Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Nikki S. IJzerman, Stefanie L. Groenland, Anne Miek Koenen, Martijn Kerst, Winette T.A. van der Graaf, Hilde Rosing, Jos H. Beijnen, Alwin D.R. Huitema, Neeltje Steeghs
Sat Jul 18, 2020 13:35
Publication date: Available online 17 July 2020Source: European Journal of Surgical OncologyAuthor(s): Qi-Yue Chen, Qing Zhong, Zhi-Yu Liu, Xiao-Bo Huang, Si-Jin Que, Wen-Ze Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Fri Jul 17, 2020 18:51
Publication date: Available online 17 July 2020Source: European Journal of Surgical OncologyAuthor(s): Liguang Zhou, Haipeng Li, Weili Liang, Chao Gao, Bo Chen
Fri Jul 17, 2020 18:51
Publication date: Available online 17 July 2020Source: European Journal of Surgical OncologyAuthor(s): Antonio V. Sterpetti, Paolo Sapienza, Enrico Fiori, Luca DI. Marzo, Antonietta Lamazza
Fri Jul 17, 2020 18:51
England has experienced one of the highest excess in all-cause mortality in Europe during the current COVID-19 pandemic. As COVID-19 emerged, the excess in all-cause mortality rapidly increased, starting in March 2020. The excess observed during the pandemic was higher than excesses noted in the past 5 years. It concerned all regions and all age groups, except the 0–14 year olds, but was more pronounced in the London region and in those aged ≥ 85 years.
Thu Jul 16, 2020 03:00
Background A novel coronavirus, SARS-CoV-2, which emerged at the end of 2019 and causes COVID-19, has resulted in worldwide human infections. While genetically distinct, SARS-CoV-1, the aetiological agent responsible for an outbreak of severe acute respiratory syndrome (SARS) in 2002–2003, utilises the same host cell receptor as SARS-CoV-2 for entry: angiotensin-converting enzyme 2 (ACE2). Parts of the SARS-CoV-1 spike glycoprotein (S protein), which interacts with ACE2, appear conserved in...
Thu Jul 16, 2020 03:00
Serological reactivity was analysed in plasma from 436 individuals with a history of disease compatible with COVID-19, including 256 who had been laboratory-confirmed with SARS-CoV-2 infection. Over 99% of laboratory-confirmed cases developed a measurable antibody response (254/256) and 88% harboured neutralising antibodies (226/256). Antibody levels declined over 3 months following diagnosis, emphasising the importance of the timing of convalescent plasma collections. Binding antibody measurements...
Thu Jul 16, 2020 03:00
Most cases of coronavirus disease 2019 are mild or asymptomatic. Therefore, many cases remain unrecorded. We determined seroprevalence of IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 3,186 regular blood donors in three German federal states between 9 March and 3 June 2020. The IgG seroprevalence was 0.91% (95% confidence interval (CI): 0.58–1.24) overall, ranging from 0.66% (95% CI: 0.13–1.19) in Hesse to 1.22% (95% CI: 0.33–2.10) in Lower-Saxony.
Thu Jul 16, 2020 03:00
Introduction Guidelines for pre-exposure prophylaxis (PrEP) provide criteria to identify individuals at higher risk of HIV infection. We compared the ability to predict HIV seroconversion of four guidelines: the World Health Organization (WHO), the United States Public Health Service and Centers for Disease Control and Prevention (US CDC), the European AIDS Clinical Society (EACS) and the Portuguese National Health Service (PNHS). Aim We aimed to measure the association between guideline-specific...
Thu Jul 16, 2020 03:00
Future Oncology, Ahead of Print.
Fri Jul 17, 2020 14:23
Future Oncology, Ahead of Print.
Fri Jul 17, 2020 14:13
Future Oncology, Ahead of Print.
Fri Jul 17, 2020 14:10
Related Articles How does COVID-19 fear and anxiety affect chemotherapy adherence in patients with cancer. Future Oncol. 2020 Jul 17;: Authors: Karacin C, Bilgetekin I, B Basal F, Oksuzoglu OB Abstract Aim: To investigate how COVID-19 fear and anxiety (COV-FA) affects chemotherapy adherence in patients with cancer. Materials & methods: The records of 3661 patients with chemotherapy (CT) appointments were retrospectively reviewed. Results:...
