The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism...
Sat Jul 18, 2020 16:20
Challenging diagnosis and unknown etiology of Kawasaki disease (KD) increase the coronary artery lesions incidence. microRNAs (miRNAs) are the most promising biomarkers because of their stability in peripheral blood and noninvasive measurement procedure, whose potential utility have been proved in cancers. To explore the utility of differentially expressed (DE) miRNAs as early diagnostic markers, 44 patients (25 incomplete KD and 19 complete KD) and 31 febrile controls were recruited for small RNA...
Sat Jul 18, 2020 15:50
Abnormal lipid metabolism, oxidative stress (OS), and inflammation play a pivotal role in the increased susceptibility to neonatal fatty liver diseases associated with intrauterine growth retardation (IUGR). This study was firstly conducted to investigate whether resveratrol could alleviate IUGR-induced hepatic lipid accumulation, alteration of redox and immune status in a sucking piglet model and explore the possible mechanisms at transcriptional levels. A total of 36 pairs of 7 d old male normal...
Sat Jul 18, 2020 15:50
Gallbladder adenocarcinoma is the main histopathological type of gallbladder cancer (GBC), so it is particularly important to understand its biological characteristics. Due to the low incidence of this type of cancer, there are few studies with large sample sizes. The log of positive lymph nodes (LODDS) has been evaluated by many scholars as a lymph node stage that may play a better role than the 8th edition of the American Joint Committee on Cancer (AJCC) lymph node staging system in many cancers....
Sat Jul 18, 2020 15:35
Introduction. To identify and analyze factors that influence administration, recognition, and compliance of medicine among community residents in Jilin Province, China. Methods. A survey was carried out among 2417 community residents in Jilin Province, China, to study their administration (CRA), recognition (CRR), and compliance (CRC) of medicine. Multivariate logistic regression analyses and chi-squared tests were performed to assess factors influencing CRA, CRR, and CRC. Results. Logistic analyses...
Sat Jul 18, 2020 14:35
To investigate whether Polyphyllin I (PPI) might induce the autophagy and apoptosis of melanoma cells by regulating PI3K/Akt/mTOR signal pathway. Melanoma A375 cells were incubated with different concentrations of Polyphyllin I (0, 1.5, 3.0, and 6.0 mg/L) and PI3K/Akt/mTOR signaling pathway activator IGF-1(20 mg/L). CCK-8 assay was utilized to detect cell proliferation; Cell apoptosis and cell cycle were measured by flow cytometry; Western blot was used to examine the expressions of proteins. Immunofluorescence...
Sat Jul 18, 2020 13:50
This study was aimed at investigating the mutations in colorectal cancer (CRC) for recurrent neoantigen identification. A total of 1779 samples with whole exome sequencing (WES) data were obtained from 7 published CRC cohorts. Common HLA genotypes were used to predict the probability of neoantigens at high-frequency mutants in the dataset. Based on the WES data, we not only obtained the most comprehensive CRC mutation landscape so far but also found 1550 mutations which could be identified in at...
Sat Jul 18, 2020 10:50
Background. Results of previous studies suggest that NANOG may be an important prognostic biomarker in oral squamous cell carcinoma (OSCC), but there are contradictory results regarding NANOG expression patterns on mRNA and protein levels, and the mechanisms of its regulation are poorly understood. Our aim was to analyze the expression and diagnostic significance of NANOG in OSCC, and the possible mechanisms of its regulation, i.e., protein regulators on mRNA level (OCT4, SOX2, KLF4, AGR2, and NOTCH1),...
Sat Jul 18, 2020 09:35
Sat Jul 18, 2020 08:05
Objective. The objective of our study was to evaluate the incidence of target organ damages (TOD) in patients with arterial hypertension and the first ever episode of myocardial infarction (N-STEMI or STEMI) and to determine which of the analyzed kinds of TOD had the highest predictive value for the assessment of the likelihood of acute coronary syndrome (ACS). Material and Methods. The study group consisted of 51 patients with treated systemic hypertension, suffering from the first episode of myocardial...
Fri Jul 17, 2020 17:20
Objective. To compare the biomechanical properties of a new memory compression alloy plate and traditional titanium plate after anterior cervical discectomy and fusion (ACDF). Methods. A finite element model of the C3-7 segments was developed and validated. The C5-6 disc was removed, and an intervertebral cage made of peek material was implanted. Then, a new memory compression alloy plate composed of Ti-Ni memory alloy and a traditional titanium plate were integrated at the C5-6 segment. All models...
