Cancers, Vol. 12, Pages 837: The Inhibition of Wnt Restrain KRASG12V-Driven Metastasis in Non-Small-Cell Lung Cancer Cancers doi: 10.3390/cancers12040837 Authors: Pei-Shan Hung Ming-Hung Huang Yuan-Yeh Kuo James Chih-Hsin Yang The KRAS mutations have been an obstacle to identify therapeutic targets in cancer treatment. In this work, we clarified the distinct metastasis pattern of non-small-cell lung carcinoma (NSCLC) induced by KRASG12V/KRASG12D mutations and inhibited the KRASG12V...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 835: Therapy of Sporadic and NF2-Related Vestibular Schwannoma Cancers doi: 10.3390/cancers12040835 Authors: Longping Yao Mohammed Alahmari Yasin Temel Koos Hovinga Vestibular schwannoma (VS) is a benign primary brain tumor that occurs sporadic or as part of a genetic syndrome. The most common cause is the mutation of the NF2 tumor suppressor gene that is involved in the production of the protein merlin. Merlin plays a role in cell growth and cell adhesion....
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 834: External Validation of the Dutch SOURCE Survival Prediction Model in Belgian Metastatic Oesophageal and Gastric Cancer Patients Cancers doi: 10.3390/cancers12040834 Authors: J.J. van Kleef H.G. van den Boorn R.H.A. Verhoeven K. Vanschoenbeek A. Abu-Hanna A.H. Zwinderman M.A.G. Sprangers M.G.H. van Oijen H. De Schutter H.W.M. van Laarhoven The SOURCE prediction model predicts individualised survival conditional on various treatments...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 836: Preoperative Peak Oxygen Consumption: A Predictor of Survival in Resected Lung Cancer Cancers doi: 10.3390/cancers12040836 Authors: Joerg Lindenmann Nicole Fink-Neuboeck Melanie Fediuk Alfred Maier Gabor Kovacs Marija Balic Josef Smolle Freyja Maria Smolle-Juettner The peak oxygen consumption (VO2 peak) serves as a prognostic factor in cardio-respiratory diseases and plays an important role in cancer patients. The long-term prognostic...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 848: Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma Cells doi: 10.3390/cells9040848 Authors: Coazzoli Napoli Roux-Biejat Palma Moscheni Catalani Zecchini Conte Giovarelli Caccia Procacci Cervia Clementi Perrotta Melanoma is the most severe type of skin cancer. Its unique and heterogeneous metabolism, relying on both glycolysis and...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 847: Structural Similarity with Cholesterol Reveals Crucial Insights into Mechanisms Sustaining the Immunomodulatory Activity of the Mycotoxin Alternariol Cells doi: 10.3390/cells9040847 Authors: Del Favero Mayer Dellafiora Janker Niederstaetter Dall’Asta Gerner Marko The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 846: Role of Connexins 30, 36, and 43 in Brain Tumors, Neurodegenerative Diseases, and Neuroprotection Cells doi: 10.3390/cells9040846 Authors: Oscar F. Sánchez Andrea V. Rodríguez José M. Velasco-España Laura C. Murillo Jhon-Jairo Sutachan Sonia-Luz Albarracin Gap junction (GJ) channels and their connexins (Cxs) are complex proteins that have essential functions in cell communication processes in the central nervous system (CNS). Neurons, astrocytes,...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 849: Adipose Tissue and FoxO1: Bridging Physiology and Mechanisms Cells doi: 10.3390/cells9040849 Authors: Ioannilli Ciccarone Ciriolo Forkhead box O class proteins (FoxOs) are expressed nearly in all tissues and are involved in different functions such as energy metabolism, redox homeostasis, differentiation, and cell cycle arrest. The plasticity of FoxOs is demonstrated by post-translational modifications that determine diverse levels of transcriptional...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 845: Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection? Cells doi: 10.3390/cells9040845 Authors: Glenda M. Davison Heather L. Hendrickse Tandi E. Matsha The expression of blood group antigens varies across human populations and geographical regions due to natural selection and the influence of environment factors and disease. The red cell membrane is host to numerous surface antigens which are able to influence...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 843: The Cuprizone Model: Dos and Do Nots Cells doi: 10.3390/cells9040843 Authors: Jiangshan Zhan Teresa Mann Sarah Joost Newshan Behrangi Marcus Frank Markus Kipp Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options. During the last decade, the model...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 842: The Impact of Immunomodulatory Treatment on Kappa Free Light Chains as Biomarker in Neuroinflammation Cells doi: 10.3390/cells9040842 Authors: Franz Felix Konen Ulrich Wurster Torsten Witte Konstantin Fritz Jendretzky Stefan Gingele Hayrettin Tumani Kurt-Wolfram Sühs Martin Stangel Philipp Schwenkenbecher Thomas Skripuletz Background: Kappa free light chains (KFLC) are a promising new biomarker to detect neuroinflammation. Still, the...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 844: Lamin A/C Assembly Defects in LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery–Dreifuss Muscular Dystrophy Cells doi: 10.3390/cells9040844 Authors: Anne T. Bertrand Astrid Brull Feriel Azibani Louise Benarroch Khadija Chikhaoui Colin L. Stewart Ohad Medalia Rabah Ben Yaou Gisèle Bonne LMNA encodes for Lamin A/C, type V intermediate filaments that polymerize under the inner...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 840: The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice Cells doi: 10.3390/cells9040840 Authors: Mariyan J. Jeyarajah Gargi Jaju Bhattad Dendra M. Hillier Stephen J. Renaud Trophoblasts are the first cell type to be specified during embryogenesis, and they are essential for placental morphogenesis and function. Trophoblast stem (TS) cells are the progenitor cells for all trophoblast...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 841: The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson’s Disease Cells doi: 10.3390/cells9040841 Authors: Simoneide S. Titze-de-Almeida Cristina Soto-Sánchez Eduardo Fernandez James B. Koprich Jonathan M. Brotchie Ricardo Titze-de-Almeida MicroRNAs (miRNAs) are small double-stranded RNAs that exert a fine-tuning sequence-specific regulation of cell transcriptome. While one unique miRNA regulates hundreds of mRNAs, each...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 838: Involvement of Enteric Glia in Small Intestine Neuromuscular Dysfunction of Toll-Like Receptor 4-Deficient Mice Cells doi: 10.3390/cells9040838 Authors: Silvia Cerantola Valentina Caputi Ilaria Marsilio Manuela Ridolfi Sofia Faggin Michela Bistoletti Cristina Giaroni Maria Cecilia Giron Enteric glial cells (EGCs) influence nitric oxide (NO)− and adenosine diphosphate (ADP)− mediated signaling in the enteric nervous system (ENS). Since Toll-like...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 837: Role and Mechanisms of Mitophagy in Liver Diseases Cells doi: 10.3390/cells9040837 Authors: Xiaowen Ma Tara McKeen Jianhua Zhang Wen-Xing Ding The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy for damaged/excessive...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 839: Corticotropin-Releasing Factor Family: A Stress Hormone-Receptor System’s Emerging Role in Mediating Sex-Specific Signaling Cells doi: 10.3390/cells9040839 Authors: Lahari Vuppaladhadiam Cameron Ehsan Meghana Akkati Aditi Bhargava No organ in the body is impervious to the effects of stress, and a coordinated response from all organs is essential to deal with stressors. A dysregulated stress response that fails to bring systems back to homeostasis leads...
Tue Mar 31, 2020 03:00
Cells, Vol. 9, Pages 836: Characterization of Sialic Acid-Binding Immunoglobulin-Type Lectins in Fish Reveals Teleost-Specific Structures and Expression Patterns Cells doi: 10.3390/cells9040836 Authors: Kim F. Bornhöfft Joan Martorell Ribera Torsten Viergutz Marzia T. Venuto Ulrike Gimsa Sebastian P. Galuska Alexander Rebl The cellular glycocalyx of vertebrates is frequently decorated with sialic acid residues. These sialylated structures are recognized by sialic acid-binding...
Tue Mar 31, 2020 03:00
Chemosensors, Vol. 8, Pages 26: Silver Nanoparticles as Colorimetric Sensors for Water Pollutants Chemosensors doi: 10.3390/chemosensors8020026 Authors: Paolo Prosposito Luca Burratti Iole Venditti This review provides an up-to-date overview on silver nanoparticles-based materials suitable as optical sensors for water pollutants. The topic is really hot considering the implications for human health and environment due to water pollutants. In fact, the pollutants present in the...
Tue Mar 31, 2020 03:00
Diagnostics, Vol. 10, Pages 194: Key Stakeholders’ Perspectives on Implementation and Scale up of HIV Self-Testing in Rwanda Diagnostics doi: 10.3390/diagnostics10040194 Authors: Tafadzwa Dzinamarira Collins Kamanzi Tivani Phosa Mashamba-Thompson Introduction: The World Health Organisation recommends HIV self-testing as an alternative testing method to help reach underserved populations, such as men in sub-Saharan Africa. Successful implementation and scale-up of HIV self-testing...
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Diagnostics, Vol. 10, Pages 193: Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms Diagnostics doi: 10.3390/diagnostics10040193 Authors: Masahiko Ayaki Kazuno Negishi Motoko Kawashima Miki Uchino Minako Kaido Kazuo Tsubota Purpose: The reported signs and symptoms of dry eye (DE) have been discordant. This study evaluated risk factors of DE-related symptoms and signs to explore their association with patient demographics, focusing on the age factor. Methods:...
Tue Mar 31, 2020 03:00
Diversity, Vol. 12, Pages 133: Effects of Forest Composition and Disturbance on Arbuscular Mycorrhizae Spore Density, Arbuscular Mycorrhizae Root Colonization and Soil Carbon Stocks in a Dry Afromontane Forest in Northern Ethiopia Diversity doi: 10.3390/d12040133 Authors: Birhane Gebretsadik Taye Aynekulu Rannestad Norgrove We investigated arbuscular mycorrhizal fungi (AMF) spore density and root colonization in three distinct dry Afromontane forest plant communities,...
Tue Mar 31, 2020 03:00
Diversity, Vol. 12, Pages 132: Using ISSR Genomic Fingerprinting to Study the Genetic Differentiation of Artemia Leach, 1819 (Crustacea: Anostraca) from Iran and Neighbor Regions with the Focus on the Invasive American Artemia franciscana Diversity doi: 10.3390/d12040132 Authors: Amin Eimanifar Alireza Asem Pei-Zheng Wang Weidong Li Michael Wink Due to the rapid developments in the aquaculture industry, Artemia franciscana, originally an American species, has been introduced...
Tue Mar 31, 2020 03:00
Diversity, Vol. 12, Pages 131: Functional Diversity Effects of Vegetation on Runoff to Design Herbaceous Hedges for Sediment Retention Diversity doi: 10.3390/d12040131 Authors: Léa Kervroëdan Romain Armand Mathieu Saunier Michel-Pierre Faucon Background: Functional diversity effects on ecosystem processes, like on soil erosion, are not fully understood. Runoff and soil erosion in agricultural landscapes are reduced by the hydraulic roughness (HR) of vegetation patches, which...
Tue Mar 31, 2020 03:00
Environments, Vol. 7, Pages 26: Effect of Sinkholes on Groundwater Resources in Arid and Semi-Arid Karst Area in Abarkooh, Iran Environments doi: 10.3390/environments7040026 Authors: Božo Soldo Siamak Mahmoudi Sivand Ardalan Afrasiabian Bojan Đurin Despite protection measurements and their natural position, groundwater resources are very vulnerable due to natural and anthropogenic impacts. This is especially emphasized in karst arid and semi-arid zones, due to increased requirements...
Tue Mar 31, 2020 03:00
Environments, Vol. 7, Pages 25: Revised Estimation Method for Emissions from Automated Plunger Lift Liquid Unloadings Environments doi: 10.3390/environments7040025 Authors: Adam Pacsi David W. Sullivan David T. Allen A variety of liquid unloading techniques are used to clear accumulated liquids from the wellbore to increase production rates for oil and gas wells. Data from national measurement studies indicate that a small subset of wells with plunger lift assist, that vent with...
Tue Mar 31, 2020 03:00
Foods, Vol. 9, Pages 399: Facilitating Consumers Choice of Healthier Foods: A Comparison of Different Front-of-Package Labelling Schemes Using Slovenian Food Supply Database Foods doi: 10.3390/foods9040399 Authors: Pivk Kupirovič Hristov Hribar Lavriša Pravst Summary indicator front-of-package nutrition labelling schemes are gaining momentum. In Europe, an example of such a scheme is Nutri-Score, which was first introduced in France. Supported by additional research,...
Tue Mar 31, 2020 03:00
Foods, Vol. 9, Pages 397: Analysis of the Anthocyanin Degradation in Blue Honeysuckle Berry under Microwave Assisted Foam-Mat Drying Foods doi: 10.3390/foods9040397 Authors: Yu Sun Yuhan Zhang Wei Xu Xianzhe Zheng Changes in nutrient content and bioactivity are important indicators to evaluate the quality of products. Berries are rich in antioxidant anthocyanins, which are prone to degradation during drying. The effects of different variables on the stability of anthocyanins...
Tue Mar 31, 2020 03:00
Foods, Vol. 9, Pages 398: Comparison of Three Extraction Techniques for the Determination of Volatile Flavor Components in Broccoli Foods doi: 10.3390/foods9040398 Authors: Martyna Natalia Wieczorek Małgorzata Majcher Henryk Jeleń To analyze aroma active components in a food product, the crucial step is to select a suitable extraction technique. It should provide isolation of all components responsible for aroma creation, without the formation of any artifacts during the procedure....
