Related Articles Intramuscular adipose tissue: a cause for concern. J Physiol. 2020 Jul 16;: Authors: Hucik B PMID: 32677054 [PubMed - as supplied by publisher]
Sat Jul 18, 2020 13:04
Related Articles Kinetochore proteins suppress neuronal microtubule dynamics and promote dendrite regeneration. Mol Biol Cell. 2020 Jul 16;:mbcE20040237T Authors: Hertzler JI, Simonovitch SI, Albertson RM, Weiner AT, Nye DMR, Rolls MM Abstract Kinetochores connect centromeric chromatin to spindle microtubules during mitosis. Neurons are post-mitotic, so it was surprising to identify transcripts of structural kinetochore (KT) proteins and regulatory...
Sat Jul 18, 2020 00:54
Related Articles A novel mechanism for the retention of Golgi membrane proteins mediated by the Bre5p/Ubp3p de-ubiquitinase complex. Mol Biol Cell. 2020 Jul 16;:mbcE20030168 Authors: Wang P, Ye Z, Banfield DK Abstract The mechanisms employed in the retention of Golgi resident membrane proteins are diverse and include features such as the composition and length of the protein's transmembrane domain and motifs that mediate direct or indirect associations...
Sat Jul 18, 2020 00:54
Related Articles Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Yao X, Fan X, Yan N Abstract Membrane proteins (MPs) used to be the most difficult targets for structural biology when X-ray crystallography was the mainstream approach. With the resolution revolution of single-particle electron cryo-microscopy (cryo-EM), rapid progress has been made for structural elucidation of...
Sun Jul 19, 2020 13:04
Related Articles V1 neurons encode the perceptual compensation of false torsion arising from Listing's law. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Khazali MF, Ramezanpour H, Thier P Abstract We try to deploy the retinal fovea to optimally scrutinize an object of interest by directing our eyes to it. The horizontal and vertical components of eye positions acquired by goal-directed saccades are determined by the object's location. However,...
Sun Jul 19, 2020 13:04
Related Articles Cavity molecular dynamics simulations of liquid water under vibrational ultrastrong coupling. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Li TE, Subotnik JE, Nitzan A Abstract We simulate vibrational strong coupling (VSC) and vibrational ultrastrong coupling (V-USC) for liquid water with classical molecular dynamics simulations. When the cavity modes are resonantly coupled to the O-H stretch mode of liquid water, the infrared...
Sun Jul 19, 2020 13:04
Related Articles Plato's cube and the natural geometry of fragmentation. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Domokos G, Jerolmack DJ, Kun F, Török J Abstract Plato envisioned Earth's building blocks as cubes, a shape rarely found in nature. The solar system is littered, however, with distorted polyhedra-shards of rock and ice produced by ubiquitous fragmentation. We apply the theory of convex mosaics to show that the average geometry...
Sun Jul 19, 2020 13:04
Related Articles Reconfigurable microbots folded from simple colloidal chains. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Yang T, Sprinkle B, Guo Y, Qian J, Hua D, Donev A, Marr DWM, Wu N Abstract To overcome the reversible nature of low-Reynolds-number flow, a variety of biomimetic microrobotic propulsion schemes and devices capable of rapid transport have been developed. However, these approaches have been typically optimized for a specific...
Sun Jul 19, 2020 13:04
Related Articles Bacterial immunotherapy for cancer induces CD4-dependent tumor-specific immunity through tumor-intrinsic interferon-γ signaling. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Antonelli AC, Binyamin A, Hohl TM, Glickman MS, Redelman-Sidi G Abstract Bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer is the only bacterial cancer therapy approved for clinical use. Although presumed to induce T cell-mediated immunity,...
Sun Jul 19, 2020 13:04
Related Articles Morphological profiling of tubercle bacilli identifies drug pathways of action. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Smith TC, Pullen KM, Olson MC, McNellis ME, Richardson I, Hu S, Larkins-Ford J, Wang X, Freundlich JS, Ando DM, Aldridge BB Abstract Morphological profiling is a method to classify target pathways of antibacterials based on how bacteria respond to treatment through changes to cellular shape and spatial...
Sun Jul 19, 2020 13:04
Related Articles Two-step reaction mechanism reveals new antioxidant capability of cysteine disulfides against hydroxyl radical attack. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Adhikari S, Crehuet R, Anglada JM, Francisco JS, Xia Y Abstract Cysteine disulfides, which constitute an important component in biological redox buffer systems, are highly reactive toward the hydroxyl radical (•OH). The mechanistic details of this reaction, however,...
Sun Jul 19, 2020 13:04
Related Articles Evolutionary stalling and a limit on the power of natural selection to improve a cellular module. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Venkataram S, Monasky R, Sikaroodi SH, Kryazhimskiy S, Kacar B Abstract Cells consist of molecular modules which perform vital biological functions. Cellular modules are key units of adaptive evolution because organismal fitness depends on their performance. Theory shows that in rapidly...
Sun Jul 19, 2020 13:04
Related Articles Maladaptive response of arterial myocytes to chronic exposure to Ca2+ channel blockers. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: O'Dwyer SC, Navedo MF, Santana LF PMID: 32680960 [PubMed - as supplied by publisher]
Sun Jul 19, 2020 13:04
Related Articles Crystallographic evidence of Watson-Crick connectivity in the base pair of anionic adenine with thymine. Proc Natl Acad Sci U S A. 2020 Jul 17;: Authors: Mishra MK, Kelley SP, Smetana V, Dixon DA, McNeill AS, Mudring AV, Rogers RD Abstract Utilizing an ionic liquid strategy, we report crystal structures of salts of free anionic nucleobases and base pairs previously studied only computationally and in the gas phase. Reaction...
Sun Jul 19, 2020 13:04
Related Articles Bioinspired conductive cellulose liquid-crystal hydrogels as multifunctional electrical skins. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Zhang Z, Chen Z, Wang Y, Zhao Y Abstract Bionic electronic skin (E-skin) that could convert external physical or mechanical stimuli into output signals has a wide range of applications including wearable devices, artificial prostheses, software robots, etc. Here, we present a chameleon-inspired...
Sat Jul 18, 2020 13:30
Related Articles High plant diversity and slow assembly of old-growth grasslands. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Nerlekar AN, Veldman JW Abstract Earth's ancient grasslands and savannas-hereafter old-growth grasslands-have long been viewed by scientists and environmental policymakers as early successional plant communities of low conservation value. Challenging this view, emerging research suggests that old-growth grasslands...
Sat Jul 18, 2020 13:30
Related Articles The gain-of-function allele bamA E470K bypasses the essential requirement for BamD in β-barrel outer membrane protein assembly. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Hart EM, Gupta M, Wühr M, Silhavy TJ Abstract The outer membrane (OM) of gram-negative bacteria confers innate resistance to toxins and antibiotics. Integral β-barrel outer membrane proteins (OMPs) function to establish and maintain the selective permeability...
Sat Jul 18, 2020 13:30
Related Articles Behavioral traits that define social dominance are the same that reduce social influence in a consensus task. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Rodriguez-Santiago M, Nührenberg P, Derry J, Deussen O, Francisco FA, Garrison LK, Garza SF, Hofmann HA, Jordan A Abstract Dominant individuals are often most influential in their social groups, affecting movement, opinion, and performance across species and contexts....
Sat Jul 18, 2020 13:30
Related Articles What ATP binding does to the Ca2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Kabashima Y, Ogawa H, Nakajima R, Toyoshima C Abstract Under physiological conditions, most Ca2+-ATPase (SERCA) molecules bind ATP before binding the Ca2+ transported. SERCA has a high affinity for ATP even in the absence of Ca2+, and ATP accelerates Ca2+ binding...
Sat Jul 18, 2020 13:30
Related Articles Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Hakim-Eshed V, Boulos A, Cohen-Rosenzweig C, Yu-Taeger L, Ziv T, Kwon YT, Riess O, Phuc Nguyen HH, Ziv NE, Ciechanover A Abstract Huntington's disease (HD) is a progressive incurable neurodegenerative disorder characterized by motor and neuropsychiatric symptoms. It is caused by expansion...
Sat Jul 18, 2020 13:30
Related Articles Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Ren W, Fan H, Grimm SA, Guo Y, Kim JJ, Yin J, Li L, Petell CJ, Tan XF, Zhang ZM, Coan JP, Gao L, Cai L, Detrick B, Çetin B, Cui Q, Strahl BD, Gozani O, Wang Y, Miller KM, O'Leary SE, Wade PA, Patel DJ, Wang GG, Song J Abstract In mammals, repressive histone modifications such as trimethylation...
Sat Jul 18, 2020 13:30
Related Articles T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Mohan RA, Bosada FM, van Weerd JH, van Duijvenboden K, Wang J, Mommersteeg MTM, Hooijkaas IB, Wakker V, de Gier-de Vries C, Coronel R, Boink GJJ, Bakkers J, Barnett P, Boukens BJ, Christoffels VM Abstract Genome-wide association studies have identified...
Sat Jul 18, 2020 13:30
Related Articles Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid-liquid phase separation. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Ladouceur AM, Parmar BS, Biedzinski S, Wall J, Tope SG, Cohn D, Kim A, Soubry N, Reyes-Lamothe R, Weber SC Abstract Once described as mere "bags of enzymes," bacterial cells are in fact highly organized, with many macromolecules exhibiting nonuniform localization...
Sat Jul 18, 2020 13:30
Related Articles Discovery of the world's highest-dwelling mammal. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Storz JF, Quiroga-Carmona M, Opazo JC, Bowen T, Farson M, Steppan SJ, D'Elía G Abstract Environmental limits of animal life are invariably revised when the animals themselves are investigated in their natural habitats. Here we report results of a scientific mountaineering expedition to survey the high-altitude rodent fauna of Volcán...
Sat Jul 18, 2020 13:30
Related Articles HEDGES error-correcting code for DNA storage corrects indels and allows sequence constraints. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Press WH, Hawkins JA, Jones SK, Schaub JM, Finkelstein IJ Abstract Synthetic DNA is rapidly emerging as a durable, high-density information storage platform. A major challenge for DNA-based information encoding strategies is the high rate of errors that arise during DNA synthesis and...
Sat Jul 18, 2020 13:30
Related Articles High-throughput discovery of phage receptors using transposon insertion sequencing of bacteria. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Kortright KE, Chan BK, Turner PE Abstract As the most abundant microbes on Earth, novel bacteriophages (phages; bacteria-specific viruses) are readily isolated from environmental samples. However, it remains challenging to characterize phage-bacteria interactions, such as the host receptor(s)...
Sat Jul 18, 2020 13:30
Related Articles Qualitative crop condition survey reveals spatiotemporal production patterns and allows early yield prediction. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Beguería S, Maneta MP Abstract Large-scale continuous crop monitoring systems (CMS) are key to detect and manage agricultural production anomalies. Current CMS exploit meteorological and crop growth models, and satellite imagery, but have underutilized legacy sources...
Sat Jul 18, 2020 13:30
Related Articles Predicting the long-term stability of compact multiplanet systems. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Tamayo D, Cranmer M, Hadden S, Rein H, Battaglia P, Obertas A, Armitage PJ, Ho S, Spergel DN, Gilbertson C, Hussain N, Silburt A, Jontof-Hutter D, Menou K Abstract We combine analytical understanding of resonant dynamics in two-planet systems with machine-learning techniques to train a model capable of robustly...
Sat Jul 18, 2020 13:30
Related Articles A mechanism-aware and multiomic machine-learning pipeline characterizes yeast cell growth. Proc Natl Acad Sci U S A. 2020 Jul 16;: Authors: Culley C, Vijayakumar S, Zampieri G, Angione C Abstract Metabolic modeling and machine learning are key components in the emerging next generation of systems and synthetic biology tools, targeting the genotype-phenotype-environment relationship. Rather than being used in isolation, it is...
Sat Jul 18, 2020 13:30
18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/07/17PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Jul 18, 2020 01:44
18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/07/17PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jul 17, 2020 14:00
Ο κίνδυνος σοβαρής νόσου και θανάτου από Covid-19 είναι υψηλότερος σε παχύσαρκα άτομα σύμφωνα με πρόσφατη μελέτη που δημοσιεύθηκε στο European Journal of Endocrinology (M Rottoli et al. How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre. European Journal of Endocrinology 2020. DOI: https://doi.org/10.1530/EJE-20-0541). Οι Matteo Rottoli και συνεργάτες από το πανεπιστήμιο της...
Sat Jul 18, 2020 10:38
Η ατμοσφαιρική ρύπανση αποτελεί σημαντικό επιβαρυντικό παράγοντα για την υγεία, ενώ μελέτες την έχουν συσχετίσει με πλήθος παθήσεων. Αρκεί να σημειωθεί πως, σύμφωνα με φετινή έρευνα του Εθνικού Κέντρου Περιβάλλοντος και Αειφόρου Ανάπτυξης (ΕΚΠΑΑ), περισσότεροι από 8.500 θάνατοι οφείλονται στις αυξημένες συγκεντρώσεις ατμοσφαιρικής ρύπανσης. Πρόσφατη έρευνα από το Πανεπιστήμιο Κολούμπια, με επίκεντρο τη φθορά που προκαλούν οι ατμοσφαιρικοί ρύποι στην εγκεφαλική υγεία, διαπίστωσε πως η μεγαλύτερη...
Fri Jul 17, 2020 12:45
Ελπίδα καλύτερης ζωής έχουν στις μέρες μας, τόσο στην Ελλάδα όσο και παγκοσμίως, τα παιδιά που πάσχουν από Νωτιαία Μυϊκή Ατροφία (SMA), την σπάνια και απειλητική για τη ζωή του πάσχοντα γενετική, νευρομυϊκή ασθένεια, που οδηγεί προοδευτικά σε παράλυση και -στην πιο σοβαρή μορφή της- σε θάνατο. Τι είναι η Νωτιαία Μυϊκή Ατροφία Η Νωτιαία Μυϊκή Ατροφία, όπως προαναφέρθηκε, είναι μια σπάνια και μοιραία γενετική ασθένεια, που οδηγεί προοδευτικά σε μυϊκή αδυναμία, παράλυση και, αν μείνει χωρίς θεραπεία,...
Fri Jul 17, 2020 11:00
Οι άνθρωποι που έχουν βιώσει στρες πολύ νωρίς στη ζωή τους είναι πιο πιθανό να εκδηλώσουν μείζονα καταθλιπτική διαταραχή σε παιδική ή εφηβική ηλικία, σύμφωνα με μελέτη που δημοσιεύεται στο Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP). «Μελέτες έχουν δείξει ότι το στρες στα πρώιμα στάδια της ζωής του ανθρώπου αυξάνει τον κίνδυνο κατάθλιψης στην ενήλικη ζωή. Θελήσαμε λοιπόν να δούμε σε ποιον βαθμό σχετίζεται με την εκδήλωση κατάθλιψης νωρίτερα, ειδικά στην παιδική και...
Fri Jul 17, 2020 09:10
Συστηματική ανασκόπηση και μετα-ανάλυση δημοσιευμένων μελετών από τρεις περιοχές του πλανήτη που επλήγησαν από την πανδημία COVID-19 δείχνει ότι η συνολική θνησιμότητα των ασθενών που νοσηλεύονται στις Μονάδες Εντατικής Θεραπείας (ΜΕΘ) έχει μειωθεί από σχεδόν 60% στα τέλη Μαρτίου στο 42% στα τέλη Μαΐου. Στο άρθρο που δημοσιεύεται στο Anaesthesia, οι ερευνητές με επικεφαλής τον καθηγητή Tim Cook, από την Ιατρική Σχολή του Πανεπιστημίου του Μπρίστολ αναζήτησαν στοιχεία από τις ιατρικές βάσεις MEDLINE,...
Fri Jul 17, 2020 08:15
Τα επίπεδα σιδήρου στο αίμα ενδεχομένως να αποτελούν το κλειδί για την επιβράδυνση του ρυθμού γήρανσης υποστηρίζει νέα γονιδιακή έρευνα από το Πανεπιστήμιο του Εδιμβούργου που δημοσιεύθηκε στο Nature Communications. Τα γονίδια που σχετίζονται με την γήρανση μπορούν να εξηγήσουν έως ένα βαθμό το διαφορετικό ρυθμό γήρανσης μεμονωμένων ατόμων υποστηρίζουν οι ερευνητές. Η διεθνής έρευνα αξιολόγησε στοιχεία από περισσότερα από ένα εκατομμύριο άτομα και κατέληξε στο συμπέρασμα ότι η διατήρηση υγιών επιπέδων...
Fri Jul 17, 2020 07:55
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