Fri Jul 17, 2020 13:56
Abstract Background It is generally believed that intervention on skin while on isotretinoin or within 6‐12 months after treatment can lead to prolonged healing and abnormal scarring. Objective The objective of this systematic review is to evaluate the body of evidence on concomitant use of isotretinoin and lasers for adverse events as a consequence of treatment. Methods & Materials A PRISMA‐compliant systematic review (Systematic Review Registration Number: CRD42017056492) of...
Fri Jul 17, 2020 13:56
ABSTRACT Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease. Biological therapy has revolutionized it's the treatment. Paradoxical HS occur with various biological and targeted agents. We report a patient with juvenile rheumatoid arthritis who developed HS after 6 months of tofacitinib therapy. A comprehensive literature review identified 43 cases of paradoxical HS among patients on biological and targeted agents. Pooled analysis of the cases showed Crohn's disease...
Thu Jul 16, 2020 21:56
Abstract Emollients are acknowledged as a part of standard care in therapeutic and prevention protocols as well as a part of everyday skin care routine. When it comes to making a final decision between two emollient products, the ingredient list i.e. the formulation composition could be the determining factor. In such cases the consumer, and some healthcare providers, believe that products with the same qualitative composition (ingredient list) must have the same efficacy. In this work we have investigated...
Thu Jul 16, 2020 21:29
Thu Jul 16, 2020 15:48
Old World porcupines (Family: Hystricidae) are the third-largest rodents and inhabit southern Europe, Asia, and most regions of Africa. They are a typical indicator of warm climate and their distribution is re...
Sat Jul 18, 2020 03:00
The blood-feeding behavior evolved multiple times in Insecta lineages and it represents an excellent opportunity to study patterns of convergent molecular evolution regarding this habit. In insects the expansi...
Fri Jul 17, 2020 03:00
Abstract Transient abnormal myelopoiesis (TAM) raises the risk for acute myeloid leukemia of Down syndrome (DS) (ML‐DS), and both are related to GATA1 pathogenic variants. Here, we analyzed which findings on complete blood count (CBC) are associated with TAM in a cohort of neonates with DS screened for GATA1 pathogenic variants. The CBCs were compared among 70 newborns with DS, including 16 patients (22.9%) with TAM (cases), and 54 patients (77.1%) without TAM (controls). TAM was defined as peripheral...
Sat Jul 18, 2020 14:29
Abstract A family with three affected males and a second family with a single affected male with intellectual disability, microcephaly, ophthalmoplegia, deafness, and Involuntary limb movements were reported by Schimke and Associates in 1984. The affected males with Schimke X‐linked intellectual disability (XLID) syndrome (OMIM# 312840) had a similar facial appearance with deep‐set eyes, downslanting palpebral fissures, hypotelorism, narrow nose and alae nasi, cupped ears and spacing of the teeth....
Sat Jul 18, 2020 13:22
Abstract Orofaciodigital syndrome (OFD) can have variable phenotype and presents with oral anomalies, facial dysmorphism, and digital malformations like syndactyly, and polydactyly. Other presentations also include renal and cardiac defects, and central nervous system anomalies like hydrocephalus and cerebellar abnormalities. OFD1 is a X‐linked dominant form of the syndrome presenting in females with mutations in CXorf5 or OFD1 gene. We describe a young child with sparse hairs, milia over face...
Fri Jul 17, 2020 12:10
Abstract Sotos syndrome is one of the overgrowth syndromes, and can present with intellectual disability, behavioral problems and tall stature. In some cases, seizures, pectus deformity, cardiac and renal anomalies may be identified. Here we report two Indian children with Sotos syndrome whose initial presentation was macrocephaly and behavioral problems, respectively. The pathogenic variants in NSD1 gene were confirmed by next generation sequencing. The gene variants in the two children, one male...
Fri Jul 17, 2020 12:08
Abstract Fetal alcohol spectrum disorders (FASD) describe a range of physical, behavioral, and neurologic deficits in individuals exposed to alcohol prenatally. Reduced palpebral fissure length is one of the cardinal facial features of FASD. However, other ocular measurements have not been studied extensively in FASD. Using the Fetal Alcohol Syndrome Epidemiologic Research (FASER) database, we investigated how inner canthal distance (ICD), interpupillary distance (IPD), and outer canthal distance...
