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Front Oncol. 2020 Feb 27;10:112. doi: 10.3389/fonc.2020.00112. eCollection 2020.
Xi X1, Gao L2, Wu Q2,3, Fang S3, Xu J4, Liu R2, Yang X2, Zhu S2, Zhao R2, Lai X2, Zhang X2, Zhang B1,2, Jiang Y2.
Author information
Abstract
According to the 2015 American Thyroid Association (ATA), referred risk stratification and thyroid nodules with intermediate- and low-suspicion patterns are difficult to diagnose. The objective of this study is to evaluate the diagnostic performance of contrast-enhanced ultrasonography (CEUS) and elastosonography (ES) for the differentiation of these thyroid nodules. From November 2011 to June 2016, a total of 163 thyroid nodules with intermediate- and low-suspicion patterns in 150 consecutive patients at our hospital were studied before surgery. With surgical pathology as the standard, the diagnostic value of CEUS and ES was analyzed. There were 29 (17.8%) malignant lesions and 134 (82.2%) benign lesions. The enhancement patterns of CEUS, the echogenicity, and the elastography were significantly different between malignant and benign lesions (P < 0.05). Heterogenous enhancement was more common in malignant nodules, and the sensitivity, specificity, positive predictive value, negative predictive value, and odds ratio were 51.7, 88.1, 48.4, 89.4, and 10.1%, respectively. The diagnostic accuracy of CEUS was better than the conventional ultrasound [area under the curve (AUC), 0.729 vs. 0.616, P = 0.021]. The enhancement patterns of CEUS were helpful in the differential diagnosis of thyroid nodules with intermediate and low suspicion.
Copyright © 2020 Xi, Gao, Wu, Fang, Xu, Liu, Yang, Zhu, Zhao, Lai, Zhang, Zhang and Jiang.
KEYWORDS:
American Thyroid Association; contrast-enhanced ultrasonography; elastosonography; intermediate- and low-suspicion patterns; thyroid carcinoma
PMID: 32175270 PMCID: PMC7056834 DOI: 10.3389/fonc.2020.00112
Front Oncol. 2020 Feb 27;10:112. doi: 10.3389/fonc.2020.00112. eCollection 2020.
Xi X1, Gao L2, Wu Q2,3, Fang S3, Xu J4, Liu R2, Yang X2, Zhu S2, Zhao R2, Lai X2, Zhang X2, Zhang B1,2, Jiang Y2.
Author information
Abstract
According to the 2015 American Thyroid Association (ATA), referred risk stratification and thyroid nodules with intermediate- and low-suspicion patterns are difficult to diagnose. The objective of this study is to evaluate the diagnostic performance of contrast-enhanced ultrasonography (CEUS) and elastosonography (ES) for the differentiation of these thyroid nodules. From November 2011 to June 2016, a total of 163 thyroid nodules with intermediate- and low-suspicion patterns in 150 consecutive patients at our hospital were studied before surgery. With surgical pathology as the standard, the diagnostic value of CEUS and ES was analyzed. There were 29 (17.8%) malignant lesions and 134 (82.2%) benign lesions. The enhancement patterns of CEUS, the echogenicity, and the elastography were significantly different between malignant and benign lesions (P < 0.05). Heterogenous enhancement was more common in malignant nodules, and the sensitivity, specificity, positive predictive value, negative predictive value, and odds ratio were 51.7, 88.1, 48.4, 89.4, and 10.1%, respectively. The diagnostic accuracy of CEUS was better than the conventional ultrasound [area under the curve (AUC), 0.729 vs. 0.616, P = 0.021]. The enhancement patterns of CEUS were helpful in the differential diagnosis of thyroid nodules with intermediate and low suspicion.
Copyright © 2020 Xi, Gao, Wu, Fang, Xu, Liu, Yang, Zhu, Zhao, Lai, Zhang, Zhang and Jiang.
KEYWORDS:
American Thyroid Association; contrast-enhanced ultrasonography; elastosonography; intermediate- and low-suspicion patterns; thyroid carcinoma
PMID: 32175270 PMCID: PMC7056834 DOI: 10.3389/fonc.2020.00112
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