain Sciences doi: 10.3390/brainsci10070461 Authors: Megan Polden Thomas D. W. Wilcockson Trevor J. Crawford Various studies have shown that Alzheimer’s disease (AD) is associated with an impairment of inhibitory control, although we do not have a comprehensive understanding of the associated cognitive processes. The ability to engage...
Sat Jul 18, 2020 03:00
Brain Sciences, Vol. 10, Pages 460: Concentrations of Essential Trace Metals in the Brain of Animal Species—A Comparative Study Brain Sciences doi: 10.3390/brainsci10070460 Authors: Chiara Alessia DeBenedictis Andrea Raab Ellen Ducie Shauna Howley Joerg Feldmann Andreas Martin Grabrucker The essential trace metals iron, zinc, and copper have a significant physiological role in healthy brain development and function. Especially zinc is important for neurogenesis, synaptogenesis,...
Fri Jul 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 457: A New Palmitoylethanolamide Form Combined with Antioxidant Molecules to Improve Its Effectivess on Neuronal Aging Brain Sciences doi: 10.3390/brainsci10070457 Authors: Vera Morsanuto Rebecca Galla Claudio Molinari Francesca Uberti Palmitoylethanolamide is a nutraceutical compound naturally produced in many plants and animal source foods, but the natural form is poorly water-soluble. It has demonstrated an anti-inflammatory role as a neuroprotective...
Fri Jul 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 458: Impact of Aquatic Exercise on Respiratory Outcomes and Functional Activities in Children with Neuromuscular Disorders: Findings from an Open-Label and Prospective Preliminary Pilot Study Brain Sciences doi: 10.3390/brainsci10070458 Authors: Marta Huguet-Rodríguez José Luis Arias-Buría Belén Huguet-Rodríguez Rocío Blanco-Barrero Daniel Braña-Sirgo Javier Güeita-Rodríguez Neuromuscular disorders (NMD) lead to the progressive loss of motor...
Fri Jul 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 456: Machine Learning Detects Pattern of Differences in Functional Magnetic Resonance Imaging (fMRI) Data between Chronic Fatigue Syndrome (CFS) and Gulf War Illness (GWI) Brain Sciences doi: 10.3390/brainsci10070456 Authors: Destie Provenzano Stuart D. Washington Yuan J. Rao Murray Loew James Baraniuk Background: Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) are two debilitating disorders that share similar symptoms of chronic pain,...
Fri Jul 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 459: “No Pain No Gain”: Evidence from a Parcel-Wise Brain Morphometry Study on the Volitional Quality of Elite Athletes Brain Sciences doi: 10.3390/brainsci10070459 Authors: Gaoxia Wei Ruoguang Si Youfa Li Ying Yao Lizhen Chen Shu Zhang Tao Huang Liye Zou Chunxiao Li Stephane Perrey Volition is described as a psychological construct with great emphasis on the sense of agency. During volitional behavior, an individual always presents...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1966: Combined C-Reactive Protein and Novel Inflammatory Parameters as a Predictor in Cancer—What Can We Learn from the Hematological Experience? Cancers doi: 10.3390/cancers12071966 Authors: Øystein Bruserud Helene Hersvik Aarstad Tor Henrik Anderson Tvedt The acute phase reaction is a systemic response to acute or chronic inflammation. The serum level of C-reactive protein (CRP) is the only acute phase biomarker widely used in routine clinical practice,...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1965: Use of Biomarkers and Imaging for Early Detection of Pancreatic Cancer
Cancers, Vol. 12, Pages 1965: Use of Biomarkers and Imaging for Early Detection of Pancreatic Cancer Cancers doi: 10.3390/cancers12071965 Authors: Shingo Kato Kazufumi Honda Pancreatic cancer remains one of the deadliest cancers worldwide, and it is typically diagnosed late, with a poor prognosis. Early detection is the most important underlying factor for improving the prognosis of pancreatic cancer patients. One of the most effective strategies for detecting cancers at an early...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1964: The Emerging Role of Extracellular Vesicles in the Glioma Microenvironment: Biogenesis and Clinical Relevance Cancers doi: 10.3390/cancers12071964 Authors: Anjali Balakrishnan Sabrina Roy Taylor Fleming Hon S. Leong Carol Schuurmans Gliomas are a diverse group of brain tumors comprised of malignant cells (‘tumor’ cells) and non-malignant ‘normal’ cells, including neural (neurons, glia), inflammatory (microglia,...