Soft tissue sarcoma (STS) is a rare and diverse group of solid tumors with poor survival. For the first time, we showed that anlotinib, a multikinase angiogenesis inhibitor, combined with epirubicin was an effective and safe therapy in a sarcoma patient‐derived xenografts model, which suggested combined therapy drug as a promising therapeutic strategy for STS patients. Abstract Background Anlotinib is a novel, orally administered, multitarget receptor tyrosine kinase inhibitor. It functions...
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In the present study, we constructed and validated nomograms for predicting the 1‐, 3‐, and 5‐year OS and CSS rates after surgical resection of PDAC. The nomograms established in the present study showed good performance for the prediction of OS and CSS, which was superior to that of the existing, conventional AJCC staging system with an improved net benefit. Therefore, these nomograms hold promise as novel prognosis models for improving the prediction of individualized postoperative survival and...
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Related ArticlesEthics in musculoskeletal regenerative medicine; guidance in choosing the appropriate comparator in clinical trials. Osteoarthritis Cartilage. 2019 01;27(1):34-40 Authors: de Windt TS, Niemansburg SL, Vonk LA, van Delden JM, Roes KCB, Dhert WJA, Saris DBF, Bredenoord AL Abstract BACKGROUND: Regenerative Medicine (RM) techniques aimed at the musculoskeletal system are increasingly translated to clinical trials and patient care. This...
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Related ArticlesMultisite Randomized Clinical Trial Evaluating an Online Self-Management Program for Adolescents With Juvenile Idiopathic Arthritis. J Pediatr Psychol. 2019 04 01;44(3):363-374 Authors: Connelly M, Schanberg LE, Ardoin S, Blakley M, Carrasco R, Chira P, Hayward K, Ibarra M, Kimura Y, Kingsbury DJ, Klein-Gitelman MS, Lawson E, Stinson J Abstract OBJECTIVE: To determine the efficacy in improving pain and health-related quality of life...
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Related ArticlesTelling the truth to young children: Ethical reasons for information disclosure in paediatrics. J Paediatr Child Health. 2019 Jan;55(1):13-17 Authors: Hudson N, Spriggs M, Gillam L Abstract When parents ask doctors not to disclose certain information to a child, doctors are challenged to articulate ethical reasons for giving information to children. This paper maps out the professional and legal landscape in which information-giving...
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Related ArticlesHymenoptera Venom Allergy: Management of Children and Adults in Clinical Practice. J Investig Allergol Clin Immunol. 2019;29(3):180-205 Authors: Bilò MB, Pravettoni V, Bignardi D, Bonadonna P, Mauro M, Novembre E, Quercia O, Cilia M, Cortellini G, Costantino MT, Cremonte L, Lodi Rizzini F, Macchia L, Marengo F, Murzilli F, Patella V, Reccardini F, Ricciardi L, Ridolo E, Romano A, Savi E, Schiavino D, Severino M, Pastorello EA Abstract ...
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Related ArticlesHome Telemonitoring of Community-Dwelling Heart Failure Patients After Home Care Discharge. Telemed J E Health. 2019 06;25(6):447-454 Authors: Nouryan CN, Morahan S, Pecinka K, Akerman M, Lesser M, Chaikin D, Castillo S, Zhang M, Pekmezaris R Abstract Background: Home telemonitoring (HTM) is a promising approach to improve quality of life (QoL) and decrease hospital utilization. Methods: This randomized-controlled study followed 89 community-dwelling...
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Related ArticlesDevice representatives in hospitals: are commercial imperatives driving clinical decision-making? J Med Ethics. 2018 09;44(9):589-592 Authors: Grundy Q, Hutchison K, Johnson J, Blakely B, Clay-Wlliams R, Richards B, Rogers WA Abstract Despite concerns about the relationships between health professionals and the medical device industry, the issue has received relatively little attention. Prevalence data are lacking; however, qualitative...
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Related ArticlesConsenting to invasive contraceptives: an ethical analysis of adolescent decision-making authority for long-acting reversible contraception. J Med Ethics. 2018 09;44(9):585-588 Authors: Behmer Hansen RT, Arora KS Abstract Since USA constitutional precedent established in 1976, adolescents have increasingly been afforded the right to access contraception without first obtaining parental consent or authorisation. There is general agreement...
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Related ArticlesThinking clearly about the FIRST trial: addressing ethical challenges in cluster randomised trials of policy interventions involving health providers. J Med Ethics. 2018 09;44(9):593-598 Authors: Horn AR, Weijer C, Hey SP, Brehaut J, Fergusson DA, Goldstein CE, Grimshaw J, Taljaard M Abstract The ethics of the Flexibility In duty hour Requirements for Surgical Trainees (FIRST) trial have been vehemently debated. Views on the ethics of...
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Related ArticlesDoes cross-cultural communication training for physicians improve pediatric asthma outcomes? A randomized trial. J Asthma. 2019 03;56(3):273-284 Authors: Patel MR, Song PXK, Bruzzese JM, Hao W, Evans D, Thomas LJ, Pinkett-Heller M, Meyerson K, Brown RW Abstract OBJECTIVE: Adverse cross-cultural interactions are a persistent problem within medicine impacting minority patients' use of services and health outcomes. To test whether 1) enhancing...
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Related ArticlesThe number and function of T regulatory cells in obese atopic female asthmatics. J Asthma. 2019 03;56(3):303-310 Authors: Cohen RI, Ye X, Ramdeo R, Liu SF Abstract BACKGROUND: Mechanisms underlying the association between asthma and obesity remain poorly understood. Obesity appears to be a risk factor for asthma, and obese asthmatics fare poorly compared to lean asthmatics. OBJECTIVES: To explore the possibility that reduced...
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Related ArticlesCerebral organoids: ethical issues and consciousness assessment. J Med Ethics. 2018 09;44(9):606-610 Authors: Lavazza A, Massimini M Abstract Organoids are three-dimensional biological structures grown in vitro from different kinds of stem cells that self-organise mimicking real organs with organ-specific cell types. Recently, researchers have managed to produce human organoids which have structural and functional properties very similar...
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Related ArticlesDevelopment of an exercise intervention as part of rehabilitation in a glioblastoma multiforme survivor during irradiation treatment: a case report. Disabil Rehabil. 2019 06;41(13):1608-1614 Authors: Hansen A, Søgaard K, Minet LR Abstract INTRODUCTION: This case report describes the rationale and development of an exercise intervention in a patient with glioblastoma multiforme (GBM ) and discusses potential relations of observed effects...
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Related ArticlesAdaptation of an Evidence-Based Diabetes Management Intervention for Delivery in Community Settings: Findings From a Pilot Randomized Effectiveness Trial. J Pediatr Psychol. 2019 01 01;44(1):110-125 Authors: Ellis DA, Carcone AI, Naar-King S, Rajkumar D, Palmisano G, Moltz K Abstract Objective: To adapt an evidence-based intervention targeting diabetes management in adolescents with poorly controlled type 1 diabetes for use in a community...
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Related ArticlesNurturing gerontology students' intrinsic motivation to cocreate: The design of a powerful learning environment. Gerontol Geriatr Educ. 2019 Oct-Dec;40(4):432-441 Authors: Jukema JS, Veerman M, Van Alphen J, Visser G, Smits C, Kingma T Abstract Professionals such as gerontologists play an important role in the design, development and implementation of age-friendly services. and products, by using working methods and principles of co-creation....
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Related ArticlesWearing humanism on your sleeve. J Med Ethics. 2018 09;44(9):646-647 Authors: DuBroff JJ PMID: 28887359 [PubMed - indexed for MEDLINE]
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Related ArticlesCarbon monoxide poisoning. Undersea Hyperb Med. 2020 First Quarter;47(1):151-169 Authors: Weaver LK Abstract Despite established exposure limits and safety standards as well as the availability of carbon monoxide (CO) alarms, each year 50,000 people in the United States visit emergency departments for CO poisoning. Carbon monoxide poisoning can occur from brief exposures to high levels of CO or from longer exposures to lower levels. Common...
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Related ArticlesHyperbaric oxygen for refractory hemorrhagic cystitis after stem cell transplantation: case report. Undersea Hyperb Med. 2020 First Quarter;47(1):125-129 Authors: Maken K, Bland DK Abstract Hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (AHSCT) in both children and adults has been associated with significant morbidity and mortality. Early HC can occur within 48 hours of completing the chemotherapy conditioning...
