Related Articles Chemometric and Transcriptomic Profiling, Microtubule Disruption and Cell Death Induction by Secalonic Acid in Tumor Cells. Molecules. 2020 Jul 15;25(14): Authors: Özenver N, Dawood M, Fleischer E, Klinger A, Efferth T Abstract Nature is an indispensable source of new drugs, providing unique bioactive lead structures for drug discovery. In the present study, secalonic acid F (SAF), a naturally occurring ergochrome pigment,...
Sun Jul 19, 2020 13:40
lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer. Mol Ther Nucleic Acids. 2020 Jun 18;21:480-491 Authors: Na H, Li X, Zhang X, Xu Y, Sun Y, Cui J, Chen Z, Shi X, Ren S, Zuo Y Abstract Previous studies have reported that long noncoding RNAs (lncRNAs) have acted as new players during tumorigenesis. Metallothionein also plays an important role in tumor progression. It is mainly...
Sat Jul 18, 2020 13:34
PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP. Biochim Biophys Acta Rev Cancer. 2020 Jul 14;:188393 Authors: Roberts O, Paraoan L Abstract The tetraspan plasma membrane protein PERP (p53 apoptosis effector related to PMP22) is a lesser-known transcriptional target of p53 and p63. A member of the PMP22/GAS3/EMP membrane protein family, PERP was originally identified as a p53 target...
Sat Jul 18, 2020 13:34
Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway. Anticancer Agents Med Chem. 2020 Jul 17;: Authors: Khan I, Mahfooz S, Saeed M, Ahmad I, Ansari IA Abstract BACKGROUND: Recently Notch signaling pathway has gained attention as a potential therapeutic target for chemotherapeutic intervention. However, the efficacy of previously known Notch inhibitors in colon cancer is still unclear....
Sat Jul 18, 2020 13:34
Related Articles Gene expression profiling identifies the role of Zac1 in cervical cancer metastasis. Sci Rep. 2020 Jul 16;10(1):11837 Authors: Su HC, Wu SC, Yen LC, Chiao LK, Wang JK, Chiu YL, Ho CL, Huang SM Abstract The zinc-finger protein which regulates apoptosis and cell cycle arrest 1 (Zac1), encoded by Plagl1 gene, is a seven-zinc-finger containing transcription factor belonging to the imprinted genome and is expressed in diverse...
Sat Jul 18, 2020 13:34
Related Articles A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition. Sci Rep. 2020 Jul 16;10(1):11814 Authors: Sahin ID, Christodoulou MS, Guzelcan EA, Koyas A, Karaca C, Passarella D, Cetin-Atalay R Abstract Hepatocellular carcinoma (HCC) ranks as the fifth most common and the second deadliest cancer worldwide. HCC is extremely resistant to the conventional chemotherapeutics. Hence, it is...
Sat Jul 18, 2020 13:34
Related Articles Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma. Sci Rep. 2020 Jul 16;10(1):11807 Authors: Bolidong D, Domoto T, Uehara M, Sabit H, Okumura T, Endo Y, Nakada M, Ninomiya I, Miyashita T, Wong RW, Minamoto T Abstract Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal cancer and is often refractory to current therapies. Development of efficient...
Sat Jul 18, 2020 13:34
Related Articles Transcriptomic insight into salinomycin mechanisms in breast cancer cell lines: synergistic effects with dasatinib and induction of estrogen receptor β. BMC Cancer. 2020 Jul 16;20(1):661 Authors: Bellat V, Verchère A, Ashe SA, Law B Abstract BACKGROUND: Tumors are heterogeneous in nature, composed of different cell populations with various mutations and/or phenotypes. Using a single drug to encounter cancer progression...
Sat Jul 18, 2020 13:34
Related Articles CDK46 inhibitor palbociclib overcomes acquired resistance to third-generation EGFR inhibitor osimertinib in non-small cell lung cancer (NSCLC). Thorac Cancer. 2020 Jul 16;: Authors: Qin Q, Li X, Liang X, Zeng L, Wang J, Sun L, Zhong D Abstract BACKGROUND: The third-generation EGFR-TKI, represented by osimertinib, has been widely used in clinical practice; however, resistance eventually emerges. At present, it remains unclear...
Sat Jul 18, 2020 13:34
Related Articles Garcinone-E exhibits anticancer effects in HeLa human cervical carcinoma cells mediated via programmed cell death, cell cycle arrest and suppression of cell migration and invasion. AMB Express. 2020 Jul 16;10(1):126 Authors: Yang L, Xu Z, Wang W Abstract Xanthones are an important class of natural compounds bearing huge bioactivity profiles. Garcinone-E is one among most active xanthones showing potential anticancer activity...