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1962: Non-Conventional Treatments for Conventional Chondrosarcoma Cancers doi: 10.3390/cancers12071962 Authors: Varun Monga Hariharasudan Mani Angela Hirbe Mohammed Milhem Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1963: The Multidrug Resistance-Reversing Activity of a Novel Antimicrobial Peptide Cancers doi: 10.3390/cancers12071963 Authors: Qiu-Xu Teng Xiaofang Luo Zi-Ning Lei Jing-Quan Wang John Wurpel Zuodong Qin Dong-Hua Yang The overexpression of ATP-binding cassette (ABC) transporters is a common cause of multidrug resistance (MDR) in cancers. The intracellular drug concentration of cancer cells can be decreased relative to their normal cell counterparts...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1958: Impact of Tumor Genomic Mutations on Thrombotic Risk in Cancer Patients Cancers doi: 10.3390/cancers12071958 Authors: Orly Leiva Jean M. Connors Hanny Al-Samkari Venous thromboembolism (VTE) is common in patients with cancer and is an important contributor to morbidity and mortality in these patients. Early thromboprophylaxis initiated only in those cancer patients at highest risk for VTE would be optimal. Risk stratification scores incorporating tumor...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1960: Therapeutic Strategies for Overcoming Immunotherapy Resistance Mediated by Immunosuppressive Factors of the Glioblastoma Microenvironment Cancers doi: 10.3390/cancers12071960 Authors: Tsubasa Miyazaki Eiichi Ishikawa Narushi Sugii Masahide Matsuda Various mechanisms of treatment resistance have been reported for glioblastoma (GBM) and other tumors. Resistance to immunotherapy in GBM patients may be caused by acquisition of immunosuppressive ability...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1959: Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer Cancers doi: 10.3390/cancers12071959 Authors: Esra Küpeli Akkol Yasin Genç Büşra Karpuz Eduardo Sobarzo-Sánchez Raffaele Capasso Cancer is one of the most common causes of disease-related deaths worldwide. Despite the discovery of many chemotherapeutic drugs that inhibit uncontrolled cell division processes for the treatment of various cancers, serious side effects of these...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1961: The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile Cancers doi: 10.3390/cancers12071961 Authors: Helene Hersvik Aarstad Gigja Guðbrandsdottir Karin M. Hjelle Leif Bostad Øystein Bruserud Tor Henrik Anderson Tvedt Christian Beisland High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer....
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1957: CUX1—Transcriptional Master Regulator of Tumor Progression in Pancreatic Neuroendocrine Tumors Cancers doi: 10.3390/cancers12071957 Authors: Sebastian Krug Julia Weissbach Annika Blank Aurel Perren Johannes Haybaeck Volker Fendrich Anja Rinke Thomas Mathias Gress Jonas Rosendahl Patrick Michl Recently, we identified the homeodomain transcription factor Cut homeobox 1 (CUX1) as mediator of tumour de-differentiation and metastatic...
Sun Jul 19, 2020 03:00
Cancers, Vol. 12, Pages 1956: Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models Cancers doi: 10.3390/cancers12071956 Authors: Layla Pires Valentin Demidov Brian C. Wilson Ana Gabriela Salvio Lilian Moriyama Vanderlei S. Bagnato I. Alex Vitkin Cristina Kurachi Treatment using light-activated photosensitizers (photodynamic therapy, PDT) has shown limited efficacy in pigmented melanoma, mainly due to the...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1951: Genetics and Opioids: Towards More Appropriate Prescription in Cancer Pain Cancers doi: 10.3390/cancers12071951 Authors: Dario Bugada Luca F. Lorini Roberto Fumagalli Massimo Allegri Opioids are extensively used in patients with cancer pain; despite their efficacy, several patients can experience ineffective analgesia and/or side effects. Pharmacogenetics is a new approach to drug prescription based on the “personalized-medicine”...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1954: Use of Interferon Alfa in the Treatment of Myeloproliferative Neoplasms: Perspectives and Review of the Literature Cancers doi: 10.3390/cancers12071954 Authors: Joan How Gabriela Hobbs Interferon alfa was first used in the treatment of myeloproliferative neoplasms (MPNs) over 30 years ago. However, its initial use was hampered by its side effect profile and lack of official regulatory approval for MPN treatment. Recently, there has been renewed interest...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1952: New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer Cancers doi: 10.3390/cancers12071952 Authors: Crescenzo D’Alterio Antonella Zannetti Anna Maria Trotta Caterina Ieranò Maria Napolitano Giuseppina Rea Adelaide Greco Piera Maiolino Sandra Albanese Giosuè Scognamiglio Fabiana Tatangelo Salvatore Tafuto Luigi Portella Sara Santagata Guglielmo Nasti Alessandro Ottaiano Roberto Pacelli...