Background. Insulin promotes glucose consumption as the main cardiac energy source, while increasing myocardial efficiency. The short-term effects of insulin on cardiac function and its potential curative role in an acute diabetological cardiology setting remain unknown. Our study evaluated the role of acute insulin administration in the diabetic heart, its corresponding effective blood insulin level, and the time-course applicability of insulin treatment in a routine clinical setting. Methods. We...
18h
Aim. Connexin 43 (Cx43) has been identified to be important for cerebral ischemia/reperfusion (I/R) injury as well as protection from it. This study was aimed at investigating the relationship between phosphorylated Cx43 (p-Cx43), transforming growth factor-β1 (TGF-β1)/Smad2/3 signaling pathway, and isoflurane postconditioning (ISPOC), which has effects on brain injury in rats with cerebral ischemia/reperfusion (I/R) injury. Methods. The middle cerebral artery occlusion (MCAO) model was induced in...
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In the basement areas of the southern Pannonian Basin, Central Europe (Tisia Composite Terrane, Hungary), Variscan blocks are essential components. The existing paleogeographic reconstructions, however, are often unclear and contradictory. This paper attempts to give a contribution for paleogeographic correlation of the Tisia using paleohydrological features (e.g., vein mineralization types, inclusion fluid composition and origin) of the Pennsylvanian continental succession and neighboring crystalline...
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The risk of meat contamination with Yersinia enterocolitica poses a threat to consumers and persons who come into contact with bird carcasses. The occurrence of Y. enterocolitica in the vast majority of migratory game species, the capercaillie, and the black grouse has never been studied in Poland, Europe, or in the world. The material for the study consisted of cloacal swabs obtained from 143 Eurasian coots, 50 mallards, 30 pochards, 27 greylag geese, 22 white-fronted geese, 22 bean geese, 20 green-winged...
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Background. Immune dysfunction can occur after neoadjuvant chemotherapy (NAC) and surgery for cancer. We investigated whether preoperative oral carbohydrate affected the postoperative percentages of T cells (CD4+ and CD8+) and natural killer (NK) cells in patients with cervical cancer treated with NAC and surgery. Methods. This prospective cohort study enrolled consecutive patients with cervical cancer treated by radical hysterectomy with PLND at the Gynecologic Oncology Department of Fujian Provincial...
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This paper presents analytical solutions to Fredlund and Hasan’s one-dimensional consolidation equations for unsaturated soils subjected to various cyclic loadings. Two new variables are introduced so that the governing equations for excess pore air and water pressures can be transformed to a set of conventional diffusion equations. Based on the general solutions for two introduced variables, the analytical solutions are derived for one-dimensional consolidation of unsaturated soils under trapezoidal,...
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Aiming at the problems of poor self-adaptive ability in traditional feature extraction methods and weak generalization ability in single classifier under big data, an internal parameter-optimized Deep Belief Network (DBN) method based on grasshopper optimization algorithm (GOA) is proposed. First, the minimum Root Mean Square Error (RMSE) in the network training is taken as the fitness function, in which GOA is used to search for the optimal parameter combination of DBN. After that the learning rate...
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The involvement of immune dysfunction in the pathogenesis of lung cancer has been extensively studied. However, the potential molecular mechanisms through which the tumor immune response affects drug resistance are still unclear. Accordingly, in this study, we evaluated deviations in the immune cell landscape among patients with different stages of lung adenocarcinoma to identify key microRNAs and their targets associated with patient outcomes. CIBERSORT was used for estimating the proportions of...
18h
The interaction between water governance and tourism is complicated and significant so that the study of the coupling coordination between these two subsystems is important. This study analyzes the correlation mechanism of the water governance-tourism system, constructs the composite and aggregated evaluation system which consists of 5 dimensions and 15 indicators, uses information entropy weight technique for order preference by similarity to an ideal solution method to evaluate the development...
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Purpose. Human papillomavirus (HPV) antigens had been found in colorectal cancer (CRC) tissue, but little evidence demonstrates the association of HPV with oncogene mutations in CRC. We aim to elucidate the mutated genes that link HPV infection and CRC carcinogenesis. Methods. Cancerous and adjacent noncancerous tissues were obtained from CRC patients. HPV antigen was measured by using the immunohistochemical (IHC) technique. The differentially expressed genes (DEGs) in HPV-positive and HPV-negative...
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Nanohybrids of zinc oxide/cellulose nanocrystals (ZnO/CNCs) were successfully prepared by using a low cost and green method for adsorption and photocatalytic degradation of methylene blue (MB). CNCs have been derived through the hydrolysis reaction by citric/hydrochloric acid from the pure cellulose isolated from Vietnamese Nypa fruticans trunk. The influence of the Zn2+ ion concentration on the morphology, microstructure, and thermal properties as well as the photocatalytic activity of the ZnO/CNC...
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Objective. To investigate the effects of Cyclocarya paliurus polysaccharide (CPP) on the proliferation, migration, invasion, and apoptosis of human glioma U251 cells and further explore the underlying mechanism. Methods. U251 cells were cultured in vitro and treated with various concentrations (25, 50, 75, 100, 125, and 150 μmol/L) of CPP for 24, 48, and 72 h. Cell counting kit-8 was used to detect the activity of cell proliferation. Wound-healing assay, Transwell assay, and flow cytometry were used...
18h
Caesalpinia bonduc has been used in herbal medicines for the treatment of a wide range of diseases from decades. The present study has explored the remedial potential and underlying mechanism of polyphenol extract of Caesalpinia bonduc in alloxanized diabetic rats. HPLC/MS analysis confirmed the presence of phenolics in considerable concentrations in Caesalpinia bonduc extract. Administration of different doses (250 and 500 mg/kg) of CPP extract to hyperglycemic rats for 8 weeks restored blood and...
18h
Hyperhomocysteinemia plays a crucial role in the pathogenesis of many diseases of the central nervous system (CNS). The nervous system is particularly sensitive to high homocysteine (Hcy) level mainly due to its prooxidative and cytotoxic effects. Cladribine, a drug recently registered for the treatment of multiple sclerosis (MS), possesses additionally neuroprotective effects which are independent of its peripheral immunosuppressant action. Accumulating evidence suggests that oxidative stress and...
18h
Background. The prognostic value of tumor deposit (TD) count in colorectal cancer (CRC) patients has been rarely evaluated. This study is aimed at exploring the prognostic value of TD count and finding out the optimal cutoff point of TD count to differentiate the prognoses of TD-positive CRC patients. Method. Patients diagnosed with CRC from Surveillance, Epidemiology, and End Results (SEER) database from January 1, 2010, to December 31, 2012, were analyzed. X-tile program was used to identify the...
18h
Background. Tetanus is a life-threatening disease in developing countries and is accompanied by a high mortality rate. Although China is the world’s largest developing country, there have been few clinical studies on tetanus in China. The purpose of this study was to investigate the epidemiology, incidence, and management of tetanus in Fujian Province and to understand the current treatment and prognosis of tetanus patients. Methods. This was a retrospective, multicenter observational study of patients...
18h
There is little research on the facial colour; for example, choice of cosmetics usually was focused on fashion or impulse purchasing. People never try to make right decision with facial colour. Meanwhile, facial colour can be also a method for health or disease prevention. This research puts forward one set of intelligent skin colour collection method based on human facial identification. Firstly, it adopts colour photos on the facial part and then implements facial position setting of the face in...
18h
Background. Osimertinib is the first-line therapeutic option for the T790M-mutant non-small-cell lung cancer and the acquired resistance obstructs its application. It is an urgent challenge to identify the potential mechanisms of osimertinib resistance for uncovering some novel therapeutic approaches. Methods. In the current study, the cell metabolomics based on ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry and the qualitative and tandem mass...
18h
Rheumatoid arthritis is a chronic autoimmune syndrome associated with several genetic, epigenetic, and environmental factors affecting the articular joints contributing to cartilage and bone damage. Although etiology of this disease is not clear, several immune pathways, involving immune (T cells, B cells, dendritic cells, macrophages, and neutrophils) and nonimmune (fibroblasts and chondrocytes) cells, participate in the secretion of many proinflammatory cytokines, chemokines, proteases (MMPs, ADAMTS),...
18h
The lung is the second most commonly involved organ in humans by hydatid disease. Management of large pulmonary hydatid cysts is a great challenge for thoracic surgeons. Lung resections should be considered the last choice for huge pulmonary hydatid cysts when the lung expansion is not optimal after cyst removal. Here, we present a case of huge lung hydatid cyst involving the entire right lower lobe which was successfully managed by lung-preserving surgery in which the postoperative course showed...
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Histoplasmosis is caused by Histoplasma capsulatum, and commonly it causes an asymptomatic illness. Although Histoplasma is the commonest organism to infect adrenal glands, disseminated histoplasmosis in an immune-competent host leading to adrenal insufficiency is rare in current literature. Here, we report a case of possible disseminated histoplasmosis leading to adrenal crisis in a young Asian immunocompetent male. A 42-year-old Sri Lankan male with noninsulin-dependent diabetes mellitus presented...
18h
A nonautomatic bamboo-splitting machine must charge with material and change tools manually. However, manual charging is very dangerous. An intelligent bamboo-splitting machine can feed automatically and change tools intelligently and has broad application prospects. A charging manipulator is an important part of an intelligent bamboo-splitting machine. The size of the manipulator was optimized here using a genetic algorithm. The capture rate, centering rate, and dynamic characteristics of an intelligent...