Sat Jul 18, 2020 16:22
Related Articles FIGHT-302: first-line pemigatinib vs gemcitabine plus cisplatin for advanced cholangiocarcinoma with FGFR2 rearrangements. Future Oncol. 2020 Jul 17;: Authors: Bekaii-Saab TS, Valle JW, Cutsem EV, Rimassa L, Furuse J, Ioka T, Melisi D, Macarulla T, Bridgewater J, Wasan H, Borad MJ, Abou-Alfa GK, Jiang P, Lihou CF, Zhen H, Asatiani E, Féliz L, Vogel A Abstract FGFR2 rearrangements resulting in dysregulated signaling are drivers...
Sat Jul 18, 2020 16:22
Related Articles Brentuximab vedotin and its use in the treatment of advanced Hodgkin's lymphoma. Future Oncol. 2020 Jul 17;: Authors: Nikolaenko L, Nademanee A Abstract Brentuximab vedotin (BV), a CD30-directed antibody-drug conjugate, is US FDA approved for treatment of classic Hodgkin lymphoma (cHL) after progression or relapse of at least two prior lines of chemotherapy or autologous stem cell transplantation, as consolidation therapy after...
Sat Jul 18, 2020 16:22
Abstract Uterine leiomyomas are the most common benign tumor of the female genital tract. Previous studies have shown that conventional leiomyomas often harbor specific alterations including rearrangements involving HMGA2 . Cellular leiomyomas are a variant of uterine leiomyoma that are less well studied from a genomic point of view. Morphologically and immunohistochemically, cellular leiomyomas may be confused with low grade endometrial stromal neoplasms, a group of tumors which frequently harbor...
Fri Jul 17, 2020 14:19
Abstract National Comprehensive Cancer Network (NCCN) guidelines are the most comprehensive and widely used standard for clinical care, financial reimbursements and quality improvement initiatives in oncology. We studied the distribution of categories of evidence and consensus (EC) in the guidelines for the common cancers in the US. We evaluated the EC categories in staging, therapy and surveillance recommendations in 2019 guidelines and compared them with the same in 2010. The latest 2019 version...
Thu Jul 16, 2020 12:10
Abstract The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new 5th Edition, the series has gone digital with the launch of a website as well as a series of books, known widely as the WHO Blue Books. The first volume to be produced is on the classification of Digestive System tumours, replacing the successful 2010 version. It has been rewritten and updated...
Thu Jul 16, 2020 12:07
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Wed Jul 15, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue Jul 14, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue Jul 14, 2020 10:00
The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant ph...
Sat Jul 18, 2020 03:00
Hypoxia, a fundamental characteristic of glioma, is considered to promote tumor malignancy by inducing process of epithelial mesenchymal transition (EMT). Ferritin Light Chain (FTL) is one of the iron metaboli...
Thu Jul 16, 2020 03:00
Accumulating evidence have highlighted the importance of long noncoding RNAs (lncRNAs) in multiple cancers development and progression. Cancer susceptibility candidate 9 (CASC9) is a novel long non-coding RNA ...
Thu Jul 16, 2020 03:00
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with poor prognosis and high incidence. The clinical data analysis of liver hepatocellular carcinoma samples downloaded from The Cance...
Wed Jul 15, 2020 03:00
Abstract Background Recent studies suggest a relatively high prevalence of autoimmune disorders (AD) among primary CNS lymphoma (PCNSL) patients, however, the literature is limited to case reports. To gain a better understanding of AD-PCNSL we reviewed and analyzed all cases described in the literature. Methods We searched the MEDLINE database using...
Sat Jul 18, 2020 03:00
Abstract Triple-negative breast cancer (TNBC) is characterized by aggressive phenotype and a poorer prognosis compared to the estrogen and progesterone receptor positive, Her2 negative (ER + PR + Her2-) breast cancer. Increasing evidence suggests that sirtuins, a family of histone deacetylases, could have an important role in aggressiveness of TNBC’s. The current study evaluated the potential clinical relevance of SIRT1, SIRT3 and SIRT6 gene expressions in two prognostically distinctive...
Fri Jul 17, 2020 03:00
Abstract Tumor immune microenvironment (TIME) is a significant prognostic parameter for triple negative breast carcinomas (TNBC) due to being a target for immunotherapeutic agents and its essential role during the cancer immunoediting process. In this study, CD8, FOXP3, CD163, PD-L1/SP142 and PD-L1/SP263 antibodies were examined in a sample of 51 TNBC cases. Patients who received neoadjuvant therapy were excluded. CD8, FOXP3 and CD163 antibodies were evaluated separately in intratumoral...