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1953: Postoperative Morbidity and Failure to Rescue in Surgery for Gastric Cancer: A Single Center Retrospective Cohort Study of 1107 Patients from 1972 to 2014 Cancers doi: 10.3390/cancers12071953 Authors: Christian Galata Ulrich Ronellenfitsch Susanne Blank Christoph Reißfelder Julia Hardt Background: The aim of this study was to evaluate postoperative morbidity, mortality, and failure to rescue following complications after radical resection for...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1955: Advanced Pancreatic Ductal Adenocarcinoma: Moving Forward Cancers doi: 10.3390/cancers12071955 Authors: Caspar Franck Christian Müller Rosa Rosania Roland S. Croner Maciej Pech Marino Venerito Globally, the death rate of pancreatic ductal adenocarcinoma (PDAC) has doubled over 30 years and is likely to further increase, making PDAC a leading cause of cancer-related death in the coming years. PDAC is typically diagnosed at an advanced stage,...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1950: The Role of Palliative Radiotherapy in the Treatment of Spinal Bone Metastases from Head and Neck Tumors—A Multicenter Analysis of a Rare Event Cancers doi: 10.3390/cancers12071950 Authors: Tilman Bostel Alexander Rühle Tilmann Rackwitz Arnulf Mayer Tristan Klodt Laura Oebel Robert Förster Ingmar Schlampp Daniel Wollschläger Harald Rief Tanja Sprave Jürgen Debus Anca-Ligia Grosu Heinz Schmidberger Sati Akbaba Nils Henrik...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1948: Head and Neck Osteosarcoma—The Ongoing Challenge about Reconstruction and Dental Rehabilitation Cancers doi: 10.3390/cancers12071948 Authors: Andrea Cassoni Edoardo Brauner Resi Pucci Valentina Terenzi Nicolò Mangini Andrea Battisti Marco Della Monaca Alessandro Ciolfi Federico Laudoni Stefano Di Carlo Valentino Valentini Head and Neck osteosarcoma is an uncommon disease. Hitherto, the treatment is surgical resection and survival...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1949: Photobiomodulation Therapy in Oral Mucositis and Potentially Malignant Oral Lesions: A Therapy Towards the Future Cancers doi: 10.3390/cancers12071949 Authors: Reem Hanna Snehal Dalvi Stefano Benedicenti Andrea Amaroli Tudor Sălăgean Ioana Delia Pop Doina Todea Ioana Roxana Bordea Photobiomodulation therapy (PBMT) is an effective treatment modality, which has the significant advantage of enhancing a patient’s quality of life...
Sat Jul 18, 2020 03:00
Cancers, Vol. 12, Pages 1946: Pancreatic Macrophages: Critical Players in Obesity-Promoted Pancreatic Cancer Cancers doi: 10.3390/cancers12071946 Authors: Yaroslav Teper Guido Eibl Obesity is a known risk factor for the development of pancreatic cancer, one of the deadliest types of malignancies. In recent years it has become clear that the pancreatic microenvironment is critically involved and a contributing factor in accelerating pancreatic neoplasia. In this context obesity-associated...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1944: Machine Learning Approach to Forecast Chemotherapy-Induced Haematological Toxicities in Patients with Rhabdomyosarcoma Cancers doi: 10.3390/cancers12071944 Authors: Vesna Cuplov Nicolas André Developing precision medicine is a major trend in clinical oncology. The main adverse effects of ifosfamide, actinomycin D and vincristine (IVA) treatment for rhabdomyosarcoma are haematological toxicities such as neutropenia or thrombocytopenia. The severity of...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1947: Characterization of mTOR Activity and Metabolic Profile in Pediatric Rhabdomyosarcoma Cancers doi: 10.3390/cancers12071947 Authors: Luca Felkai Ildikó Krencz Dorottya Judit Kiss Noémi Nagy Gábor Petővári Titanilla Dankó Tamás Micsík András Khoor Tamás Tornóczky Zoltán Sápi Anna Sebestyén Monika Csóka mTOR activation has been observed in rhabdomyosarcoma (RMS); however, mTOR complex (mTORC) 1 inhibition has had limited success...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1942: Supplementary Oral Anamorelin Mitigates Anorexia and Skeletal Muscle Atrophy Induced by Gemcitabine Plus Cisplatin Systemic Chemotherapy in a Mouse Model Cancers doi: 10.3390/cancers12071942 Authors: Makito Miyake Shunta Hori Yoshitaka Itami Yuki Oda Takuya Owari Tomomi Fujii Sayuri Ohnishi Yosuke Morizawa Daisuke Gotoh Yasushi Nakai Satoshi Anai Kazumasa Torimoto Nobumichi Tanaka Kiyohide Fujimoto Chemotherapy-induced...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1939: Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting Cancers doi: 10.3390/cancers12071939 Authors: Alice Bradbury Rachel O’Donnell Yvette Drew Nicola J. Curtin Sweta Sharma Saha In order to be effective models to identify biomarkers of chemotherapy response, cancer cell lines require thorough characterization. In this...
Fri Jul 17, 2020 03:0
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