Sat Jul 18, 2020 13:34
Related Articles Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal Cancer. Front Oncol. 2020;10:1035 Authors: Shen Z, Chen Y, Li L, Liu L, Peng M, Chen X, Wu X, Sferra TJ, Wu M, Lin X, Cheng Y, Chu J, Shen A, Peng J Abstract Early B cell factor 1 (EBF1) has been identified as an upstream transcription factor of the potential oncogene PNO1 and is involved...
Sat Jul 18, 2020 13:34
Related Articles Methyl-Cantharidimide (MCA) Has Anticancer Efficacy in ABCB1- and ABCG2-Overexpressing and Cisplatin Resistant Cancer Cells. Front Oncol. 2020;10:932 Authors: Li YD, Mao Y, Dong XD, Lei ZN, Yang Y, Lin L, Ashby CR, Yang DH, Fan YF, Chen ZS Abstract In this study, we investigated the efficacy of methyl-cantharidimide (MCA), a cantharidin (CTD) analog, as an anticancer drug, in cancer cells overexpressing either ABCB1 or...
Sat Jul 18, 2020 13:34
Related Articles TAF15 contributes to the radiation-inducible stress response in cancer. Oncotarget. 2020 Jul 07;11(27):2647-2659 Authors: Singh AK, Kapoor V, Thotala D, Hallahan DE Abstract Resistance to radiation therapy is a significant problem in the treatment of non-small cell lung cancer (NSCLC). There is an unmet need to discover new molecular targets for drug development in combination with standard of care cancer therapy. We found...
Sat Jul 18, 2020 13:34
Related Articles Intracellular Growth and Cell Cycle Progression are Dependent on (p)ppGpp Synthetase/Hydrolase in Brucella abortus. Pathogens. 2020 Jul 14;9(7): Authors: Van der Henst M, Carlier E, De Bolle X Abstract Brucella abortus is a pathogenic bacterium able to proliferate inside host cells. During the first steps of its trafficking, it is able to block the progression of its cell cycle, remaining at the G1 stage for several hours,...
Sat Jul 18, 2020 13:34
Related Articles The Ubiquitin Proteasome System in Hematological Malignancies: New Insight into Its Functional Role and Therapeutic Options. Cancers (Basel). 2020 Jul 14;12(7): Authors: Di Costanzo A, Del Gaudio N, Conte L, Altucci L Abstract The ubiquitin proteasome system (UPS) is the main cellular degradation machinery designed for controlling turnover of critical proteins involved in cancer pathogenesis, including hematological malignancies....
Sat Jul 18, 2020 13:34
Related Articles Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability. Int J Mol Sci. 2020 Jul 14;21(14): Authors: Jimenez-Gutierrez GE, Mondragon-Gonzalez R, Soto-Ponce LA, Gómez-Monsiváis WL, García-Aguirre I, Pacheco-Rivera RA, Suárez-Sánchez R, Brancaccio A, Magaña JJ, C R Perlingeiro R, Cisneros B Abstract Nuclear β-dystroglycan (β-DG) is involved in the maintenance of nuclear architecture...
Sat Jul 18, 2020 13:34
Related Articles Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer. Int J Nanomedicine. 2020;15:3193-3206 Authors: Jin X, Lu X, Zhang Z, Lv H Abstract Background: Certain patients with triple-negative breast cancer cannot tolerate the serious adverse effects of cytotoxic chemotherapy agents, which significantly affect the disease prognosis. Purpose: Research into the combined...
Sat Jul 18, 2020 13:34
Related Articles A novel approach to increase robustness, precision and high-throughput capacity of single cell gel electrophoresis. ALTEX. 2020;1(37):95-109 Authors: Cassano JC, Roesslein M, Kaufmann R, Luethi T, Schicht O, Wick P, Hirsch C Abstract The routine use of single cell gel electrophoresis assay in medical diagnostics and biomonitoring is prevented by its high variability. Several factors have been identified and can be grouped...
Sat Jul 18, 2020 13:34
Related Articles Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development. Cell Death Dis. 2019 06 12;10(6):460 Authors: Liu X, Zhang P, Xie C, Sham KWY, Ng SSM, Chen Y, Cheng CHK Abstract Transient receptor potential vanilloid type 4 (TRPV4) is a Ca2+-permeable cation channel that is known to be an osmosensor and thermosensor. Currently, limited evidence shows that TRPV4 plays opposite roles in either promoting or inhibiting...
Sat Jul 18, 2020 13:34
Related Articles ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation. Cell Death Dis. 2019 06 12;10(6):459 Authors: Gomes LR, Rocha CRR, Martins DJ, Fiore APZP, Kinker GS, Bruni-Cardoso A, Menck CFM Abstract Tissue architecture and cell-extracellular matrix (cell-ECM) interaction determine the organ specificity; however, the influences of these factors on anticancer drugs preclinical...
