Exosomal miR-1255b-5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial-to-mesenchymal transition. Mol Oncol. 2020 Jul 17;: Authors: Zhang X, Bai J, Hang Y, Long L, Zheng Z, Wang Q, Chen F, Yu X, Zhou Y Abstract Cancer cells undergo epithelial-to-mesenchymal transition (EMT) in response to hypoxia. Exosomes produced in tumor microenvironments carry microRNAs that affect proliferation, metastasis,...
Sat Jul 18, 2020 14:26
Prognostic significance of quantitative metastatic lymph node burden on magnetic resonance imaging in nasopharyngeal carcinoma:a retrospective study of 1224 patients from two centers. Radiother Oncol. 2020 Jul 14;: Authors: Ma H, Liang S, Cui C, Zhang Y, Xie F, Zhou J, Dong A, Chen M, Xie C, Li H, Liu L Abstract BACKGROUND AND PURPOSE: The number of metastatic lymph nodes (LNs) has been demonstrated to be an important prognosticator in some...
Sat Jul 18, 2020 14:26
Intraoperative radiation therapy (IORT) for soft tissue sarcoma - ESTRO IORT Task Force / ACROP recommendations. Radiother Oncol. 2020 Jul 14;: Authors: Roeder F, Morillo V, Saleh-Ebrahimi L, Calvo FA, Poortmans P, Ferrer Albiach C Abstract PURPOSE: To describe guidelines for the use of intraoperative radiation therapy (IORT) in the treatment of soft-tissue sarcomas (STS) METHODS: A panel of experts in the field performed a systematic literature...
Sat Jul 18, 2020 14:26
Development and application of an elastic net logistic regression model to investigate the impact of cardiac substructure dose on radiation-induced pericardial effusion in patients with NSCLC. Acta Oncol. 2020 Jul 17;:1-8 Authors: Niedzielski JS, Wei X, Xu T, Gomez DR, Liao Z, Bankson JA, Lai SY, Court LE, Yang J Abstract BACKGROUND: Typically, cardiac substructures are neither delineated nor analyzed during radiation treatment planning. Therefore,...
Sat Jul 18, 2020 14:26
Related Articles Shared Decision-Making Competency: Provider-Specific Factors in Hematology-Oncology Clinical Practice. Clin J Oncol Nurs. 2020 Aug 01;24(4):346-351 Authors: Tariman JD, Tarvainis A, Webber-Ritchey KJ, Simonovich SD Abstract A computerized database search was performed using PubMed®, CINAHL®, and EBSCOhost to identify provider-specific factors associated with shared decision-making (SDM) competency among direct patient care providers...
Sat Jul 18, 2020 14:26
Related Articles Uniaxial compression testing and Cauchy stress modeling to design anatomical silicone replicas. Sci Rep. 2020 Jul 16;10(1):11849 Authors: Hattab G, Ahlfeld T, Klimova A, Koepp A, Schuerer M, Speidel S Abstract Anatomically realistic organ replicas or phantoms allow for accurate studies and reproducible research. To recreate a human kidney, mimicry of the elastic properties of the human kidney is crucial. However, none of the...
Sat Jul 18, 2020 14:26
Related Articles Role of single-site and mini-laparoscopy in gynecologic surgery. Minerva Ginecol. 2020 Jul 17;: Authors: Delgado-Sánchez E, Peay-Pinacho JA, Hernández Gutiérrez A, Álvarez Bernardi J, Zapardiel I Abstract INTRODUCTION: Laparoscopy is a surgical procedure that has been used widely in medicine over the last thirty years. In gynecology, laparoscopy is the "gold standard" for the majority of gynecological procedures, as its superiority...
Sat Jul 18, 2020 14:26
Related Articles Epigenomic programming in early fetal brain development. Epigenomics. 2020 Jul 17;: Authors: Li L, Maire CL, Bilenky M, Carles A, Heravi-Moussavi A, Hong C, Tam A, Kamoh B, Cho S, Cheung D, Li I, Wong T, Nagarajan RP, Mungall AJ, Moore R, Wang T, Kleinman CL, Jabado N, Jones SJ, Marra MA, Ligon KL, Costello JF, Hirst M Abstract Aim: To provide a comprehensive understanding of gene regulatory networks in the developing human...
