Recent events make it clear that it couldn't hurt to elect someone who applies the scientific method to thinking and decision making -- Read more on ScientificAmerican.com
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Both are existential challenges—and a president who belittles and neglects science has made them both tougher to address -- Read more on ScientificAmerican.com
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Social distancing imposes hardships, but it can save many millions of lives -- Read more on ScientificAmerican.com
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A new view of the Milky Way, the trouble with teeth, ice age survivors, and more -- Read more on ScientificAmerican.com
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Those black-and-white squares can help us understand how memory works -- Read more on ScientificAmerican.com
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Publication date: Available online 16 March 2020Source: Journal of Controlled ReleaseAuthor(s): Chuanqi Peng, Yingyu Huang, Jie Zheng
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Publication date: Available online 16 March 2020Source: Journal of Controlled ReleaseAuthor(s): Zhongyu Li, William Ho, Xin Bai, Fengqiao Li, Yen-jui Chen, Xue-Qing Zhang, Xiaoyang Xu
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Publication date: Available online 16 March 2020Source: Clinical BiochemistryAuthor(s): Xuan Liu, Xiuqing Gao, Rui Zhang, Ziyan Liu, Na Shen, Yanbo Di, Tao Fang, Huanming Li, Fengshi Tian
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Publication date: Available online 16 March 2020Source: New BiotechnologyAuthor(s): Alberto Jiménez, Birgit Hoff, José Luis Revuelta
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A82846B, producing by Kibdelosporangium aridum, is an important precursor of the semi-synthetic glycopeptide antibiotic Oritavancin. K. aridum produces three components A82846A, B and C, so it is essential to inc...
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Publication date: Available online 16 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nayara Freitas Fernandes, Marcos de Queiroz Teles Gomes, Robinson Koji Tsuji, Ricardo Ferreira Bento, Maria Valéria Schimdt Goffi-Gomez
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Publication date: 30 May 2020Source: Gene, Volume 741Author(s): Yali Tao, Yuxian Mei, Rongbiao Ying, Shasha Chen, Zhiping Wei
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Abstract Abdominopelvic vascular compression syndromes include a variety of uncommon conditions characterized by either extrinsic compression of blood vessels by adjacent anatomical structures (i.e., median arcuate ligament syndrome, nutcracker syndrome, May-Thurner syndrome) or compression of hollow viscera by adjacent vessels (i.e., superior mesenteric artery syndrome, ureteropelvic junction obstruction, ureteral vascular compression syndromes, portal biliopathy). These syndromes...
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The Multiple Sclerosis Health Resource Utilization Survey (MS-HRS): Development and Validation Study
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By: Leanne Armstrong Wondering how to manage tasks better without the tedious juggling act? One of the best ways to stay organized at work is with a well-structured plan. Not only does a task management plan provide firm direction in your own daily efforts, it gives you better control over group or collaborative goals. A handful of basic planning components form the foundation of most management tactics. So if you’re ready to discover how to organize tasks at work...
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Publication date: Available online 16 March 2020Source: Health PolicyAuthor(s): Francesca Taylor, Vari M Drennan, Mary Halter, Melania Calestani
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Publication date: Available online 16 March 2020Source: Health PolicyAuthor(s): Tomasz Zaprutko, Dorota Kopciuch, Maria Bronisz, Michał Michalak, Krzysztof Kus, Elżbieta Nowakowska
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Abstract Objectives To compare the postprocedural optical coherence tomography (OCT) findings and in‐hospital outcomes among the three subtypes of calcified plaques: eruptive calcified nodules, superficial calcific sheet, and calcified protrusion. Background Recently, three subtypes of calcified culprit plaques were reported in patients with acute coronary syndrome (ACS). How these subtypes respond to stenting is unknown. Methods ACS patients with calcified plaque at the...
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Abstract Objective Via subclavian/jugular vein, successful puncture of interventricular septum (IVS) has been achieved transvenously. However, the approach was limited by acute entry‐angle. The study was conducted to investigate a novel transcatheter puncture of IVS via femoral access and transfemoral‐venous access to left ventricle (LV) through IVS. Methods Via femoral artery, transcatheter puncture of mid‐IVS was performed with a custom‐made nickel–titanium needle and 6F‐sheath...
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Abstract Objectives We compared the effect of bivalirudin or heparin and use or nonuse of glycoprotein IIb/IIIa inhibitors (GPI) on the outcome of left main coronary artery (LMCA) percutaneous coronary intervention (PCI) in the randomized EXCEL trial. Background The optimal antithrombotic regimen to support PCI of the LMCA remains controversial because of low representation of this subset in clinical trials. Methods The PCI cohort (n = 928) in EXCEL was divided according...
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Abstract Background Patients with concomitant cardiac arrest (CA) and shock are at increased risk of mortality, even when stratified according to shock severity. We sought to determine whether the presence of ventricular fibrillation (VF) modified the relationship between CA and mortality in cardiac intensive care unit (CICU) patients. Methods We retrospectively analyzed unique Mayo Clinic CICU patients admitted between 2007 and 2015. Society for Cardiovascular Angiography and Intervention...
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Abstract Background Transcatheter edge‐to‐edge repair with MitraClip is only approved for treatment of mitral regurgitation but is increasingly used to treat concomitant tricuspid regurgitation (TR) due to its common coexistence and association with poor outcomes. This study aimed to describe the learning curve associated with the challenge of off‐label treatment of concomitant TR. Methods This is a retrospective review of initial and consecutive patients who underwent combined edge‐to‐edge...
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Zusammenfassung Referenzwerte/-intervalle dienen in der Medizin generell einer diagnostischen Einordnung von am Patienten erhobenen Befunden. Für die Schlafmedizin sind nach den Empfehlungen der American Academy of Sleep Medicine (AASM) eine Reihe von Variablen im Befundbericht einer polysomnographischen Untersuchung mitzuteilen. Dazu zählen respiratorische Ereignisse, Bewegungsereignisse, kardiale Ereignisse, Arousalereignisse sowie Parameter der Schlafarchitektur. In der vorliegenden...
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Biomolecules, Vol. 10, Pages 463: The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on The DNA Lesion Type Biomolecules doi: 10.3390/biom10030463 Authors: Seelinger Søgaard Otterlei Helicase-like transcription factor (HLTF) and SNF2, histone-linker, PHD and RING finger domain-containing helicase (SHPRH), the two human homologs of yeast Rad5, are believed to have a vital role in DNA damage tolerance (DDT). Here we show that HLTF,...
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Biomolecules, Vol. 10, Pages 462: p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction Biomolecules doi: 10.3390/biom10030462 Authors: Ryuta Mikawa Tadashi Sato Yohei Suzuki Hario Baskoro Koichiro Kawaguchi Masataka Sugimoto Senescent cells accumulate in tissues during aging or pathological settings. The semi-genetic or pharmacological targeting of senescent cells revealed that cellular senescence underlies many aspects of the aging-associated phenotype and...
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Publication date: Available online 16 March 2020Source: Cancer LettersAuthor(s): Chenyu Ding, Xuehan Yi, Xiyue Wu, Xingyao Bu, Desheng Wang, Zanyi Wu, Gaoqi Zhang, Jianjun Gu, Dezhi Kang
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Genes, Vol. 11, Pages 320: Genome-Wide Analysis and Function Prediction of Long Noncoding RNAs in Sheep Pituitary Gland Associated with Sexual Maturation Genes doi: 10.3390/genes11030320 Authors: Hua Yang Jianyu Ma Zhibo Wang Xiaolei Yao Jie Zhao Xinyue Zhao Feng Wang Yanli Zhang Long noncoding RNA (lncRNA) plays a crucial role in the hypothalamic-pituitary-testis (HPT) axis associated with sheep reproduction. The pituitary plays a connecting role in the HPT axis....
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Genes, Vol. 11, Pages 319: The Critical Role of miRNAs in Regulation of Flowering Time and Flower Development Genes doi: 10.3390/genes11030319 Authors: Waheed Zeng Flowering is an important biological process for plants that ensures reproductive success. The onset of flowering needs to be coordinated with an appropriate time of year, which requires tight control of gene expression acting in concert to form a regulatory network. MicroRNAs (miRNAs) are non-coding RNAs known as master...
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Genes, Vol. 11, Pages 318: Conservation Genetics and Genomics Genes doi: 10.3390/genes11030318 Authors: Michael Russello George Amato Robert DeSalle Michael Knapp For more than thirty years, methods and theories from evolutionary biology, phylogenetics, population genetics and molecular biology have been used by conservation biologists to better understand threats to endangered species due to anthropogenic changes [...]
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Publication date: Available online 16 March 2020Source: Translational ResearchAuthor(s): Gauri S. Shetye, Scott G. Franzblau, SanghyunCho
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Publication date: Available online 16 March 2020Source: Translational ResearchAuthor(s): Stefi F. Lee, Rebecca Harris, Heather W. Stout-Delgado
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Publication date: Available online 16 March 2020Source: Translational ResearchAuthor(s): Kevin Egan, Lauren M. Hook, Philip LaTourette, Angela Desmond, Sita Awasthi, Harvey M. Friedman
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