Abstract Sleep problems have a high prevalence and negative daytime consequences in adolescents. Current sleep measures for this age group have limitations. The Patient‐Reported Outcomes Measurement Information System (PROMIS®) developed sleep item banks for adults. In a previous validation study, these item banks were adapted to a shortened version for adolescents. The current study aimed to further explore the psychometric properties of the 11‐item Sleep‐Related Impairment and 23‐item Sleep Disturbance...
Tue Mar 17, 2020 14:13
Abstract Purpose The relationship between postoperative complications and long-term survival after surgery for esophageal squamous cell carcinoma (ESCC) is controversial. Method A total of 210 patients with ESCC who underwent subtotal esophagectomy with a reconstructed gastric tube were investigated according to the development of postoperative complications....
Tue Mar 17, 2020 02:00
Abstract Objective This article explores the differences in the effectiveness and safety of the treatment of bladder cancer (BC) by robotic-assisted radical cystectomy (RARC) and laparoscopic radical cystectomy (LRC). Methods A systematic search was performed using databases including Medline, PubMed and Web of Science within a limited period from...
Tue Mar 17, 2020 02:00
Related ArticlesEvaluation of NID2 promoter methylation for screening of Oral squamous cell carcinoma. BMC Cancer. 2020 Mar 14;20(1):218 Authors: Srisuttee R, Arayataweegool A, Mahattanasakul P, Tangjaturonrasme N, Kerekhanjanarong V, Keelawat S, Mutirangura A, Kitkumthorn N Abstract BACKGROUND: Oral squamous cell carcinoma (OSCC) is an aggressive human malignancy. Because of late diagnosis and recurrence of OSCC, the treatment of patients with OSCC...
Tue Mar 17, 2020 14:08
Related ArticlesSynergistic Antitumor Potency of a Self-Assembling Peptide Hydrogel for the Local Co-delivery of Doxorubicin and Curcumin in the Treatment of Head and Neck Cancer. Mol Pharm. 2019 06 03;16(6):2326-2341 Authors: Karavasili C, Andreadis DA, Katsamenis OL, Panteris E, Anastasiadou P, Kakazanis Z, Zoumpourlis V, Markopoulou CK, Koutsopoulos S, Vizirianakis IS, Fatouros DG Abstract Combination therapy has been conferred with manifold assets...
Tue Mar 17, 2020 14:08
Related ArticlesAllergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology. J Allergy Clin Immunol. 2019 03;143(3):864-879 Authors: Bousquet J, Hellings PW, Agache I, Amat F, Annesi-Maesano I, Ansotegui IJ, Anto JM, Bachert C, Bateman ED, Bedbrook A, Bennoor K, Bewick M, Bindslev-Jensen C, Bosnic-Anticevich S, Bosse I, Brozek J, Brussino L, Canonica GW, Cardona V, Casale T,...
Tue Mar 17, 2020 14:08
Related ArticlesA Rare, Yet Treatable Pancreatic Tumor: Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma. Am J Case Rep. 2020 Mar 16;21:e921269 Authors: Xie J, Rinker E, Zaarour M Abstract BACKGROUND Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a rare subtype of B-cell neoplasm that can have diverse presentations. When it involves the pancreas (i.e., pancreatic lymphoma), it can mimic metastatic pancreatic adenocarcinoma....
Tue Mar 17, 2020 14:03
Related ArticlesA Case of Linear Cutaneous Lupus Erythematosus in a 55-Year-Old Woman. Am J Case Rep. 2020 Mar 16;21:e921495 Authors: Milosavljevic K, Fibeger E, Virata AR Abstract BACKGROUND Linear cutaneous lupus erythematosus (LCLE) is uncommon and occurs mainly in children and young adults. To our knowledge, only ten cases of LCLE in adults have been previously reported. A case is presented of LCLE of the left arm in a 55-year-old woman. CASE REPORT...
Tue Mar 17, 2020 14:03
Related ArticlesAn Incidental Diagnosis of Microscopic Renal Angiomyolipoma Completely Excised on Renal Biopsy: A Case Report. Am J Case Rep. 2020 Mar 15;21:e921353 Authors: Hyodo T, Kono K, Nishi S, Itoh T, Hara S Abstract BACKGROUND Microscopic tumor foci have been detected incidentally on renal biopsy, including renal cell carcinoma and renomedullary interstitial cell tumor (medullary fibroma). A report is presented of a case of an incidental finding...
Tue Mar 17, 2020 14:03
Related ArticlesPitfalls and controversies in pathology impacting breast cancer management. Expert Rev Anticancer Ther. 2020 Mar 14;:1-15 Authors: Kim WG, Cummings MC, Lakhani SR Abstract Introduction: Breast cancer is a heterogeneous disease, at morphological, molecular, and clinical levels and this has significant implications for the diagnosis and management of the disease. The introduction of breast screening, and the use of small tissue sampling...