Sat Jul 18, 2020 14:26
Related Articles How does COVID-19 fear and anxiety affect chemotherapy adherence in patients with cancer. Future Oncol. 2020 Jul 17;: Authors: Karacin C, Bilgetekin I, B Basal F, Oksuzoglu OB Abstract Aim: To investigate how COVID-19 fear and anxiety (COV-FA) affects chemotherapy adherence in patients with cancer. Materials & methods: The records of 3661 patients with chemotherapy (CT) appointments were retrospectively reviewed. Results:...
Sat Jul 18, 2020 14:26
Related Articles FIGHT-302: first-line pemigatinib vs gemcitabine plus cisplatin for advanced cholangiocarcinoma with FGFR2 rearrangements. Future Oncol. 2020 Jul 17;: Authors: Bekaii-Saab TS, Valle JW, Cutsem EV, Rimassa L, Furuse J, Ioka T, Melisi D, Macarulla T, Bridgewater J, Wasan H, Borad MJ, Abou-Alfa GK, Jiang P, Lihou CF, Zhen H, Asatiani E, Féliz L, Vogel A Abstract FGFR2 rearrangements resulting in dysregulated signaling are drivers...
Sat Jul 18, 2020 14:26
Related Articles Brentuximab vedotin and its use in the treatment of advanced Hodgkin's lymphoma. Future Oncol. 2020 Jul 17;: Authors: Nikolaenko L, Nademanee A Abstract Brentuximab vedotin (BV), a CD30-directed antibody-drug conjugate, is US FDA approved for treatment of classic Hodgkin lymphoma (cHL) after progression or relapse of at least two prior lines of chemotherapy or autologous stem cell transplantation, as consolidation therapy after...
Sat Jul 18, 2020 14:26
Related Articles Stakeholder-Engaged Derivation of Patient-Informed Value Elements. Patient. 2020 Jul 17;: Authors: dosReis S, Butler B, Caicedo J, Kennedy A, Hong YD, Zhang C, Slejko JF Abstract OBJECTIVES: Our objective was to identify patient-informed value elements that can be used to make value assessment more patient centered. METHODS: Mixed methods were used iteratively to collect and integrate qualitative and quantitative data...
Sat Jul 18, 2020 14:26
Related Articles Emergence of a HER2-amplified clone during disease progression in an ALK-rearranged NSCLC patient treated with ALK-inhibitors: a case report. Transl Lung Cancer Res. 2020 Jun;9(3):787-792 Authors: Minari R, Gnetti L, Lagrasta CA, Squadrilli A, Bordi P, Azzoni C, Bottarelli L, Cosenza A, Ferri L, Caruso G, Silini EM, Tiseo M Abstract Anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs) are the standard treatment for...
Sat Jul 18, 2020 14:26
Related Articles Low prevalence of upper endoscopic gastrointestinal findings despite high frequency of alarm symptoms at the time of diagnosis in adult coeliac disease. Eur J Gastroenterol Hepatol. 2020 Jul 14;: Authors: Maimaris S, Schiepatti A, Gabrielli GM, Costetti M, Costa S, Sanders DS, Zingone F, Carroccio A, Ciacci C, Di Sabatino A, Biagi F Abstract OBJECTIVES: Exclusion of organic disorders involving the upper gastrointestinal (UGI)...
Sat Jul 18, 2020 14:26
Related Articles HIPEC in advanced epithelial ovarian cancer: why is there controversy? Curr Opin Oncol. 2020 Jul 15;: Authors: Vermorken JB, van Dam P, Brand A Abstract PURPOSE OF REVIEW: The randomized OVHIPEC study provided further evidence that adding heated intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery significantly improved recurrence-free and overall survival in stage III epithelial ovarian cancer (EOC) patients,...
