Cancers, Vol. 12, Pages 712: Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of Age Cancers doi: 10.3390/cancers12030712 Authors: Simon J. Johnston Binafsha M. Syed Ruth M. Parks Cíntia J. Monteiro Joseph A. Caruso Andrew R. Green Ian O. Ellis Kelly K. Hunt Cansu Karakas Khandan Keyomarsi Kwok-Leung Cheung Multi-cohort analysis demonstrated that cytoplasmic...
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Cancers, Vol. 12, Pages 713: Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy Cancers doi: 10.3390/cancers12030713 Authors: Marc Castellví Eudald Felip Ifeanyi Jude Ezeonwumelu Roger Badia Edurne Garcia-Vidal Maria Pujantell Lucía Gutiérrez-Chamorro Iris Teruel Anna Martínez-Cardús Bonaventura Clotet Eva Riveira-Muñoz Mireia Margelí Ester Ballana Sterile alpha motif and histidine-aspartic...
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Related ArticlesSleep across early childhood: implications for internalizing and externalizing problems, socioemotional skills, and cognitive and academic abilities in preschool. J Child Psychol Psychiatry. 2020 Mar 15;: Authors: Hoyniak CP, Bates JE, McQuillan ME, Staples AD, Petersen IT, Rudasill KM, Molfese VJ Abstract BACKGROUND: Sleep is thought to be important for behavioral and cognitive development. However, much of the prior research on sleep's...
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Related ArticlesEffect of Continuous Positive Airway Pressure on glycated hemoglobin in patients with type 2 diabetes and Obstructive Sleep Apnea. Tunis Med. 2019 Dec;97(12):1345-1352 Authors: Gharsalli H, Oueslati I, Sahnoun I, Neffati O, Ghrairi N, Maalej S, Douik El Gharbi L Abstract INTRODUCTION: Obstructive sleep apnea (OSA) is a risk factor for type 2 diabetes that adversely impacts glycemic control. However, there is little evidence about the...
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Related ArticlesDisease Burden and Long-Term Risk of Persistent Very Poorly Controlled Asthma: TENOR II. J Allergy Clin Immunol Pract. 2020 Mar 12;: Authors: Haselkorn T, Szefler SJ, Chipps BE, Bleecker ER, Harkins MS, Paknis B, Kianifard F, Ortiz B, Zeiger RS Abstract BACKGROUND: Severe/difficult-to-treat disease occurs in 5-10% of asthma patients, but accounts for >50% of related economic costs. Understanding factors associated with persistent very...
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Related ArticlesAdherence and acceptability of light therapies to improve sleep in intrinsic circadian rhythm sleep disorders and neuropsychiatric illness: a systematic review. Sleep Health. 2020 Mar 12;: Authors: Faulkner SM, Dijk DJ, Drake RJ, Bee PE Abstract Sleep problems and circadian misalignment affect health and well-being and are highly prevalent in those with co-morbid neuropsychiatric disorders. Interventions altering light exposure patterns...
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Related ArticlesObstructive sleep apnea in late-onset Pompe disease treated by enzyme replacement therapy. Neuromuscul Disord. 2020 Feb 12;: Authors: Bhui R, Spector AR Abstract Obstructive sleep apnea is a common complication of Pompe disease. Treatment for obstructive sleep apnea in patients with Pompe disease is similar to treatment in the general population, typically involving positive airway pressure therapy. We present a case in which a patient...
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Related ArticlesEffect of Health Education on Level of Awareness and Knowledge of Nigerian In-School adolescents on Stroke and Its Risk Factors. J Stroke Cerebrovasc Dis. 2020 Mar 12;:104757 Authors: Komolafe MA, Olorunmoteni OE, Fehintola FO Abstract BACKGROUND: Stroke education in adolescents has been established as an effective method of creating awareness about stroke, its warning signs and risk factors. It contributes to desired behavioural change...
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Related ArticlesEffects of repetitive transcranial magnetic stimulation in subjects with sleep disorders. Sleep Med. 2020 Feb 19;: Authors: Nardone R, Sebastianelli L, Versace V, Brigo F, Golaszewski S, Pucks-Faes E, Saltuari L, Trinka E Abstract In this review, we aimed at identifying the studies that have employed repetitive transcranial magnetic stimulation (rTMS) in patients with sleep disorders. Low-frequency (LF) rTMS stimulating the right dorsolateral...
