Cancers, Vol. 12, Pages 1945: The Value of PD-L1 Expression as Predictive Biomarker in Metastatic Renal Cell Carcinoma Patients: A Meta-Analysis of Randomized Clinical Trials Cancers doi: 10.3390/cancers12071945 Authors: Alberto Carretero−González David Lora Isabel Martín Martín Sobrino Irene Sáez Sáez Sanz María T Bourlon Urbano Anido Anido Herranz Nieves Martínez Martínez Chanzá Daniel Castellano Guillermo de de Velasco Immune checkpoint inhibitors (ICIs)...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1941: “To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers Cancers doi: 10.3390/cancers12071941 Authors: Mattia Garutti Silvia Buriolla Elisa Bertoli Maria Grazia Vitale Ernesto Rossi Giovanni Schinzari Alessandro Marco Minisini Fabio Puglisi Despite surgical resection and adjuvant therapies, stage III melanomas still have a substantial risk of relapse. Neoadjuvant therapy is an emerging strategy that might...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1940: The Therapeutic Potential of Targeting BARF1 in EBV-Associated Malignancies Cancers doi: 10.3390/cancers12071940 Authors: Angela Kwok-Fung Lo Christopher W. Dawson Hong Lok Lung Ka-Leung Wong Lawrence S. Young Epstein-Barr virus (EBV) is closely linked to the development of a number of human cancers. EBV-associated malignancies are characterized by a restricted pattern of viral latent protein expression which is sufficient for the virus to both...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1936: DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages Cancers doi: 10.3390/cancers12071936 Authors: Nicholas A. Pease Miranda S. Shephard Mathieu Sertorio Susan E. Waltz Lisa M. Privette Vinnedge Breast cancer (BC) is the second leading cause of cancer deaths among women. DEK is a known oncoprotein that is highly expressed in over 60% of breast cancers and is an independent marker of poor prognosis....
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1938: Tele-Monitoring of Cancer Patients’ Rhythms during Daily Life Identifies Actionable Determinants of Circadian and Sleep Disruption Cancers doi: 10.3390/cancers12071938 Authors: Francis Lévi Sandra Komarzynski Qi Huang Teresa Young Yeng Ang Claire Fuller Matei Bolborea Julia Brettschneider Joanna Fursse Bärbel Finkenstädt David Pollard White Pasquale Innominato The dichotomy index (I < O), a quantitative estimate of...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1937: Immune Checkpoint Inhibitors in Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review Cancers doi: 10.3390/cancers12071937 Authors: Omar Kujan Bede van Schaijik Camile S. Farah Cancers of the oral cavity cause significant cancer-related death worldwide. While survival rates have improved in recent years, new methods of treatment are being investigated to limit disease progression and to improve outcomes,...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1943: Pre-Treatment Mutational and Transcriptomic Landscape of Responding Metastatic Melanoma Patients to Anti-PD1 Immunotherapy Cancers doi: 10.3390/cancers12071943 Authors: Carol M. Amato Jennifer D. Hintzsche Keith Wells Allison Applegate Nicholas T. Gorden Victoria M. Vorwald Richard P. Tobin Kelsey Nassar Yiqun G. Shellman Jihye Kim Theresa M. Medina Matthew Rioth Karl D. Lewis Martin D. McCarter Rene Gonzalez Aik-Choon...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1934: Adenoviral Vectors Armed with PAPILLOMAVIRUs Oncogene Specific CRISPR/Cas9 Kill Human-Papillomavirus-Induced Cervical Cancer Cells Cancers doi: 10.3390/cancers12071934 Authors: Eric Ehrke-Schulz Sonja Heinemann Lukas Schulte Maren Schiwon Anja Ehrhardt Human papillomaviruses (HPV) cause malignant epithelial cancers including cervical carcinoma, non-melanoma skin and head and neck cancer. They drive tumor development through the expression of...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1933: Profiling of Mitochondrial DNA Heteroplasmy in a Prospective Oral Squamous Cell Carcinoma Study Cancers doi: 10.3390/cancers12071933 Authors: Liane Fendt Federica Fazzini Hansi Weissensteiner Emanuel Bruckmoser Sebastian Schönherr Georg Schäfer Jamie Lee Losso Gertraud A. Streiter Claudia Lamina Michael Rasse Helmut Klocker Barbara Kofler Anita Kloss-Brandstätter Christian W. Huck Florian Kronenberg Johannes Laimer...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1935: TP5, a Peptide Inhibitor of Aberrant and Hyperactive CDK5/p25: A Novel Therapeutic Approach against Glioblastoma Cancers doi: 10.3390/cancers12071935 Authors: Emeline Tabouret Herui Wang Niranjana Amin Jinkyu Jung Romain Appay Jing Cui Qi Song Antonio Cardone Deric M. Park Mark R. Gilbert Harish Pant Zhengping Zhuang We examined the efficacy of selective inhibition of cyclin-dependent kinase 5 (CDK5) in glioblastoma by TP5....