Fri Jul 17, 2020 11:50
Objective. To evaluate the prevalence of nonsevere maternal morbidity (including overall health, domestic and sexual violence, functionality, and mental health) in women during antenatal care and further analyze factors associated with compromised mental functioning and clinical health by administration of the WHO’s WOICE 2.0 instrument. Method. A cross-sectional study was conducted at a referral center in Brazil with an interview and questionnaire administered to pregnant women at 28 weeks of gestation...
Fri Jul 17, 2020 11:20
Enzalutamide (ENZ) has been approved for the treatment of advanced prostate cancer (PCa), but some patients develop ENZ resistance initially or after long-term administration. Although a few key genes have been discovered by previous efforts, the complete mechanisms of ENZ resistance remain unsolved. To further identify more potential key genes and pathways in the development of ENZ resistance, we employed the GSE104935 dataset, including 5 ENZ-resistant (ENZ-R) and 5 ENZ-sensitive (ENZ-S) PCa cell...
Fri Jul 17, 2020 09:50
Objective. To evaluate the prevalence rate and survival situation of bone metastases in initial nasopharyngeal carcinoma (NPC) patients and the hazard and forecast elements of bone metastases NPC patients. Patients and Methods. The data collected from Surveillance, Epidemiology, and End Results (SEER) program between 2010 and 2016 were evaluated. Univariate and multivariable logistic analysis and the Cox regression were carried out to estimate predictors and elements of the being of bone metastases...
Fri Jul 17, 2020 09:50
Researchers at the University of Michigan have developed robotic prosthetic legs which use motors that were originally designed for use on the robotic arm of the International Space Station. The motors allow the prostheses to move more naturally, producing less stress on the hips of users, and they are also quieter and more energy efficient than pre-existing robotic legs. Conventional prosthetic legs require the wearer to move their hips abnormally to raise the foot and swing...
Fri Jul 17, 2020 19:07
Publication date: Available online 19 July 2020Source: Medical Image AnalysisAuthor(s): Jiawen Yao, Xinliang Zhu, Jitendra Jonnagaddala, Nicholas Hawkins, Junzhou Huang
Sun Jul 19, 2020 18:48
Publication date: Available online 19 July 2020Source: Medical Image AnalysisAuthor(s): Gabriel Bernardino, Oualid Benkarim, María Sanz de la Garza, Susanna Prat-Gonzàlez, Alvaro Sepulveda-Martinez, Fátima Crispi, Marta Sitges, Constantine Butakoff, Mathieu De Craene, Bart Bijnens, Miguel A. González Ballester
Sun Jul 19, 2020 18:48
Publication date: Available online 19 July 2020Source: Medical Image AnalysisAuthor(s): Lisa Herzog, Elvis Murina, Oliver Dürr, Susanne Wegener, Beate Sick
Sun Jul 19, 2020 18:48
Publication date: Available online 18 July 2020Source: Medical Image AnalysisAuthor(s): Bingchao Zhao, Xin Chen, Zhi Li, Zhiwen Yu, Su Yao, Lixu Yan, Yuqian Wang, Zaiyi Liu, Changhong Liang, Chu Han
Sun Jul 19, 2020 18:48
Publication date: Available online 18 July 2020Source: Medical Image AnalysisAuthor(s): Riqiang Gao, Yucheng Tang, Kaiwen Xu, Yuankai Huo, Shunxing Bao, Sanja L. Antic, Emily S. Epstein, Steve Deppen, Alexis B. Paulson, Kim L. Sandler, Pierre P. Massion, Bennett A. Landman
Sun Jul 19, 2020 18:48
Publication date: August 2020Source: Medical Image Analysis, Volume 64Author(s):
Sat Jul 18, 2020 16:45
Publication date: August 2020Source: Medical Image Analysis, Volume 64Author(s):
Sat Jul 18, 2020 16:45
Publication date: Available online 18 July 2020Source: Medical Image AnalysisAuthor(s): Yong Pi, Zhen Zhao, Yongzhao Xiang, Yuhao Li, Huawei Cai, Zhang Yi
Sat Jul 18, 2020 16:45
Publication date: Available online 18 July 2020Source: Medical Image AnalysisAuthor(s): Liangliang Liu, Lukasz Kurgan, Fang-Xiang Wu, Jianxin Wang
Sat Jul 18, 2020 16:45
Publication date: Available online 18 July 2020Source: Medical Image AnalysisAuthor(s): Guotai Wang, Tao Song, Qiang Dong, Mei Cui, Ning Huang, Shaoting Zhang
Sat Jul 18, 2020 16:45
Publication date: Available online 18 July 2020Source: Medical Image AnalysisAuthor(s): Fei Liu, Dan Liu, Jie Tian, Xiaoyan Xie, Xin Yang, Kun Wang
Sat Jul 18, 2020 16:45
Passive bottom-set nets are the most widely used fishing gears in Mediterranean small-scale fisheries (SSFs). Trammel nets, in particular, have key advantages such as their ease of use and handling and high capture efficiency for numerous commercial species. However, they entail high discard rates (5–44% of the total catch) connected to high mortality, thus exerting an adverse impact on benthic communities, besides catching individuals of commercial species under the minimum conservation reference...
