IJMS, Vol. 21, Pages 5087: Integrated Omics Analyses Identify Key Pathways Involved in Petiole Rigidity Formation in Sacred Lotus International Journal of Molecular Sciences doi: 10.3390/ijms21145087 Authors: Ming Li Ishfaq Hameed Dingding Cao Dongli He Pingfang Yang Sacred lotus (Nelumbo nucifera Gaertn.) is a relic aquatic plant with two types of leaves, which have distinct rigidity of petioles. Here we assess the difference from anatomic structure to the expression of...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5085: Combination of NKT14m and Low Dose IL-12 Promotes Invariant Natural Killer T Cell IFN-γ Production and Tumor Control International Journal of Molecular Sciences doi: 10.3390/ijms21145085 Authors: Peng Guan Robert Schaub Kim E. Nichols Rupali Das Invariant natural killer T (iNKT) cells are innate-like T lymphocytes characterized by the expression of an invariant T cell receptor (iTCR) that recognizes glycolipid antigens presented by the MHC I-like CD1d...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5084: Downregulation of GLI3 Expression Mediates Chemotherapy Resistance in Acute Myeloid Leukemia International Journal of Molecular Sciences doi: 10.3390/ijms21145084 Authors: Fabian Freisleben Lena Behrmann Vanessa Thaden Jana Muschhammer Carsten Bokemeyer Walter Fiedler Jasmin Wellbrock Aberrant activation of the hedgehog (HH) pathway is observed in many neoplasms, including acute myeloid leukemia (AML). The glioma-associated oncogene homolog...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5081: Loss of miR-145-5p Causes Ceruloplasmin Interference with PHD-Iron Axis and HIF-2α Stabilization in Lung Adenocarcinoma-Mediated Angiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21145081 Authors: Tsai Wu Chang Chang Huang Jian Tsai Lin Chong Hung Hsu For decades, lung cancer has been the leading cause of cancer-related death worldwide. Hypoxia-inducible factors (HIFs) play critical roles in mediating...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5082: The Cellular and Molecular Bases of Allergy, Inflammation and Tissue Fibrosis in Patients with IgG4-related Disease International Journal of Molecular Sciences doi: 10.3390/ijms21145082 Authors: Song-Chou Hsieh Chieh-Yu Shen Hsien-Tzung Liao Ming-Han Chen Cheng-Han Wu Ko-Jen Li Cheng-Shiun Lu Yu-Min Kuo Hung-Cheng Tsai Chang-Youh Tsai Chia-Li Yu IgG4-related disease (IgG4-RD) is a spectrum of complex fibroinflammatory disorder...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5080: A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNFα-Induced MMP9 Expression via EGR-1 Downregulation in MDA-MB-231 Human Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21145080 Authors: Munki Jeong Euitaek Jung Young Han Lee Jeong Kon Seo Seunghyun Ahn Dongsoo Koh Yoongho Lim Soon Young Shin Breast cancer is a common malignancy among...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5083: Molecular Basis of the Pathogenic Mechanism Induced by the m.9191T>C Mutation in Mitochondrial ATP6 Gene International Journal of Molecular Sciences doi: 10.3390/ijms21145083 Authors: Xin Su Alain Dautant François Godard Marine Bouhier Teresa Zoladek Roza Kucharczyk Jean-Paul di Rago Déborah Tribouillard-Tanvier Probing the pathogenicity and functional consequences of mitochondrial DNA (mtDNA) mutations from patient’s cells...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5079: Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control International Journal of Molecular Sciences doi: 10.3390/ijms21145079 Authors: Dina Khedr Mona Hafez Jairo Lumpuy-Castillo Soha Emam Antoine Abdel-Massih Fatma Elmougy Rasha Elkaffas Ignacio Mahillo-Fernández Oscar Lorenzo Noha Musa Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5078: Vesicular Transport of Encapsulated microRNA between Glial and Neuronal Cells International Journal of Molecular Sciences doi: 10.3390/ijms21145078 Authors: Walter J. Lukiw Aileen I. Pogue Exosomes (EXs) and extracellular microvesicles (EMVs) represent a diverse assortment of plasma membrane-derived nanovesicles, 30–1000 nm in diameter, released by all cell lineages of the central nervous system (CNS). They are examples of a very active and dynamic...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5076: Expression Profiling and Functional Characterization of miR-26a and miR-130a in Regulating Zhongwei Goat Hair Development via the TGF-β/SMAD Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21145076 Authors: Yangyang Ding Xianglan Xue Zhanfa Liu Yong Ye Ping Xiao Yabin Pu Weijun Guan Joram Mwashigadi Mwacharo Yuehui Ma Qianjun Zhao The Zhongwei goat is an important and unique goat breed indigenous to China. It...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5077: A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb International Journal of Molecular Sciences doi: 10.3390/ijms21145077 Authors: Bin Zhang Ting Zhang Tian-Yi Zhang Ning Wang Shan He Bin Wu Hai-Xiao Jin Chronic myeloid leukemia (CML) is a malignant tumor caused by the abnormal proliferation of hematopoietic...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5074: Recent Progress in the Identification of Aptamers Against Bacterial Origins and Their Diagnostic Applications International Journal of Molecular Sciences doi: 10.3390/ijms21145074 Authors: Nevina E. Trunzo Ka Lok Hong Aptamers have gained an increasing role as the molecular recognition element (MRE) in diagnostic assay development, since their first conception thirty years ago. The process to screen for nucleic acid-based binding elements (aptamers) was...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5075: HLA-G Expression in Human Mesenchymal Stem Cells (MSCs) Is Related to Unique Methylation Pattern in the Proximal Promoter as well as Gene Body DNA International Journal of Molecular Sciences doi: 10.3390/ijms21145075 Authors: B. Linju Yen Hsiao-Lin Hwa Pei-Ju Hsu Pei-Min Chen Li-Tzu Wang Shih-Sheng Jiang Ko-Jiunn Liu Huey-Kang Sytwu Men-Luh Yen Multipotent human mesenchymal stem cells (MSCs) harbor clinically relevant immunomodulation,...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5073: Ubiquitin Pathway Is Associated with Worsening Left Ventricle Function after Mitral Valve Repair: A Global Gene Expression Study International Journal of Molecular Sciences doi: 10.3390/ijms21145073 Authors: Feng-Chun Tsai Gwo-Jyh Chang Ying-Ju Lai Shang-Hung Chang Wei-Jan Chen Yung-Hsin Yeh The molecular mechanism for worsening left ventricular (LV) function after mitral valve (MV) repair for chronic mitral regurgitation remains unknown. We...
Sat Jul 18, 2020 03:00
IJMS, Vol. 21, Pages 5058: Genetic Dissection and Identification of Candidate Genes for Salinity Tolerance Using Axiom®CicerSNP Array in Chickpea International Journal of Molecular Sciences doi: 10.3390/ijms21145058 Authors: Khela Ram Soren Praveen Madugula Neeraj Kumar Rutwik Barmukh Menu Singh Sengar Chellapilla Bharadwaj Parbodh Chander Sharma Sarvjeet Singh Aditi Bhandari Jogendra Singh Satish Kumar Sanwal Madan Pal Sneha Priya P.R. Anita Mann Someswar...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5065: Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA International Journal of Molecular Sciences doi: 10.3390/ijms21145065 Authors: Sultan Alanazi Mirjana Grujic Maria Lampinen Ola Rollman Christian P. Sommerhoff Gunnar Pejler Fabio Rabelo Melo Tryptase is a tetrameric serine protease located within the secretory granules of mast cells. In the secretory granules, tryptase is stored in complex with negatively charged heparin proteoglycans...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5072: Cells Derived from Human Long Bone Appear More Differentiated and More Actively Stimulate Osteoclastogenesis Compared to Alveolar Bone-Derived Cells International Journal of Molecular Sciences doi: 10.3390/ijms21145072 Authors: Cindy Kelder Cornelis J. Kleverlaan Marjolijn Gilijamse Astrid D. Bakker Teun J. de Vries Osteoblasts derived from mouse skulls have increased osteoclastogenic potential compared to long bone osteoblasts when stimulated with...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5056: Integrated Analysis of Tissue-Specific Promoter Methylation and Gene Expression Profile in Complex Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21145056 Authors: Kibaick Lee Sanghoon Moon Mi-Jin Park In-Uk Koh Nak-Hyeon Choi Ho-Yeong Yu Young Jin Kim Jinhwa Kong Hee Gyung Kang Song Cheol Kim Bong-Jo Kim This study investigated whether the promoter region of DNA methylation positively or negatively regulates...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5052: Synergistic Interaction of Phytohormones in Determining Leaf Angle in Crops International Journal of Molecular Sciences doi: 10.3390/ijms21145052 Authors: Xi Li Pingfan Wu Ying Lu Shaoying Guo Zhuojun Zhong Rongxin Shen Qingjun Xie Leaf angle (LA), defined as the angle between the plant stem and leaf adaxial side of the blade, generally shapes the plant architecture into a loosen or dense structure, and thus influences the light interception...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5057: Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies International Journal of Molecular Sciences doi: 10.3390/ijms21145057 Authors: Jérôme Clatot Nathalie Neyroud Robert Cox Charlotte Souil Jing Huang Pascale Guicheney Charles Antzelevitch Background: Genetic variants in voltage-gated sodium channels (Nav) encoded by SCNXA genes, responsible for INa, and Kv4.3 channels...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5059: Clinical and Molecular Features of Early Infantile Niemann Pick Type C Disease International Journal of Molecular Sciences doi: 10.3390/ijms21145059 Authors: Berna Seker Yilmaz Julien Baruteau Ahad A. Rahim Paul Gissen Niemann Pick disease type C (NPC) is a neurovisceral disorder due to mutations in NPC1 or NPC2. This review focuses on poorly characterized clinical and molecular features of early infantile form of NPC (EIF) and identified 89 cases...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5071: Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21145071 Authors: Geoffroy Walbrecq Christiane Margue Iris Behrmann Stephanie Kreis Hypoxia is a common hallmark of solid tumors and is associated with aggressiveness, metastasis and poor outcome. Cancer cells under hypoxia undergo changes in metabolism and there is an intense crosstalk...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5061: Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly International Journal of Molecular Sciences doi: 10.3390/ijms21145061 Authors: Oscar Palomino-Hernandez Fiamma A. Buratti Pamela S. Sacco Giulia Rossetti Paolo Carloni Claudio O. Fernandez Recent studies suggest that Tyr-39 might play a critical role for both the normal function and the pathological dysfunction of...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5070: Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21145070 Authors: Alejandro Lillo Eva Martínez-Pinilla Irene Reyes-Resina Gemma Navarro Rafael Franco The aim of this paper was to check the possible interaction of two of the four purinergic P1 receptors, the A2A and the A3. Discovery of the A2A–A3...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5060: Selective Gold Recovery from Homogenous Aqueous Solutions Containing Gold and Platinum Ions by Aromatic Amino Acid-Containing Peptides International Journal of Molecular Sciences doi: 10.3390/ijms21145060 Authors: Kin-ya Tomizaki Takuya Okamoto Tatsuki Tonoda Takahito Imai Masahiro Asano There is increasing interest in the development of noble metal separation/recovery processes, especially for applications to “urban mining”....
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5068: A Novel ceRNA Regulatory Network Involving the Long Non-Coding Antisense RNA SPACA6P-AS, miR-125a and Its mRNA Targets in Hepatocarcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21145068 Authors: Armando Di Palo Chiara Siniscalchi Nicola Mosca Aniello Russo Nicoletta Potenza MicroRNAs (miRNA), and more recently long non-coding RNAs (lncRNA), are emerging as a driving force for hepatocellular carcinoma (HCC), one of the...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5066: Signaling of Tumor-Derived sEV Impacts Melanoma Progression International Journal of Molecular Sciences doi: 10.3390/ijms21145066 Authors: Aneta Zebrowska Piotr Widlak Theresa Whiteside Monika Pietrowska Small extracellular vesicles (sEV or exosomes) are nanovesicles (30–150 nm) released both in vivo and in vitro by most cell types. Tumor cells produce sEV called TEX and disperse them throughout all body fluids. TEX contain a cargo of proteins,...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5067: Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels International Journal of Molecular Sciences doi: 10.3390/ijms21145067 Authors: Alexander G. Markov Arina A. Fedorova Violetta V. Kravtsova Anastasia E. Bikmurzina Larisa S. Okorokova Vladimir V. Matchkov Valeria Cornelius Salah Amasheh Igor I. Krivoi The ability of exogenous low ouabain concentrations to affect claudin expression and therefore...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5062: Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury International Journal of Molecular Sciences doi: 10.3390/ijms21145062 Authors: Rui Lima Susana Monteiro Eduardo D. Gomes Natália L. Vasconcelos Rita Assunção-Silva Mónica Morais António J. Salgado Nuno A. Silva Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5069: Alterations in Concentration/Activity of Superoxide Dismutases in Context of Obesity and Selected Single Nucleotide Polymorphisms in Genes: SOD1, SOD2, SOD3 International Journal of Molecular Sciences doi: 10.3390/ijms21145069 Authors: Lewandowski Kepinska Milnerowicz Little is known about the contribution of each of the three superoxide dismutase isozymes (SODs) to the total SOD activity in extracellular fluids. This study was aimed to investigate...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5064: Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products International Journal of Molecular Sciences doi: 10.3390/ijms21145064 Authors: Dongchen An Steve Peigneur Louise Antonia Hendrickx Jan Tytgat Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5063: Bio-inspired Surface Texture Modification as a Viable Feature of Future Aquatic Antifouling Strategies: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21145063 Authors: Chloe Richards Asma Slaimi Noel E. O’Connor Alan Barrett Sandra Kwiatkowska Fiona Regan The imitation of natural systems to produce effective antifouling materials is often referred to as “biomimetics”. The world of biomimetics is a multidisciplinary...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5055: Time-Restricted G-Protein Signaling Pathways via GPR176, Gz, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus International Journal of Molecular Sciences doi: 10.3390/ijms21145055 Authors: Shumpei Nakagawa Khanh Tien Nguyen Pham Xinyan Shao Masao Doi G-protein-coupled receptors (GPCRs) are an important source of drug targets with diverse therapeutic applications. However, there are still more than one hundred orphan...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5054: Sperm Motility of Mice under Simulated Microgravity and Hypergravity International Journal of Molecular Sciences doi: 10.3390/ijms21145054 Authors: Irina V. Ogneva Maria A. Usik Nikolay S. Biryukov Yuliya S. Zhdankina For deep space exploration, reproductive health must be maintained to preserve the species. However, the mechanisms underlying the effect of changes in gravity on male germ cells remain poorly understood. The aim of this study was to...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5047: Cardiomyopathies and Adrenal Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21145047 Authors: Luigi Petramala Antonio Concistrè Federica Olmati Vincenza Saracino Cristina Chimenti Andrea Frustaci Matteo A. Russo Claudio Letizia Cardiomyopathies are myocardial disorders in which heart muscle is structurally and/or functionally abnormal. Previously, structural cardiomyocyte disorders due to adrenal diseases, such as...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5051: Podocytes—The Most Vulnerable Renal Cells in Preeclampsia International Journal of Molecular Sciences doi: 10.3390/ijms21145051 Authors: Ewa Kwiatkowska Katarzyna Stefańska Maciej Zieliński Justyna Sakowska Martyna Jankowiak Piotr Trzonkowski Natalia Marek-Trzonkowska Sebastian Kwiatkowski Preeclampsia (PE) is a disorder that affects 3–5% of normal pregnancies. It was believed for a long time that the kidney, similarly to all...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5053: Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21145053 Authors: Alessia Filippone Grazia M. L. Consoli Giuseppe Granata Giovanna Casili Marika Lanza Alessio Ardizzone Salvatore Cuzzocrea Emanuela Esposito Irene Paterniti Curcumin (CUR) has shown remarkable efficacy in the treatment of skin...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5049: Dysregulated Cardiac IGF-1 Signaling and Antioxidant Response Are Associated with Radiation Sensitivity International Journal of Molecular Sciences doi: 10.3390/ijms21145049 Authors: Saeed Y. Aghdam Doreswamy Kenchegowda Neel K. Sharma Gregory P. Holmes-Hampton Betre Legesse Maria Moroni Sanchita P. Ghosh Acute exposure to ionizing radiation leads to Hematopoietic Acute Radiation Syndrome (H-ARS). To understand the inter-strain cellular and...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5050: Gemfibrozil Induces Anemia, Leukopenia and Reduces Hematopoietic Stem Cells via PPAR-α in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21145050 Authors: Gabriel Rufino Estrela Adriano Cleis Arruda Heron Fernandes Vieira Torquato Leandro Ceotto Freitas-Lima Mauro Sérgio Perilhão Frederick Wasinski Alexandre Budu Ricardo Ambrósio Fock Edgar Julian Paredes-Gamero Ronaldo Carvalho Araujo Hypercholesterolemia, also...
Fri Jul 17, 2020 03:00
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