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1931: Multi-Marker Longitudinal Algorithms Incorporating HE4 and CA125 in Ovarian Cancer Screening of Postmenopausal Women Cancers doi: 10.3390/cancers12071931 Authors: Aleksandra Gentry-Maharaj Oleg Blyuss Andy Ryan Matthew Burnell Chloe Karpinskyj Richard Gunu Jatinderpal K. Kalsi Anne Dawnay Ines P. Marino Ranjit Manchanda Karen Lu Wei-Lei Yang John F. Timms Max Parmar Steven J. Skates Robert C. Bast Ian J. Jacobs Alexey...
Fri Jul 17, 2020 03:00
Cancers, Vol. 12, Pages 1932: We Don’t Talk about It: Cancer Pain and American Indian Survivors Cancers doi: 10.3390/cancers12071932 Authors: Felicia Schanche Hodge Tracy Line Itty Christine Samuel-Nakamura Mary Cadogan Pain is a common symptom among cancer survivors, yet is rarely talked about by American Indians. Understanding the reasons for reduced communication by American Indian cancer survivors is important for healthcare providers, family members, and others providing...
Fri Jul 17, 2020 03:00
Cells, Vol. 9, Pages 1728: Ebola Virus Nucleocapsid-Like Structures Utilize Arp2/3 Signaling for Intracellular Long-Distance Transport Cells doi: 10.3390/cells9071728 Authors: Katharina Grikscheit Olga Dolnik Yuki Takamatsu Ana Raquel Pereira Stephan Becker The intracellular transport of nucleocapsids of the highly pathogenic Marburg, as well as Ebola virus (MARV, EBOV), represents a critical step during the viral life cycle. Intriguingly, a population of these nucleocapsids...
Sun Jul 19, 2020 03:00
Cells, Vol. 9, Pages 1727: Modulation of Determinant Factors to Improve Therapeutic Combinations with Immune Checkpoint Inhibitors Cells doi: 10.3390/cells9071727 Authors: Magalie Dosset Elodie Lauret-Marie Joseph Thaiz Rivera Vargas Lionel Apetoh Immune checkpoint inhibitors (ICPi) have shown their superiority over conventional therapies to treat some cancers. ICPi are effective against immunogenic tumors. However, patients with tumors poorly infiltrated with immune cells do...
Sun Jul 19, 2020 03:00
Cells, Vol. 9, Pages 1724: The Secretome Analysis of Activated Human Renal Fibroblasts Revealed Beneficial Effect of the Modulation of the Secreted Peptidyl-Prolyl Cis-Trans Isomerase A in Kidney Fibrosis Cells doi: 10.3390/cells9071724 Authors: Gry H. Dihazi Marwa Eltoweissy Olaf Jahn Björn Tampe Michael Zeisberg Hauke S. Wülfrath Gerhard A. Müller Hassan Dihazi The secretome is an important mediator in the permanent process of reciprocity between cells and their...
Sat Jul 18, 2020 03:00
Cells, Vol. 9, Pages 1726: miR-22-3p Negatively Affects Tumor Progression in T-Cell Acute Lymphoblastic Leukemia Cells doi: 10.3390/cells9071726 Authors: Valentina Saccomani Angela Grassi Erich Piovan Deborah Bongiovanni Ludovica Di Martino Sonia Minuzzo Valeria Tosello Paola Zanovello T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precursors. NOTCH1 plays an important role both in T-cell development and leukemia progression,...