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Related ArticlesAnnals Consult Guys - Palpitations and Sleep Apnea. Ann Intern Med. 2020 Mar 17;172(6):CG1 Authors: Merli GJ, Weitz HH PMID: 32176915 [PubMed - as supplied by publisher]
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Related ArticlesUpdate in Critical Care 2019. Am J Respir Crit Care Med. 2020 Mar 16;: Authors: Arabi Y, Mallampalli R, Englert JA, Bosch NA, Walkey AJ, Al-Dorzi HM PMID: 32176850 [PubMed - as supplied by publisher]
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Related ArticlesTraining, detraining, and retraining: Two 12-week respiratory muscle training regimens in a child with infantile-onset Pompe disease. J Pediatr Rehabil Med. 2020 Mar 02;: Authors: Crisp KD, Case LE, Kravitz RM, Kishnani PS, Jones HN Abstract BACKGROUND: Respiratory muscle weakness is a primary cause of morbidity and mortality in patients with Pompe disease. We previously described the effects of our 12-week respiratory muscle training...
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Related ArticlesLow Cost Screening for Features of Prodromal Parkinson's Disease in General Medical Practice in Italy. J Parkinsons Dis. 2020 Mar 11;: Authors: Baldin E, Zenesini C, Bauleo S, Montanari F, Santi S, Spampinato M, Cortelli P, D'Alessandro R, Ascherioå A Abstract The aim of the study was to determine the feasibility of screening older adults attending general medical practice for features suggesting prodromal Parkinson's disease (PD). Four...
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Related ArticlesA Quantitative Analysis of Sleep Quality in Women with Endometriosis. J Womens Health (Larchmt). 2020 Mar 13;: Authors: Arion K, Orr NL, Noga H, Allaire C, Williams C, Bedaiwy MA, Yong PJ Abstract Background: Endometriosis is a complex condition that can negatively affect a woman's quality of life, including her sleep. This study aims to assess the multifactorial variables associated with poorer quality of sleep in women with endometriosis....
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Related ArticlesStrategies for effective intern orientation. Clin Teach. 2020 Mar 16;: Authors: Lui JK, Walsh KF, Philbin M PMID: 32176457 [PubMed - as supplied by publisher]
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Related ArticlesDevelopment of a validated short-form of the Childhood Atopic Dermatitis Impact Scale, the CADIS-SF15. J Eur Acad Dermatol Venereol. 2020 Mar 16;: Authors: Gabes M, Chamlin SL, Lai JS, Cella D, Mancini AJ, Apfelbacher CJ Abstract BACKGROUND: The Childhood Atopic Dermatits Impact Scale (CADIS) with 45 items may be burdensome to complete. We therefore aimed to develop a CADIS short-form. METHODS: Parents of 300 children completed...
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Related ArticlesDistinct Non-motor Features of Essential Tremor with Head Tremor Patients. Acta Neurol Scand. 2020 Mar 16;: Authors: Peng J, Wang L, Li N, Li J, Duan L, Peng R Abstract BACKGROUND: There have been few comprehensive scale studies on the non-motor symptoms (NMS) of patients with essential tremor (ET) with head tremor (ETh) and those with ET without head tremor (ETol). We aimed to explore the motor symptoms and NMS of these two subgroups....
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Related ArticlesEfficacy and safety of Chinese herbal medicine Long Dan Xie Gan Tang in insomnia: A systematic review and meta-analysis. Medicine (Baltimore). 2020 Mar;99(11):e19410 Authors: Fan X, Su Z, Nie S, Yang J, Zhang X, Tan D, Xie S, Xu Y, Zhao Y, Feng L, Gu M, Sun X Abstract BACKGROUND: Insomnia is a global public problem, which has a significant negative impact on both physical and mental health, while increasing the economic burden placed...
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Related ArticlesTreating Postpartum Depression: Beyond the Baby Blues. IEEE Pulse. 2020 Jan-Feb;11(1):17-20 Authors: Berglund J Abstract Amanda Bumgarner knows about babies. As a pediatric nurse in Richmond, VA, she's spent her working life consoling sleep-deprived parents, administering shots to screaming infants, and tenderly attending to the needs of fragile premature babies, often in the most heartbreaking and dire circumstances. When she gave birth...
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Related ArticlesAssociations of Inflammation, Physical Activity, and Sleep in a Diverse Population of Women. J Womens Health (Larchmt). 2020 Mar 12;: Authors: Mayat Z, Giardina EV, Liao M, Aggarwal B Abstract Background: Cardiovascular disease (CVD) is the leading cause of mortality in United States with a recent rise seen in young adults, particularly women. Systemic inflammation, physical activity, and sleep are each individually linked to CVD risk....
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Related ArticlesPhysical activity, sedentary time and sleep and associations with mood states, shift work disorder and absenteeism among nurses: an analysis of the cross-sectional Champlain Nurses' Study. PeerJ. 2020;8:e8464 Authors: Hajo S, Reed JL, Hans H, Tulloch HE, Reid RD, Prince SA Abstract Background: Research has suggested ideal combinations of sleep, physical activity (PA) and sedentary time (ST) (i.e., optimal sleep/high PA/low ST) are associated...
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Related ArticlesEfficacy of Levetiracetam in Treatment of Childhood Stuttering. Int J Prev Med. 2020;11:17 Authors: Ghazavi M, Rastgu F, Nasiri J, Yaghini O Abstract Background: Stuttering is a kind of speech disorder that affects about 1% of total population. As the origin of this disorder is not obviously diagnosed yet, various remedies have been practiced and among them different medicines have been studied, but unfortunately no significant effective...
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Related ArticlesMedications for sleep disturbance in children and adolescents with depression: a survey of Canadian child and adolescent psychiatrists. Child Adolesc Psychiatry Ment Health. 2020;14:10 Authors: Boafo A, Greenham S, Sullivan M, Bazaid K, Suntharalingam S, Silbernagel L, Magner K, Robillard R Abstract Background: Primary care physicians and child and adolescent psychiatrists often treat sleep disturbances in children and adolescents with...
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Excessive Daytime Sleepiness Measurements in Children With Attention Deficit Hyperactivity Disorder.
Related ArticlesExcessive Daytime Sleepiness Measurements in Children With Attention Deficit Hyperactivity Disorder. Front Psychiatry. 2020;11:3 Authors: Bioulac S, Taillard J, Philip P, Sagaspe P Abstract Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood. It is a heterogeneous disorder in terms of clinical presentation that is probably due to the frequent occurrence of comorbidity....
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Related ArticlesPredictors of difficult airway in the obese are closely related to safe apnea time! J Anaesthesiol Clin Pharmacol. 2020 Jan-Mar;36(1):25-30 Authors: Sinha A, Jayaraman L, Punhani D Abstract Background and Aims: We aimed to redefine the preoperative factors that may challenge the airway and safe apnea time (SAT) in the obese. Material and Methods: We analyzed 834 patients with body mass index (BMI) >35 kg/m2 for their difficult...
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Related ArticlesVarious causative factors and associated complications of childhood obesity in Jeddah, Western Region, Saudi Arabia. Ann Afr Med. 2020 Jan-Mar;19(1):15-19 Authors: Al-Agha AE, Mabkhoot YM, Bahwirith AS, Mohammed AN, Ragbi R, Allhabi E, Dumyati BK, Milyani A Abstract Objective: The objective of the study was to investigate the causative factors and complications attributable to obesity in children living in Jeddah, Saudi Arabia. ...
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Related ArticlesEffects of cognitive and visual loads on driving performance after take-over request (TOR) in automated driving. Appl Ergon. 2020 May;85:103074 Authors: Choi D, Sato T, Ando T, Abe T, Akamatsu M, Kitazaki S Abstract The present study investigated effects of cognitive and visual loads on driving performance after take-over request (TOR) in an automated driving task. Participants completed automated driving in a driving simulator without...
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Related ArticlesFood insecurity and mental health: a systematic review and meta-analysis. Public Health Nutr. 2020 Mar 16;:1-13 Authors: Pourmotabbed A, Moradi S, Babaei A, Ghavami A, Mohammadi H, Jalili C, Symonds ME, Miraghajani M Abstract OBJECTIVE: Food security has been suggested to be a risk factor for depression, stress and anxiety. We therefore undertook a systematic review and meta-analysis of available publications to examine these associations...
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Related ArticlesNapping in high-performance athletes: sleepiness or sleepability? Eur J Sport Sci. 2020 Mar 16;:1-25 Authors: Gupta L, Morgan K, North C, Gilchrist S Abstract Daytime napping is a common practice in high-performance athletes, and is widely assumed to reflect sleepiness arising from sports-related sleep debt. The possibility that athlete naps may also be indicative of 'sleepability', a capacity to nap on demand that is only weakly related...
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