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This paper deals with the event-triggered dissipative filtering problem for semi-Markovian jump systems with time-varying delays. The purpose is to design a filter which guarantees that the filtering error system is not only stochastically stable but also satisfies dissipativity. First, based on Lyapunov–Krasovskii theory and matrix integral inequality, a sufficient condition is established for the existence of such a filter. Then, the codesign method of event-triggered matrices and the desired filter...
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Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells obtained from human menstrual blood, whose positive therapeutic effects have been validated in several experimental models. Stromal cell-derived factor-1 (SDF-1), the ligand for CXCR4, plays an important role in the migration of mesenchymal stromal cells. The purpose of this study was to investigate the role of the SDF-1/CXCR4 pathway in the therapeutic effects of ERCs in a mouse sepsis model. Through preexperiment and confirmation,...
18h
Mutomo hill plant sanctuary is a ten-hectare piece of land in Kenya listed as a botanical garden under the Botanical Gardens Conservation International, originally established in 1964 with the aim of conserving indigenous flora from destructive anthropogenic activities. This paper presents ethnobotanical documentation of medicinal plants of Mutomo hill plant sanctuary and its environs. An ethnobotanical survey was carried out in Mutomo hill plant sanctuary and its environs with 48 herbalists aged...
18h
Electroacupuncture (EA) has been widely applied for overactive bladder, but the mechanism of its action remains to be clarified. This study was aimed to investigate EA regulating the effect of purinergic signaling in the OAB of rats. Electroacupuncture (continuous wave, 30 Hz, 1 mA) was applied to stimulate the Ciliao point (BL32) and the Huiyang point (BL35) of rats. Results showed that when the P2X3 receptor in bladder peripheral level and the spinal cord central level was involved in the bladder...
18h
The accurate prediction of the remaining useful life (RUL) of rolling bearings is of great significance for a rational formulation of maintenance strategies and the reduction of maintenance costs. According to the two-stage nonlinear degradation characteristics of rolling bearing operation, this paper proposes a prognosis model based on modified stochastic filtering. First, multiple features reextracted from the time domain, frequency domain, and complexity angles, and the baseline Gaussian mixture...
18h
Car following is the most common phenomenon in single-lane traffic. The accuracy of acceleration prediction can be effectively improved by the driver’s memory in car-following behaviour. In addition, the Apollo autonomous driving platform launched by Baidu Inc. provides fast test vehicle following vehicle models. Therefore, this paper proposes a car-following model (CFDT) with driver time memory based on real-world traffic data. The CFDT model is firstly constructed by embedded gantry control unit...
18h
Background. The pediatric intensive care units (PICUs) in developing countries have a higher mortality outcome due to a wide variety of causes. Identifying differences in the structure, patient characteristics, and outcome between PICUs with different resources may add evidence to the need for incorporating more PICUs with limited resources in the contemporary critical care research to improve the care provided for severely ill children. Methods. A retrospective study was conducted at Egyptian and...
18h
Sequences with high linear complexity have wide applications in cryptography. In this paper, a new class of quaternary sequences over with period is constructed using generalized cyclotomic classes. Results show that the linear complexity of these sequences attains the maximum.
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Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon. Methods. A group of 85 homozygote SS patients (male and female) were enrolled at the Central hospital of Yaounde in Cameroon between May and October...
18h
A Displacement Frequency Response Function-Based Approach for Locating Damage to Building Structures
Frequency response function (FRF) data can provide considerably more information on damage in the desired frequency range as compared to modal data extracted from a very limited range around resonances. Among structural health monitoring techniques, FRF-based methods have the potential to locate structural damage. Conventional structural damage detection technology collects structural response data using contact systems, such as displacement or acceleration transducers. However, installing these...
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Relevant research results have suggested that fermentation can increase the content of sorghum amylose chains and their retrogradation value. Therefore, this study explored the effect of fermentation pretreatment on the yield, digestibility, molecular structure, and in vitro fermentation property of sorghum-resistant starch by conducting fermentation pretreatment of sorghum and extracting the resistant starch from fermented sorghum with pressure-heat compound enzyme method. The results were as follows....
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In this article, we investigate spectrum estimation of law order moving average (MA) process. The main tool is the lag window which is one of the important components of the consistent form to estimate spectral density function (SDF). We show, based on a computer simulation, that the Blackman window is the best lag window to estimate the SDF of and at the most values of parameters and series sizes , except for a special case when and in . In addition, the Hanning–Poisson window appears as the...
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The purpose of this study is to investigate the effects of demographic variables on tea consumption in China. A total of 12,745 samples collected from the China Health and Nutrition Survey in 2011 and a double hurdle model were used to analyze the effects of demographic variables on the extent of tea participation and consumption quantity for men and women. The results of this study indicate that the effects of demographic variables differ between genders in terms of tea participation decisions and...
18h
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