ABSTRACT Background Currently, no estimates can be made on the impact of hematopoietic stem cell transplantation on allergy transfer or cure of the disease. By using component‐resolved diagnosis we prospectively investigated fifty donor‐recipient pairs undergoing allogeneic stem cell transplantation. This allowed calculating the rate of transfer or maintenance of allergen‐specific responses in the context of stem cell transplantation. Methods Allergen‐specific IgE and IgG to 156...
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ABSTRACT Background Multiple regulatory mechanisms have been identified employing conventional hypothesis‐driven approaches as contributing to allergen‐specific immunotherapy outcomes, but understanding of how these integrate to maintain immunological homeostasis is incomplete. Objective To explore the potential for unbiased systems‐level gene co‐expression network analysis to advance understanding of immunotherapy mechanisms. Methods We profiled genome‐wide allergen‐induced...
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Abstract Conventional T cells recognise protein‐derived antigens in the context of Major Histocompatibility Complex (MHC) class Ia and class II molecules and provide anti‐microbial and anti‐tumour immunity. Conventional T cells have also been implicated in type IV (also termed delayed‐type or T cell mediated) hypersensitivity reactions in response to protein‐derived allergen antigens. In addition to conventional T cells, subsets of unconventional T cells exist, which recognise non‐protein antigens...
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Publication date: Available online 16 March 2020Source: Translational ResearchAuthor(s): Alejandra Garate-Carrillo, Julisa Gonzalez, Guillermo Ceballos, Israel Ramirez-Sanchez, Francisco Villarreal
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Publication date: Available online 16 March 2020Source: Translational ResearchAuthor(s): Qinglong Wu, Tor C. Savidge
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Publication date: Available online 16 March 2020Source: Translational ResearchAuthor(s): Devika M. Varma, M. Shamim Hasan Zahid, Eric M. Bachelder, Kristy M. Ainslie
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Antioxidants, Vol. 9, Pages 243: The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours Antioxidants doi: 10.3390/antiox9030243 Authors: Białek Jelińska Białek Lepionka Czerwonka Czauderna The aim of this study was to present overall lipid profile of organisms with ongoing neoplastic process and applied diet supplementation with pomegranate seed oil (PSO) and bitter melon...
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Antioxidants, Vol. 9, Pages 242: Variations in Anthocyanin Profiles and Antioxidant Activity of 12 Genotypes of Mulberry (Morus spp.) Fruits and Their Changes during Processing Antioxidants doi: 10.3390/antiox9030242 Authors: Inhwan Kim Jihyun Lee Mulberry fruits are known as rich sources of anthocyanins and are consumed in syrup form after the addition of sugar and acid; however, there is little information on the anthocyanin composition and antioxidant activity of mulberries of...
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Publication date: June 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1867, Issue 6Author(s):
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Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Jermaine Goveia, Katerina Rohlenova, Federico Taverna, Lucas Treps, Lena-Christin Conradi, Andreas Pircher, Vincent Geldhof, Laura P.M.H. de Rooij, Joanna Kalucka, Liliana Sokol, Melissa García-Caballero, Yingfeng Zheng, Junbin Qian, Laure-Anne Teuwen, Shawez Khan, Bram Boeckx, Els Wauters, Herbert Decaluwé, Paul De Leyn, Johan Vansteenkiste
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Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Jacqulyne P. Robichaux, Yasir Y. Elamin, R.S.K. Vijayan, Monique B. Nilsson, Lemei Hu, Junqin He, Fahao Zhang, Marlese Pisegna, Alissa Poteete, Huiying Sun, Shuai Li, Ting Chen, Han Han, Marcelo Vailati Negrao, Jordi Rodon Ahnert, Lixia Diao, Jing Wang, Xiuning Le, Funda Meric-Bernstam, Mark Routbort
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Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Jie Xiong, Bo-Wen Cui, Nan Wang, Yu-Ting Dai, Hao Zhang, Chao-Fu Wang, Hui-Juan Zhong, Shu Cheng, Bin-Shen Ou-Yang, Yu Hu, Xi Zhang, Bin Xu, Wen-Bin Qian, Rong Tao, Feng Yan, Jian-Da Hu, Ming Hou, Xue-Jun Ma, Xin Wang, Yuan-Hua Liu
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Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Sharon M. Sagnella, Lu Yang, Gemma E. Stubbs, Ebru Boslem, Estefania Martino-Echarri, Katarzyna Smolarczyk, Stacey L. Pattison, Natasha Vanegas, Eva St. Clair, Stephen Clarke, John Boockvar, Jennifer A. MacDiarmid, Himanshu Brahmbhatt
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Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Hong Liu, Xinwei Kuang, Yongchang Zhang, Youqiong Ye, Jialu Li, Long Liang, Zuozhong Xie, Liang Weng, Jia Guo, Hui Li, Fangyu Ma, Xiaodan Chen, Shuang Zhao, Juan Su, Nong Yang, Fang Fang, Yang Xie, Juan Tao, Jianglin Zhang, Mingliang Chen
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Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Samarth Hegde, Varintra E. Krisnawan, Brett H. Herzog, Chong Zuo, Marcus A. Breden, Brett L. Knolhoff, Graham D. Hogg, Jack P. Tang, John M. Baer, Cedric Mpoy, Kyung Bae Lee, Katherine A. Alexander, Buck E. Rogers, Kenneth M. Murphy, William G. Hawkins, Ryan C. Fields, Carl J. DeSelm, Julie K. Schwarz, David G. DeNardo
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Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Huilin Huang, Hengyou Weng, Jianjun Chen
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Antibiotics, Vol. 9, Pages 126: Nonocarbolines A–E, β-Carboline Antibiotics Produced by the Rare Actinobacterium Nonomuraea sp. from Indonesia Antibiotics doi: 10.3390/antibiotics9030126 Authors: Gian Primahana Chandra Risdian Tjandrawati Mozef Enge Sudarman Matthias Köck Joachim Wink Marc Stadler During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, Nonomuraea sp. 1808210CR was found to...
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Antibiotics, Vol. 9, Pages 125: Application of Response Surface Methodology to Evaluate Photodynamic Inactivation Mediated by Eosin Y and 530 nm LED against Staphylococcus aureus Antibiotics doi: 10.3390/antibiotics9030125 Authors: Adriele R. Santos Alex F. da Silva Andréia F. P. Batista Camila F. Freitas Evandro Bona Maria J. Sereia Wilker Caetano Noburu Hioka Jane M. G. Mikcha Photodynamic antimicrobial chemotherapy (PAC) is an efficient tool for...
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Abstract Background Moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP) are associated with organ failure (OF), which can be lethal. Aims This study determined the factors that predict the severity of AP at admission in elderly patients. Methods In...
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This article is a report of designing a rapid and effective guide for paramedics who take care of patients in a pre-hospital setting to answer developing demands.
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ABSTRACT Stat1 is a ubiquitously expressed latent transcription factor that is activated by many cytokines and growth factors. Global Stat1 knockout mice are prone to chemical‐induced lung and liver fibrosis, suggesting roles for Stat1 in tissue repair. However, the importance of Stat1 in fibroblast‐mediated and vascular smooth muscle (VSMC)‐mediated injury response has not been directly evaluated in vivo. Here, we focused on two models of tissue repair in conditional Stat1 knockout mice: excisional...
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Abstract Microbial biofilms have become increasingly recognized as a cause of wound chronicity. There are several topical antimicrobial wound care products available for use, however their effectiveness has routinely been demonstrated with planktonic microorganisms. There is no target reference value for antimicrobial effectiveness of wound care products in biofilm models. In addition, data on antimicrobial activity of products in biofilm models is scattered across many test methods in a variety...
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Biosensors, Vol. 10, Pages 26: The Emergence of Insect Odorant Receptor-Based Biosensors Biosensors doi: 10.3390/bios10030026 Authors: Jonathan D. Bohbot Sefi Vernick The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance in the fields of medicine, agriculture and public health....
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Publication date: Available online 16 March 2020Source: CryobiologyAuthor(s): M. Bashawat, B.C. Braun, K. Müller
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JCM, Vol. 9, Pages 818: Clinical, Immunological, and Functional Characterization of Six Patients with Very High IgM Levels Journal of Clinical Medicine doi: 10.3390/jcm9030818 Authors: Vera Gallo Emilia Cirillo Rosaria Prencipe Alessio Lepore Luigi Del Vecchio Giulia Scalia Vincenzo Martinelli Gigliola Di Matteo Carol Saunders Anne Durandy Viviana Moschese Antonio Leonardi Giuliana Giardino Claudio Pignata Very high IgM levels represent the hallmark...
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JCM, Vol. 9, Pages 817: Evaluation of the Dimensional Accuracy of 3D-Printed Anatomical Mandibular Models Using FFF, SLA, SLS, MJ, and BJ Printing Technology Journal of Clinical Medicine doi: 10.3390/jcm9030817 Authors: Bilal Msallem Neha Sharma Shuaishuai Cao Florian S. Halbeisen Hans-Florian Zeilhofer Florian M. Thieringer With the rapid progression of additive manufacturing and the emergence of new 3D printing technologies, accuracy assessment is mostly being performed...
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JCM, Vol. 9, Pages 816: Twenty Years of Cerebral Ultrasound Perfusion Imaging—Is the Best yet to Come? Journal of Clinical Medicine doi: 10.3390/jcm9030816 Authors: Jens Eyding Christian Fung Wolf-Dirk Niesen Christos Krogias Over the past 20 years, ultrasonic cerebral perfusion imaging (UPI) has been introduced and validated applying different data acquisition and processing approaches. Clinical data were collected mainly in acute stroke patients. Some efforts were undertaken...
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JCM, Vol. 9, Pages 815: Bedside 3D Visualization of Lymphatic Vessels with a Handheld Multispectral Optoacoustic Tomography Device Journal of Clinical Medicine doi: 10.3390/jcm9030815 Authors: Guido Giacalone Takumi Yamamoto Florence Belva Akitatsu Hayashi Identification of lymphatics by Indocyanine Green (ICG) lymphography in patients with severe lymphedema is limited due to the overlying dermal backflow. Nor can the method detect deep and/or small vessels. Multispectral optoacoustic...
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JCM, Vol. 9, Pages 814: Assessing the Implementation of Pharmacogenomic Panel-Testing in Primary Care in the Netherlands Utilizing a Theoretical Framework Journal of Clinical Medicine doi: 10.3390/jcm9030814 Authors: Cathelijne H. van der Wouden Ellen Paasman Martina Teichert Matty R. Crone Henk-Jan Guchelaar Jesse J. Swen Despite overcoming many implementation barriers, pharmacogenomic (PGx) panel-testing is not routine practice in the Netherlands. Therefore, we aim to...
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Abstract Purpose of Review Ongoing investigations of the human skin microbiome strongly suggest a connection to skin diseases and skin health. This review provides an overview of recent literature on the skin microbiome in relation to skin diseases, with a specific focus on common inflammatory skin conditions, such as atopic dermatitis, psoriasis, hidradenitis suppurativa, acne, and rosacea. ...
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J. Intell., Vol. 8, Pages 13: How Mighty Are the Mitochondria in Causing Individual Differences in Intelligence?—Some Questions for David Geary Journal of Intelligence doi: 10.3390/jintelligence8010013 Authors: Robert J. Sternberg David Geary (2019) has written a summary of his fascinating Psychological Review article on the purported role of the mitochondria in the development of intelligence (Geary 2018) [...]
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Background: The present study sought to evaluate host-related factors as predictors in patients receiving chemotherapy for recurrent advanced gastric cancer. Methods: Sixty-three patients were enrolled in the study and received chemotherapy for recurrent gastric cancer at the Kochi Medical School from 2008 to 2015. Clinicopathological information and systemic inflammatory response data were obtained retrospectively to investigate associations between baseline cancer-related prognostic variables and...
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Background: The Oncotype DX® (ODX) is a genomic assay that provides clinicians with a prediction of benefit of chemotherapy in node-negative, tamoxifen-treated breast cancer. However, the relationship between ODX recurrence score (RS) and diabetes, a common comorbidity in breast cancer patients, has been inadequately described in the literature. Specifically, the association of diabetes treatment with metformin and RS is inconclusive, with different studies reporting conflicting results. Because...
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Background: Bullous pemphigoid (BP) is a rare autoimmune blistering condition characterized by antibodies to the structural proteins BP1 and BP2 at the dermal-epidermal junction. The link between BP and malignancy remains unclear. Due to the rarity of the disease, there have been few studies with small sample sizes characterizing the association between BP and malignancy. Objectives: There were two main goals of this retrospective cohort study: (1) to look at the associated risk of malignancy in...
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Vaccines, Vol. 8, Pages 132: Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection Vaccines doi: 10.3390/vaccines8010132 Authors: Malihe Masomian Zuleeza Ahmad Lai Ti Gew Chit Laa Poh Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million deaths annually, especially in young children and the elderly. To date, at least 98 different pneumococcal capsular serotypes have been identified. Currently, the vaccines for...
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Vaccines, Vol. 8, Pages 131: Immunologic Dose-Response to Adenovirus-Vectored Vaccines in Animals and Humans: A Systematic Review of Dose-Response Studies of Replication Incompetent Adenoviral Vaccine Vectors when Given via an Intramuscular or Subcutaneous Route Vaccines doi: 10.3390/vaccines8010131 Authors: Afrough Rhodes Evans White Benest Optimal vaccine dosing is important to ensure the greatest protection and safety. Analysis of dose-response data, from previous...
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Abstract Purpose The relationship between postoperative complications and long-term survival after surgery for esophageal squamous cell carcinoma (ESCC) is controversial. Method A total of 210 patients with ESCC who underwent subtotal esophagectomy with a reconstructed gastric tube were investigated according to the development of postoperative complications....
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