Fri Jul 17, 2020 11:22
Abstract COG6‐congenital disorder of glycosylation (COG6‐CDG) is caused by biallelic mutations in COG 6. To‐date, 12 variants causing COG6‐CDG in less than 20 patients have been reported. Using whole exome sequencing we identified two siblings with a novel homozygous deletion of 26 bp in COG6 , creating a splicing variant (c.518_540 + 3del) and a shift in the reading frame. The phenotype of COG6‐CDG includes growth and developmental retardation, microcephaly, liver and gastrointestinal...
Sat Jul 18, 2020 20:53
Abstract Asthenozoospermia is a common cause of male infertility associated with the reduced motility and/or abnormal morphology of spermatozoa, although its etiology remains incompletely understood. Multiple morphological abnormalities of the sperm flagella (MMAF) is one of the main causes of asthenozoospermia. However, the MMAF‐associated genes identified to date cannot explain all the human MMAF cases. Herein, a loss‐of‐function mutation of DNAH8 was identified in an asthenozoospermia...
Sat Jul 18, 2020 14:54
The facial nerve connections and pathways from the cortex to the brainstem are intricate and complicated. The extra‐axial part of the facial nerve leaves the lateral part of the pontomedullary sulcus and enters the temporal bone through the internal acoustic meatus. In the temporal bone, the facial nerve branches into fibers innervating the glands and tongue. After it emerges from the temporal bone it supplies various facial muscles. It contains motor, general sensory, special sensory, and autonomic...
Sat Jul 18, 2020 20:43
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has had enormous effects on anatomy education. During the pandemic, students have had no access to cadavers, which has been the principal way to learn anatomy since the 17th century. As it is difficult to predict future access to cadavers for students or in‐person classes, anatomy educators are encouraged to revisit all possible teaching methods in order to develop innovations. Here, we review anatomy education methods to apply to current...
Sat Jul 18, 2020 19:43
ABSTRACT Female ejaculation is a contentious topic. From a review of the literature, history indicates that it is not a modern concept; some females were aware of it in times past without understanding the role of the fluid or composition of the ejaculate. Over time, scholars experimented, mainly with anatomical studies, in an attempt to identify the source of the ejaculate and explore its physiological and anatomical benefits for the female sexual experience. Despite these studies, views about...
Sat Jul 18, 2020 19:08
A sapphire shaped capillary needle designed for collimating and focusing of laser radiationwas proposed and fabricated by the edge‐defined film‐fed growth technique. It features an as‐grown surface quality, high transparency for visible and near‐infrared radiation, high thermal and chemical resistance, and the complex shape of the tip, which protects silica fibers. The needle's geometrical parameters can be adjusted for use in various situations, such as type of tissue, modality of therapy, and treatment...
Sat Jul 18, 2020 13:49
ABSTRACT Confocal Raman Mapping (CRM) is a powerful, label free, non‐destructive tool, enabling molecular characterisation of human skin with applications in the dermo‐cosmetic field. Coupling CRM to multivariate analysis can be used to monitor the penetration and permeation of Active Cosmetic Ingredients (ACI) after topical application. It is presently illustrated how Multivariate Curve Resolution Alternating Least Squares (MCR‐ALS) can be applied to detect and semi‐quantitatively describe the...
Fri Jul 17, 2020 19:01
Sun Jul 19, 2020 03:00
Interventions to improve hand hygiene (HH) compliance are a key element in the practice infection prevention and control. It was our objective to assess the effect of a multimodal intervention on HH compliance...
Sat Jul 18, 2020 03:00
Staphylococcus aureus (S. aureus), including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA), is an eminent human pathogen that can colonize the human host and cause severe lif...
Fri Jul 17, 2020 03:00
The global spread of methicillin-resistant Staphylococcus aureus (MRSA) infections necessitates the use of validated methods for the identification and typing of this bacterium. This study aimed to determine the ...
Fri Jul 17, 2020 03:00
Increasing numbers of critically ill patients experience a prolonged intensive care unit stay contributing to greater physical and psychological morbidity, strain on families and cost to health systems. Qualit...