Tue Mar 17, 2020 14:01
Related ArticlesAttitudes of Israeli medical students towards the medical treatment of uninsured migrants. BMC Med Educ. 2020 Mar 14;20(1):72 Authors: Mor Z, Cadesky A, Halleluyan R, Sheffer R Abstract BACKGROUND: Undocumented migration to developed countries poses practical concerns, as migrants are not medically insured. This cross-sectional study aims to appraise the attitudes of Israeli medical students towards the uninsured migrant population. ...
Tue Mar 17, 2020 14:01
Related ArticlesLearning clinical reasoning: how virtual patient case format and prior knowledge interact. BMC Med Educ. 2020 Mar 14;20(1):73 Authors: Kiesewetter J, Sailer M, Jung VM, Schönberger R, Bauer E, Zottmann JM, Hege I, Zimmermann H, Fischer F, Fischer MR Abstract INTRODUCTION: Clinical reasoning has been fostered with varying case formats including the use of virtual patients. Existing literature points to different conclusions regarding which...
Tue Mar 17, 2020 14:01
Related ArticlesThe Use of Virtual Reality in Non-Burn Dermatological Care - A Review of the Literature. J Dermatolog Treat. 2020 Mar 16;:1-23 Authors: Harper HE, Hirt PA, Lev-Tov H Abstract Virtual Reality (VR) is the artificial depiction of a three-dimensional (3D) environment using computer-generated technology which allows users to interact with a simulated setting. VR has been used in a variety of clinical scenarios due to its efficacy as a distraction...
Tue Mar 17, 2020 13:58
Related ArticlesProof-of-Concept for Gas-Entrapping Membranes Derived from Water-Loving SiO2/Si/SiO2 Wafers for Green Desalination. J Vis Exp. 2020 Mar 01;(157): Authors: Das R, Arunachalam S, Ahmad Z, Manalastas E, Syed A, Buttner U, Mishra H Abstract Desalination through direct contact membrane distillation (DCMD) exploits water-repellent membranes to robustly separate counterflowing streams of hot and salty seawater from cold and pure water, thus...
Tue Mar 17, 2020 13:58
Related ArticlesObtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors. J Vis Exp. 2020 Mar 01;(157): Authors: Laranjo M, Carvalho MJ, Serambeque B, Alves A, Marto CM, Silva I, Paiva A, Botelho MF Abstract Cancer stem cells (CSC) are a small population with self-renewal and plasticity which are responsible for tumorigenesis, resistance to treatment and recurrent disease. This population can be identified by surface markers,...
Tue Mar 17, 2020 13:58
Related ArticlesIsolation, Culture, and Adipogenic Induction of Neural Crest Original Adipose-Derived Stem Cells from Periaortic Adipose Tissue. J Vis Exp. 2020 Mar 02;(157): Authors: Qi Y, Miao X, Xu L, Fu M, Peng S, Shi K, Li J, Ye M, Li R Abstract An excessive amount of adipose tissue surrounding the blood vessels (perivascular adipose tissue, also known as PVAT) is associated with a high risk of cardiovascular disease. ADSCs derived from different...
Tue Mar 17, 2020 13:58
Related ArticlesDifferentiation of Mouse Breast Epithelial HC11 and EpH4 Cells. J Vis Exp. 2020 Feb 27;(156): Authors: Geletu M, Hoskin V, Starova B, Niit M, Adan H, Elliott B, Gunning P, Raptis L Abstract Cadherins play an important role in the regulation of cell differentiation as well as neoplasia. Here we describe the origins and methods of the induction of differentiation of two mouse breast epithelial cell lines, HC11 and EpH4, and their use...
Tue Mar 17, 2020 13:58
Related ArticlesVisualization of Bacterial Resistance using Fluorescent Antibiotic Probes. J Vis Exp. 2020 Mar 02;(157): Authors: Stone MRL, Phetsang W, Cooper MA, Blaskovich MAT Abstract Fluorescent antibiotics are multipurpose research tools that are readily used for the study of antimicrobial resistance, due to their significant advantage over other methods. To prepare these probes, azide derivatives of antibiotics are synthesized, then coupled...
Tue Mar 17, 2020 13:58
Related ArticlesAssembly and Characterization of Polyelectrolyte Complex Micelles. J Vis Exp. 2020 Mar 02;(157): Authors: Marras AE, Vieregg JR, Tirrell MV Abstract Polyelectrolyte complex micelles (PCMs), core-shell nanoparticles formed by self-assembly of charged polymers in aqueous solution, provide a powerful platform for exploring the physics of polyelectrolyte interactions and also offer a promising solution to the pressing problem of delivering...
