Related ArticlesEpilepsy in Papua New Guinea: a longitudinal cohort study. Arch Dis Child. 2019 10;104(10):941-946 Authors: Mond C, Duke T, Vince J Abstract Epilepsy affects up to 1-4% of children living in low income and middle countries, however there are few studies of the problems faced by children with epilepsy in such settings. We aimed to document the situation for children with epilepsy in Port Moresby, an urban area in Papua New Guinea, a low-middle...
Tue Mar 17, 2020 12:49
Related ArticlesMetabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors. J Biol Chem. 2019 08 09;294(32):12220-12230 Authors: Parakala ML, Zhang Y, Modgil A, Chadchankar J, Vien TN, Ackley MA, Doherty JJ, Davies PA, Moss SJ Abstract Neuroactive steroids (NASs) are synthesized within the brain and exert profound effects on behavior. These effects are primarily believed to arise...
Tue Mar 17, 2020 12:49
Related ArticlesFentanyl inhibits the progression of gastric cancer through the suppression of MMP-9 via the PI3K/Akt signaling pathway. Ann Transl Med. 2020 Feb;8(4):118 Authors: Li C, Qin Y, Zhong Y, Qin Y, Wei Y, Li L, Xie Y Abstract Background: Fentanyl is a drug commonly used for perioperative and postoperative analgesia. Previous studies have confirmed that fentanyl can affect the progression of gastric cancer; however, this effect has not...
Tue Mar 17, 2020 12:48
Related ArticlesA novel topoisomerase I inhibitor DIA-001 induces DNA damage mediated cell cycle arrest and apoptosis in cancer cell. Ann Transl Med. 2020 Feb;8(4):89 Authors: Liu J, Geng G, Liang G, Wang L, Luo K, Yuan J, Zhao S Abstract Background: DNA topoisomerase enzyme plays an essential role in controlling the DNA topology structure by binding to DNA and cutting the phosphate backbone of either one or both of the DNA strands. Here, we have...
Tue Mar 17, 2020 12:48
Related ArticlesTherapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma. Int J Biol Sci. 2020;16(7):1207-1217 Authors: Chen HD, Huang CS, Xu QC, Li F, Huang XT, Wang JQ, Li SJ, Zhao W, Yin XY Abstract Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy with high mortality and lack of effective therapeutic targets. Here, we found that expression of cyclin-dependent kinase 7 (CDK7) was significantly associated...
Tue Mar 17, 2020 12:48
Related ArticlesOxidative Stress Down-Regulates MiR-20b-5p, MiR-106a-5p and E2F1 Expression to Suppress the G1/S Transition of the Cell Cycle in Multipotent Stromal Cells. Int J Med Sci. 2020;17(4):457-470 Authors: Tai L, Huang CJ, Choo KB, Cheong SK, Kamarul T Abstract Oxidative stress has been linked to senescence and tumorigenesis via modulation of the cell cycle. Using a hydrogen peroxide (H2O2)-induced oxidative stress-induced premature senescence...
Tue Mar 17, 2020 12:48
Related ArticlesMiR-524-5p inhibits angiogenesis through targeting WNK1 in colon cancer cells. Am J Physiol Gastrointest Liver Physiol. 2020 Mar 16;: Authors: Li X, Li Z, Zhu Y, Li Z, Yao L, Zhang L, Yuan L, Shang Y, Liu J, Li C Abstract There is increasing evidence that microRNA (miRNA) abnormity is involved in the occurrence and the development of various malignancies, including colon cancer. MiRNA-524-5p has been reported to possess anti-cancer...
Tue Mar 17, 2020 12:48
Related ArticlesTargeting replication stress response using polypurine reverse hoogsteen hairpins directed against WEE1 and CHK1 genes in human cancer cells. Biochem Pharmacol. 2020 Mar 12;:113911 Authors: Aubets E, Noé V, Ciudad CJ Abstract In response to DNA damage, cell cycle checkpoints produce cell cycle arrest to repair and maintain genomic integrity. Due to the high rates of replication and genetic abnormalities, cancer cells are dependent...
Tue Mar 17, 2020 12:48
Related ArticlesPhysicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity. Carbohydr Polym. 2020 May 15;236:116056 Authors: Liu X, Liu D, Chen Y, Zhong R, Gao L, Yang C, Ai C, El-Seedi HR, Zhao C Abstract The aim of the present study is to characterize the structure of a novel natural polysaccharide from Agrocybe aegirita (AAPS) and evaluate its anti-aging activity. The MALLS and GC-MS analysis indicated...
Tue Mar 17, 2020 12:48
Related ArticlesOverexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness. Expert Opin Ther Targets. 2020 Mar 14;:1-11 Authors: Mansoori B, Duijf PHG, Mohammadi A, Najafi S, Roshani E, Shanehbandi D, Hajiasgharzadeh K, Shirjang S, Ditzel HJ, Kazemi T, Mokhtarzadeh A, Gjerstorff MF, Baradaran B Abstract Despite improved therapeutic strategies for early-stage breast cancer, the most common cancer type in...
Tue Mar 17, 2020 12:48
Related ArticlesBeta-blockers and glioma: a systematic review of preclinical studies and clinical results. Neurosurg Rev. 2020 Mar 14;: Authors: Tewarie IA, Senders JT, Hulsbergen AFC, Kremer S, Broekman MLD Abstract Given the median survival of 15 months after diagnosis, novel treatment strategies are needed for glioblastoma. Beta-blockers have been demonstrated to inhibit angiogenesis and tumor cell proliferation in various cancer types. The aim...
Tue Mar 17, 2020 12:48
Related ArticlesMethoxy-enriched cationic stilbenes as anticancer therapeutics. Bioorg Chem. 2020 Mar 03;98:103719 Authors: Yousuf M, Jinka S, Adhikari SS, Banerjee R Abstract Stilbene-based compounds are largely described for their antioxidant activity. But their use as anticancer chemotherapeutics is hampered by poor pharmacokinetic properties and non-selectivity towards cancer and non-cancer potency. To overcome these drawbacks, twin chain cationic...
Tue Mar 17, 2020 12:48
Related ArticlesEllagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells. Genes Cells. 2019 Nov;24(11):688-704 Authors: Tan YH, Shudo T, Yoshida T, Sugiyama Y, Si JY, Tsukano C, Takemoto Y, Kakizuka A Abstract In Chinese medicine, herbal medicine is commonly used to treat individuals suffering from many types of diseases. We thus expected that some herbal medicines would contain promising...
Tue Mar 17, 2020 12:48
Related ArticlesHIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells. Proc Natl Acad Sci U S A. 2019 05 07;116(19):9568-9577 Authors: Yan J, Shun MC, Zhang Y, Hao C, Skowronski J Abstract Lentiviruses, including HIV-1, possess the ability to enter the nucleus through nuclear pore complexes and can infect interphase cells, including those actively replicating chromosomal DNA. Viral accessory proteins hijack host cell E3 enzymes...
Tue Mar 17, 2020 12:48
Related ArticlesRight ventricular remodeling in response to volume overload in fetal sheep. Am J Physiol Heart Circ Physiol. 2019 05 01;316(5):H985-H991 Authors: Karamlou T, Giraud GD, McKeogh D, Jonker SS, Shen I, Ungerleider RM, Thornburg KL Abstract The fetal myocardium is known to be sensitive to hemodynamic load, responding to systolic overload with cellular hypertrophy, proliferation, and accelerated maturation. However, the fetal cardiac growth...
Tue Mar 17, 2020 12:48
Related ArticlesFusion with mesenchymal stem cells differentially affects tumorigenic and metastatic abilities of lung cancer cells. J Cell Physiol. 2019 04;234(4):3570-3582 Authors: Zhang LN, Kong CF, Zhao D, Cong XL, Wang SS, Ma L, Huang YH Abstract Cell fusion plays a crucial role in cancer progression and leads to massive aberrant changes in chromosome and gene expression involved in tumor metastasis. Cancer cells can fuse with many cell types,...
Tue Mar 17, 2020 12:48
Related ArticlesMicroRNA-520a-3p suppresses epithelial-mesenchymal transition, invasion, and migration of papillary thyroid carcinoma cells via the JAK1-mediated JAK/STAT signaling pathway. J Cell Physiol. 2019 04;234(4):4054-4067 Authors: Bi CL, Zhang YQ, Li B, Guo M, Fu YL Abstract Papillary thyroid cancer (PTC) is a kind of thyroid cancer and frequently presents with epithelial-mesenchymal transition (EMT). MicroRNAs (miRNAs) were previously reported...
Tue Mar 17, 2020 12:48
Related ArticlesCircular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway. J Cell Physiol. 2019 04;234(4):3887-3896 Authors: Zeng Z, Zhou W, Duan L, Zhang J, Lu X, Jin L, Yu Y Abstract Increasing reports indicate that circular RNAs (circRNAs) are very important regulators in human diseases, including cancers. In bladder cancer (BC), several circRNAs have been reported to...
Tue Mar 17, 2020 12:48
Related ArticlesAstragaloside IV enhances taxol chemosensitivity of breast cancer via caveolin-1-targeting oxidant damage. J Cell Physiol. 2019 04;234(4):4277-4290 Authors: Zheng Y, Dai Y, Liu W, Wang N, Cai Y, Wang S, Zhang F, Liu P, Chen Q, Wang Z Abstract Accumulating evidence suggests that caveolin-1 (CAV-1) is a stress-related oncotarget and closely correlated to chemoresistance. Targeting CAV-1 might be a promising strategy to improve chemosensitivity...
Tue Mar 17, 2020 12:48
Related ArticlesADP sensitizes ZL55 cells to the activity of cisplatin. J Cell Physiol. 2019 04;234(4):4409-4417 Authors: Muscella A, Cossa LG, Vetrugno C, Antonaci G, Marsigliante S Abstract Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor in which cisplatin therapy is commonly used, although its effectiveness is limited. It follows that research efforts dedicated to identify promising combinations that can synergistically kill...
Tue Mar 17, 2020 12:48
Related ArticlesSeptal Nasal Extramedullary Plasmacytoma: A Rare Tumor in an Unusual Area. Ear Nose Throat J. 2020 Mar 15;:145561320911735 Authors: Di Stadio A, Ralli M, Messineo D, Ciancia G, Cascone A, Salzano G, De Vincentiis M, Salzano FA Abstract We present an extreme rare case of extramedullary nasal plasmacitoma that arise from nasal septum. The mass surgically removed was analyzed by a pathologist who diagnosed an extramedullary nasal plasmacytoma....
Tue Mar 17, 2020 12:44
Related ArticlesHormone Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Metastatic Breast Cancer in Young Women: Emerging Data in the Era of Molecularly Targeted Agents. Oncologist. 2020 Mar 16;: Authors: Shah AN, Metzger O, Bartlett CH, Liu Y, Huang X, Cristofanilli M Abstract Breast cancer is the most common malignancy in young women worldwide, accounting for an estimated 30% of new cancer diagnoses and 25% of cancer deaths. Approximately...
Tue Mar 17, 2020 12:41
Related ArticlesCaregivers of Patients With Brain Metastases: A Description of Caregiving Responsibilities and Psychosocial Well-being. J Neurosci Nurs. 2020 Mar 13;: Authors: Ketcher D, Otto AK, Reblin M Abstract BACKGROUND: There are increasing numbers of cancer patients with brain metastases, and there is a high potential for caregiving burden. Little work has explored caregiving responsibilities and psychosocial well-being in informal family caregivers...
Tue Mar 17, 2020 12:41
Related ArticlesThe emerging data on choice of optimal therapy for locally advanced nasopharyngeal carcinoma. Curr Opin Oncol. 2020 Mar 13;: Authors: Hui EP, Ma BBY, Chan ATC Abstract PURPOSE OF REVIEW: We focus on the emerging data from randomized clinical trials for optimal integration of induction, concurrent, and/or adjuvant chemotherapy with intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma (NPC), and the use of plasma...
Tue Mar 17, 2020 12:41
Related ArticlesThe current state and future perspectives of high intensity focused ultrasound (HIFU) ablation for benign thyroid nodules. Gland Surg. 2020 Feb;9(Suppl 2):S95-S104 Authors: Pałyga I, Pałyga R, Młynarczyk J, Kopczyński J, Góźdź S, Kowalska A Abstract High intensity focused ultrasound (HIFU) is a new thermoablation technique used to treat benign thyroid nodules. In this method, the ultrasound beam passes through the patient's skin and focuses...
Tue Mar 17, 2020 12:41
Related ArticlesClinical factors associated with the development of postoperative atrial fibrillation in esophageal cancer patients receiving multimodality therapy before surgery. J Gastrointest Oncol. 2020 Feb;11(1):68-75 Authors: Song EY, Venkat P, Fradley M, Frakes JM, Klocksieben F, Fontaine J, Mehta R, Saeed S, Hoffe SE, Pimiento JM Abstract Background: The incidence of esophageal cancer (EC) is increasing in the USA. Neoadjuvant therapy for locally...
Tue Mar 17, 2020 12:41
International incidence trends in early- and late-onset colorectal cancer: a population-based study.
Related ArticlesInternational incidence trends in early- and late-onset colorectal cancer: a population-based study. Int J Colorectal Dis. 2020 Mar 16;: Authors: Lu XQ, Li Y, Wang W, Feng WT, Shi OM, Wang Q Abstract PURPOSE: Knowing the global incidence of colorectal cancer (CRC), by sex and age of onset, is of great importance for understanding the disease burden of CRC. METHODS: The CRC incidence data, by cancer site, age of onset, sex, country,...
Tue Mar 17, 2020 12:41
Related ArticlesNovel insights into astrocyte-mediated signaling of proliferation, invasion and tumor immune microenvironment in glioblastoma. Biomed Pharmacother. 2020 Mar 12;126:110086 Authors: Zhang H, Zhou Y, Cui B, Liu Z, Shen H Abstract Glioblastoma (GBM) continues to be the most aggressive cancer of the brain. The dismal prognosis is largely attributed to the microenvironment surrounding tumor cells. Astrocytes, the main component of the GBM microenvironment,...
Tue Mar 17, 2020 12:41
Related ArticlesMolecular targeted therapies: ready for "prime time" in biliary tract cancer. J Hepatol. 2020 Mar 11;: Authors: Lamarca A, Barriuso J, McNamara MG, Valle JW Abstract Patients with biliary tract cancers (cholangiocarcinoma (CCA) and gallbladder cancer (GBC)) have a poor prognoses and incidence is increasing. Most patients are diagnosed with advanced disease when options of treatment are limited to palliative approaches, mainly focused...
Tue Mar 17, 2020 12:41
Related ArticlesComparing Provider-Led Sexual Health Counseling of Male and Female Patients Undergoing Radical Cystectomy. J Sex Med. 2020 Mar 11;: Authors: Gupta N, Kucirka LM, Semerjian A, Wainger J, Pierorazio PM, Herati AS, Bivalacqua TJ Abstract BACKGROUND: Sexual dysfunction is a common quality-of-life issue among patients undergoing radical cystectomy (RC) for bladder cancer, but patients report deficiencies in sexual health counseling. ...
Tue Mar 17, 2020 12:41
Related ArticlesFunctions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance. Mol Cancer. 2020 Mar 14;19(1):58 Authors: Cui C, Yang J, Li X, Liu D, Fu L, Wang X Abstract Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diverse molecules, including non-coding RNAs, mRNAs,...
Tue Mar 17, 2020 12:41
Related ArticlesLRNA9884, a Novel Smad3-Dependent Long Noncoding RNA, Promotes Diabetic Kidney Injury in db/db Mice via Enhancing MCP-1-Dependent Renal Inflammation. Diabetes. 2019 07;68(7):1485-1498 Authors: Zhang YY, Tang PM, Tang PC, Xiao J, Huang XR, Yu C, Ma RCW, Lan HY Abstract Transforming growth factor-β/Smad3 signaling plays an important role in diabetic nephropathy, but its underlying working mechanism remains largely unexplored. The current...
Tue Mar 17, 2020 12:41
Related ArticlesThe Effect of Parental Smoking on Voice-Related Quality of Life in the Pediatric Population. J Voice. 2020 Mar 12;: Authors: Tahir E, Kavaz E, Cangökçe Yaşar Ö Abstract OBJECTIVES: Exposure to cigarette smoke has significant effects on the respiratory mucosa. However, little is known about the effects of household smoke exposure on children's voice-related quality of life. The aim of this study was to elucidate the effect of parental...
Tue Mar 17, 2020 12:40
Related ArticlesSecondary Voice Outcomes of a Randomized Clinical Trial Comparing Two Head/Neck Strengthening Exercises in Healthy Older Adults: A Preliminary Report. J Speech Lang Hear Res. 2019 02 26;62(2):318-323 Authors: Fujiki RB, Oliver AJ, Sivasankar MP, Craig BA, Malandraki GA Abstract Purpose The aim of this study was to investigate secondary voice outcomes and detraining effects of 2 head and neck strengthening exercises, which have been used...
Tue Mar 17, 2020 12:40
Related ArticlesInhalational injury and the larynx: A review. Burns. 2019 09;45(6):1266-1274 Authors: Reid A, Ha JF Abstract OBJECTIVE: To review and discuss the existing research on the pathophysiology, impact and management of inhalational injury on the larynx and lower respiratory tract. DATA SOURCES: A literature search was conducted on the PubMed, MedLine, Embase, Web of Science and Google Scholar databases based on the keywords "airway...
Tue Mar 17, 2020 12:40
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