Sun Jul 19, 2020 03:00
Over 4.2 million confirmed cases and more than 285,000 deaths, COVID-19 pandemic continues to harm significant number of people worldwide. Several studies have reported the impact of COVID-19 in general popula...
Sat Jul 18, 2020 03:00
Exergaming is a fun, engaging, and interactive form of exercising that may help overcome some of the traditional exercise barriers and help improve adherence on the part of older adults, providing therapeutic ...
Sat Jul 18, 2020 03:00
Decision-makers increasingly request rapid answers to clinical or public health questions. To save time, personnel, and financial resources, rapid reviews streamline the methodological steps of the systematic ...
Sat Jul 18, 2020 03:00
Despite the achievements reported from using rainwater harvesting systems, the contribution and drawbacks that affect their usage in mountainous landscapes have received little attention. The uptake and usage of domestic rooftop rainwater harvesting systems (RRWHS) in developing countries is on the increase due to increasing water scarcities. We explored the effect of rainfall variability on water supply and the downsides of using the systems by rural households in Uganda. The objectives were to...
Sat Jul 18, 2020 18:35
The increase in demand for thermoplastics as a light-weight material for automobile application and other commercial purposes prompts more research into the available polymer resources. In this research, the possibility of enhancing the performance of recycled waste plastics (RWP) as polymer-based composites was examined. Particulate snail shell was obtained by grounding and sieving snail shells to obtain 53–63 μm passing which was used as reinforcement in the recycled waste plastics. The composites...
Fri Jul 17, 2020 12:05
This study was aimed to develop in vitro micropropagation protocol of Aloe trichosantha Berger using offshoots as explants. MS media supplemented with plant growth regulators helped explants develop shoots within about 14 to 17 days. The mean number of days to shooting has decreased from 16.8 ± 0.8 with 0.5/0.5 mg/L BAP/NAA supplement to 15.5 ± 0.5 with 2.0/0.5 mg/L BAP/NAA. While the mean shoot number has increased with increasing the concentration of BAP supplements, the reverse was true with mean...
Thu Jul 16, 2020 18:35
Cyclophosphamide (CPA) represents a widely used anti-cancer prodrug that is converted by liver cytochrome P450 (CYP) enzymes into the primary metabolite 4-hydroxycyclophosphamide (4-OH-CPA), followed by non-en...
Sat Jul 18, 2020 03:00
Acanthamoeba castellanii can cause granulomatous amoebic encephalitis and Acanthamoeba keratitis. Currently, no single drug has been developed to effectively treat infections caused by Acanthamoeba. Recent studie...
Fri Jul 17, 2020 03:00
Sat Jul 18, 2020 03:00
Along with swift economic evolution and continuous amelioration of lifestyle, people at present are paying more attention to health issues. Synthetic drugs will be compensated with other natural ones that belo...
Fri Jul 17, 2020 03:00
We document a case of a 24-year-old woman who presented with cerebral granuloma and optic papillitis associated to Brucella sp. infection, whose diagnosis was made with a brain biopsy and serology tests, with clinical improvement following specific antibiotic therapy. The patient was followed up for over a year without evidence of relapse.
Sat Jul 18, 2020 16:50
Abstract Prosthetic feet have generally been designed experimentally by adopting a trial-and-error technique. The objective of this research is to introduce a novel numerical approach for the a priori evaluation of the roll-over shape (ROS) of a prosthetic foot for application in its systematic design and development. The ROS was achieved numerically by employing a non-linear finite element model incorporating the augmented Lagrangian and multi-point constraint contact formulations,...
Sat Jul 18, 2020 03:00
Abstract Pathogenesis of different diseases showed that some of them, especially thalassemia (T) and rheumatoid arthritis (RA) have an implicit association with oxidative stress and altered levels of reactive oxygen species (ROS). Introducing ROS level and the balance between ROS and antioxidants as essential metrics, an attempt was made to classify T and RA from normal individuals (treated as controls)(C) using synchronous fluorescence spectroscopy (SFS) and Raman line intensity...
Fri Jul 17, 2020 03:00
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