Sat Jul 18, 2020 14:26
Related Articles Casting A Wide Net On Surgery: The Central Role of Neutrophil Extracellular Traps. Ann Surg. 2020 Aug;272(2):277-283 Authors: Eustache JH, Tohme S, Milette S, Rayes RF, Tsung A, Spicer JD Abstract : Since their discovery, neutrophil extracellular traps (NETs) have been implicated in a broad array of functions, both beneficial and detrimental to the host. Indeed, NETs have roles in infection, sepsis, wound healing, thrombotic...
Sat Jul 18, 2020 14:26
Related Articles Ovarian Cancer: Lifestyle, Diet and Nutrition. Nutr Cancer. 2020 Jul 16;:1-16 Authors: El-Sherif A, El-Sherif S, Taylor AH, Ayakannu T Abstract BACKGROUND AND AIMS: Ovarian cancer is the leading cause of female reproductive cancer death. It is estimated that dietary habits accounts for 30% of all cancers. This review sets out what we know about the food, nutrition and lifestyle factors that cause ovarian cancer, affect women...
Sat Jul 18, 2020 14:26
Related Articles ERBB2 mRNA Expression and Response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-Positive Breast Cancer. Cancers (Basel). 2020 Jul 14;12(7): Authors: Griguolo G, Brasó-Maristany F, González-Farré B, Pascual T, Chic N, Saurí T, Kates R, Gluz O, Martínez D, Paré L, Tsvetkova V, Pesantez D, Vidal M, Adamo B, Muñoz M, Galván P, Barberá L, Cuatrecasas M, Christgen M, Kreipe H, Monge-Escartín I, Villagrasa P, Soy D, Giarratano T, Dieci MV, Conte P,...
Sat Jul 18, 2020 14:26
Related Articles Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update. Nutrients. 2020 Jul 14;12(7): Authors: Labrosse R, Graham F, Caubet JC Abstract Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of...
Sat Jul 18, 2020 14:26
Related Articles Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives. Cancers (Basel). 2020 Jul 14;12(7): Authors: Hacker UT, Bentler M, Kaniowska D, Morgan M, Büning H Abstract Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery systems in gene therapy for inherited monogenetic diseases. First market approvals, excellent...
Sat Jul 18, 2020 14:26
Related Articles Telemedicine During the COVID-19 Pandemic: Impact on Care for Rare Cancers. JCO Glob Oncol. 2020 07;6:1046-1051 Authors: Smrke A, Younger E, Wilson R, Husson O, Farag S, Merry E, Macklin-Doherty A, Cojocaru E, Arthur A, Benson C, Miah AB, Zaidi S, Gennatas S, Jones RL Abstract PURPOSE: Many patients with cancer, often those with rare cancers such as sarcomas, travel long distances to access expert care. The COVID-19 pandemic...
Sat Jul 18, 2020 14:26
Related Articles Mass spectrometric quantification of urinary 6-sulfatoxymelatonin: age-dependent excretion and biological variation. Clin Chem Lab Med. 2020 Jul 16;: Authors: van Faassen M, van der Veen A, van Ockenburg S, de Jong H, de Vries EGE, Kema IP Abstract Objectives Regulators of circadian rhythm, including melatonin, influence fundamental biological processes. Measuring the melatonin metabolite 6-sulfatoxymelatonin in urine can estimate...
Fri Jul 17, 2020 22:52
Related Articles Pregnancy After Breast Cancer in Patients With Germline BRCA Mutations. J Clin Oncol. 2020 Jul 16;:JCO1902399 Authors: Lambertini M, Ameye L, Hamy AS, Zingarello A, Poorvu PD, Carrasco E, Grinshpun A, Han S, Rousset-Jablonski C, Ferrari A, Paluch-Shimon S, Cortesi L, Senechal C, Miolo G, Pogoda K, Pérez-Fidalgo JA, De Marchis L, Ponzone R, Livraghi L, Estevez-Diz MDP, Villarreal-Garza C, Dieci MV, Clatot F, Berlière M, Graffeo R, Teixeira L,...
Fri Jul 17, 2020 22:52
Related Articles Ongoing and future clinical trials in particle therapy in the Nordic countries. Acta Oncol. 2020 Jul 16;:1-6 Authors: Witt Nyström P, Bratland Å, Minn H, Grau C Abstract In the Nordic countries, as in the rest of the world, particle therapy as a radiotherapy modality, is evolving, albeit the hard evidence for the clinical benefit still is scarce. However, a common goal for the Nordic countries is to include a minimum of 80%...
Fri Jul 17, 2020 22:52
Related Articles Working Together to Build a Better Future for Children With Cancer in Africa. JCO Glob Oncol. 2020 Jul;6:1076-1078 Authors: Chitsike I, Paintsil V, Sung L, Njuguna F, Mavinkurve-Groothuis A, Kouya F, Hesseling P, Kaspers G, Afungchwi GM, Ilbawi A, Renner L, Pritchard-Jones K, Hessissen L, Molyneux E, Chagaluka G, Israels T PMID: 32673078 [PubMed - as supplied by publisher]
Fri Jul 17, 2020 22:52
Related Articles An integrated electronic health record facilitates a safer and more efficient rural outreach haematology service. Intern Med J. 2020 Jul 16;: Authors: Cashman H, Mayson E, Kliman D, Kesby J, Bell J, Vachalec S, Withers B, Lavee O, Milliken S, Moore J, Hamad N Abstract BACKGROUND: Rural Australian oncology patients are known to have inferior mortality rates compared to metropolitan patients, possibly related to access to appropriate...
Fri Jul 17, 2020 22:52
Related Articles Factors influencing loneliness in cancer caregivers: A longitudinal study. Psychooncology. 2020 Jul 16;: Authors: Ross A, Perez A, Wehrlen L, Lee LJ, Yang L, Robert C, Bevans M, Ding A, Wiener L, Wallen G Abstract OBJECTIVE: to describe levels of loneliness in cancer caregivers over a six month time period, and to examine factors that influence changes in loneliness in caregivers over time. METHODS: prospective, repeated...
Fri Jul 17, 2020 22:52
Related Articles Effectiveness of a Multimedia Educational Intervention to Improve Understanding of the Risks and Benefits of Palliative Chemotherapy in Patients With Advanced Cancer: A Randomized Clinical Trial. JAMA Oncol. 2020 Jul 16;: Authors: Enzinger AC, Uno H, McCleary N, Frank E, Sanoff H, Van Loon K, Matin K, Bullock A, Cronin C, Cibotti H, Bagley J, Schrag D Abstract Importance: Despite requirements of informed consent, patients with...
Fri Jul 17, 2020 22:52
Related Articles The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology. Int J Hyperthermia. 2020 Jul;37(2):27-34 Authors: Srinivasan ES, Sankey EW, Grabowski MM, Chongsathidkiet P, Fecci PE Abstract The rise of immunotherapy (IT) in oncological treatment has greatly improved outcomes in a number of disease states. However, its use in tumors of the central nervous system (CNS) remains...
Fri Jul 17, 2020 22:52
Related Articles The use of laser interstitial thermal therapy in the treatment of brain metastases: a literature review. Int J Hyperthermia. 2020 Jul;37(2):53-60 Authors: Bastos DCA, Fuentes DT, Traylor J, Weinberg J, Kumar VA, Stafford J, Li J, Rao G, Prabhu SS Abstract PURPOSE: The aim of this paper is to discuss the current evidence for Laser Interstitial Thermal Therapy (LITT) in the treatment of brain metastases, our current recommendations...
Fri Jul 17, 2020 22:52
Related Articles Laser thermal therapy in the management of high-grade gliomas. Int J Hyperthermia. 2020 Jul;37(2):44-52 Authors: Avecillas-Chasin JM, Atik A, Mohammadi AM, Barnett GH Abstract Laser interstitial thermal therapy (LITT) is a minimally invasive therapy that have been used for brain tumors, epilepsy, chronic pain, and other spine pathologies. This therapy is performed under imaging and stereotactic guidance to precisely direct the...
Fri Jul 17, 2020 22:52
Related Articles Finding new lanes: Chimeric antigen receptor (CAR) T-cells for myeloid leukemia. Cancer Rep (Hoboken). 2020 Apr;3(2):e1222 Authors: Pratap S, Zhao ZJ Abstract BACKGROUND: Myeloid leukemia represents a heterogeneous group of cancers of blood and bone marrow which arise from clonal expansion of hematopoietic myeloid lineage cells. Acute myeloid leukemia (AML) has traditionally been treated with multi-agent chemotherapy, but conventional...
Fri Jul 17, 2020 13:34
Related Articles The impact of intimate partner violence on breast and cervical cancer survivors in an integrated, safety-net setting. J Cancer Surviv. 2020 Jul 15;: Authors: Jetelina KK, Carr C, Murphy CC, Sadeghi N, S Lea J, Tiro JA Abstract PURPOSE: Characterize prevalence of intimate partner violence (IPV) among breast and cervical survivors receiving care in an urban safety-net healthcare system; Examine the relationship between IPV and...
Fri Jul 17, 2020 13:34
Related Articles Association of Obesity-Related Genetic Variants (FTO and MC4R) with Breast Cancer Risk: A Population-Based Case-Control Study in Iran. Iran J Biotechnol. 2019 Dec;17(4):e2460 Authors: Mozafarizadeh M, Parvizi Omran S, Kordestani Z, Manshadi Dehghan H, Faridazar A, Houshmand M Abstract Background: Heterogeneous breast cancer is the most common cause of cancer-related mortality. Obesity defined by BMI is a known major risk factor...
Fri Jul 17, 2020 22:52
Related Articles Stereotactic Radiotherapy for the Management of Refractory Ventricular Tachycardia: Promise and Future Directions. Front Cardiovasc Med. 2020;7:108 Authors: Jumeau R, Ozsahin M, Schwitter J, Elicin O, Reichlin T, Roten L, Andratschke N, Mayinger M, Saguner AM, Steffel J, Blanck O, Vozenin MC, Moeckli R, Zeverino M, Vallet V, Herrera-Siklody C, Pascale P, Bourhis J, Pruvot E Abstract Ventricular tachycardia (VT) caused by myocardial...
Fri Jul 17, 2020 22:52
Related Articles Radiation Boost After Adjuvant Whole Breast Radiotherapy: Does Evidence Support Practice for Close Margin and Altered Fractionation? Front Oncol. 2020;10:772 Authors: Gulstene S, Raziee H Abstract Adding a boost to whole breast radiation (WBI) following breast-conserving surgery (BCS) may help improve local control, but it increases the total cost of treatment and may worsen cosmetic outcomes. Therefore, it is reserved for...
Fri Jul 17, 2020 22:52
Related Articles Brainstem Organoids From Human Pluripotent Stem Cells. Front Neurosci. 2020;14:538 Authors: Eura N, Matsui TK, Luginbühl J, Matsubayashi M, Nanaura H, Shiota T, Kinugawa K, Iguchi N, Kiriyama T, Zheng C, Kouno T, Lan YJ, Kongpracha P, Wiriyasermkul P, Sakaguchi YM, Nagata R, Komeda T, Morikawa N, Kitayoshi F, Jong M, Kobashigawa S, Nakanishi M, Hasegawa M, Saito Y, Shiromizu T, Nishimura Y, Kasai T, Takeda M, Kobayashi H, Inagaki Y, Tanaka Y,...
Fri Jul 17, 2020 22:52
Related Articles Knowledge and Attitude of Medical Residents Towards Cancer Clinical Trials in Jordan. Int J Gen Med. 2020;13:337-342 Authors: Al-Azayzih A, Alzoubi KH Abstract Background: Clinical trials are an important tool to test the efficacy of new treatment modalities for cancer patients. Physicians, including medical residents, should play a major role in carrying out clinical trials to generate a strong body of evidence to determine...
Fri Jul 17, 2020 22:52
Related Articles A budget impact analysis of lenalidomide in multiple myeloma Egyptian patients. J Med Econ. 2020 Jul 16;:1 Authors: Elsisi GH, Carapinha JL, Afify R, Abd Elmoty M, Khalaf M Abstract Introduction: The aim of this study was to estimate the budget impact of lenalidomide and dexamethasone (RD) versus bortezomib, cyclophosphamide and dexamethasone (VCD) in newly diagnosed multiple myeloma (NDMM) and relapsed refractory (RR) MM patients,...
Fri Jul 17, 2020 13:34
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