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Related ArticlesEvaluation of Diagnostic Criteria for Hashimoto's Encephalopathy Among Children and Adolescents. Pediatr Neurol. 2020 Feb 08;: Authors: Adams AV, Mooneyham GC, Van Mater H, Gallentine W Abstract BACKGROUND: The recently proposed adult diagnostic criteria for the Hashimoto's encephalopathy (HE) include a requirement of subclinical or mild thyroid disease. However, most case reports indicate that most children treated for HE do not have...
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Related ArticlesPhysical activity interventions can improve emotion regulation and dimensions of empathy in persons with multiple sclerosis: An exploratory study. Mult Scler Relat Disord. 2020 Jan;37:101380 Authors: Sadeghi Bahmani D, Razazian N, Motl RW, Farnia V, Alikhani M, Pühse U, Gerber M, Brand S Abstract BACKGROUND: Persons with multiple sclerosis (PwMS) report difficulties with emotion regulation and empathy. Regular physical activity (RPA)...
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Related ArticlesRole of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis. Crit Care Clin. 2020 Apr;36(2):255-265 Authors: Sungurlu S, Kuppy J, Balk RA Abstract The pathobiology of the septic process includes a complex interrelationship between inflammation and the coagulations system. Antithrombin (AT) and tissue factor are important components of the coagulation system and have potential roles in the production and amplification...
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Related ArticlesFactors associated with frequent consumption of fast food among Australian secondary school students. Public Health Nutr. 2020 Mar 16;:1-10 Authors: Scully M, Morley B, Niven P, Crawford D, Pratt IS, Wakefield M, NaSSDA Study Team Abstract OBJECTIVE: To examine demographic and behavioural correlates of frequent consumption of fast food among Australian secondary school students and explore the associations between fast food consumption...
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Related ArticlesAdults with cystic fibrosis: spiritual coping with lifelong disease. J Health Care Chaplain. 2020 Mar 14;:1-13 Authors: Grossoehme DH, Cole AG, Lewis K, Stamper SM, Teeters A, Joseph PM Abstract Cystic fibrosis (CF) is a chronic life-shortening disease requiring significant coping. Spiritual belief relates to treatment behaviors. Little is known about spirituality's role in adults diagnosed as children, nor how it compares with adults...
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Related ArticlesEffect of Gender, Age, and Profound Disease on Upper Airway Stimulation Outcomes. Ann Otol Rhinol Laryngol. 2020 Mar 16;:3489420911656 Authors: Patel J, Daniels K, Bogdan L, Huntley C, Boon M Abstract OBJECTIVE: To evaluate treatment outcomes of upper airway stimulation (UAS) in obstructive sleep apnea (OSA) patients based on patient age, gender, and preoperative disease severity. METHODS: Retrospective chart review of patients...
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Related ArticlesMastering nocturnal jigsaws in Parkinson's disease: a dusk-to-dawn review of night-time symptoms. J Neural Transm (Vienna). 2020 Mar 14;: Authors: Bhidayasiri R, Sringean J, Trenkwalder C Abstract Finding out about night-time symptoms from Parkinson's disease (PD) patients can be a challenge as many patients and their carers cannot recall many symptoms that occur during the night, resulting in an under-recognition or a large variability...
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Related ArticlesRelationship between trajectory of sleep quality and short-term changes in residual renal function in stage 3-5 chronic kidney disease patients. Clin Exp Nephrol. 2020 Mar 14;: Authors: Chang W, Han Y, Song X, Liu Y, Zhang W, Hao J, Chen JB Abstract BACKGROUND: Chronic kidney disease (CKD) is commonly associated with sleep disturbance. However, the relationship between the trajectory of sleep quality and short-term residual renal function...
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Related ArticlesDifferent aspects of electronic media use, symptoms and neurocognitive outcomes of children and adolescents in the rural Western Cape region of South Africa. Environ Res. 2020 Mar 04;184:109315 Authors: Chetty-Mhlanga S, Fuhrimann S, Eeftens M, Basera W, Hartinger S, Dalvie MA, Röösli M Abstract BACKGROUND: Electronic media use is increasing in low- and middle-income countries, thus we aim to investigate the prevalence of different aspects...
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Related ArticlesManipulating sleep duration perception changes cognitive performance - An exploratory analysis. J Psychosom Res. 2020 Mar 04;132:109992 Authors: Rahman SA, Rood D, Trent N, Solet J, Langer EJ, Lockley SW Abstract OBJECTIVES: To test the effect of perceived sleep duration on cognitive performance. METHODS: Sixteen healthy individuals [8F; mean age (± SD): 24.2 ± 3.0 years)] received an 8-h sleep opportunity followed by a 5-h opportunity...
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Related ArticlesCircadian and Sleep Dysfunction in Alzheimer's Disease. Ageing Res Rev. 2020 Mar 11;:101046 Authors: Uddin MS, Tewari D, Mamun AA, Kabir MT, Niaz K, Wahed MII, Barreto GE, Ashraf GM Abstract Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the most common type of dementia. Along with progressive cognitive impairment, dysfunction of the circadian rhythms also play a pivotal role in the progression of...
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Related ArticlesEvidence of Possible Irritable Larynx Syndrome in Obstructive Sleep Apnea: An Epidemiologic Approach. J Voice. 2020 Mar 11;: Authors: Roy N, Merrill RM, Pierce J, Sundar KM Abstract OBJECTIVE: "Irritable larynx syndrome" (ILS) often refers to a constellation of laryngeal-based symptoms including chronic cough (CC), diurnal dyspnea, and dysphonia. In patients with OSA, we examined: (1) the frequency, severity, comorbidity, risks and triggers...
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Related ArticlesSleep and Glycemia in Youth With Type 1 Diabetes. J Pediatr Health Care. 2020 Mar 11;: Authors: Rechenberg K, Griggs S, Jeon S, Redeker N, Yaggi HK, Grey M Abstract INTRODUCTION: Short sleep duration and quality are problems for many youth, and are associated with difficulties in executive function. Our purpose was to describe subjective and objective sleep characteristics and their associations with executive function, stress and coping,...
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Related ArticlesEdentulism Is Associated With More Severe Obstructive Sleep Apnea Syndrome. J Oral Maxillofac Surg. 2020 Feb 19;: Authors: Cillo JE, Schorr R, Dattilo DJ Abstract PURPOSE: The relationship between edentulism and the severity of obstructive sleep apnea syndrome (OSAS) is not well established. The purpose of the present study was to evaluate the relationship of edentulism on the severity of OSAS compared with equally at-risk dentate subjects....
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Related ArticlesAdapting the Auckland Sleep Screening Tool for pharmacy: pharmacists' experience and feedback. J Prim Health Care. 2019 Jul;11(2):170-177 Authors: Gauld N, Braganza C, Arroll B Abstract INTRODUCTION Insomnia has negative health effects and may indicate underlying serious conditions, but is underdiagnosed and often not discussed with a doctor. AIM This study aimed to explore the utility and workability in New Zealand community pharmacies...
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Related ArticlesAn evaluation of paediatric tinnitus services in UK National Health Service audiology departments. BMC Health Serv Res. 2020 Mar 14;20(1):214 Authors: Smith H, Fackrell K, Kennedy V, Barry JG, Broomhead E, Hoare DJ Abstract BACKGROUND: Whilst evidence indicates many children experience troublesome tinnitus, specialist services for children are far less established than those available for adults. To date, there is limited understanding...
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Related ArticlesSpatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram: a pilot study. BMC Psychiatry. 2020 Mar 14;20(1):124 Authors: Wu L, Wang XQ, Yang Y, Dong TF, Lei L, Cheng QQ, Li SX Abstract BACKGROUND: Previous studies have shown escitalopram is related to sleep quality. However, effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different...
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Related ArticlesPlasma sCD36 as non-circadian marker of chronic circadian disturbance in shift workers. PLoS One. 2019;14(10):e0223522 Authors: van de Langenberg D, Vlaanderen JJ, Dolle MET, Handberg A, Vermeulen RCH, van Kerkhof LWM Abstract Shift work induces chronic circadian disturbance, which might result in increased health risks, including cardio-metabolic diseases. Previously, we identified sCD36 as a potential non-circadian biomarker of chronic...
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Related ArticlesPleural dye marking of lung nodules by electromagnetic navigation bronchoscopy. Clin Respir J. 2019 Nov;13(11):700-707 Authors: Bowling MR, Folch EE, Khandhar SJ, Arenberg DA, Awais O, Minnich DJ, Pritchett MA, Rickman OB, Sztejman E, Anciano CJ Abstract INTRODUCTION: Electromagnetic navigation bronchoscopy (ENB)-guided pleural dye marking is useful to localize small peripheral pulmonary nodules for sublobar resection. OBJECTIVE:...
