IJMS, Vol. 21, Pages 2071: Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21062071 Authors: Jia Xu Fang Wang Jiejie Guo Chunshuang Xu Yanzi Cao Zhiling Fang Qinwen Wang Alpinia oxyphylla Miq. (i.e., A. oxyphylla), a traditional Chinese medicine, can exert neuroprotective effects in ameliorating mild cognitive impairment and improving...
now
IJMS, Vol. 21, Pages 2073: Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion International Journal of Molecular Sciences doi: 10.3390/ijms21062073 Authors: Tomas Zikmund Helena Paszekova Juraj Kokavec Paul Kerbs Shefali Thakur Tereza Turkova Petra Tauchmanova Philipp A. Greif Tomas Stopka ISWI chromatin remodeling ATPase SMARCA5 (SNF2H) is a well-known factor for its role in regulation...
now
Cruciferous vegetables have been of special interest due to the rich presence of bioactive compounds such as sulforaphane which show promising potential on cancer prevention and therapy as an epigenetic dietary strategy. Abnormal epigenetic alteration as one of the primary contributors to tumor development is closely related to breast cancer initiation and progression. In the present study, we investigated the effect of dietary broccoli sprouts (BSp), a common cruciferous vegetable, on prevention...
7h
7h
ACS NanoDOI: 10.1021/acsnano.9b08166
7h
ACS NanoDOI: 10.1021/acsnano.0c00291
7h
ACS NanoDOI: 10.1021/acsnano.0c00696
7h
ACS NanoDOI: 10.1021/acsnano.0c01312
7h
ACS NanoDOI: 10.1021/acsnano.9b09676
11h
ACS NanoDOI: 10.1021/acsnano.9b08326
11h
ACS NanoDOI: 10.1021/acsnano.9b10148
15h
ACS NanoDOI: 10.1021/acsnano.0c01281
15h
ACS NanoDOI: 10.1021/acsnano.9b09625
15h
Abstract This article provides a theoretical case-study risk assessment report for a low-risk monoclonal antibody (mAb) therapeutic. In terms of risk, there are considerations around risks to safety, but also risks regarding effects on pharmacokinetics (PK), pharmacodynamics (PD), and efficacy. Much of the discussion in this document is around the risk of immunogenicity incidence. A higher incidence of immunogenicity would necessitate a detailed review of the PK, efficacy and...
8h
Abstract Disease status is often measured with bounded outcome scores (BOS) which report a discrete set of values on a finite range. The distribution of such data is often non-standard, such as J- or U-shaped, for which standard analysis methods assuming normal distribution become inappropriate. Most BOS analysis methods aim to either predict the data within its natural range or accommodate data skewness, but not both. In addition, a frequent modeling objective is to predict...
8h
Abstract Irinotecan (CPT-11) is an anticancer agent widely used in the treatment of a variety of adult solid tumors. The objective of this study was to develop an optimal sampling strategy model that accurately estimates pharmacokinetic parameters of CPT-11 and its active metabolite, SN-38. This study included 221 patients with advanced solid tumors or lymphoma receiving CPT-11 single or combination therapy with 5-fluorouracil (5-FU)/leucovorin (LV) (FOLFIRI) plus bevacizumab...
12h
Abstract Total tumor size (TS) metrics used in TS models in oncology do not consider tumor heterogeneity, which could help to better predict drug efficacy. We analyzed individual target lesions (iTLs) of patients with metastatic colorectal carcinoma (mCRC) to determine differences in TS dynamics by using the ClassIfication Clustering of Individual Lesions (CICIL) methodology. Results from subgroup analyses comparing genetic mutations and TS metrics were assessed and applied...
21h
During the production process, the author order of Zhandong Don Zhong and Lynn L. Jiang were inadvertently placed. Lynn L. Jiang is the first author of this manuscript; Zhandong Don Zhong is the last author.
23h
Rejuvenation Research, Ahead of Print.
9h
Abstract Amorphous solid dispersions (ASD) are one of the most important supersaturating drug delivery systems (SDDS) for poorly water-soluble drugs to improve their bioavailability. As a result of thermodynamic instability, drug molecules tend to precipitate during storage and dissolution in gastrointestinal tract. Various precipitation inhibitors (PI) have been widely used to improve the stability in the past decade. However, most studies have investigated the inhibiting capability...
9h
Abstract To investigate the effect of polyethylene glycol (PEG) molecular weights on circulation time of PEGylated emulsions and the second injection of injected PEGylated emulsions, we studied the effect of molecular weights on the pharmacokinetic behavior of PEG-DSPE (modified emulsions with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[methoxy (polyethyleneglycol)]) and PEG-CHMC (modified emulsions with poly(ethyleneglycol)-cholesteryl carbonate) emulsions in beagle...
13h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου