IJMS, Vol. 21, Pages 2430: Evaluation of the Potential Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Niemann–Pick Disease, Type C1 International Journal of Molecular Sciences doi: 10.3390/ijms21072430 Authors: Cawley Lyons Abebe Wassif Porter Niemann–Pick disease, type C1, is a cholesterol storage disease where unesterified cholesterol accumulates intracellularly. In the cerebellum this causes neurodegeneration of the Purkinje neurons that...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2429: CBD reverts the mesenchymal invasive phenotype of breast cancer cells induced by the inflammatory cytokine IL-1β International Journal of Molecular Sciences doi: 10.3390/ijms21072429 Authors: García-Morales Castillo Ramírez Zamudio-Meza Domínguez-Robles Meza Cannabidiol (CBD) has been used to treat a variety of cancers and inflammatory conditions with controversial results. In previous work, we have shown that breast cancer MCF-7 cells,...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2428: Activation of AMPK under Hypoxia: Many Roads Leading to Rome International Journal of Molecular Sciences doi: 10.3390/ijms21072428 Authors: Dengler AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor, mediating the adaptation to low energy levels by deactivating anabolic processes and activating catabolic processes in order to restore the cellular ATP supply when the cellular AMP/ATP ratio is increased. Besides this well-known...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2427: Amination of Graphene Oxide Leads to Increased Cytotoxicity in Hepatocellular Carcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21072427 Authors: Georgieva Vasileva Speranza Wang Stoyanov Draganova-Filipova Zagorchev Sarafian Miloshev Krasteva Clinically, there is an urgent need to identify new therapeutic strategies for selectively treating cancer cells. One of the directions in this research...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2432: Molecular Characterization of Tc964, A Novel Antigenic Protein from Trypanosoma cruzi International Journal of Molecular Sciences doi: 10.3390/ijms21072432 Authors: Elizabeth Ruiz-Márvez César Augusto Ramírez Eliana Rocío Rodríguez Magda Mellisa Flórez Gabriela Delgado Fanny Guzmán Paulino Gómez-Puertas José María Requena Concepción J. Puerta The Tc964 protein was initially identified by its presence in the interactome associated with...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2423: miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2 International Journal of Molecular Sciences doi: 10.3390/ijms21072423 Authors: Villanova Barbini Piccolo Boe De Maria Fiori MicroRNAs are tiny but powerful regulators of gene expression at the post-transcriptional level. Aberrant expression of oncogenic and tumor-suppressor microRNAs has been recognized as a common feature of human cancers. Colorectal...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2425: Antxr1, Which Is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis International Journal of Molecular Sciences doi: 10.3390/ijms21072425 Authors: Jiang Qin Yoshida Komori Yamana Ohba Hojo Croix Kawata-Matsuura Komori Antxr1/Tem8 is highly expressed in tumor endothelial cells and is a receptor for anthrax toxin. Mutation of Antxr1 causes GAPO syndrome, which is characterized by growth retardation, alopecia,...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2424: Functional Study of the Retrotransposon-Derived Human PEG10 Protease International Journal of Molecular Sciences doi: 10.3390/ijms21072424 Authors: Golda Mótyán Mahdi Tőzsér Paternally expressed gene 10 (PEG10) is a human retrotransposon-derived imprinted gene. The mRNA of PEG10 encodes two protein isoforms: the Gag-like protein (RF1PEG10) is coded by reading frame 1, while the Gag-Pol-like polyprotein (RF1/RF2PEG10) is coded by reading frames...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2426: Zinc Differentially Modulates the Assembly of Soluble and Polymerized Vimentin International Journal of Molecular Sciences doi: 10.3390/ijms21072426 Authors: Mónico Zorrilla Rivas Pérez-Sala The intermediate filament protein vimentin constitutes a critical sensor for electrophilic and oxidative stress. We previously showed that vimentin interacts with zinc, which affects its assembly and redox sensing. Here, we used vimentin wt and C328S, an oxidation-resistant...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2422: A Novel Highly Sensitive Method for Measuring Inflammatory Neural-Derived APC Activity in Glial Cell Lines, Mouse Brain and Human CSF International Journal of Molecular Sciences doi: 10.3390/ijms21072422 Authors: Valery Golderman Shany G. Gofrit Nicola Maggio Orna Gera Alexandra Gerasimov Dar Laks Joab Chapman Efrat Shavit-Stein Background: Neural inflammation is linked to coagulation. Low levels of thrombin have a neuroprotective effect,...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2421: Inhibition of Proinflammatory Enzymes and Attenuation of IL-6 in LPS-Challenged RAW 264.7 Macrophages Substantiates the Ethnomedicinal Use of the Herbal Drug Homalium bhamoense Cubitt & W.W.Sm International Journal of Molecular Sciences doi: 10.3390/ijms21072421 Authors: Suksungworn Andrade Oliveira Valentão Duangsrisai Gomes Commonly used to treat skin injuries in Asia, several Homalium spp. have been found to promote skin regeneration...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2419: Targeting PKCθ Promotes Satellite Cell Self-Renewal International Journal of Molecular Sciences doi: 10.3390/ijms21072419 Authors: Anna Benedetti Piera Filomena Fiore Luca Madaro Biliana Lozanoska-Ochser Marina Bouché Skeletal muscle regeneration following injury depends on the ability of satellite cells (SCs) to proliferate, self-renew, and eventually differentiate. The factors that regulate the process of self-renewal are poorly understood. In...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2420: DNA Methylation Profiles in a Group of Workers Occupationally Exposed to Nanoparticles International Journal of Molecular Sciences doi: 10.3390/ijms21072420 Authors: Andrea Rossnerova Katerina Honkova Daniela Pelclova Vladimir Zdimal Jaroslav A. Hubacek Irena Chvojkova Kristyna Vrbova Pavel Rossner Jan Topinka Stepanka Vlckova Zdenka Fenclova Lucie Lischkova Pavlina Klusackova Jaroslav Schwarz Jakub Ondracek Lucie Ondrackova...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2417: Transcriptomic Profiling in Fins of Atlantic Salmon Parasitized with Sea Lice: Evidence for an Early Imbalance Between Chalimus-Induced Immunomodulation and the Host’s Defense Response International Journal of Molecular Sciences doi: 10.3390/ijms21072417 Authors: Umasuthan Xue Caballero-Solares Kumar Westcott Chen Fast Skugor Nowak Taylor Rise Parasitic sea lice (e.g., Lepeophtheirus salmonis) cause costly outbreaks...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2418: Chronic Regulation of miR-124-3p in the Perilesional Cortex after Experimental and Human TBI International Journal of Molecular Sciences doi: 10.3390/ijms21072418 Authors: Vuokila Aronica Korotkov van Vliet Nuzhat Puhakka Pitkänen Traumatic brain injury (TBI) dysregulates microRNAs, which are the master regulators of gene expression. Here we investigated the changes in a brain-enriched miR-124-3p, which is known to associate with major...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2415: Chromosomal Signatures Corroborate the Phylogenetic Relationships within Akodontini (Rodentia, Sigmodontinae) International Journal of Molecular Sciences doi: 10.3390/ijms21072415 Authors: Willam Oliveira da Silva Stella Miranda Malcher Adenilson Leão Pereira Julio Cesar Pieczarka Malcolm Andrew Ferguson-Smith Patricia Caroline Mary O’Brien Ana Cristina Mendes-Oliveira Lena Geise Cleusa Yoshiko Nagamachi Comparative chromosome-painting...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2412: Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis International Journal of Molecular Sciences doi: 10.3390/ijms21072412 Authors: Uris Ros Lohans Pedrera Ana J. Garcia-Saez Pyroptosis, necroptosis, and ferroptosis are well-characterized forms of regulated necrosis that have been associated with human diseases. During regulated necrosis, plasma membrane damage facilitates the movement of ions and molecules across the bilayer,...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2416: Inhibitory Effective Perturbations of Cilobradine (DK-AH269), A Blocker of HCN Channels, on the Amplitude and Gating of Both Hyperpolarization-Activated Cation and Delayed-Rectifier Potassium Currents International Journal of Molecular Sciences doi: 10.3390/ijms21072416 Authors: Te-Ling Lu Te-Jung Lu Sheng-Nan Wu Cilobradine (CIL, DK-AH269), an inhibitor of hyperpolarization-activated cation current (Ih), has been observed to possess pro-arrhythmic properties....
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2413: Role of Oxidative Stress in Metabolic and Subcellular Abnormalities in Diabetic Cardiomyopathy International Journal of Molecular Sciences doi: 10.3390/ijms21072413 Authors: Naranjan S. Dhalla Anureet K. Shah Paramjit S. Tappia Although the presence of cardiac dysfunction and cardiomyopathy in chronic diabetes has been recognized, the pathophysiology of diabetes-induced metabolic and subcellular changes as well as the therapeutic approaches for the prevention...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2410: Using the Cardio-Ankle Vascular Index (CAVI) or the Mathematical Correction Form (CAVI0) in Clinical Practice International Journal of Molecular Sciences doi: 10.3390/ijms21072410 Authors: Javad Alizargar Nan-Chen Hsieh Shu-Fang Vivienne Wu Shih-Yen Weng Tonhajzerova et al [...]
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2414: Development and Proof-of-Concept Application of Genome-Enabled Selection for Pea Grain Yield under Severe Terminal Drought International Journal of Molecular Sciences doi: 10.3390/ijms21072414 Authors: Paolo Annicchiarico Nelson Nazzicari Meriem Laouar Imane Thami-Alami Massimo Romani Luciano Pecetti Terminal drought is the main stress limiting pea (Pisum sativum L.) grain yield in Mediterranean environments. This study aimed to investigate genotype...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2411: Systemic Blood Immune Cell Populations as Biomarkers for the Outcome of Immune Checkpoint Inhibitor Therapies International Journal of Molecular Sciences doi: 10.3390/ijms21072411 Authors: Carlos Hernandez Hugo Arasanz Luisa Chocarro Ana Bocanegra Miren Zuazo Gonzalo Fernandez-Hinojal Ester Blanco Ruth Vera David Escors Grazyna Kochan The development of cancer immunotherapy in the last decade has followed a vertiginous rhythm. Nowadays,...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2409: Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21072409 Authors: Katja Jakobi Sandra Beyer Alexander Koch Dominique Thomas Stephanie Schwalm Stefan Zeuzem Josef Pfeilschifter Georgios Grammatikos Hepatocellular carcinoma (HCC) shows a remarkable heterogeneity and is recognized as a chemoresistant...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2408: Tie-2 Cre-Mediated Deficiency of Extracellular Signal-Regulated Kinase 2 Potentiates Experimental Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Neonatal Mice International Journal of Molecular Sciences doi: 10.3390/ijms21072408 Authors: Renuka T. Menon Amrit Kumar Shrestha Roberto Barrios Corey Reynolds Binoy Shivanna Bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) is a significant lung morbidity of infants,...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2406: Cytotoxic Mechanism of Excess Polyamines Functions through Translational Repression of Specific Proteins Encoded by Polyamine Modulon International Journal of Molecular Sciences doi: 10.3390/ijms21072406 Authors: Akihiko Sakamoto Junpei Sahara Gota Kawai Kaneyoshi Yamamoto Akira Ishihama Takeshi Uemura Kazuei Igarashi Keiko Kashiwagi Yusuke Terui Excessive accumulation of polyamines causes cytotoxicity, including inhibition of cell growth...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2407: Recent Strategic Advances in CFTR Drug Discovery: An Overview International Journal of Molecular Sciences doi: 10.3390/ijms21072407 Authors: Marco Rusnati Pasqualina D’Ursi Nicoletta Pedemonte Chiara Urbinati Robert C. Ford Elena Cichero Matteo Uggeri Alessandro Orro Paola Fossa Cystic fibrosis transmembrane conductance regulator (CFTR)-rescuing drugs have already transformed cystic fibrosis (CF) from a fatal disease to a treatable chronic...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2401: Optimization of rVAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells International Journal of Molecular Sciences doi: 10.3390/ijms21072401 Authors: Nicolai T. Sand Tobias B. Petersen Sara R. Bang-Christensen Theresa D. Ahrens Caroline Løppke Amalie M. Jørgensen Tobias Gustavsson Swati Choudhary Thor G. Theander Ali Salanti Mette Ø. Agerbæk Early detection and...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2404: Placental Galectin-2 Expression in Gestational Diabetes: A Systematic, Histological Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21072404 Authors: Paula Hepp Laura Unverdorben Stefan Hutter Christina Kuhn Nina Ditsch Eva Groß Sven Mahner Udo Jeschke Julia Knabl Helene H. Heidegger Gestational diabetes mellitus (GDM) is the most common pregnancy-associated metabolic disorder that negatively impacts on the health...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2402: Transcriptome Analysis Reveals the Neuro-Immune Interactions in Duck Tembusu Virus-Infected Brain International Journal of Molecular Sciences doi: 10.3390/ijms21072402 Authors: Junqin Zhang Yunzhen Huang Linlin Li Jiawen Dong Ming Liao Minhua Sun The duck Tembusu virus (DTMUV) is a mosquito-borne flavivirus. It causes severe symptoms of egg-drop, as well as neurological symptoms and brain damage in ducks. However, the specific molecular mechanisms...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2403: Novel Autoantibody Signatures in Sera of Patients with Pancreatic Cancer, Chronic Pancreatitis and Autoimmune Pancreatitis: A Protein Microarray Profiling Approach International Journal of Molecular Sciences doi: 10.3390/ijms21072403 Authors: Sahar Ghassem-Zadeh Katrin Hufnagel Andrea Bauer Jean-Louis Frossard Masaru Yoshida Hiromu Kutsumi Hans Acha-Orbea Matthias Neulinger-Muñoz Johannes Vey Christoph Eckert Oliver Strobel Jörg D....
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2400: Trefoil Factor Family (TFF) Modules Are Characteristic Constituents of Separate Mucin Complexes in the Xenopus laevis Integumentary Mucus: In Vitro Binding Studies with FIM-A.1 International Journal of Molecular Sciences doi: 10.3390/ijms21072400 Authors: René Stürmer Jana Reising Werner Hoffmann The skin of the frog Xenopus laeevis is protected from microbial infections by a mucus barrier that contains frog integumentary mucins (FIM)-A.1, FIM-B.1, and...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2405: Novel Osteogenic Behaviors around Hydrophilic and Radical-Free 4-META/MMA-TBB: Implications of an Osseointegrating Bone Cement International Journal of Molecular Sciences doi: 10.3390/ijms21072405 Authors: Yoshihiko Sugita Takahisa Okubo Makiko Saita Manabu Ishijima Yasuyoshi Torii Miyuki Tanaka Chika Iwasaki Takeo Sekiya Masako Tabuchi Naser Mohammadzadeh Rezaei Takashi Taniyama Nobuaki Sato Juri Saruta Masakazu Hasegawa Makoto...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2399: Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21072399 Authors: Woan Ting Tay Yi-Hsien Fang Suet Theng Beh Yen-Wen Liu Ling-Wei Hsu Chia-Jui Yen Ping-Yen Liu Aim: Immunological checkpoint therapy is considered a powerful method for cancer therapy and acts by re-activating...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2397: Treatment of Delirium in Older Persons: What We Should Not Do! International Journal of Molecular Sciences doi: 10.3390/ijms21072397 Authors: Fulvio Lauretani Giuseppe Bellelli Giovanna Pelà Simonetta Morganti Sara Tagliaferri Marcello Maggio The presentation of common acute diseases in older age is often referred to as “atypical”. Frequently, the symptoms are neither single nor tissue related. In most cases, the onset of...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2396: A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome International Journal of Molecular Sciences doi: 10.3390/ijms21072396 Authors: Magdalena Wysocka Anita Romanowska Natalia Gruba Michalina Michalska Artur Giełdoń Adam Lesner This work describes the chemical synthesis, combinatorial selection, and enzymatic evaluation of peptidomimetic fluorescent substrates specific for the trypsin-like (β2)...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2398: Treatment of Cystic Fibrosis Patients Homozygous for F508del with Lumacaftor-Ivacaftor (Orkambi®) Restores Defective CFTR Channel Function in Circulating Mononuclear Cells International Journal of Molecular Sciences doi: 10.3390/ijms21072398 Authors: Maria Favia Crescenzio Gallo Lorenzo Guerra Domenica De Venuto Anna Diana Angela Maria Polizzi Pasqualina Montemurro Maria Addolorata Mariggiò Giuseppina Leonetti Antonio Manca Valeria Casavola...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2394: Comparative Proteomic Analysis by iTRAQ Reveals that Plastid Pigment Metabolism Contributes to Leaf Color Changes in Tobacco (Nicotiana tabacum) during Curing International Journal of Molecular Sciences doi: 10.3390/ijms21072394 Authors: Shengjiang Wu Yushuang Guo Muhammad Faheem Adil Shafaque Sehar Bin Cai Zhangmin Xiang Yonggao Tu Degang Zhao Imran Haider Shamsi Tobacco (Nicotiana tabacum), is a world’s major non-food agricultural...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2393: Calebin A Potentiates the Effect of 5-FU and TNF-β (Lymphotoxin α) against Human Colorectal Cancer Cells: Potential Role of NF-κB International Journal of Molecular Sciences doi: 10.3390/ijms21072393 Authors: Constanze Buhrmann Ajaikumar B. Kunnumakkara Bastian Popper Muhammed Majeed Bharat B. Aggarwal Mehdi Shakibaei Objective: The majority of chemotherapeutic agents stimulate NF-κB signaling that mediates cell survival, proliferation...
Tue Mar 31, 2020 03:00
IJMS, Vol. 21, Pages 2395: Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice International Journal of Molecular Sciences doi: 10.3390/ijms21072395 Authors: Elisabetta Bonfanti Tiziana Bonifacino Stefano Raffaele Marco Milanese Erica Morgante Giambattista Bonanno Maria P. Abbracchio Marta Fumagalli Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons...
Tue Mar 31, 2020 03:00
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