Antibiotics, Vol. 9, Pages 152: Antibiotic Resistance and Virulence Traits in Vancomycin-Resistant Enterococci (VRE) and Extended-Spectrum -Lactamase/AmpC-producing (ESBL/AmpC) Enterobacteriaceae from Humans and Pets Antibiotics doi: 10.3390/antibiotics9040152 Authors: Iseppi Di Cerbo Messi Sabia Background: We investigated the virulence factors, genes, antibiotic resistance patterns, and genotypes (VRE and ESBL/AmpC) production in Enterococci and Enterobacteriaceae strains...
Tue Mar 31, 2020 03:00
Antibiotics, Vol. 9, Pages 151: Bacteriology and Antimicrobial Resistance in Vanuatu: January 2017 to December 2019 Antibiotics doi: 10.3390/antibiotics9040151 Authors: Foxlee Townell Tosul McIver Lau Keywords: drug resistance; antimicrobial; public health surveillance; Pacific Islands; bacteriology; epidemiology
Tue Mar 31, 2020 03:00
Antibiotics, Vol. 9, Pages 150: Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery Antibiotics doi: 10.3390/antibiotics9040150 Authors: Lewis Marquez Cassandra L. Quave Antimicrobial resistance is a global issue that threatens the effective practice of modern medicine and global health. The emergence of multidrug-resistant (MDR) fungal strains of Candida auris and azole-resistant Aspergillus fumigatus were highlighted in the Centers...
Tue Mar 31, 2020 03:00
Antibiotics, Vol. 9, Pages 149: Rosmarinus officinalis L. (Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors of Staphylococcus aureus Virulence Antibiotics doi: 10.3390/antibiotics9040149 Authors: Seitaro Nakagawa Greg G. Hillebrand Gabriel Nunez Staphylococcus aureus is an opportunistic pathogen and a common cause of skin infection. S. aureus also plays a role in the pathogenesis of the chronic inflammatory skin disease, atopic dermatitis....
Tue Mar 31, 2020 03:00
Antioxidants, Vol. 9, Pages 292: Rhus coriaria L. Fruit Extract Prevents UV-A-Induced Genotoxicity and Oxidative Injury in Human Microvascular Endothelial Cells Antioxidants doi: 10.3390/antiox9040292 Authors: Emma Nozza Gloria Melzi Laura Marabini Marina Marinovich Stefano Piazza Saba Khalilpour Mario Dell’Agli Enrico Sangiovanni Rhus coriaria L. (sumac) is a small plant widely diffused in the Mediterranean region. Its fruit are often consumed as a spice but are...
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Antioxidants, Vol. 9, Pages 291: Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke Antioxidants doi: 10.3390/antiox9040291 Authors: Emma Martínez-Alonso Alejandro Escobar-Peso Maria I. Ayuso Rafael Gonzalo-Gobernado Mourad Chioua Juan J. Montoya Joan Montaner Israel Fernández José Marco-Contelles Alberto Alcázar Nitrones have a well-recognized capacity as spin-traps and are considered powerful free...
Tue Mar 31, 2020 03:00
Antioxidants, Vol. 9, Pages 290: Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approches in Non Communicable Diseases Antioxidants doi: 10.3390/antiox9040290 Authors: Chiara Nediani Lisa Giovannelli As recently reported by the World Health Organization (WHO), Non-Communicable Diseases (NCDs) has been rising over the last century representing the main cause of death and disability for the general population regardless of age, region, or gender [...]
Tue Mar 31, 2020 03:00
Atmosphere, Vol. 11, Pages 347: Analyzing Trend and Variability of Rainfall in The Tafna Basin (Northwestern Algeria) Atmosphere doi: 10.3390/atmos11040347 Authors: Bougara Hamed Borgemeister Tischbein Kumar Northwest Algeria has experienced fluctuations in rainfall between the two decades 1940s and 1990s from positive to negative anomalies, which reflected a significant decline in rainfall during the mid-1970s. Therefore, further analyzing rainfall in this region is...
Tue Mar 31, 2020 03:00
Atmosphere, Vol. 11, Pages 346: Spatiotemporal Distribution of Malaria in Spain in a Global Change Context Atmosphere doi: 10.3390/atmos11040346 Authors: Sousa Aguilar-Alba Vetter García-Barrón Morales Malaria is one of the most cited vector-borne infectious diseases by climate change expert panels. Malaria vectors often need water sheets or wetlands to complete the disease life cycle. The current context of population mobility and global change requires detailed monitoring...
Tue Mar 31, 2020 03:00
Atmosphere, Vol. 11, Pages 348: A Hybrid Deep Learning Model to Forecast Particulate Matter Concentration Levels in Seoul, South Korea Atmosphere doi: 10.3390/atmos11040348 Authors: Yang Lee Lee Both long- and short-term exposure to high concentrations of airborne particulate matter (PM) severely affect human health. Many countries now regulate PM concentrations. Early-warning systems based on PM concentration levels are urgently required to allow countermeasures to reduce harm...
Tue Mar 31, 2020 03:00
Atmosphere, Vol. 11, Pages 345: Simulating Real Atmospheric Boundary Layers at Gray-Zone Resolutions: How Do Currently Available Turbulence Parameterizations Perform? Atmosphere doi: 10.3390/atmos11040345 Authors: Paula Doubrawa Domingo Muñoz-Esparza Recent computational and modeling advances have led a diverse modeling community to experiment with atmospheric boundary layer (ABL) simulations at subkilometer horizontal scales. Accurately parameterizing turbulence at these scales is...
Tue Mar 31, 2020 03:00
Atmosphere, Vol. 11, Pages 344: Influence of the Background Nitrogen Oxides on the Tropospheric Ozone Depletion Events in the Arctic during Springtime Atmosphere doi: 10.3390/atmos11040344 Authors: Jiashu Zhou Le Cao Simeng Li Ozone depletion events (ODEs) in the springtime of the Arctic have been frequently observed since the early 1980s, and the correlation between the ozone mixing ratio during the ODEs and the nitrogen oxides (NOx) concentration is still unclear. In the present...
Tue Mar 31, 2020 03:00
Atmosphere, Vol. 11, Pages 343: 21st Century Projections of Extreme Precipitation Indicators for Cyprus Atmosphere doi: 10.3390/atmos11040343 Authors: George Zittis Adriana Bruggeman Corrado Camera According to observational and model-based studies, the eastern Mediterranean region is one of the most prominent climate-change hotspots in the world. The combined effect of warming and drying is expected to augment the regional impacts of global warming. In addition to changes in mean...
Tue Mar 31, 2020 03:00
Atmosphere, Vol. 11, Pages 342: Using Satellite Data to Determine Empirical Relationships between Volcanic Ash Source Parameters Atmosphere doi: 10.3390/atmos11040342 Authors: Zidikheri Lucas Poor knowledge of dispersion model source parameters related to quantities such as the total fine ash mass emission rate, its effective spatial distribution, and particle size distribution makes the provision of quantitative forecasts of volcanic ash a difficult problem. To ameliorate this...
Tue Mar 31, 2020 03:00
Bioengineering, Vol. 7, Pages 33: Collagen Fibril Density Modulates Macrophage Activation and Cellular Functions during Tissue Repair Bioengineering doi: 10.3390/bioengineering7020033 Authors: Sapudom Mohamed Garcia-Sabaté Alatoom Karaman Mahtani Teo Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into specific macrophage phenotypes to fulfill the immunological needs of tissues. During the tissue repair process, tissue density...
Tue Mar 31, 2020 03:00
Bioengineering, Vol. 7, Pages 32: 3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs Bioengineering doi: 10.3390/bioengineering7020032 Authors: Jeong Nam Jang Lee It is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes....
Tue Mar 31, 2020 03:00
Biology, Vol. 9, Pages 67: Tumor-infiltrating Leukocytes Suppress Local Inflammation Via Interleukin-1 Receptor Antagonist in a Syngeneic Prostate Cancer Model Biology doi: 10.3390/biology9040067 Authors: Fan Chen Lee Tsai Background: Several lines of evidence have demonstrated the tumor-promoting function of inflammation. Since many chemokines are important in coordinating immune cells during inflammation, monitoring intratumoral chemokines provides a way to study the tumor...
Tue Mar 31, 2020 03:00
Biology, Vol. 9, Pages 66: Role of PA2G4P4 pseudogene in bladder cancer tumorigenesis Biology doi: 10.3390/biology9040066 Authors: Laura Pisapia Sara Terreri Pasquale Barba Marianna Mastroianni Maria Donnini Vincenzo Mercadante Alessandro Palmieri Paolo Verze Vincenzo Mirone Vincenzo Altieri Gianluigi Califano Giovanna Lucia Liguori Maria Strazzullo Amelia Cimmino Giovanna Del Pozzo Background: Many pseudogenes possess biological activities and...
Tue Mar 31, 2020 03:00
Biomedicines, Vol. 8, Pages 73: Progesterone-Calcitriol Combination Enhanced Cytotoxicity of Cisplatin in Ovarian and Endometrial Cancer Cells In Vitro Biomedicines doi: 10.3390/biomedicines8040073 Authors: Paucarmayta Taitz McGlorthan Casablanca Maxwell Darcy Syed : Initially, patients that respond to cisplatin (DDP) treatment later relapse and develop chemoresistance. Agents that enhance DDP effectiveness will have a significant impact on cancer treatment....
Tue Mar 31, 2020 03:00
Biomimetics, Vol. 5, Pages 13: Flow Interactions Between Low Aspect Ratio Hydrofoils in In-line and Staggered Arrangements Biomimetics doi: 10.3390/biomimetics5020013 Authors: Melike Kurt Azar Eslam Panah Keith W. Moored Many species of fish gather in dense collectives or schools where there are significant flow interactions from their shed wakes. Commonly, these swimmers shed a classic reverse von Kármán wake, however, schooling eels produce a bifurcated...
Tue Mar 31, 2020 03:00
Biomolecules, Vol. 10, Pages 531: Cleavage of the APE1 N-Terminal Domain in Acute Myeloid Leukemia Cells Is Associated with Proteasomal Activity Biomolecules doi: 10.3390/biom10040531 Authors: Lisa Lirussi Giulia Antoniali Pasqualina Liana Scognamiglio Daniela Marasco Emiliano Dalla Chiara D’Ambrosio Simona Arena Andrea Scaloni Gianluca Tell Apurinic/apyrimidinic endonuclease 1 (APE1), the main mammalian AP-endonuclease for the resolution of DNA damages through...
Tue Mar 31, 2020 03:00
Biomolecules, Vol. 10, Pages 530: Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer Biomolecules doi: 10.3390/biom10040530 Authors: Woong Sub Byun Won Kyung Kim Ji-seong Yoon Dnyandev B. Jarhad Lak Shin Jeong Sang Kook Lee Triple-negative breast cancer (TNBC) is among the most aggressive and potentially metastatic malignancies. Most affected patients have poor clinical outcomes...
Tue Mar 31, 2020 03:00
Biomolecules, Vol. 10, Pages 528: (20S)G-Rh2 Inhibits NF-κB Regulated Epithelial-Mesenchymal Transition by Targeting Annexin A2 Biomolecules doi: 10.3390/biom10040528 Authors: Yu-Shi Wang He Li Yang Li Shiyin Zhang Ying-Hua Jin (1) Background: Epithelial-mesenchymal transition (EMT) is an essential step for cancer metastasis; targeting EMT is an important path for cancer treatment and drug development. NF-κB, an important transcription factor, has been shown to...
Tue Mar 31, 2020 03:00
Biomolecules, Vol. 10, Pages 529: SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract Biomolecules doi: 10.3390/biom10040529 Authors: Andrea Floris Michael Mazarei Xi Yang Aaron Elias Robinson Jennifer Zhou Antonio Barberis Guy D’hallewin Emanuela Azara Ylenia Spissu Ainhoa Iglesias-Ara Sandro Orrù Maria Lauda Tomasi Existing therapeutic strategies for breast cancer are limited by tumor recurrence...
Tue Mar 31, 2020 03:00
Biomolecules, Vol. 10, Pages 526: Effect of Substrate Reduction Therapy in Comparison to Enzyme Replacement Therapy on Immune Aspects and Bone Involvement in Gaucher Disease Biomolecules doi: 10.3390/biom10040526 Authors: Renuka P. Limgala Ozlem Goker-Alpan Gaucher disease (GD) is caused by mutations in the GBA gene, leading to deficient activity of the lysosomal enzyme glucocerebrosidase. Among all the symptoms across various organ systems, bone disease is a major concern as it causes...
Tue Mar 31, 2020 03:00
Biomolecules, Vol. 10, Pages 527: Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II Biomolecules doi: 10.3390/biom10040527 Authors: Jacob Andring Jacob Combs Robert McKenna Carbonic anhydrase II (CAII) is a metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. In addition, CAII is attributed to other catalytic reactions, including esterase activity. Aspirin (acetyl-salicylic acid), an everyday over-the-counter drug, has both ester and carboxylic...
Tue Mar 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 203: Movidea: A Software Package for Automatic Video Analysis of Movements in Infants at Risk for Neurodevelopmental Disorders Brain Sciences doi: 10.3390/brainsci10040203 Authors: Baccinelli Bulgheroni Simonetti Fulceri Caruso Gila Scattoni Early detecting the presence of neurodevelopmental disorders plays an important role in the effectiveness of the treatment. In this paper, we present a novel tool to extract motion features...
Tue Mar 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 202: Syntactic Comprehension of Relative Clauses and Center Embedding Using Pseudowords Brain Sciences doi: 10.3390/brainsci10040202 Authors: Cheon Kim Yoon Nam Lee Jeon Relative clause (RC) formation and center embedding (CE) are two primary syntactic operations fundamental for creating and understanding complex sentences. Ample evidence from previous cross-linguistic studies has revealed several similarities and differences between...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 847: Lactotransferrin Downregulation Drives the Metastatic Progression in Clear Cell Renal Cell Carcinoma Cancers doi: 10.3390/cancers12040847 Authors: Chiu Hsu Chang Yang Chiu Lin : Clear cell renal cell carcinoma (ccRCC) is the main type of RCC, which is the most common type of malignant kidney tumor in adults. A subpopulation (>30%) of ccRCC patients develop metastasis; however, the molecular mechanism remains largely unknown. Here,...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 848: Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer Cancers doi: 10.3390/cancers12040848 Authors: Kutasovic McCart Reed Sokolova Lakhani Simpson : Breast cancer is a remarkably complex and diverse disease. Subtyping based on morphology, genomics, biomarkers and/or clinical parameters seeks to stratify optimal approaches for management, but it is clear that every breast cancer is fundamentally unique. Intra-tumour...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 846: Validation of an Automated Quantitative Digital Pathology Approach for Scoring TMEM, a Prognostic Biomarker for Metastasis Cancers doi: 10.3390/cancers12040846 Authors: Entenberg Oktay D’Alfonso Ginter Robinson Xue Rohan Sparano Jones Condeelis Metastasis causes ~90% of breast cancer mortality. However, standard prognostic tests based mostly on proliferation genes do not measure metastatic potential. Tumor MicroEnvironment...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 841: Discoidin Domain Receptor-1 (DDR1) is Involved in Angiolymphatic Invasion in Oral Cancer Cancers doi: 10.3390/cancers12040841 Authors: Chen Tsai Ko Lai Cheng Shiah Hsiao Chang Lin The discoidin domain receptor-1 (DDR1) is a non-integrin collagen receptor recently implicated in the collective cell migration of other cancer types. Previously, we identified an elevated expression of DDR1 in oral squamous cell carcinoma (OSCC)...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 844: Safety of Aflibercept in Metastatic Colorectal Cancer: A Literature Review and Expert Perspective on Clinical and Real-World Data Cancers doi: 10.3390/cancers12040844 Authors: Muro Salinardi Singh Macarulla : Background: Metastatic colorectal cancer (mCRC) represents a substantial health burden globally and an increasing challenge in Asian countries. Treatment options include chemotherapy plus a vascular endothelial growth factor (VEGF) inhibitor...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 845: Combination Treatment with Cold Physical Plasma and Pulsed Electric Fields Augments ROS Production and Cytotoxicity in Lymphoma Cancers doi: 10.3390/cancers12040845 Authors: Wolff Kolb Weltmann von Woedtke Bekeschus New approaches in oncotherapy rely on the combination of different treatments to enhance the efficacy of established monotherapies. Pulsed electric fields (PEFs) are an established method (electrochemotherapy) for enhancing cellular...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 842: Chimeric Antigen Receptor Cell Therapy: Overcoming Obstacles to Battle Cancer Cancers doi: 10.3390/cancers12040842 Authors: Petty Heyman Yang Chimeric antigen receptors (CAR) are fusion proteins engineered from antigen recognition, signaling, and costimulatory domains that can be used to reprogram T cells to specifically target tumor cells expressing specific antigens. Current CAR-T cell technology utilizes the patient’s own T cells to...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 843: Plasma and Tissue Specific miRNA Expression Pattern and Functional Analysis Associated to Colorectal Cancer Patients Cancers doi: 10.3390/cancers12040843 Authors: Cojocneanu Braicu Raduly Jurj Zanoaga Magdo Irimie Muresan Ionescu Grigorescu Berindan-Neagoe An increasing number of studies suggest the implication of microRNAs (miRNAs) in colorectal (CRC) carcinogenesis and disease progression. Nevertheless, the basic...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 839: Effectiveness and Costs Associated to Adding Cetuximab or Bevacizumab to Chemotherapy as Initial Treatment in Metastatic Colorectal Cancer: Results from the Observational FABIO Project Cancers doi: 10.3390/cancers12040839 Authors: Matteo Franchi Donatella Garau Ursula Kirchmayer Mirko Di Martino Marilena Romero Ilenia De Carlo Salvatore Scondotto Giovanni Corrao Evidence available on the effectiveness and costs of biological therapies...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 840: Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors Cancers doi: 10.3390/cancers12040840 Authors: Giuseppe Donato Ivan Presta Biagio Arcidiacono Marco F.M. Vismara Annalidia Donato Nastassia C. Garo Natalia Malara In the adult, many embryologic processes can be co-opted by during cancer progression. The mechanisms of divisions, migration, and the ability to escape immunity recognition linked...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 838: Immunomodulatory Molecules On Lung Cancer Stem Cells From Lymph Nodes Aspirates Cancers doi: 10.3390/cancers12040838 Authors: Agata Raniszewska Iwona Kwiecień Rafał Sokołowski Elżbieta Rutkowska Joanna Domagała-Kulawik Over the past decade, immune checkpoint inhibitors have revolutionized the treatment of non-small cell lung cancer (NSCLC). Unfortunately, not all patients benefit from PD-(L)1 blockade, yet, the PD-L1 tumor cell expression is the...
Tue Mar 31, 2020 03:00
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