Sat Jul 18, 2020 13:34
Related Articles Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression. Cell Death Dis. 2019 06 06;10(6):446 Authors: Hasselluhn MC, Schmidt GE, Ellenrieder V, Johnsen SA, Hessmann E Abstract Given its aggressive tumor biology and its exceptional therapy resistance, pancreatic ductal adenocarcinoma (PDAC) remains a major challenge in cancer medicine and is characterized by...
Sat Jul 18, 2020 13:34
Related Articles Secreted frizzled-related protein 5 suppresses aggressive phenotype and reverses docetaxel resistance in prostate cancer. J Investig Med. 2019 08;67(6):1009-1017 Authors: Xu Q, Lü Z, Wang X, Zhu Q, Wu H Abstract Secreted frizzled-related protein 5 (SFRP5) has been reported to be downregulated in prostate cancer. However, its biological role in this malignancy has not been clarified yet. In the present study, we performed SFRP5...
Sat Jul 18, 2020 13:34
Related Articles Iron: Key player in cancer and cell cycle? J Trace Elem Med Biol. 2020 Jul 09;62:126582 Authors: Khan A, Singh P, Srivastava A Abstract BACKGROUND: Iron is an essential element for growth and metabolic activities of all living organisms but remains in its oxyhydroxide ferric ion form in the surrounding. Unavailability of iron in soluble ferrous form led to development of specific pathways and machinery in different organisms...
Fri Jul 17, 2020 23:06
Related Articles Synthesis, cytotoxicity of some pyrazoles and pyrazolo[1,5-a]pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action. Bioorg Chem. 2020 Jun 30;102:104053 Authors: Husseiny EM Abstract A novel series of pyrazoles and pyrazolo[1,5-a]pyrimidines bearing benzothiazole moiety were designed and synthesized. Chemical structures were confirmed by spectral data and elemental analyses. Nine compounds...
Fri Jul 17, 2020 23:06
Related Articles Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity. Islets. 2020 Jul 16;:1-12 Authors: Lee YH, Jung HS, Kwon MJ, Jang JE, Kim TN, Lee SH, Kim MK, Park JH Abstract INTRODUCTION: Melatonin is a hormone known as having very strong anti-oxidant property. Senescence is a biological state characterized by the loss of cell replication and the changes consisting...
Fri Jul 17, 2020 23:06
Related Articles Phytochemical Characterization and Effects on Cell Proliferation of Lentisk (Pistacia lentiscus) Berry Oil: a Revalued Source of Phenolics. Plant Foods Hum Nutr. 2020 Jul 15;: Authors: Siano F, Cutignano A, Moccia S, Russo GL, Volpe MG, Picariello G Abstract The ethno-pharmaceutical use of the edible fixed oil produced from lentisk (Pistacia lentiscus) berries covers a long tradition in several Mediterranean regions. Many...
Fri Jul 17, 2020 13:29
Related Articles A Small Molecule Inhibitor, OGP46, Is Effective against Imatinib-Resistant BCR-ABL Mutations via the BCR-ABL/JAK-STAT Pathway. Mol Ther Oncolytics. 2020 Sep 25;18:137-148 Authors: Wei L, Yang Y, Gupta P, Wang A, Zhao M, Zhao Y, Qu M, Ke Y, Liu Y, Liu HM, Xu X, Sun Y, Chen ZS, Hu Z Abstract Chronic myeloid leukemia (CML) is caused by the Philadelphia (Ph+) chromosome carrying the BCR-ABL oncogene, a constitutively active tyrosine...
Fri Jul 17, 2020 23:06
Related Articles Hypoxia-Induced lncRNA-NEAT1 Sustains the Growth of Hepatocellular Carcinoma via Regulation of miR-199a-3p/UCK2. Front Oncol. 2020;10:998 Authors: Zhang Q, Cheng Q, Xia M, Huang X, He X, Liao J Abstract Objective: The long noncoding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) has emerged as a novel player in hepatocellular carcinoma (HCC). Hypoxia is a common characteristic of the microenvironment of HCC....
Fri Jul 17, 2020 23:06
Related Articles Genome-Wide Identification of Genes Involved in General Acid Stress and Fluoride Toxicity in Saccharomyces cerevisiae. Front Microbiol. 2020;11:1410 Authors: Johnston NR, Nallur S, Gordon PB, Smith KD, Strobel SA Abstract Hydrofluoric acid elicits cell cycle arrest through a mechanism that has long been presumed to be linked with the high affinity of fluoride to metals. However, we have recently found that the acid stress from...
Fri Jul 17, 2020 23:06
Related Articles Evaluation of Modulators of cAMP-Response in Terms of Their Impact on Cell Cycle and Mitochondrial Activity of Leishmania donovani. Front Pharmacol. 2020;11:782 Authors: Saha A, Bhattacharjee A, Vij A, Das PK, Bhattacharya A, Biswas A Abstract With the identification of novel cAMP binding effector molecules in Trypanosoma, the role of cAMP in kinetoplastida parasites gained an intriguing breakthrough. Despite earlier demonstrations...
Fri Jul 17, 2020 23:06
Related Articles Arnicolide D Inhibits Triple Negative Breast Cancer Cell Proliferation by Suppression of Akt/mTOR and STAT3 Signaling Pathways. Int J Med Sci. 2020;17(11):1482-1490 Authors: Qu Z, Lin Y, Mok DK, Bian Q, Tai WC, Chen S Abstract Triple-Negative Breast Cancer (TNBC) is a most dangerous breast cancer subtype. The naturally occurring sesquiterpene lactone, arnicolide D (AD), has proven effective against a variety of tumors, however,...
Fri Jul 17, 2020 23:06
Related Articles Honokiol Suppressed Pancreatic Cancer Progression via miR-101/Mcl-1 Axis. Cancer Manag Res. 2020;12:5243-5254 Authors: Wang Y, Liu Z, Liu Q, Han Y, Zang Y, Zhang H, Du X, Qin T, Wu Y Abstract Background: Pancreatic cancer is one of the most aggressive malignancies. The present study aimed to examine the anti-tumor effects of honokiol in pancreatic cancer and to explore the underlying molecular mechanisms. Materials...
Fri Jul 17, 2020 23:06
Related Articles Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway. Drug Des Devel Ther. 2020;14:2535-2547 Authors: Zeng Q, Che Y, Zhang Y, Chen M, Guo Q, Zhang W Abstract Purpose: Colorectal cancer (CRC) is one of the most commonly occurring cancers and is associated with high morbidity and mortality. Nevertheless, there is currently no safe and effective...
Fri Jul 17, 2020 23:06
Related Articles Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by heat shock protein 90 inhibition. Mol Cancer Res. 2020 Jul 15;: Authors: Nassar ZD, Mah CY, Centenera MM, Irani S, Sadowski MC, Scott JS, Nguyen EV, Nagarajan SR, Moldovan M, Lynn DJ, Daly RJ, Hoy AJ, Butler LM Abstract HSP90 is a molecular chaperone required for stabilisation and activation of hundreds of client proteins, including many...
Fri Jul 17, 2020 13:29
Related Articles PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN. Cancer Discov. 2020 Jul 15;: Authors: Pastore F, Bhagwat N, Pastore A, Radzisheuskaya A, Karzai A, Krishnan A, Li B, Bowman RL, Xiao W, Viny AD, Zouak A, Park YC, Cordner KB, Braunstein S, Maag JLV, Grego A, Mehta J, Wang M, Lin H, Durham BH, Koche RP, Rampal RK, Helin K, Scherle P, Vaddi K, Levine RL Abstract...
Fri Jul 17, 2020 23:06
Related Articles MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway. Am J Chin Med. 2020;48(5):1221-1241 Authors: Wu HT, Liu YE, Hsu KW, Wang YF, Chan YC, Chen Y, Chen DR Abstract Tamoxifen is one of the most common hormone therapy drug for estrogen receptor (ER)-positive breast cancer. Tumor cells with drug resistance often cause...
Fri Jul 17, 2020 13:29
Related Articles 4-Acetylantrocamol LT3, a New Ubiquinone from Antrodia cinnamomea, Inhibits Hepatocellular Carcinoma HepG2 Cell Growth by Targeting YAP/TAZ, mTOR, and WNT/β-Catenin Signaling. Am J Chin Med. 2020;48(5):1243-1261 Authors: Chen YL, Yen IC, Lin KT, Lai FY, Lee SY Abstract 4-acetylantrocamol LT3 (4AALT3), a new ubiquinone from the mycelium of Antrodia cinnamomea (Polyporaceae), has been recently shown to possess anticancer...
Fri Jul 17, 2020 13:29
Related Articles Synthesis and bioevaluation of new vascular-targeting and anti-angiogenic thieno[2,3-d]pyrimidin-4(3H)-ones. Eur J Med Chem. 2020 Mar 01;189:112060 Authors: Gold M, Köhler L, Lanzloth C, Andronache I, Anant S, Dandawate P, Biersack B, Schobert R Abstract A series of forty-six 5,6-annulated 2-arylthieno [2,3-d]pyrimidin-4(3H)-ones were prepared as potentially pleiotropic anticancer drugs with variance in the tubulin-binding...
Fri Jul 17, 2020 13:29
Related Articles Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase. Eur J Med Chem. 2020 Mar 01;189:112041 Authors: Hua S, Chen F, Wang X, Gou S Abstract A series of novel conjugates comprising tublin and IDO inhibitors were designed, synthesized and evaluated for their antiproliferative activity. Among them, HI5, composed of combretastatin A-4 (CA-4) and (D)-1-methyltryptophan...
Fri Jul 17, 2020 13:29
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