Sat Jul 18, 2020 03:00
Cells, Vol. 9, Pages 1725: The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment Cells doi: 10.3390/cells9071725 Authors: Saveria Aquila Marta Santoro Annalisa Caputo Maria Luisa Panno Vincenzo Pezzi Francesca De Amicis Recent studies conducted over the past 10 years evidence the intriguing role of the tumor suppressor gene Phosphatase and Tensin Homolog deleted on Chromosome...
Sat Jul 18, 2020 03:00
Cells, Vol. 9, Pages 1723: High-Dimensional Single-Cell Quantitative Profiling of Skeletal Muscle Cell Population Dynamics during Regeneration Cells doi: 10.3390/cells9071723 Authors: Lucia Lisa Petrilli Filomena Spada Alessandro Palma Alessio Reggio Marco Rosina Cesare Gargioli Luisa Castagnoli Claudia Fuoco Gianni Cesareni The interstitial space surrounding the skeletal muscle fibers is populated by a variety of mononuclear cell types. Upon acute or chronic...
Sat Jul 18, 2020 03:00
Cells, Vol. 9, Pages 1722: Characteristics of Extracellular Vesicles Released by the Pathogenic Yeast-Like Fungi Candida glabrata, Candida parapsilosis and Candida tropicalis Cells doi: 10.3390/cells9071722 Authors: Justyna Karkowska-Kuleta Kamila Kulig Elzbieta Karnas Ewa Zuba-Surma Olga Woznicka Elzbieta Pyza Patryk Kuleta Artur Osyczka Maria Rapala-Kozik Andrzej Kozik Candida spp. yeast-like fungi are opportunistic pathogens in humans and have been recently...
Sat Jul 18, 2020 03:00
Cells, Vol. 9, Pages 1720: The Quest for the Best: How TCR Affinity, Avidity, and Functional Avidity Affect TCR-Engineered T-Cell Antitumor Responses Cells doi: 10.3390/cells9071720 Authors: Diana Campillo-Davo Donovan Flumens Eva Lion Over the past decades, adoptive transfer of T cells has revolutionized cancer immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked important milestones in developing more precise and personalized cancer immunotherapies....
Sat Jul 18, 2020 03:00
Cells, Vol. 9, Pages 1721: Engineering CD4+ T Cells to Enhance Cancer Immunity Cells doi: 10.3390/cells9071721 Authors: Francesca Sillito Angelika Holler Hans J. Stauss This review presents key advances in combining T cell receptor (TCR) gene transfer to redirect T-cell specificity with gene engineering in order to enhance cancer-protective immune function. We discuss how emerging insights might be applied to CD4+ T cells. Although much attention has been paid to the role of CD8+...
Sat Jul 18, 2020 03:00
Cells, Vol. 9, Pages 1716: CD38: T Cell Immuno-Metabolic Modulator Cells doi: 10.3390/cells9071716 Authors: Anwesha Kar Shikhar Mehrotra Shilpak Chatterjee Activation and subsequent differentiation of T cells following antigenic stimulation are triggered by highly coordinated signaling events that lead to instilling cells with a discrete metabolic and transcriptional feature. Compelling studies indicate that intracellular nicotinamide adenine dinucleotide (NAD+) levels have profound...
Fri Jul 17, 2020 03:00
Cells, Vol. 9, Pages 1717: Microglia: Agents of the CNS Pro-Inflammatory Response Cells doi: 10.3390/cells9071717 Authors: José A. Rodríguez-Gómez Edel Kavanagh Pinelopi Engskog-Vlachos Mikael K.R. Engskog Antonio J. Herrera Ana M. Espinosa-Oliva Bertrand Joseph Nabil Hajji José L. Venero Miguel A. Burguillos The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research...
Fri Jul 17, 2020 03:00
Cells, Vol. 9, Pages 1719: Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations Cells doi: 10.3390/cells9071719 Authors: Pilar Rivero-Ríos Maria Romo-Lozano Belén Fernández Elena Fdez Sabine Hilfiker Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson’s disease, and sequence variations are associated with the sporadic form of the disease. LRRK2 phosphorylates a subset of RAB...
Fri Jul 17, 2020 03:00
Cells, Vol. 9, Pages 1718: The Distribution of Circulating Tumor Cells Is Different in Metastatic Lobular Compared to Ductal Carcinoma of the Breast—Long-Term Prognostic Significance Cells doi: 10.3390/cells9071718 Authors: Ulrik Narbe Pär-Ola Bendahl Kristina Aaltonen Mårten Fernö Carina Forsare Charlotte Levin Tykjær Jørgensen Anna-Maria Larsson Lisa Rydén Background: Invasive lobular carcinoma (ILC) has distinguishing features when compared to invasive ductal...
Fri Jul 17, 2020 03:00
Cells, Vol. 9, Pages 1715: Evaluation of Fat Accumulation and Adipokine Production during the Long-Term Adipogenic Differentiation of Porcine Intramuscular Preadipocytes and Study of the Influence of Immunobiotics Cells doi: 10.3390/cells9071715 Authors: Asuka Tada AKM Humayun Kober Md. Aminul Islam Manami Igata Michihiro Takagi Masahiko Suzuki Hisashi Aso Wakako Ikeda-Ohtsubo Kazutoyo Yoda Kenji Miyazawa Fang He Hideki Takahashi Julio Villena Haruki...
Fri Jul 17, 2020 03:00
Cells, Vol. 9, Pages 1714: Regulation of Neurogenesis in Mouse Brain by HMGB1 Cells doi: 10.3390/cells9071714 Authors: Xiang Zhao Ari Rouhiainen Zhilin Li Su Guo Heikki Rauvala The High Mobility Group Box 1 (HMGB1) is the most abundant nuclear nonhistone protein that is involved in transcription regulation. In addition, HMGB1 has previously been found as an extracellularly acting protein enhancing neurite outgrowth in cultured neurons. Although HMGB1 is widely expressed in...
Fri Jul 17, 2020 03:00
Chemosensors, Vol. 8, Pages 56: Evaluation of an Anti-Thrombotic Continuous Lactate and Blood Pressure Monitoring Catheter in an In Vivo Piglet Model undergoing Open-Heart Surgery with Cardiopulmonary Bypass Chemosensors doi: 10.3390/chemosensors8030056 Authors: Kenneth Kwun Yin Ho Yun-Wen Peng Minyi Ye Lise Tchouta Bailey Schneider McKenzie Hayes John Toomasian Marie Cornell Alvaro Rojas-Pena John Charpie Hao Chen Blood lactate and blood pressure measurements...
Fri Jul 17, 2020 03:00
Clocks & Sleep, Vol. 2, Pages 273-281: Work-Related Dreams: An Online Survey Clocks & Sleep doi: 10.3390/clockssleep2030021 Authors: Michael Schredl Lilian Marie Anderson Lea Katharina Kahlert Celine Sophie Kumpf Professional work is an integral part of modern life. According to the continuity hypothesis of dreaming, which states that dreams reflect waking life, work-related dreams should be quite common. As most dream content analytic studies are carried out in student...
Fri Jul 17, 2020 03:00
Dentistry Journal, Vol. 8, Pages 76: Evaluation of Two Resin Composites Having Different Matrix Compositions Dentistry Journal doi: 10.3390/dj8030076 Authors: Tarek M. Elshazly Christoph Bourauel Dalia I. Sherief Dalia I. El-Korashy This study compared two resin composites with similar filler systems and different matrix compositions. The depth of cure (DoC), polymerization shrinkage, and marginal leakage were evaluated. A Filtek Bulk Fill resin composite (FB) and a Filtek Supreme...
Fri Jul 17, 2020 03:00
Diagnostics, Vol. 10, Pages 495: Two-Dimensional Image-Based Screening Tool for Infants with Positional Cranial Deformities: A Machine Learning Approach Diagnostics doi: 10.3390/diagnostics10070495 Authors: Cecilia A. Callejas Pastor Il-Young Jung Shinhye Seo Soon Bin Kwon Yunseo Ku Jayoung Choi Positional cranial deformities are relatively common conditions, characterized by asymmetry and changes in skull shape. Although three-dimensional (3D) scanning is the gold standard...
Sun Jul 19, 2020 03:00
Diagnostics, Vol. 10, Pages 492: Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging Diagnostics doi: 10.3390/diagnostics10070492 Authors: Maria Adele Marino Doris Leithner Janice Sung Daly Avendano Elizabeth A. Morris Katja Pinker Maxine S. Jochelson The aim of our intra-individual comparison study was to investigate and compare the potential of radiomics analysis...
Sat Jul 18, 2020 03:00
Diagnostics, Vol. 10, Pages 494: Concurrent Validity of Digital Vascular Auscultation for the Assessment of Blood Flow Obliteration on the Radial Artery in Healthy Subjects Diagnostics doi: 10.3390/diagnostics10070494 Authors: Cortés-Vega Casuso-Holgado Oliva-Pascual-Vaca García-Bernal González-García Rodríguez-Blanco This study aimed to determine the validity of digital vascular auscultation for the assessment of changes in the radial pulse in healthy subjects,...
Sat Jul 18, 2020 03:00
Diagnostics, Vol. 10, Pages 493: Validation of the Use of Automated and Manual Quantitative Analysis of Corneal Nerve Plexus Following Refractive Surgery Diagnostics doi: 10.3390/diagnostics10070493 Authors: Chin Yang Ji Nubile Mastropasqua Allen Mehta Liu Following refractive surgery, the cornea is denervated and re-innervated, hence a reproducible tool to objectively quantify this change is warranted. This study aimed to determine the repeatability and...
Sat Jul 18, 2020 03:00
Diagnostics, Vol. 10, Pages 490: Animal Models for Studying Stone Disease Diagnostics doi: 10.3390/diagnostics10070490 Authors: Szu-Ju Chen Kun-Yuan Chiu Huey-Yi Chen Wei-Yong Lin Yung-Hsiang Chen Wen-Chi Chen Animals have stone disease too. There are several animal models for the research of human stone disease. Rodents are the most frequently used for stone research, although they are not prone to forming crystals in the kidneys. Ethylene glycol (EG), sodium oxalate...
Sat Jul 18, 2020 03:00
Diagnostics, Vol. 10, Pages 491: COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B Diagnostics doi: 10.3390/diagnostics10070491 Authors: Thuy Thi Bich Phung Son Van Chu Son Thien Vu Hanh Thi Pham Hang Minh Nguyen Hoan Dang Nguyen Ngan Thi Le Dung Van Nguyen Phuong Thai Truong Van Thi Tuong Vu Anh Thi Van Nguyen We investigated Nucleos(t)ide-analogue (NA)-resistance mutations (mt)...
Sat Jul 18, 2020 03:00
Diagnostics, Vol. 10, Pages 489: Impact of Physical Activity on Cognitive Functions: A New Field for Research and Management of Cystic Fibrosis Diagnostics doi: 10.3390/diagnostics10070489 Authors: Valentina Elce Alessandro Del Pizzo Ersilia Nigro Giulia Frisso Lucia Martiniello Aurora Daniele Ausilia Elce Cystic Fibrosis (CF) is a genetic disease inherited by an autosomal recessive mechanism and characterized by a progressive and severe multi-organ failure. Mutations...
Sat Jul 18, 2020 03:00
Diagnostics, Vol. 10, Pages 487: Automatic Identification of Down Syndrome Using Facial Images with Deep Convolutional Neural Network Diagnostics doi: 10.3390/diagnostics10070487 Authors: Bosheng Qin Letian Liang Jingchao Wu Qiyao Quan Zeyu Wang Dongxiao Li Down syndrome is one of the most common genetic disorders. The distinctive facial features of Down syndrome provide an opportunity for automatic identification. Recent studies showed that facial recognition technologies...
Fri Jul 17, 2020 03:00
Diagnostics, Vol. 10, Pages 488: Multidisciplinary Approach to Interstitial Lung Diseases: Nothing Is Better than All of Us Together Diagnostics doi: 10.3390/diagnostics10070488 Authors: Carlo Vancheri Antonio Basile Interstitial Lung Diseases (ILDs) are a large family of disorders characterized by inflammation and/or fibrosis of areas of the lung dedicated to gas exchange. In this Special Issue entitled “Clinical and Radiological Features of Interstitial Lung Diseases”,...
Fri Jul 17, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου