Abstract Background Although estrogen deficiency has been proposed as a risk factor for oral mucosal inflammatory diseases in post‐menopausal women, the mechanisms involved remain unclear. This study aimed to investigate the effect of 17β‐estradiol (E2) on the inflammatory response stimulated by interleukin‐1 beta (IL‐1β) in human oral mucosal epithelial cells (hOMECs) and its possible mechanism. Methods Primary hOMECs were obtained from female infants and cultured in keratinocyte...
12h
Abstract Pasteurella multocida is the main cause of haemorrhagic septicaemia (HS) outbreak in livestock, such as cattle and buffaloes. Conventional vaccines such as alum-precipitated or oil-adjuvant broth bacterins were injected subcutaneously to provide protection against HS. However, the immunity developed is only for short term and needed to be administered frequently. In our previous study, a short gene fragment from Pasteurella multocida serotype B was obtained via shotgun...
12h
Abstract Microalgal chloroplasts have a substantial potential as a sustainable alternative to conventional hosts for recombinant protein production, due to their photosynthetic ability. However, realization of microalgal chloroplast as a platform for the production of recombinant proteins has suffered from difficulties in genetic manipulation and development of molecular tools, including reporter proteins. Here, we investigated the suitability of a fluorescent protein, mCherry,...
12h
Identifying the early-stage colon adenocarcinoma (ECA) patients who have lower risk cancer vs. the higher risk cancer could improve disease prognosis. Our study aimed to explore whether the glandular morpholog...
13h
Abstract The presence of activated T cells in colorectal cancer tissues is a strong predictor of patient survival. Our previous studies have shown that regulatory T cells (Treg) are able to reduce T cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo in the murine APCMin/+ model for microsatellite stable intestinal tumors. In this study, we investigated the effect of Treg depletion on the density and effector functions of...
13h
The US president, Donald Trump, made secret overtures to the German company CureVac—one of the leading contenders to create a covid-19 vaccine—in the hope of luring it to the United States, say...
13h
The BMA has said that it is working to ensure that all doctors have appropriate protective equipment and that those who are self-isolating with minor respiratory symptoms have access to rapid...
13h
A UK based charity that provides healthcare to residents at Europe’s largest refugee camp has warned that overcrowding could prompt a humanitarian catastrophe in the wake of the covid-19...
13h
Events are moving so quickly that whatever I write today (15 March) is likely to be out of date by the time it’s printed. Last week most GPs realised that waiting for instructions was inappropriate,...
13h
I agree that clinicians should write directly to patients and “copy in” other professionals involved in their care.1 This will be challenging for UK trained, native speakers of advanced English, and...
13h
The covid-19 pandemic that was declared on 11 March 2020 has affected countries on all continents.1 Reported case numbers are certainly underestimates given the shortages or unavailability of test...
13h
The US president, Donald Trump, made secret overtures to the German company CureVac—one of the leading contenders to create a covid-19 vaccine—in the hope of luring it to the United States, say...
15h
The BMA has said that it is working to ensure that all doctors have appropriate protective equipment and that those who are self-isolating with minor respiratory symptoms have access to rapid...
15h
A UK based charity that provides healthcare to residents at Europe’s largest refugee camp has warned that overcrowding could prompt a humanitarian catastrophe in the wake of the covid-19...
16h
Events are moving so quickly that whatever I write today (15 March) is likely to be out of date by the time it’s printed. Last week most GPs realised that waiting for instructions was inappropriate,...
16h
I agree that clinicians should write directly to patients and “copy in” other professionals involved in their care.1 This will be challenging for UK trained, native speakers of advanced English, and...
16h
The covid-19 pandemic that was declared on 11 March 2020 has affected countries on all continents.1 Reported case numbers are certainly underestimates given the shortages or unavailability of test...
16h
A leading lung specialist who was cautioned by police for possessing extreme pornography involving bestiality has been suspended from the UK medical register for 12 months.Peter Davies, an...
17h
Rayner and colleagues present an interesting summary of the essentials of writing outpatient letters to patients.1 This is perhaps one of the last frontiers of delivering personalised care to...
18h
Key messagesPopulations across the globe are highly dependent on commercial food systems for daily nourishmentCommercial food systems rely heavily on high volume sales of foods high in unhealthy...
18h
“Don’t panic. That’s the most important thing.“The second thing is hygiene. Keep a distance [from people] of at least a metre and avoid handshaking. Of course, doctors have to look after patients,...
19h
The situation with covid-19 is quickly evolving and coming to a critical point. As public health experts and doctors, it’s been worrying to see the rapid spread of the virus and the relatively high...
20h
The UK government has been forced to change its plan of attack for covid-19 after modelling showed that, although the plan might reduce peak healthcare demand by two thirds and cut deaths by half, it...
20h
Eisenhower said that “what is important is seldom urgent and what is urgent is seldom important.” Breaching a waiting list target—urgent! Celebrity admission to hospital—urgent! But major future...
20h
Postgraduate trainees will not rotate to new roles on 1 April as previously planned because of the covid-19 pandemic, training organisations have announced.A joint letter to trainees from the four UK...
21h
Scientists and senior doctors have backed claims by France’s health minister that people showing symptoms of covid-19 should use paracetamol (acetaminophen) rather than ibuprofen, a drug they said...
22h
Abstract Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell cycle arrest with suppressed apoptosis and concomitant secretion of multiple bioactive factors (the senescence-associated secretory phenotype—SASP) that plays...
13h
Abstract Introduction To evaluate the effects of a new lubricating, antioxidant solution (VisuEvo®) on dry eye disease (DED) in patients undergoing cataract surgery. Methods Patients requiring cataract surgery with either healthy ocular surface or mild DED (tear break-up time, TBUT > 7, Schirmer I test > 15 mm/5 min) were enrolled in this multicenter,...
15h
Abstract The prostate imaging reporting and data system (PI-RADS) has revolutionized the use of magnetic resonance imaging (MRI) for the management of prostate cancer (PCa). The most recent version 2.1, PI-RADS v2.1, provides specific refinements in the performance, relaxing some recommendations which were not found to be helpful, while reinforcing and clarifying others. The interpretation of T2-weighted imaging (T2WI) in the transition zone (TZ), and the overall assessment of...
15h
Abstract Background The amount of intra-abdominal fat on CT correlates positively with the severity of acute pancreatitis (AP). The objective of the study was to evaluate a fat-modified CT severity index (FMCTSI) and compare its performance with MCTSI. Materials and methods For this retrospective study, 99 patients with AP who underwent contrast-enhanced...
21h
Abstract Objectives This study aimed to evaluate the feasibility of using the hepatocyte enhancement fraction (HEF) based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for assessing the liver function in patients with chronic hepatitis B. Methods Sixty patients with Child–Pugh grade A (CP-A), 18 with Child–Pugh grade B (CP-B), 2 with Child–Pugh...
21h
Abstract Purpose Cervical cancer disproportionately burdens low-resource populations where access to quality screening services is limited. A greater understanding of sustainable approaches to implement cervical cancer screening services is needed. Methods We conducted a systematized literature review of evaluations from cervical cancer screening programs...
13h
Marine microbes form the base of ocean food webs and drive ocean biogeochemical cycling. Yet little is known about the ability of microbial populations to adapt as they are advected through changing conditions. Here, we investigated the interplay between physical and biological timescales using a model of adaptation and an...
14h
NEUROSCIENCE Correction for “Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1,” by D. Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A. Vaine, Nichita J. Kulkarni, David Shin, Rachita Yadav, Jyotsna Dhakal, Mai-Linh Ton, Anne Cheng, Christopher T. Russo, Mark Ang, Patrick Acuña,...
14h
IMMUNOLOGY AND INFLAMMATION Correction for “Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration,” by Alan Y. Hsu, Decheng Wang, Sheng Liu, Justice Lu, Ramizah Syahirah, David A. Bennin, Anna Huttenlocher, David M. Umulis, Jun Wan, and Qing Deng, which was first published August 26, 2019;...
14h
BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “High-resolution structural insights into the heliorhodopsin family,” by K. Kovalev, D. Volkov, R. Astashkin, A. Alekseev, I. Gushchin, J. M. Haro-Moreno, I. Chizhov, S. Siletsky, M. Mamedov, A. Rogachev, T. Balandin, V. Borshchevskiy, A. Popov, G. Bourenkov, E. Bamberg, F. Rodriguez-Valera, G. Büldt, and...
14h
ENGINEERING Correction for “Deep elastic strain engineering of bandgap through machine learning,” by Zhe Shi, Evgenii Tsymbalov, Ming Dao, Subra Suresh, Alexander Shapeev, and Ju Li, which was first published February 15, 2019; 10.1073/pnas.1818555116 (Proc. Natl. Acad. Sci. U.S.A. 116, 4117–4122). The authors note that “In Fig. 2A, the 6D...
14h
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