New England Journal of Medicine, Ahead of Print.
Fri Jul 17, 2020 07:01
New England Journal of Medicine, Ahead of Print.
Fri Jul 17, 2020 07:01
New England Journal of Medicine, Ahead of Print.
Fri Jul 17, 2020 07:00
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (Covid-19), emerged in China in late 2019 from a zoonotic source. The majority of Covid-19 cases either are asymptomatic or result in only mild disease. However, in a substantial percentage of…
Fri Jul 17, 2020 03:00
The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
Thu Jul 09, 2020 03:00
Bilateral tumors in paired organs are assumed to be hereditary in nature, because a family history of cancer and an earlier age at onset are often associated with such tumors. These observations led Knudson to develop a seminal "two-hit" model that established a statistical basis for evaluating…
Thu Jul 16, 2020 03:00
Rheumatoid arthritis, like many autoimmune diseases, has a course characterized by intermittent flares, yet our understanding of the mechanisms underlying flares remains limited. In an article published in this issue of the Journal, Orange and colleagues describe a study in which serial fingerstick…
Thu Jul 16, 2020 03:00
Rheumatoid arthritis symptoms are highly dynamic, with periods of stability interrupted by unpredictable flares of disease activity. Such waxing and waning clinical courses are characteristic of many autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and inflammatory…
Thu Jul 16, 2020 03:00
To the Editor: We propose a genetic epidemiologic metric derived from sequencing tumor cells and matched "normal" cells (typically peripheral-blood mononuclear cells); this metric can be used to evaluate the relevance of germline pathogenic variants (GPVs) in tumor-suppressor genes to the…
Thu Jul 16, 2020 03:00
Before I become your doctor, you have been intubated for weeks. I am a point in time, unattached to the greater narrative. I call your husband each afternoon, tell him you are stable. He asks about the medicine that props up your blood pressure. He calls it the levo, acquainted by now with the…
Fri Jul 17, 2020 03:00
The current literature on the treatment of coronavirus disease 2019 (Covid-19) is filled with anecdotal reports of therapeutic successes in clinical trials with small numbers of patients and observational cohort studies claiming efficacy with little regard to the effect of unrecognized confounders.…
Fri Jul 17, 2020 03:00
Among patients with an acute ischemic stroke or transient ischemic attack (TIA), the risk of a subsequent ischemic stroke is approximately 5 to 10% in the first few months. Aspirin has been used to prevent a stroke in these patients, and two trials have shown that the combination of aspirin and…
Thu Jul 16, 2020 03:00
Without urgent treatment, the risk of major stroke in the week after a transient ischemic attack (TIA) or minor stroke can be as high as 10%. Some studies have shown that immediate medical treatment with antiplatelet agents and statins, as well as blood-pressure control, reduces that risk by 70 to…
Thu Jul 16, 2020 03:00
"I know you are worried about Xin — all of us are, as well," I told the patient’s mother. "We are not sure why he is confused, but we are trying our best to find out. I cannot imagine how difficult it is for you, but our team will take care of both of you." I carefully selected an accurate Mandarin…
Thu Jul 16, 2020 03:00
Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 62-year-old,…
Thu Jul 16, 2020 03:00
High-potency topical glucocorticoids and vitamin D derivatives are the main treatments for psoriasis. Topical glucocorticoids are effective in the treatment of psoriasis, but their use is usually limited to no more than 2 to 8 weeks, and they may be associated with adverse events that resolve…
Thu Jul 16, 2020 03:00
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