Researchers from Switzerland, Germany, and the U.S. have outlined the key applications...Read more on AuntMinnieEurope.comRelated Reading: Spanish team visualizes 3D patient models on smartphones Cardiac patients gain from 3D printing, AR advances Augmented reality can help guide aneurysm repair AR helps transform minimally invasive surgery Milan group uses AR, 3D printing to assist in heart surgery
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Obese urban students with asthma appear more susceptible to the effects of classroom indoor NO2 exposure. Obese BMI status and the school environment should be taken into consideration when assessing childhood asthma risk factors.
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Myosin light chain 1, designated Gal d 7, represents a major chicken meat allergen for patients primarily sensitized to poultry meat and recombinant Gal d 7 can be used for diagnosis of genuine poultry meat sensitization.
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Omeprazole inhibits IgE-mediated mast cell activation and allergic responses to food allergen.
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The use of metrics is necessary for decision making when it comes to evaluating the need for interventions and improve healthcare delivery (Adams, Metrics: What Counts in Global Health, 2016). They inform poli...
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Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton’s tyrosine kinase (BTK) such as ibrutinib is limited by primary or secondary resistance to this drug. Examinations of CLL patients with late relapses while on ibrutinib, which inhibits BTK’s catalytic activity, revealed several mutations in BTK, most frequently resulting in the C481S substitution, and disclosed many mutations in PLCG2, encoding phospholipase C-γ2 (PLCγ2). The PLCγ2 variants do typically not exhibit...
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The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations in order to maintain a proper energy balance in cells. We show here that suckling-weaning and fasting-refeeding transitions in rodents are associated with changes in AMPK activation and the cellular energy state in the liver. These nutritional transitions were characterized by a metabolic switch from lipid to glucose utilization, orchestrated by modifications...
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Heat shock factor-1 (HSF1) regulates cellular adaptation to challenges such as heat shock and oxidative and proteotoxic stresses. We have recently reported a previously unappreciated role of HSF1 in the regulation of energy metabolism in fat tissues; however, whether HSF1 is differentially expressed in adipose depots and how its levels are regulated in fat tissues remains unclear. Here, we show that HSF1 levels are higher in brown and subcutaneous fat tissues than in those in the visceral depot,...
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Lens proteins become increasingly crosslinked through non-disulfide linkages during aging and cataract formation. One mechanism that has been implicated in this crosslinking is glycation through formation of advanced glycation endproducts (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein-crosslinking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like...
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Prostate cancer (PCa) cells heavily rely on an active androgen receptor (AR) pathway for their survival. Enzalutamide (MDV3100) is a second-generation antiandrogenic drug that was approved by the Food and Drug Administration in 2012 to treat patients with castration-resistant prostate cancer (CRPC). However, emergence of resistance against this drug is inevitable, and it has been a major challenge to develop interventions that help manage enzalutamide-resistant CRPC. Erythropoietin-producing human...
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The atypical trichromatic cyanobacterial phytochrome NpTP1 from Nostoc punctiforme ATCC 29133 is a linear tetrapyrrole (bilin)-binding photoreceptor protein that possesses tandem-cysteine residues responsible for shifting its light-sensing maximum to the violet spectral region. Using bioinformatics and phylogenetic analyses, here we established that tandem-cysteine cyanobacterial phytochromes (TCCPs) compose a well-supported monophyletic phytochrome lineage distinct from prototypical red/far-red...
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Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims antigenic peptide precursors to generate mature antigenic peptides for presentation by major histocompatibility complex class I (MHCI) molecules and regulates adaptive immune responses. ERAP1 has been proposed to trim peptide precursors both in solution and in pre-formed MHCI–peptide complexes, but which mode is more relevant to its biological function remains controversial. Here, we compared ERAP1-mediated trimming of antigenic peptide precursors...
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Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this posttranslational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important...
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Telomeres are specific nucleoprotein structures that are located at the ends of linear eukaryotic chromosomes and play crucial roles in genomic stability. Telomere DNA consists of simple repeats of a short G-rich sequence: TTAGGG in mammals and TTTAGGG in most plants. In recent years, the mammalian telomeric G-rich repeats have been shown to form G-quadruplex (G4) structures, which are crucial for modulating telomere functions. Surprisingly, even though plant telomeres are essential for plant growth,...
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Bacterial type VII secretion systems (T7SSs) secrete a wide range of extracellular proteins that play important roles in bacterial viability and in interactions of pathogenic mycobacteria with their hosts. Mycobacterial T7SSs consist of five subtypes, ESX-1–5, and have four substrate classes, namely, Esx, PE, PPE, and Esp proteins. At least some of these substrates are secreted as heterodimers. Each ESX system mediates the secretion of a specific set of Esx, PE, and PPE proteins, raising the question...
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British Journal of Cancer, Published online: 18 March 2020; doi:10.1038/s41416-020-0795-9A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma
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Planta MedDOI: 10.1055/a-1130-0590The importance of hops (the flowers of Humulus lupulus) as food and an herbal remedy is reflected by a large number of analytical methods published. However, supercritical fluid chromatography, a highly efficient, rapid, and “green” separation technique, has not been considered for hops samples so far. This prompted us to establish the first supercritical fluid chromatography-based protocol for the separation, identification, and quantitation of five prenylated constituents...
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Abstract Melanocortin 4 receptor gene plays an important role in food intake, energy balance, and weight control. The autosomal dominantly inherited MC4R variants cause obesity by causing hyperphagia and decreased sense of satiety. Homozygous variants are rarely reported, and they cause earlier/severe obesity. Our objective is to determine the MC4R gene variant frequency in children and adolescents with familial early-onset obesity. One hundred thirty-nine children and adolescents...
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Abstract Lack of availability of age-appropriate dosage forms for children often results in use of adult dosage forms, which are administered to children after crushing or breaking. This can result in inappropriate doses being given to the children. This study was done to assess the prescribing pattern of use of medicines that had to be fragmented or crushed for use in relation to the age of the child. A prescription audit of 1200 outpatients and 400 inpatient records was done...
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A method to solve a family of third-order nonlinear ordinary complex differential equations (NLOCDEs) —nonlinear ODEs in the complex plane—by generalizing Prelle–Singer has been developed. The approach that the authors generalized is a procedure of obtaining a solution to a kind of second-order nonlinear ODEs in the real line. Some theoretical work has been illustrated and applied to several examples. Also, an extended technique of generating second and third motion integrals in the complex domain...
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A new model-free adaptive robust control method has been proposed for the robotic exoskeleton, and the proposed control scheme depends only on the input and output data, which is different from model-based control algorithms that require exact dynamic model knowledge of the robotic exoskeleton. The dependence of the control algorithm on the prior knowledge of the robotic exoskeleton dynamics model is reduced, and the influence of the system uncertainties are compensated by using the model-free adaptive...
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Aiming at the requirements of vehicle safety collision avoidance system, a safety collision avoidance algorithm based on environmental characteristics and driver characteristics is proposed. By analyzing the relationship between collision avoidance time and the environment, a safety time model is established. In the established safety time model, parameters based on driver characteristics are added, which increases the flexibility of the algorithm. The algorithm can adapt to more different driving...
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The deformation of Muzhailing deep tunnel is about 2.3 m in the process of construction, which is difficult to be controlled by the traditional “anchor-grouting integration” support system. This paper deeply analyzes the geological characteristics, rock mechanics characteristics, and surrounding rock failure characteristics of Muzhailing tunnel. The deformation mechanism and the failure of the support system are analyzed through the numerical simulation, theoretical analysis, and field test. The...
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Epithelioid angiomyolipomas (EAMLs) are mesenchymal tumors that are part of the family of the perivascular epithelioid cell neoplasms (PEComas). These tumors portray a potential aggressive behavior with metastatic lesions found in around 30% of reported cases. EAMLs might present sporadically or in association with the tuberous sclerosis complex (TSC). They typically involve the kidneys, liver, and lungs. It is extremely rare for these tumors to arise from other organs. The present report describes...
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Emotion recognition based on multichannel electroencephalogram (EEG) signals is a key research area in the field of affective computing. Traditional methods extract EEG features from each channel based on extensive domain knowledge and ignore the spatial characteristics and global synchronization information across all channels. This paper proposes a global feature extraction method that encapsulates the multichannel EEG signals into gray images. The maximal information coefficient (MIC) for all...
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Street foods have become a major source of cooked food for most households and individuals in many developing countries including Ghana. However, the rising concern about food-borne illness has questioned the knowledge of the street food vendors to constitute safety practices for food handling. This study assessed the knowledge of street food vendors on food safety and food-handling practices in the Ejisu-Juaben Municipality of Ghana. The study used a cross-sectional mixed approach involving 340...
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Takotsubo syndrome is a rare but emerging form of acute reversible myocardial injury characterized by transient systolic LV dysfunction, often related to emotional or physical stress. Pheochromocytoma is increasingly recognised as another possible trigger. Pheochromocytoma is a rare catecholamine-secreting tumour arising from chromaffin cells within the adrenal medulla or extra-adrenal paraganglia. The pathognomonic quartet of paroxysmal hypertension, palpitations, headache, and diaphoresis is rarely...
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In this paper, we present an approach to drug addiction simulation and forecasting in the medium and long terms in cities having a high population density and a high rate of social communication. Drug addiction forecasting is one of the basic components of the antidrug policy, giving informational and analytic support both at the regional and at the governmental level. However, views on the drug consumption problem vary in different regions, and as a consequence, several approaches to antidrug policy...
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The X-ray repair cross-complementing (XRCC) gene family has been revealed to participate in the carcinogenesis and development of numerous cancers. However, the expression profiles and prognostic values of XRCCs (XRCC1-6) in hepatocellular carcinoma (HCC) have not been explored up to now. The transcriptional levels of XRCCs in primary HCC tissues were analyzed by UALCAN and GEPIA. The relationship between XRCCs expression and HCC clinical characteristics was evaluated using UALCAN. Moreover, the...
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