Fri Jul 17, 2020 03:00
The diversity and community distribution of soil bacteria in different land use types in Yangtze River Basin, Chongqing Municipality were studied by using Illumina MiSeq analysis methods. Soil physical and chemical properties were determined, and correlation analyses were performed to identify the key factors affecting bacterial numbers and α-diversity in these soils. The results showed that the soil physical and chemical properties of different land use types decrease in the order: mixed forest...
Fri Jul 17, 2020 03:00
Background The Aegean Sea coast of Turkey hosts one of the most important nesting grounds for loggerhead sea turtles (Caretta caretta) in the Mediterranean Sea. Previous studies have revealed that the sea turtle carapace provides favourable conditions for various epibiontic organisms. Epibionts occurring on the carapace have been examined from different locations in the oceans. Methods This is the first time such a high...
Fri Jul 17, 2020 03:00
Background Lake Sinai Viruses (LSV) are common RNA viruses of honey bees (Apis mellifera) that frequently reach high abundance but are not linked to overt disease. LSVs are genetically heterogeneous and collectively widespread, but despite frequent detection in surveys, the ecological and geographic factors structuring their distribution in A. mellifera are not understood. Even less is known about their distribution in other species. Better understanding of LSV prevalence and ecology...
Fri Jul 17, 2020 03:00
Background Substitution can be defined as the consciously motivated choice to use one drug, either licit or illicit, instead of another, due to perceptions of cost, availability, safety, legality, substance characteristics, and substance attributions. Substitution represents a potential risk to drug users, mainly when substitutes are of higher potency and toxicity. This study offers a basic conceptualization of illicit substitution behavior and describes substitution patterns among...
Fri Jul 17, 2020 03:00
The impacts of grazing by meso- and microzooplankton on phytoplankton primary production (PP) was investigated in the surface layer of the western North Atlantic during spring. Shipboard experiments were performed on a latitudinal transect at three stations that differed in mixed layer depth, temperature, and mesozooplankton taxonomic composition. The mesozooplankton community was numerically dominated by Calanus finmarchicus at the northern and central station, with Calanus hyperboreus also present...
Fri Jul 17, 2020 03:00
The Ethylene-Response Factor (ERF) subfamily transcription factors (TFs) belong to the APETALA2/Ethylene-Responsive Factor (AP2/ERF) superfamily and play a vital role in plant growth and development. However, identification and analysis of the ERF subfamily genes in maize have not yet been performed at genome-wide level. In this study, a total of 76 ERF subfamily TFs were identified and were found to be unevenly distributed on the maize chromosomes. These maize ERF (ZmERF) TFs were classified into...
Fri Jul 17, 2020 03:00
Anthropogenic eutrophication is altering aquatic environments by promoting primary production. This influences the population dynamics of consumers through bottom-up effects, but the underlying mechanisms and pathways are not always clear. To evaluate and mitigate effects of eutrophication on ecological communities, more research is needed on the underlying factors. Here we show that anthropogenic eutrophication increases population fecundity in the threespine stickleback (Gasterosteus aculeatus)...
Fri Jul 17, 2020 03:00
Coronovirus disease 2019 (COVID-19) infection, which originated from Wuhan, China, has seized the whole world in its grasp and created a huge pandemic situation before humanity. Since December 2019, genomes of numerous isolates have been sequenced and analyzed for testing confirmation, epidemiology, and evolutionary studies. In the first half of this article, we provide a detailed review of the history and origin of COVID-19, followed by the taxonomy, nomenclature and genome organization of its causative...
Fri Jul 17, 2020 03:00
Publication date: Available online 16 July 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Anders B. Olin, Adam E. Hansen, Jacob H. Rasmussen, Claes N. Ladefoged, Anne K. Berthelsen, Katrin Håkansson, Ivan R. Vogelius, Lena Specht, Anita B. Gothelf, Andreas Kjaer, Barbara M. Fischer, Flemming L. Andersen
Fri Jul 17, 2020 17:37
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου