Abstract Follicle stimulating hormone (FSH) and luteinizing hormone (LH) play critical roles in female reproduction, while the underlying genetic basis is poorly understood. GWASs of FSH and LH levels were conducted in 2590 Chinese females including 1882 PCOS cases and 708 controls. GWAS for FSH level identified multiple variants at FSHR showing genome‐wide significance with the top variant (rs2300441) located in the intron of FSHR. The A allele of rs2300441 led to a reduced level of FSH...
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ABSTRACT Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by defects in the function or structure of motile cilia. In most cases, causative variants result in axonemal dynein arm anomalies, however, PCD due to radial spoke (RS) and central pair (CP) of microtubules has been rarely reported. To identify the molecular basis of PCD characterized by RS/CP defects, we performed whole exome sequencing in PCD patients with RS/CP defects. We identified a homozygous...
09:16
Abstract Encephalopathy due to defective mitochondrial and peroxisomal fission 2 caused by MFF (mitochondrial fission factor) gene mutation is a rare neurogenetic disorder. Pathogenic MFF mutations have been described in three reports in literature till date. We report a young child of Indian descent who presented to us with global developmental followed by regression of acquired milestones, spasticity, visual and auditory impairment, and was found to harbour a novel pathogenic homozygous...
09:16
Abstract This is a case presentation of successful defect repair after radical surgical excision of a moderately large basal cell carcinoma by a simple procedure taking advantage of a patient's individual face features. This article is protected by copyright. All rights reserved.
09:16
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Front Oncol"[jour] These pubmed results were generated on 2020/03/17PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Mar 17, 2020 12:09
109 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2020/03/17PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Mar 17, 2020 12:09
Abstract Background Although estrogen deficiency has been proposed as a risk factor for oral mucosal inflammatory diseases in post‐menopausal women, the mechanisms involved remain unclear. This study aimed to investigate the effect of 17β‐estradiol (E2) on the inflammatory response stimulated by interleukin‐1 beta (IL‐1β) in human oral mucosal epithelial cells (hOMECs) and its possible mechanism. Methods Primary hOMECs were obtained from female infants and cultured in keratinocyte...
Tue Mar 17, 2020 21:40
Publication date: Available online 16 March 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Ruixia Zhu, Qian wen wang, Jingjing zhao, Xu Liu, Zhiyi He
Tue Mar 17, 2020 21:20
Publication date: Available online 16 March 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Kyle B. Mueller, David Zhao, Ehsan Dowlati, Matthew D’Antuono, Daniel Felbaum, Jason Chang, Michael Hockstein, Jeffery Mai, Bryan Mason, Edward Aulisi, Rocco Armonda
Tue Mar 17, 2020 21:20
Publication date: Available online 16 March 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Bin Yuan, Xiao-ming Zhou, Jie-mei Fan, Shu-juan Chen, Zong-qi You, Wei-dong Xu, Li-li Wen, Jin-long Deng, Qi Wu, Xin Zhang
Tue Mar 17, 2020 21:20
Publication date: Available online 16 March 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Cuiping Xu, Tao Yu, Xiaohua Zhang, Guojun Zhang, Ping Zhuang, Yuping Wang, Yongjie Li
Tue Mar 17, 2020 21:20
Publication date: Available online 16 March 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): André Luis Silveira Barezani, Aline Michele Batista de Figueiredo Feital, Bernardo Machado Gonçalves, Paulo Pereira Christo, Paula Luciana Scalzo
Tue Mar 17, 2020 21:20
Surgical Infections, Ahead of Print.
Tue Mar 17, 2020 09:00
Disclaimer: I am not an epidemiologist, but there is an interesting potentially important pattern in the data that seems worth understanding. World healthcare authorities appear to be primarily shifting towards Social Distancing. However, there is potential to pursue a different strategy in the medium term that exploits a vulnerability of this disease: the 5 day incubation time is much longer than a 4 hour detection time. This vulnerability is real—it has proved exploitable at scale in South...
Tue Mar 17, 2020 20:45
Publication date: Available online 17 March 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Carlo Lajolo, Romeo Patini, Luisa Limongelli, Gianfranco Favia, Angela Tempesta, Maria Contaldo, Eugenio De Corso, Michele Giuliani
Tue Mar 17, 2020 21:02
An in vitro model system was developed to capture tissue architectural changes during lung squamous carcinoma (LUSC) progression in a 3-dimensional (3D) co-culture with cancer-associated fibroblasts (CAFs). This organoid system provides a unique platform to investigate the roles of diverse tumor cell-intrinsic and extrinsic changes that modulate the tumor phenotype.
Tue Mar 17, 2020 20:57
Cardiomyocyte proliferation following injury is a dynamic process that requires a symphony of extracellular cues from non-myocyte cell populations. Utilizing lineage tracing, passive CLARITY, and three-dimensional whole-mount confocal microscopy techniques, we can analyze the influence of a variety of cell types on cardiac repair and regeneration.
Tue Mar 17, 2020 19:57
Graft-versus-host disease is a major complication after allogeneic bone marrow transplantation. Dendritic cells play a critical role in the pathogenesis of graft-versus-host disease. The current article describes a novel bone marrow transplantation platform to investigate the role of dendritic cells in the development of graft-versus-host disease and the graft-versus-leukemia effect.
Tue Mar 17, 2020 18:57
Abstract Background Here we present performance evaluation methodology that distinguishes the performance of a haptic device from end‐user skill level in a tele‐robotic system. Methods A pick‐&‐place experiment was designed and 8 participants micro‐manipulated cotton strips, similar to maneuvers performed during microsurgery. Using three non‐redundant haptic devices: neuroArmPLUS HD , a custom developed master manipulator, and two commercially available products, sigma.7...
Tue Mar 17, 2020 20:53
Abstract The presence of activated T cells in colorectal cancer tissues is a strong predictor of patient survival. Our previous studies have shown that regulatory T cells (Treg) are able to reduce T cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo in the murine APCMin/+ model for microsatellite stable intestinal tumors. In this study, we investigated the effect of Treg depletion on the density and effector functions of...
Tue Mar 17, 2020 02:00
BACKGROUND AND PURPOSE:We evaluated modifications to our contrast-enhanced MR imaging grading system for symptomatic patients with suspected nasopharyngeal carcinoma, aimed at improving discrimination of early-stage cancer and benign hyperplasia. We evaluated a second non-contrast-enhanced MR imaging grading system for asymptomatic patients from nasopharyngeal carcinoma plasma screening programs. MATERIALS AND METHODS:Dedicated nasopharyngeal MR imaging before (plain scan system) and after intravenous...
Tue Mar 17, 2020 19:17
BACKGROUND AND PURPOSE:There is no consensus on endovascular treatment for terminal ICA. The purpose of this study was to evaluate the comparative safety and efficacy of preferred aspiration thrombectomy and stent retriever thrombectomy for revascularization in patients with isolated terminal ICA occlusion. MATERIALS AND METHODS:We conducted a retrospective analysis of patients with terminal ICA occlusion treated with aspiration thrombectomy or stent retriever thrombectomy in our center, from September...
Tue Mar 17, 2020 19:17
BACKGROUND AND PURPOSE:Graph theory uses structural similarity to analyze cortical structural connectivity. We used a voxel-based definition of cortical covariance networks to quantify and assess the relationship of network characteristics to cognition in a cohort of patients with relapsing-remitting MS with and without cognitive impairment. MATERIALS AND METHODS:We compared subject-specific structural gray matter network properties of 18 healthy controls, 25 patients with MS with cognitive impairment,...
Tue Mar 17, 2020 19:17
Tue Mar 17, 2020 19:17
BACKGROUND AND PURPOSE:Flow diverter–induced hemodynamic change plays an important role in the mechanism of intracranial aneurysm occlusion. Our aim was to explore the relationship between aneurysm features and flow-diverter treatment of unruptured sidewall intracranial aneurysms. MATERIALS AND METHODS:MR imaging, 4D phase-contrast, was prospectively performed before flow diverter implantation in each patient with unruptured intracranial aneurysm. Two postprocedure follow-ups were scheduled at...
Tue Mar 17, 2020 19:17
BACKGROUND AND PURPOSE:There is increasing evidence of abnormal neurodevelopmental outcomes in very preterm infants with low-grade intraventricular hemorrhage grades I and II. Our purpose was to evaluate the effects of low-grade intraventricular hemorrhage on gray and white matter integrity. MATERIALS AND METHODS:MR imaging at around term-equivalent age was performed in 16 very preterm infants (mean gestational age, 28.8 ± 5.3 weeks) with mild intraventricular hemorrhage on brain sonography and...
Tue Mar 17, 2020 19:17
Tue Mar 17, 2020 19:17
SUMMARY:The study aim was to compare the ratio of T1WI to T2WI signal intensity (T1/T2) with magnetization transfer ratio, a marker of myelin integrity, in patients with multiple sclerosis. A moderate correlation (r = 0.50, P = .034) was found between the magnetization transfer ratio and T1/T2 in normal-appearing gray matter, and a strong correlation for normal-appearing white matter (r = 0.63, P = .005) and lesions (r = 0.70, P = .001). Results suggest that besides myelin integrity, other factors...
Tue Mar 17, 2020 19:17
BACKGROUND AND PURPOSE:The angiographic collar sign has been recently described in patients with incompletely occluded aneurysms after Pipeline Embolization Device implantation. The long-term implications of this sign are unknown. We report angiographic outcomes of patients with the collar sign with follow-up of up to 45 months and the implications of this angiographic finding. MATERIALS AND METHODS:We performed a retrospective review of a prospectively maintained data base of patients who underwent...
Tue Mar 17, 2020 19:17
BACKGROUND AND PURPOSE:The natural history and optimal treatment of extracranial carotid artery aneurysms are unknown. Gadolinium enhancement of the aneurysm wall may reflect aneurysm wall inflammation and instability. In this study, we investigated the feasibility of extracranial carotid artery aneurysm wall imaging and explored a potential relationship of aneurysm wall enhancement with aneurysm growth and the presence of (silent) brain infarcts and white matter lesions. MATERIALS AND METHODS:Fourteen...
Tue Mar 17, 2020 19:17
SUMMARY:Intracranial aneurysms with subarachnoid hemorrhage lead to high morbidity and mortality. It is of critical importance to detect aneurysms, identify risk factors of rupture, and predict treatment response of aneurysms to guide clinical interventions. Artificial intelligence has received worldwide attention for its impressive performance in image-based tasks. Artificial intelligence serves as an adjunct to physicians in a series of clinical settings, which substantially improves diagnostic...
Tue Mar 17, 2020 19:17
BACKGROUND AND PURPOSE:Ménière disease is characterized by endolymphatic hydrops, whereas perilymphatic enhancement on MR imaging has been suggested to be of additional value in diagnosing Ménière disease. This study evaluates the presence of endolymphatic hydrops and perilymphatic enhancement in patients with Ménière disease and with other vertigo-associated inner ear pathology. MATERIALS AND METHODS:A 3D-FLAIR sequence 4 hours after intravenous gadolinium injection was performed to visualize...
Tue Mar 17, 2020 19:17
SUMMARY:Vessel wall imaging has been increasingly used to characterize plaque beyond luminal narrowing to identify patients who may be at the highest risk of cerebrovascular ischemia. Although detailed plaque information can be obtained from many imaging modalities, CTA is particularly appealing for carotid plaque imaging due to its relatively low cost, wide availability, operator independence, and ability to discern high-risk features. The present Review Article describes the current understanding...
Tue Mar 17, 2020 19:17
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