Fri Jul 17, 2020 03:00
Thu Jul 16, 2020 17:31
Abstract Objective To explore and describe exposure to suicidality in healthcare providers (HPC) working with oncological patients. Special emphasis was put on five central aspects from the HPCs perspective: Exposure, Confidence, Expertise, Distress, and Education. Methods A 48‐item online questionnaire was developed and distributed to HPCs working with cancer patients. Three hundred fifty‐four answered questionnaires were analyzed. Results Overall 83.3% of HPCs reported to have encountered...
Thu Jul 16, 2020 17:30
Abstract Objective We report results of a community‐based multisite, randomized controlled trial of Nuevo Amanecer (NA‐II), a 10‐week stress management program for rural, low literacy Latina breast cancer survivors. Methods Trained peers delivered NA‐II to Spanish‐speaking Latinas with non‐metastatic breast cancer in three rural communities. Women were randomized to receive the program immediately or wait 6 months. Assessments were conducted at baseline, 3 months, and 6 months. Primary...
Thu Jul 16, 2020 17:30
Thu Jul 16, 2020 17:30
Abstract Objective As survival rates increase, growing numbers of childhood acute lymphoblastic leukemia (ALL) survivors are at risk for somatic and psychosocial late effects. Adolescent and young adult (AYA) survivors represent a distinct and vulnerable group. This study aimed to explore how AYA survivors of childhood ALL experience everyday life after cancer while adjusting to the potential impact of prior disease and treatment. Methods Semi‐structured interviews were performed with survivors...
Thu Jul 16, 2020 17:29
Thu Jul 16, 2020 17:29
Abstract Objective to describe levels of loneliness in cancer caregivers over a six month time period, and to examine factors that influence changes in loneliness in caregivers over time. Methods prospective, repeated measures survey design was utilized to examine levels of loneliness and factors that influence loneliness in 129 family caregivers of individuals undergoing cancer treatment at three time points over a six month period. Measures included: PROMIS global health and sleep disturbance;...
Thu Jul 16, 2020 17:28
Total scalp irradiation presents technical and dosimetric challenges. While reports suggest that HyperArc, a new stereotactic radiosurgery planning technique applied to non-coplanar volumetric-modulated arc th...
Fri Jul 17, 2020 03:00
Sinonasal tumours are derived from the epithelium of the paranasal sinuses or nasal cavity. Radiotherapy remains a cornerstone in the curative treatment of sinonasal cancer (SNC), most often in combination with surgery[1–5]. At the time of diagnosis, tumour-infiltration into surrounding tissues is not uncommon, posing a challenge for the delivery of sufficient radiation dose while sparing healthy normal tissue. Radiation of normal tissue may cause permanent and potentially severe late toxicity, the...
Sun Jul 19, 2020 03:00
Head and neck squamous cell carcinomas (HNSCC) represent a high number of cancer patients worldwide, with roughly 700,000 newly diagnosed cases in 2018 (1). The three major etiologies for the development of HNSCC are tobacco use, heavy alcohol consumption and infection with the human papillomavirus (HPV), especially associated with oropharyngeal squamous cell carcinomas (2,3).
Fri Jul 17, 2020 03:00
Cyclodipeptide synthases (CDPSs) catalyze the synthesis of various cyclodipeptides by using two aminoacyl-tRNA (aa-tRNA) substrates in a sequential mechanism. Here, we studied binding of phenylalanyl-tRNAPhe to the CDPS from Candidatus Glomeribacter gigasporarum (Cglo-CDPS) by gel filtration and electrophoretic mobility shift assay. We determined the crystal structure of the Cglo-CDPS:Phe-tRNAPhe complex to 5 Å resolution and further studied it in solution using small-angle X-ray scattering (SAXS)....
Fri Jul 17, 2020 21:48
Publication date: October 2020Source: Cancer Epidemiology, Volume 68Author(s): Jennifer M. Murray, Helen G. Coleman, Ruth F. Hunter
Fri Jul 17, 2020 13:12
Abstract Background Non-small-cell lung cancer (NSCLC) is a major cause of cancer-related death globally. Endothelial PAS domain-containing protein 1 (EPAS1) is a homolog of the hypoxia-inducible factor 1α and has been reported to confer tyrosine kinase inhibitor (TKI) resistance in NSCLC, but its role in peritoneal carcinomatosis of NSCLC is unknown. Methods ...
Fri Jul 17, 2020 03:00
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