Related Articles Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC). Eur J Med Chem. 2020 Mar 01;189:112061 Authors: Zhang H, Zhao HY, Xi XX, Liu YJ, Xin M, Mao S, Zhang JJ, Lu AX, Zhang SQ Abstract Epidermal growth factor receptor (EGFR), a member of the HER family, is closely related to the development of multiple cancers. Herein, we report the discovery of small molecule EGFR degraders...
Fri Jul 17, 2020 13:29
Related Articles Differential properties of mitosis-associated events following CHK1 and WEE1 inhibitor treatments in human tongue carcinoma cells. Exp Cell Res. 2020 01 15;386(2):111720 Authors: Nojima H, Homma H, Onozato Y, Kaida A, Harada H, Miura M Abstract CHK1 and WEE1 play pivotal roles in G2/M checkpoint following exogenous DNA damage and regulation of DNA replication under normal cellular conditions. Here, we monitored and compared...
Fri Jul 17, 2020 13:29
Related Articles Is There Room for Immune Checkpoint Inhibitors in Patients Who Have NSCLC With Autoimmune Diseases? J Thorac Oncol. 2019 10;14(10):1701-1703 Authors: Remon J, Hendriks L, Aspeslagh S, Besse B PMID: 31420287 [PubMed - indexed for MEDLINE]
Fri Jul 17, 2020 13:29
Related Articles Identification of novel and potent small-molecule inhibitors of tubulin with antitumor activities by virtual screening and biological evaluations. J Comput Aided Mol Des. 2019 07;33(7):659-664 Authors: Liu G, Jiao Y, Huang C, Chang P Abstract Microtubules (made up of α and β-tubulin subunits) play an essential role in the process of mitosis and cell proliferation, thus making them an ideal target for anticancer drugs discovery....
Fri Jul 17, 2020 13:29
Related Articles Drug-free macromolecular therapeutics exhibit amplified apoptosis in G2/M phase arrested cells. J Drug Target. 2019 Jun - Jul;27(5-6):566-572 Authors: Li L, Yang J, Wang J, Kopeček J Abstract Drug-free macromolecular therapeutics (DFMT) have been recently developed to treat non-Hodgkin lymphoma (NHL). It is a consecutive delivery of two nanoconjugates: (1) bispecific engager that pretargets surface CD20, and (2) multivalent...
Fri Jul 17, 2020 13:29
Related Articles Predominant and novel de novo variants in 29 individuals with ALG13 deficiency: Clinical description, biomarker status, biochemical analysis and treatment suggestions. J Inherit Metab Dis. 2020 Jul 18;: Authors: Ng BG, Eklund EA, Shiryaev SA, Dong YY, Abbott MA, Asteggiano C, Bamshad MJ, Barr E, Bernstein JA, Chelakkadan S, Christodoulou J, Chung WK, Ciliberto MA, Cousin J, Gardiner F, Ghosh S, Graf WD, Grunewald S, Hammond K, Hauser NS, Hoganson...
Sun Jul 19, 2020 14:33
Related Articles IL-6 Receptor Blockade by Tocilizumab Has Anti-absence and Anti-epileptogenic Effects in the WAG/Rij Rat Model of Absence Epilepsy. Neurotherapeutics. 2020 Jul 17;: Authors: Leo A, Nesci V, Tallarico M, Amodio N, Gallo Cantafio EM, De Sarro G, Constanti A, Russo E, Citraro R Abstract Increased expression of interleukin-6 (IL-6) both in cerebrospinal fluid (CSF) and plasma is closely associated with convulsive epilepsy and symptom...
Sun Jul 19, 2020 14:33
Related Articles The effects of a ketogenic diet on sensorimotor function in a thoracolumbar mouse spinal cord injury model. eNeuro. 2020 Jul 17;: Authors: Mayr KA, Kwok CHT, Eaton SEA, Baker GB, Whelan PJ Abstract Spinal cord injury (SCI) and peripheral nerve injuries are traumatic events that greatly impact quality of life. One factor that is being explored throughout patient care is the idea of diet and the role it has on patient outcomes....
Sun Jul 19, 2020 14:33
Epilepsy surgery for Rasmussen encephalitis: the UCLA experience. J Neurosurg Pediatr. 2020 Jul 17;:1-9 Authors: Bellamkonda N, Phillips HW, Chen JS, Tucker AM, Maniquis C, Mathern GW, Fallah A Abstract OBJECTIVE: Rasmussen encephalitis (RE) is a rare inflammatory neurological disorder typically involving one hemisphere and resulting in drug-resistant epilepsy and progressive neurological decline. Here, the authors present seizure outcomes...
Sat Jul 18, 2020 15:41
Comparison of long-term efficacy, tolerability, and safety of oxcarbazepine, lamotrigine, and levetiracetam in patients with newly diagnosed focal epilepsy: An observational study in the real world. Epilepsy Res. 2020 Jun 26;166:106408 Authors: Li R, Zhou Q, Ou S, Wang Y, Li Y, Xia L, Pan S Abstract OBJECTIVE: We performed observational cohort study to compare the long-term efficacy, tolerability, and safety of oxcarbazepine (OXC), lamotrigine...
Sat Jul 18, 2020 15:41
A novel approach of targeting refractory epilepsy: Need of an hour. Brain Res Bull. 2020 Jul 14;: Authors: Garg N, Joshi R, Medhi B Abstract The refractory epilepsy adds to the global burden of epilepsy as about 25% of all patients with epilepsy present drug-resistant epilepsy. The P-glycoprotein (P-gp) plays a vital role in the mechanism of resistance in epilepsy. The AED levels in the brain are regulated by the P-gp transport. The upregulation...
Sat Jul 18, 2020 15:41
Related Articles Intracranial EEG in the 21st Century. Epilepsy Curr. 2020 Jul 17;:1535759720934852 Authors: Jobst BC, Bartolomei F, Diehl B, Frauscher B, Kahane P, Minotti L, Sharan A, Tardy N, Worrell G, Gotman J Abstract Intracranial electroencephalography (iEEG) has been the mainstay of identifying the seizure onset zone (SOZ), a key diagnostic procedure in addition to neuroimaging when considering epilepsy surgery. In many patients, iEEG...
Sat Jul 18, 2020 15:41
Related Articles NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor. Cell Mol Life Sci. 2020 Jul 16;: Authors: Mazzaferro S, Whiteman ST, Alcaino C, Beyder A, Sine SM Abstract Nicotinic acetylcholine receptors (nAChRs) belong to the superfamily of pentameric ligand-gated ion channels, and in neuronal tissues, are assembled from various types of α- and β-subunits. Furthermore, the subunits...
Sat Jul 18, 2020 15:41
Related Articles Homeostatic Plasticity in Epilepsy. Front Cell Neurosci. 2020;14:197 Authors: Lignani G, Baldelli P, Marra V Abstract In the healthy brain, neuronal excitability and synaptic strength are homeostatically regulated to keep neuronal network activity within physiological boundaries. Epilepsy is characterized by episodes of highly synchronized firing across in widespread neuronal populations, due to a failure in regulation of network...
Sat Jul 18, 2020 15:41
Related Articles A randomized controlled study examining a novel binaural beat technique for treatment of preoperative anxiety in a group of women undergoing elective caesarean section. J Psychosom Obstet Gynaecol. 2020 Jul 17;:1-5 Authors: Parodi A, Fodde P, Pellecchia T, Puntoni M, Fracchia E, Mazzella M Abstract IMPORTANCE: Attention is being focused on improving mothers' positive experiences of childbirth while reducing the negative ones....
Sat Jul 18, 2020 15:41
Related Articles Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression. J Cell Biochem. 2019 06;120(6):9409-9420 Authors: Liu D, Li S, Gong L, Yang Y, Han Y, Xie M, Zhang C Abstract We investigated that microRNA (miRNA)-141 protects against epilepsy-induced apoptosis and its reaction mechanism. The serum expression of miRNA-141 in epilepsy model mice and control volunteer was measured...
Sat Jul 18, 2020 15:41
Related Articles Evaluation of the Neonate with Seizures. Pediatr Ann. 2020 Jul 01;49(7):e292-e298 Authors: Martin M, Querubin J, Hagen E, Lim J Abstract Neonatal seizures are common, occurring in 2 to 5 of 1,000 live births in the United States. The neonatal brain is thought to be predisposed toward seizures due to a combination of excessive excitatory and deficient inhibitory neuronal activity. The seizures tend to be focal or multifocal without...
Fri Jul 17, 2020 23:20
Related Articles A systematic review and indirect treatment comparison of perampanel versus brivaracetam as adjunctive therapy in patients with focal-onset seizures with or without secondary generalization. Epilepsy Res. 2020 Jun 22;166:106403 Authors: Trinka E, Tsong W, Toupin S, Patten A, Wilson K, Isojarvi J, James D Abstract PURPOSE: To date, there has not been a single randomized controlled trial (RCT) conducted to directly compare the...
Fri Jul 17, 2020 23:20
Related Articles Laser thermal therapy for epilepsy surgery: current standing and future perspectives. Int J Hyperthermia. 2020 Jul;37(2):77-83 Authors: Zemmar A, Nelson BJ, Neimat JS Abstract More than 130-year ago, Sir Victor Horsley delivered a landmark address to the British Medical Association, in which he described successful localization and resection of an epileptogenic focus resulting in seizure freedom for the patient. Several important...
Fri Jul 17, 2020 23:20
Related Articles Laser thermal therapy in the management of high-grade gliomas. Int J Hyperthermia. 2020 Jul;37(2):44-52 Authors: Avecillas-Chasin JM, Atik A, Mohammadi AM, Barnett GH Abstract Laser interstitial thermal therapy (LITT) is a minimally invasive therapy that have been used for brain tumors, epilepsy, chronic pain, and other spine pathologies. This therapy is performed under imaging and stereotactic guidance to precisely direct the...
Fri Jul 17, 2020 23:20
Related Articles Emerging indications for stereotactic laser interstitial thermal therapy in pediatric neurosurgery. Int J Hyperthermia. 2020 Jul;37(2):84-93 Authors: Remick M, McDowell MM, Gupta K, Felker J, Abel TJ Abstract Surgical treatment of deep or difficult to access lesions represents a unique and significant challenge for pediatric neurosurgeons. The introduction of stereotactic magnetic resonance-guided laser interstitial thermal...
Fri Jul 17, 2020 23:20
Related Articles Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction. Ann N Y Acad Sci. 2020 Jul 15;: Authors: Reddy SD, Wu X, Kuruba R, Sridhar V, Reddy DS Abstract Nerve agents (NAs) produce acute and long-term brain injury and dysfunction, as evident from the Japan and Syria incidents. Magnetic resonance imaging (MRI) is a versatile...
Fri Jul 17, 2020 13:33
Related Articles Autophagy and Epilepsy. Adv Exp Med Biol. 2020;1207:163-169 Authors: Lv M, Ma Q Abstract Epilepsy is a long-term neurological disease characterized by convulsions that can be recurrent. It is mainly caused by an imbalance between excitation and inhibition in the central nervous system. Currently, the pathogenesis is still unclear, although it may be related to changes in ion channels, neurotransmitters and glial cells. In recent...
Fri Jul 17, 2020 13:33
Related Articles Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment. Adv Sci (Weinh). 2020 Jul;7(13):1903802 Authors: Zhang S, Zhou Z, Zhong J, Shi Z, Mao Y, Tao TH Abstract Mechanical signals such as pressure and strain reflect important psychological and physiological states of the human body. Body-integrated sensors, including skin-mounted and surgically...
Fri Jul 17, 2020 23:20
Related Articles Late diagnosis of human immunodeficiency virus infection is linked to higher rates of epilepsy in children in the Eastern Cape of South Africa. South Afr J HIV Med. 2020;21(1):1047 Authors: Michaelis IA, Nielsen M, Carty C, Wolff M, Sabin CA, Lambert JS Abstract Background: Human immunodeficiency virus (HIV)-positive children may present with a wide range of neurological disorders. Among these, epilepsy is of key concern because...
Fri Jul 17, 2020 23:20
Related Articles Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells. Front Endocrinol (Lausanne). 2020;11:417 Authors: Thomas P, Pang Y Abstract The neurosteroids progesterone and allopregnanolone regulate numerous neuroprotective functions in neural tissues including inhibition of epileptic seizures and cell death. Many of progesterone's actions are mediated...
Fri Jul 17, 2020 23:20
Related Articles Expert Opinions and Consensus Recommendations for the Evaluation and Management of Insomnia in Clinical Practice: Joint Statements of Five Italian Scientific Societies. Front Psychiatry. 2020;11:558 Authors: Palagini L, Manni R, Aguglia E, Amore M, Brugnoli R, Girardi P, Grassi L, Mencacci C, Plazzi G, Minervino A, Nobili L, Biggio G Abstract Background: Insomnia is the most commonly reported sleep problem in industrialized...
Fri Jul 17, 2020 23:20
Related Articles Modified-Distribution Entropy as the Features for the Detection of Epileptic Seizures. Front Physiol. 2020;11:607 Authors: Aung ST, Wongsawat Y Abstract Epilepsy is one of the most common chronic neurological disorders, and therefore, diagnosis and treatment methods are urgently needed for these patients. Many methods and algorithms that can detect seizures in epileptic patients have been proposed. Electroencephalogram (EEG)...
Fri Jul 17, 2020 23:20
Related Articles Significance of Autoantibodies in Autoimmune Encephalitis in Relation to Antigen Localization: An Outline of Frequently Reported Autoantibodies with a Non-Systematic Review. Int J Mol Sci. 2020 Jul 13;21(14): Authors: Tanaka K, Kawamura M, Sakimura K, Kato N Abstract Autoantibodies related to central nervous system (CNS) diseases propel research on paraneoplastic neurological syndrome (PNS). This syndrome develops autoantibodies...
Fri Jul 17, 2020 13:33
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Fri Jul 17, 2020 13:33
Related Articles GeneReviews® Book. 1993 Authors: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A Abstract CLINICAL CHARACTERISTICS: SPTBN4 disorder is typically characterized by severe-to-profound developmental delay and/or intellectual disability, although two individuals in one family had a milder phenotype, including one individual with normal cognitive development. Speech and language skills are often severely limited. Affected...
Fri Jul 17, 2020 23:20
Related Articles The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases. Front Neurosci. 2020;14:595 Authors: Jin J, Zhao X, Fu H, Gao Y Abstract Yes-associated protein (YAP) is a key effector downstream of the Hippo signaling pathway and plays an important role in the development of the physiology and pathology of the central nervous system (CNS), especially regulating cell proliferation, differentiation, migration,...
Sat Jul 18, 2020 13:16
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Fri Jul 17, 2020 23:11
Related Articles Pulse Pressure: An Emerging Therapeutic Target for Dementia. Front Neurosci. 2020;14:669 Authors: Levin RA, Carnegie MH, Celermajer DS Abstract Elevated pulse pressure can cause blood-brain barrier dysfunction and subsequent adverse neurological changes that may drive or contribute to the development of dementia with age. In short, elevated pulse pressure dysregulates cerebral endothelial cells and increases cellular production...
Fri Jul 17, 2020 23:11
Related Articles Nanogrooves for 2D and 3D Microenvironments of SH-SY5Y Cultures in Brain-on-Chip Technology. Front Neurosci. 2020;14:666 Authors: Bastiaens A, Sabahi-Kaviani R, Luttge R Abstract Brain-on-chip (BOC) technology such as nanogrooves and microtunnel structures can advance in vitro neuronal models by providing a platform with better means to maintain, manipulate and analyze neuronal cell cultures. Specifically, nanogrooves have...
Fri Jul 17, 2020 23:11
Related Articles Corrigendum: Exploring the Feasibility and Effects of a Ketogenic Diet in Patients With CNS Malignancies: A Retrospective Case Series. Front Neurosci. 2020;14:661 Authors: Panhans CM, Gresham G, Amaral LJ, Hu J Abstract [This corrects the article DOI: 10.3389/fnins.2020.00390.]. PMID: 32670013 [PubMed - in process]
Fri Jul 17, 2020 23:11
Related Articles Supervised Learning in All FeFET-Based Spiking Neural Network: Opportunities and Challenges. Front Neurosci. 2020;14:634 Authors: Dutta S, Schafer C, Gomez J, Ni K, Joshi S, Datta S Abstract The two possible pathways toward artificial intelligence (AI)-(i) neuroscience-oriented neuromorphic computing [like spiking neural network (SNN)] and (ii) computer science driven machine learning (like deep learning) differ widely in their...
Fri Jul 17, 2020 23:11
Improving Real-Time Brain State Classification of Motor Imagery Tasks During Neurofeedback Training.
Related Articles Improving Real-Time Brain State Classification of Motor Imagery Tasks During Neurofeedback Training. Front Neurosci. 2020;14:623 Authors: Bagarinao E, Yoshida A, Terabe K, Kato S, Nakai T Abstract In this study, we investigated the effect of the dynamic changes in brain activation during neurofeedback training in the classification of the different brain states associated with the target tasks. We hypothesized that ongoing...
Fri Jul 17, 2020 23:11
Related Articles MiR224-5p Inhibitor Restrains Neuronal Apoptosis by Targeting NR4A1 in the Oxygen-Glucose Deprivation (OGD) Model. Front Neurosci. 2020;14:613 Authors: Liu LL, Qiao S, Wang ML, Wu HK, Su YX, Wang KM, Liu XW Abstract This study was designed to investigate the molecular mechanism of stroke and to explore the effect of miR-224-5p in hypoxic cortical neurons. Firstly, we established a middle cerebral artery occlusion (MCAO) model...
Fri Jul 17, 2020 23:11
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