IJMS, Vol. 21, Pages 5050: Gemfibrozil Induces Anemia, Leukopenia and Reduces Hematopoietic Stem Cells via PPAR-α in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21145050 Authors: Gabriel Rufino Estrela Adriano Cleis Arruda Heron Fernandes Vieira Torquato Leandro Ceotto Freitas-Lima Mauro Sérgio Perilhão Frederick Wasinski Alexandre Budu Ricardo Ambrósio Fock Edgar Julian Paredes-Gamero Ronaldo Carvalho Araujo Hypercholesterolemia, also...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5048: NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability International Journal of Molecular Sciences doi: 10.3390/ijms21145048 Authors: Chih-Wei Chen Ning Tsao Wei Zhang Zee-Fen Chang NME3 is a member of the nucleoside diphosphate kinase (NDPK) family that binds to the mitochondrial outer membrane to stimulate mitochondrial fusion. In this study, we showed that NME3 knockdown delayed DNA repair without reducing the cellular levels of nucleotide...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5046: Proteomic Analysis in Seminal Plasma of Fertile Donors and Infertile Patients with Sperm DNA Fragmentation International Journal of Molecular Sciences doi: 10.3390/ijms21145046 Authors: Alba Fernandez-Encinas Agustín García-Peiró Javier del Rey Jordi Ribas-Maynou Carlos Abad Maria José Amengual Elena Prada Joaquima Navarro Jordi Benet Seminal plasma proteomics studies could represent a new approach for the determination of molecular...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5044: Epigenome Wide Association and Stochastic Epigenetic Mutation Analysis on Cord Blood of Preterm Birth International Journal of Molecular Sciences doi: 10.3390/ijms21145044 Authors: Elena Spada Luciano Calzari Luigi Corsaro Teresa Fazia Monica Mencarelli Anna Maria Di Blasio Luisa Bernardinelli Giulia Zangheri Michele Vignali Davide Gentilini Preterm birth (PTB) can be defined as the endpoint of a complex process that could be influenced...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5043: How Thick Is the Oral Mucosa around Implants after Augmentation with Different Materials: A Systematic Review of the Effectiveness of Substitute Matrices in Comparison to Connective Tissue Grafts International Journal of Molecular Sciences doi: 10.3390/ijms21145043 Authors: Martin Lissek Martin Boeker Arndt Happe This systematic review aimed to assess the effectiveness of xenogeneic collagen matrices (XCMs) and acellular dermal matrices (ADMs) in comparison...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5045: Evaluation of the In Vitro Damage Caused by Lipid Factors on Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence International Journal of Molecular Sciences doi: 10.3390/ijms21145045 Authors: Istvan Kovanecz Robert Gelfand Sheila Sharifzad Alec Ohanian William Brent DeCastro Carley Cooper Guiting Lin Tom Lue Nestor F. Gonzalez-Cadavid Human stem cell therapy for type 2 diabetes/obesity (T2D/O)...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5042: Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1-p300 Binding in Renal Cell Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21145042 Authors: Lee Kang Ha Lee Oh Choi Song Kim Angiogenesis and the expression of vascular endothelial growth factor (VEGF) are increased in renal cell carcinoma (RCC). Transglutaminase 2 (TGase 2), which promotes angiogenesis in endothelial cells...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5040: Cellular Mechanisms of Circulating Tumor Cells During Breast Cancer Metastasis International Journal of Molecular Sciences doi: 10.3390/ijms21145040 Authors: Han-A Park Spenser R. Brown Yonghyun Kim Circulating tumor cells (CTCs) are cancer cells that detach from the primary site and travel in the blood stream. A higher number of CTCs increases the risk of breast cancer metastasis, and it is inversely associated with the survival rates of patients with...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5041: Exclusion Zone Phenomena in Water—A Critical Review of Experimental Findings and Theories International Journal of Molecular Sciences doi: 10.3390/ijms21145041 Authors: Daniel C. Elton Peter D. Spencer James D. Riches Elizabeth D. Williams The existence of the exclusion zone (EZ), a layer of water in which plastic microspheres are repelled from hydrophilic surfaces, has now been independently demonstrated by several groups. A better understanding of...
Fri Jul 17, 2020 03:00
IJMS, Vol. 21, Pages 5039: Combinatory Treatment with miR-7-5p and Drug-Loaded Cubosomes Effectively Impairs Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21145039 Authors: Ewa Gajda Marlena Godlewska Zenon Mariak Ewa Nazaruk Damian Gawel Background: Multidrug resistance (MDR) is an emerging problem in the treatment of cancer. Therefore, there is a necessity for novel strategies that would sensitize tumor cells to the administered chemotherapeutics....
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2295: Major Bleeding Predictors in Patients with Left Atrial Appendage Closure: The Iberian Registry II Journal of Clinical Medicine doi: 10.3390/jcm9072295 Authors: José Ramón López-Mínguez Juan Manuel Nogales-Asensio Eduardo Infante De Oliveira Lino Santos Rafael Ruiz-Salmerón Dabit Arzamendi-Aizpurua Marco Costa Hipólito Gutiérrez-García Jose Antonio Fernández-Díaz Xavier Freixa Ignacio Cruz-González Raúl Moreno Andrés Íñiguez-Romo...
Sun Jul 19, 2020 03:00
JCM, Vol. 9, Pages 2294: Sociodemographic Inequalities in Outcomes of a Swedish Nationwide Self-Management Program for Osteoarthritis: Results from 22,741 Patients between Years 2008–2017 Journal of Clinical Medicine doi: 10.3390/jcm9072294 Authors: Erik Unevik Allan Abbott Stefan Fors Ola Rolfson The aim of this study is to investigate if there are educational level and birthplace related differences in joint-related pain, health-related quality of life (HRQoL), willingness...
Sun Jul 19, 2020 03:00
JCM, Vol. 9, Pages 2293: Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration Journal of Clinical Medicine doi: 10.3390/jcm9072293 Authors: Ahmed S. Ibrahim Khaled Hussein Fang Wang Ming Wan Nancy Saad Maamon Essa Ivana Kim Akbar Shakoor Leah A. Owen Margaret M. DeAngelis Mohamed Al-Shabrawey Disruption of retinal...
Sun Jul 19, 2020 03:00
JCM, Vol. 9, Pages 2292: Exercise Training Protects against Atorvastatin-Induced Skeletal Muscle Dysfunction and Mitochondrial Dysfunction in the Skeletal Muscle of Rats Journal of Clinical Medicine doi: 10.3390/jcm9072292 Authors: Dae Yun Seo Jun-Won Heo Mi-Hyun No Su-Zi Yoo Jeong Rim Ko Dong-Ho Park Ju-Hee Kang Chang-Ju Kim Su-Jeen Jung Jin Han Hyo-Bum Kwak Statins are used to prevent and treat atherosclerotic cardiovascular disease, but they also induce...
Sun Jul 19, 2020 03:00
JCM, Vol. 9, Pages 2291: Mother-to-Infant Bonding in Women with Postpartum Psychosis and Severe Postpartum Depression: A Clinical Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9072291 Authors: Janneke Gilden Nina M. Molenaar Anne K. Smit Witte J. G. Hoogendijk Anna-Sophie Rommel Astrid M. Kamperman Veerle Bergink Mother-to-infant bonding is important for long-term child development. The aim of this study was to investigate bonding in women admitted to a...
Sun Jul 19, 2020 03:00
JCM, Vol. 9, Pages 2290: Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database Journal of Clinical Medicine doi: 10.3390/jcm9072290 Authors: Mev Dominguez-Valentin Toni T. Seppälä Christoph Engel Stefan Aretz Finlay Macrae Ingrid Winship Gabriel Capella Huw Thomas Eivind Hovig Maartje Nielsen Rolf H Sijmons Lucio Bertario Bernardo Bonanni Maria Grazia Tibiletti Giulia...
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2289: Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease Journal of Clinical Medicine doi: 10.3390/jcm9072289 Authors: Andrea Baragetti Alice Ossoli Arianna Strazzella Sara Simonelli Ivano Baragetti Liliana Grigore Fabio Pellegatta Alberico L. Catapano Giuseppe Danilo Norata Laura Calabresi Low high-density lipoprotein-cholesterol (HDL-c) is the most remarkable lipid trait both in mild-to-moderate...
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2288: Clinical Management of Diabetes Mellitus in the Era of COVID-19: Practical Issues, Peculiarities and Concerns Journal of Clinical Medicine doi: 10.3390/jcm9072288 Authors: Chrysi Koliaki Anastasios Tentolouris Ioanna Eleftheriadou Andreas Melidonis George Dimitriadis Nikolaos Tentolouris The management of patients with diabetes mellitus (DM) in the era of the COVID-19 pandemic can be challenging. Even if they are not infected, they are at risk...
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2287: Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome? Journal of Clinical Medicine doi: 10.3390/jcm9072287 Authors: Philipp Kobbe Felix M. Bläsius Philipp Lichte Reiner Oberbeck Frank Hildebrand Although the treatment of multiple-injured patients has been improved during the last decades, sepsis and multiple organ failure (MOF) still remain the major cause of death. Following trauma, profound alterations...
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2285: Chronic Rhinosinusitis—An Update on Epidemiology, Pathogenesis and Management Journal of Clinical Medicine doi: 10.3390/jcm9072285 Authors: Albu Chronic rhinosinusitis (CRS) is one of the most common chronic medical conditions worldwide, affecting all age groups. [...]
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2286: Long-Term Follow-Up of Targeted Biopsy Yield (LOFTY Study) in Ulcerative Colitis Surveillance Colonoscopy Journal of Clinical Medicine doi: 10.3390/jcm9072286 Authors: Keisuke Hata Soichiro Ishihara Yoichi Ajioka Keiichi Mitsuyama Kenji Watanabe Hiroyuki Hanai Reiko Kunisaki Hiroshi Nakase Keiji Matsuda Ryuichi Iwakiri Nobuyuki Hida Shinji Tanaka Yoshiaki Takeuchi Masaru Shinozaki Noriyuki Ogata Kentaro Moriichi Fumihito...
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2284: Prolonged Length of Stay in the Emergency Department and Increased Risk of In-Hospital Cardiac Arrest: A nationwide Population-Based Study in South Korea, 2016–2017 Journal of Clinical Medicine doi: 10.3390/jcm9072284 Authors: June-sung Kim Dong Woo Seo Youn-Jung Kim Jinwoo Jeong Hyunggoo Kang Kap Su Han Su Jin Kim Sung Woo Lee Shin Ahn Won Young Kim This study was to determine whether prolonged emergency department (ED) length of stay...
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2282: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study Journal of Clinical Medicine doi: 10.3390/jcm9072282 Authors: Moran Amit Alex Sorkin Jacob Chen Barak Cohen Dana Karol Avishai M Tsur Shaul Lev Tal Rozenblat Ayana Dvir Geva Landau Lidar Fridrich Elon Glassberg Shani Kesari Sigal Sviri Ram Gelman Asaf Miller Danny Epstein Ronny Ben-Avi Moshe Matan Daniel J. Jakobson Tarif Bader David...
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2283: Identification of a Clinical Cutoff Value for Multiplex KRASG12/G13 Mutation Detection in Colorectal Adenocarcinoma Patients Using Digital Droplet PCR, and Comparison with Sanger Sequencing and PNA Clamping Assay Journal of Clinical Medicine doi: 10.3390/jcm9072283 Authors: Kyung Ha Lee Tae Hee Lee Min Kyung Choi In Sun Kwon Go Eun Bae Min-Kyung Yeo KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) is a major predictive marker for anti-epidermal...
Sat Jul 18, 2020 03:00
JCM, Vol. 9, Pages 2281: Diagnostic Value of Six Thyroid Imaging Reporting and Data Systems (TIRADS) in Cytologically Equivocal Thyroid Nodules Journal of Clinical Medicine doi: 10.3390/jcm9072281 Authors: Dorota Słowińska-Klencka Kamila Wysocka-Konieczna Mariusz Klencki Bożena Popowicz The aim was to compare the usefulness of selected thyroid sonographic risk-stratification systems in the diagnostics of nodules with indeterminate/suspicious cytology or unequivocal cytology...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2279: Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT Journal of Clinical Medicine doi: 10.3390/jcm9072279 Authors: Haider Bengs Schade Wijnen Portmann Etter Fröhlich Warnock Treyer Burger Fiechter Kudura Fuchs Pazhenkottil Buechel Kaufmann Meisel Stolzmann Gebhard Objective: Positron emission tomography/computed tomography with...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2278: Evolution of Gut Microbiome and Metabolome in Suspected Necrotizing Enterocolitis: A Case-Control Study Journal of Clinical Medicine doi: 10.3390/jcm9072278 Authors: Camille Brehin Damien Dubois Odile Dicky Sophie Breinig Eric Oswald Matteo Serino Background: Necrotizing enterocolitis (NEC) is a devastating condition in preterm infants due to multiple factors, including gut microbiota dysbiosis. NEC development is poorly understood, due to the...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2280: Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study Journal of Clinical Medicine doi: 10.3390/jcm9072280 Authors: Alessandra Berton Umile Giuseppe Longo Vincenzo Candela Federico Greco Francesca Maria Martina Carlo Cosimo Quattrocchi Vincenzo Denaro Purpose: We aimed to evaluate clinical efficacy and healing effects of conservative management of degenerative...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2276: Large-Scale Drug Screen Identifies FDA-Approved Drugs for Repurposing in Sickle-Cell Disease Journal of Clinical Medicine doi: 10.3390/jcm9072276 Authors: Cannon Phillips Smith Williams Brinton Gregory Landes Desai Byrd Lapalombella Sickle-cell disease (SCD) is a debilitating hematological disorder with very few approved treatment options. Therapeutic reactivation of fetal hemoglobin (HbF) is one of the most pursued methods...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2277: Secretagogin is Related to Insulin Secretion but Unrelated to Gestational Diabetes Mellitus Status in Pregnancy Journal of Clinical Medicine doi: 10.3390/jcm9072277 Authors: Carola Deischinger Jürgen Harreiter Karoline Leitner Dagmar Bancher-Todesca Sabina Baumgartner-Parzer Alexandra Kautzky-Willer Secretagogin (SCGN) is a calcium binding protein related to insulin release in the pancreas. Although SCGN is not co-released with insulin, plasma...