Tue Mar 17, 2020 13:58
Related ArticlesSimultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization. J Vis Exp. 2020 Feb 27;(156): Authors: Xie X, Shah S, Holtz A, Rose J, Basisty N, Schilling B Abstract Studying multiple post-translational modifications (PTMs) of proteins is a crucial step to understand PTM crosstalk and gain more holistic insights into protein function. Despite the importance of multi-PTM enrichment...
Tue Mar 17, 2020 13:58
Related ArticlesLarvaSPA, A Method for Mounting Drosophila Larva for Long-Term Time-Lapse Imaging. J Vis Exp. 2020 Feb 27;(156): Authors: Ji H, Han C Abstract Live imaging is a valuable approach for investigating cell biology questions. The Drosophila larva is particularly suited for in vivo live imaging because the larval body wall and most internal organs are transparent. However, continuous live imaging of intact Drosophila larvae for longer than...
Tue Mar 17, 2020 13:58
Related ArticlesDesign of an Open-Source, Low-Cost Bioink and Food Melt Extrusion 3D Printer. J Vis Exp. 2020 Mar 02;(157): Authors: Lanaro M, Skewes J, Spiers L, Yarlagadda PK, Woodruff MA Abstract Three-dimensional (3D) printing is an increasingly popular manufacturing technique that allows highly complex objects to be fabricated with no retooling costs. This increasing popularity is partly driven by falling barriers to entry such as system set-up...
Tue Mar 17, 2020 13:58
Related ArticlesPredictive Immune Modeling of Solid Tumors. J Vis Exp. 2020 Feb 25;(156): Authors: LaFranzo NA, Flanagan KC, Quintanilha D Abstract Immunotherapies show promise in the treatment of oncology patients, but complex heterogeneity of the tumor microenvironment makes predicting treatment response challenging. The ability to resolve the relative populations of immune cells present in and around the tumor tissue has been shown to be clinically-relevant...
Tue Mar 17, 2020 13:58
Related ArticlesExamining Bilingual Language Control Using the Stroop Task. J Vis Exp. 2020 Feb 26;(156): Authors: Sabourin L, Vīnerte S Abstract The Stroop task in its many variations has been used in fields such as psychology, linguistics, and neuroscience to examine questions regarding the automaticity of reading, language processing, and cognitive control, among others. When looking at bilingual individuals, this task can be used to obtain measures...
Tue Mar 17, 2020 13:58
Related ArticlesIntrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation. J Vis Exp. 2020 Feb 29;(156): Authors: Weiss NM, Andus I, Schneider A, Langner S, Schröder S, Schraven SP, Mlynski R Abstract In cases of cerebrospinal fluid (CSF) leaks, reliable detection of their origins is needed to seal the leak sufficiently and prevent complications, such as meningitis. A method is presented...
Tue Mar 17, 2020 13:58
Related ArticlesFabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat. J Vis Exp. 2020 Feb 25;(156): Authors: Svientek SR, Ursu DC, Cederna PS, Kemp SWP Abstract Recent advances in neuroprosthetics have enabled those living with extremity loss to reproduce many functions native to the absent extremity, and this is often accomplished through integration with the peripheral nervous system. Unfortunately, methods...
Tue Mar 17, 2020 13:58
Related ArticlesPosterior Approach for Debridement of the Psoas Abscess. J Vis Exp. 2020 Mar 02;(157): Authors: Grau-Cruz EE, Nourbakhsh A Abstract This method focuses on outlining a safe zone for irrigation and debridement of a psoas abscess through a posterior approach. Initially, an anterior approach to the spine was performed to ensure that the anterior longitudinal ligament and the psoas muscle could be visualized. All the abdominal organs were...
Tue Mar 17, 2020 13:58
Related ArticlesDetection of Lung Tumor Progression in Mice by Ultrasound Imaging. J Vis Exp. 2020 Feb 27;(156): Authors: Ghaddar N, Wang S, Michaud V, Kazimierczak U, Ah-Son N, Koromilas AE Abstract With ~1.6 million victims per year, lung cancer contributes tremendously to the worldwide burden of cancer. Lung cancer is partly driven by genetic alterations in oncogenes such as the KRAS oncogene, which constitutes ~25% of lung cancer cases. The difficulty...
Tue Mar 17, 2020 13:58
Related ArticlesBioinspired Soft Robot with Incorporated Microelectrodes. J Vis Exp. 2020 Feb 28;(156): Authors: Wang T, Migliori B, Miccoli B, Shin SR Abstract Bioinspired soft robotic systems that mimic living organisms using engineered muscle tissue and biomaterials are revolutionizing the current biorobotics paradigm, especially in biomedical research. Recreating artificial life-like actuation dynamics is crucial for a soft-robotic system. However,...
Tue Mar 17, 2020 13:58
Related ArticlesGeneration of a Human iPSC-Based Blood-Brain Barrier Chip. J Vis Exp. 2020 Mar 02;(157): Authors: Jagadeesan S, Workman MJ, Herland A, Svendsen CN, Vatine GD Abstract The blood brain barrier (BBB) is formed by neurovascular units (NVUs) that shield the central nervous system (CNS) from a range of factors found in the blood that can disrupt delicate brain function. As such, the BBB is a major obstacle to the delivery of therapeutics...
Tue Mar 17, 2020 13:58
Related ArticlesAnalysis of Complex Molecules and Their Reactions on Surfaces by Means of Cluster-Induced Desorption/Ionization Mass Spectrometry. J Vis Exp. 2020 Mar 01;(157): Authors: Bomhardt K, Schneider P, Portz A, Gebhardt CR, Dürr M Abstract Desorption/Ionization Induced by Neutral SO2 Clusters (DINeC) is employed as a very soft and efficient desorption/ionization technique for mass spectrometry (MS) of complex molecules and their reactions...
Tue Mar 17, 2020 13:58
Related ArticlesPost-Movie Subliminal Measurement (PMSM), for Investigating Implicit Social Bias. J Vis Exp. 2020 Feb 29;(156): Authors: Afdile M, Jääskeläinen IP Abstract New knowledge is continuously gained from a social environment that can influence how people respond to each other. Such responses often occur implicitly, at a subliminal perceptual level, and related brain mechanisms can be experimentally isolated by presenting the stimuli quickly....
Tue Mar 17, 2020 13:58
Related ArticlesThe CryoAPEX Method for Electron Microscopy Analysis of Membrane Protein Localization Within Ultrastructurally-Preserved Cells. J Vis Exp. 2020 Feb 27;(156): Authors: Mihelc EM, Angel S, Stahelin RV, Mattoo S Abstract Key cellular events like signal transduction and membrane trafficking rely on proper protein location within cellular compartments. Understanding precise subcellular localization of proteins is thus important for answering...
Tue Mar 17, 2020 13:58
Related ArticlesA Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery. J Vis Exp. 2020 Feb 28;(156): Authors: Shao H, Moller M, Wang D, Ting A, Boulina M, Liu ZJ Abstract Tumor-stroma interactions play an important role in cancer progression. Three-dimensional (3D) tumor spheroid models are the most widely used in vitro model in the study of cancer stem/initiating cells, preclinical...
Tue Mar 17, 2020 13:58
Related ArticlesHER2-Positive Metastatic Breast Cancer: A Retrospective Cohort Study of Healthcare Costs in the Targeted-Therapy Age. Adv Ther. 2020 Mar 14;: Authors: Sussell JA, Sheinson D, Wu N, Shah-Manek B, Seetasith A Abstract INTRODUCTION: Claims data (IBM MarketScan Commercial and MarketScan Medicare Supplemental databases) from June 30, 2011 to September 30, 2017 were used to evaluate the cost impact of human epidermal growth factor receptor 2...
Tue Mar 17, 2020 13:53
Related ArticlesRole of innate and adaptive immunity in the efficacy of anti-HER2 monoclonal antibodies for HER2-positive breast cancer. Crit Rev Oncol Hematol. 2020 Mar 02;149:102927 Authors: Musolino A, Boggiani D, Pellegrino B, Zanoni D, Sikokis A, Missale G, Silini EM, Maglietta G, Frassoldati A, Michiara M Abstract Anti-HER2 monoclonal antibodies (mAbs) such as trastuzumab are effective for all stages of HER2-positive breast cancer (BC). However,...
Tue Mar 17, 2020 13:53
Related ArticlesIs HER2-positive metastatic breast cancer still an incurable disease? Lancet Oncol. 2020 Mar 12;: Authors: Lambertini M, Vaz-Luis I PMID: 32171427 [PubMed - as supplied by publisher]
Tue Mar 17, 2020 13:53
Related ArticlesPertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study. Lancet Oncol. 2020 Mar 12;: Authors: Swain SM, Miles D, Kim SB, Im YH, Im SA, Semiglazov V, Ciruelos E, Schneeweiss A, Loi S, Monturus E, Clark E, Knott A, Restuccia E, Benyunes MC, Cortés J, CLEOPATRA study group Abstract BACKGROUND: CLEOPATRA was a phase...
Tue Mar 17, 2020 13:53
Related ArticlesPeripheral nerve blocks in the cervical region: from anatomy to ultrasound-guided techniques. Dentomaxillofac Radiol. 2020 Mar 16;:20190400 Authors: Saranteas T, Kostroglou A, Efstathiou G, Giannoulis D, Moschovaki N, Mavrogenis AF, Perisanidis C Abstract Cervical plexus nerve blocks have been employed in various head and neck operations. Both adequate anaesthesia and analgesia are attained in clinical practice. Nowadays, ultrasound...
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