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Related ArticlesThe authors reply. Crit Care Med. 2019 07;47(7):e612 Authors: Bulgarelli L, Deliberato RO, Stone DJ, Celi LA, Johnson AEW PMID: 31205091 [PubMed - indexed for MEDLINE]
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Related ArticlesCarbonic Anhydrase Inhibitors for the Treatment of High-Altitude Hypoxemia. Am J Med. 2019 11;132(11):e799-e800 Authors: Hooper PL, Swenson ER, Johnson RJ PMID: 31152716 [PubMed - indexed for MEDLINE]
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Related ArticlesCystic fibrosis year in review 2018, part 2. Pediatr Pulmonol. 2019 08;54(8):1129-1140 Authors: Savant AP, McColley SA Abstract Cystic fibrosis (CF) research and case reports were robust in the year 2018. This report summarizes publications related the multisystem effects of CF, pulmonary exacerbations, new and expanded therapies other than cystic fibrosis transmembrane conductance regulator modulator studies, and patient-reported priorities...
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Related ArticlesQuality of Life in Schizophrenia: A Meta-Analysis of Comparative Studies. Psychiatr Q. 2019 09;90(3):519-532 Authors: Dong M, Lu L, Zhang L, Zhang YS, Ng CH, Ungvari GS, Li G, Meng X, Wang G, Xiang YT Abstract Studies and findings regarding the impact of schizophrenia on quality of life (QOL) has been highly variable. This meta-analysis compared QOL between schizophrenia subjects and healthy controls with a focus on standardized measures....
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Related ArticlesTransient Lentiviral Vector Production Using a Packed-Bed Bioreactor System. Hum Gene Ther Methods. 2019 06;30(3):93-101 Authors: McCarron A, Donnelley M, McIntyre C, Parsons D Abstract Scalable lentiviral vector (LV) manufacturing is vital for successful commercialization of LV-based gene and cell therapy products. Accordingly, efforts are currently focused on developing and adapting technologies to address both upstream and downstream...
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Related ArticlesImpact of hospitalisation of children on parental dietary habits: a qualitative study. Arch Dis Child. 2019 10;104(10):967-971 Authors: Church K, Campbell D, Halliday V Abstract OBJECTIVE: To explore how prolonged hospitalisation of a child with a neurological condition influences the dietary habits of parents, taking account of their attitudes and perceptions of this experience. DESIGN: Qualitative study using semi-structured...
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Related ArticlesSymptom Clusters in People Living With HIV: A Systematic Review. J Pain Symptom Manage. 2019 07;58(1):115-133 Authors: Zhu Z, Zhao R, Hu Y Abstract CONTEXT: An increasing number of studies regarding symptom management have begun to shift their focus from managing a single symptom to multiple symptom clusters. However, there is a lack of consistency of compositions among different studies and even in two different analyses reported in...
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Related ArticlesPrevalence of unintentional infant bedsharing. Appl Nurs Res. 2019 04;46:28-30 Authors: Doering JJ, Lim PS, Salm Ward TC, Davies WH PMID: 30853072 [PubMed - indexed for MEDLINE]
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Related ArticlesCharacteristics at the time of oxygen initiation associated with its adherence: Findings from the COPD Long-term Oxygen Treatment Trial. Respir Med. 2019 03;149:52-58 Authors: Moy ML, Harrington KF, Sternberg AL, Krishnan JA, Albert RK, Au DH, Casaburi R, Criner GJ, Diaz P, Kanner RE, Panos RJ, Stibolt T, Stoller JK, Tonascia J, Yusen RD, Tan AM, Fuhlbrigge AL, LOTT Research Group Abstract RATIONALE: Characteristics associated with...
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Related ArticlesElevated Exhaled Nitric Oxide in Adolescents Is Associated With Incident Allergic Symptoms: A Prospective Cohort Study. J Investig Allergol Clin Immunol. 2019;29(3):231-238 Authors: Kalm-Stephens P, Nordvall L, Janson C, Neuman Å, Malinovschi A, Alving K Abstract BACKGROUND: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation in the airways. Elevated FeNO may precede the development of allergic disease. The aim of...
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Related ArticlesPrevalence and Pattern of Psychosocial Disorders among Caregivers of HIV-infected Children in Enugu, South-Eastern Nigeria. J Trop Pediatr. 2019 Apr 01;65(2):107-113 Authors: Ogbonna IF, Emodi IJ, Ikefuna AN, Ojinnaka NC Abstract BACKGROUND: Nigeria has the highest burden of paediatric HIV in the world. HIV infection may result in significant life stressors, on both the infected children and their caregivers. METHODS: This included...
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