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2273: Nivolumab for Previously Treated Patients with Non-Small-Cell Lung Cancer—Daily Practice versus Clinical Trials Journal of Clinical Medicine doi: 10.3390/jcm9072273 Authors: Magdalena Knetki-Wróblewska Dariusz M. Kowalski Maciej Krzakowski Based on the results of the CheckMate 017 and CheckMate 057 studies, nivolumab therapy has become a new standard treatment for both squamous and non-squamous non-small-cell lung cancer (NSCLC). However, due to the specific...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2272: Quickcard-Based Approach to Guiding Specific Nonpharmacological Treatments in a German Parkinson’s Network Journal of Clinical Medicine doi: 10.3390/jcm9072272 Authors: Linda Kerkemeyer Katharina Achtert Inga Claus Svenja Happe Jeannette Overbeck Nadine Kleen Anja Palesch Clara Schmuck Sabrina Krouß Jürgen Perick Luisa Depenbrock Michael Nagel Frank Siebecker Olaf Rose Tobias Warnecke Interdisciplinary care has been shown...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2274: Design and Early Implementation Successes and Challenges of a Pharmacogenetics Consult Clinic Journal of Clinical Medicine doi: 10.3390/jcm9072274 Authors: Arwood Dietrich Duong Smith Cook Elchynski Rosenberg Huber Nagoshi Wright Budd Holland Maska Panna Elsey Cavallari Wiisanen Johnson Gums Pharmacogenetic testing (PGT) is increasingly being used as a tool to guide clinical decisions. This...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2275: Real-World Clinical Outcomes Associated with Canagliflozin in Patients with Type 2 Diabetes Mellitus in Spain: The Real-Wecan Study Journal of Clinical Medicine doi: 10.3390/jcm9072275 Authors: Juan J. Gorgojo-Martínez Manuel A. Gargallo-Fernández Alba Galdón Sanz-Pastor Teresa Antón-Bravo Miguel Brito-Sanfiel Jaime Wong-Cruz The aims of this multicentric retrospective study were to assess in a real-world setting the effectiveness and safety of...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2271: Influence of Care Pathway on Thyroid Nodule Surgery Relevance: A Historical Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9072271 Authors: Solène Castellnou Jean-Christophe Lifante Stéphanie Polazzi Léa Pascal Françoise Borson-Chazot Antoine Duclos Background: Guidelines recommend using fine-needle aspiration cytology (FNAC) to guide thyroid nodule surgical indication. However, the extent to which these guidelines are followed remains...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2270: Role of Cardiac Computed Tomography for Etiology Evaluation of Newly Diagnosed Heart Failure with Reduced Ejection Fraction Journal of Clinical Medicine doi: 10.3390/jcm9072270 Authors: Dong Jin Im Jong-Chan Youn Hye-Jeong Lee Kyungsun Nam Young Joo Suh Yoo Jin Hong Jin Hur Young Jin Kim Byoung Wook Choi Seok-Min Kang Delayed-enhanced dual-energy computed tomography (DECT) can evaluate the extent and degree of myocardial fibrosis while...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2269: Changes in High-Density Lipoproteins Related to Outcomes in Patients with Acute Stroke Journal of Clinical Medicine doi: 10.3390/jcm9072269 Authors: Lourdes M. Varela Elena Meseguer Bertrand Lapergue David Couret Pierre Amarenco Olivier Meilhac Modifications in high-density lipoprotein (HDL) particle sizes and HDL-binding proteins have been reported in stroke patients. We evaluated whether the lipoprotein profile, HDL composition and functionality...
Fri Jul 17, 2020 03:00
JCM, Vol. 9, Pages 2268: Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients Journal of Clinical Medicine doi: 10.3390/jcm9072268 Authors: Jae-Hoon Ko Eun-Jeong Joo Su-Jin Park Jin Yang Baek Won Duk Kim Jaehwan Jee Chul Joong Kim Chul Jeong Yae-Jean Kim Hye Jin Shon Eun-Suk Kang Young Ki Choi Kyong Ran Peck Objectives: To investigate antibody production in asymptomatic and mild...
Fri Jul 17, 2020 03:00
JFMK, Vol. 5, Pages 53: Effects of Different Continuous Aerobic Training Protocols in a Heterozygous Mouse Model of Niemann-Pick Type C Disease Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5030053 Authors: Ida Cariati Manuel Scimeca Virginia Tancredi Agata Grazia D’Amico Gabriele Pallone Mattia Palmieri Claudio Frank Giovanna D’Arcangelo The positive effects of physical activity on cognitive functions are widely known. Aerobic training is known...
Sat Jul 18, 2020 03:00
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