Tue Mar 31, 2020 03:00
Foods, Vol. 9, Pages 396: Effects of Intrinsic and Extrinsic Visual Cues on Consumer Emotion and Purchase Intent: A Case of Ready-to-Eat Salad Foods doi: 10.3390/foods9040396 Authors: Pitchayapat Chonpracha Ryan Ardoin Yupeng Gao Pamarin Waimaleongora-ek Georgianna Tuuri Witoon Prinyawiwatkul With increasing demand for ready-to-eat (RTE) fresh vegetables, it is important to understand how visual information cues, both intrinsic and extrinsic, affect consumer perception...
Tue Mar 31, 2020 03:00
Healthcare, Vol. 8, Pages 81: Does Internet Use Affect Individuals’ Medical Service Satisfaction? Evidence from China Healthcare doi: 10.3390/healthcare8020081 Authors: Hu Liu Xiaomei Gong Jiaping Zhang Empirical evidence that combines traditional factors and information technology factors to predict public attitudes toward to medical services is inadequate. To fill this gap, this study investigates the impact of Internet use on people’s satisfaction with medical services...
Tue Mar 31, 2020 03:00
Humanities, Vol. 9, Pages 28: Oromo Orature: An Ecopoetic Approach, Theory and Practice (Oromia/Ethiopia, Northeast Africa) Humanities doi: 10.3390/h9020028 Authors: Dibaba Using available empirical data of Oromo Orature, particularly folksongs, obtained from the field through interview and observation in Oromia, central Ethiopia, in 2009 and 2010, and other sources in print, this study has two objectives to tackle. First, reflecting upon the questions of a native model of origin narratives...
Tue Mar 31, 2020 03:00
IJERPH, Vol. 17, Pages 2386: Analysis of the Academic Literature on Environmental Valuation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072386 Authors: Francisco Guijarro Prodromos Tsinaslanidis Environmental valuation refers to a variety of techniques to assign monetary values to environmental impacts, especially non-market impacts. It has experienced a steady growth in the number of publications on the subject in the last 30 years. We performed...
Tue Mar 31, 2020 03:00
IJERPH, Vol. 17, Pages 2387: Colorectal Polyp Prevalence According to Alcohol Consumption, Smoking and Obesity International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072387 Authors: Lee Kim This study aimed to analyze colorectal polyp prevalence associated with health behavior. Data from 1180 Korean men (young adult (YA), aged 40–49; middle age (MA) aged 50–59; old aged (OA), aged 60–79 years) were collected. Health behavior...
Tue Mar 31, 2020 03:00
IJERPH, Vol. 17, Pages 2384: Reliability and Validity of the Activity Diversity Questionnaire for Older Adults in Japan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072384 Authors: Takahashi Kawai Suzuki Fujiwara Watanabe Hirano Kim Ihara Ishii Oka Obuchi Recent research has suggested that the breadth and evenness of activity and activity diversity contribute to health outcomes among older adults. However,...
Tue Mar 31, 2020 03:00
IJERPH, Vol. 17, Pages 2385: Maintaining Preparedness to Severe Though Infrequent Threats—Can It Be Done? International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072385 Authors: Siman-Tov Davidson Adini Background: A mass casualty incident (MCI) caused by toxicological/chemical materials constitutes a potential though uncommon risk that may cause great devastation. Presentation of casualties exposed to such materials in hospitals, if not immediately...
Tue Mar 31, 2020 03:00
IJERPH, Vol. 17, Pages 2381: Impact of the COVID-19 Pandemic on Mental Health and Quality of Life among Local Residents in Liaoning Province, China: A Cross-Sectional Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072381 Authors: Yingfei Zhang Zheng Feei Ma Our study aimed to investigate the immediate impact of the COVID-19 pandemic on mental health and quality of life among local Chinese residents aged ≥18 years in Liaoning Province,...
Tue Mar 31, 2020 03:00
IJERPH, Vol. 17, Pages 2382: Epidemiological Characteristics and Spatiotemporal Trend Analysis of Human Brucellosis in China, 1950–2018 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072382 Authors: Yang Zhang Wang Zhao Zhang Hu Han Hu Luo Li Zhao Li Wang Zhen The rate of brucellosis, a zoonotic disease, has rapidly increased in humans brucellosis(HB) in recent years. In 1950–2018,...
Tue Mar 31, 2020 03:00
IJERPH, Vol. 17, Pages 2383: Entrepreneurial, Economic, and Social Well-Being Outcomes from an RCT of a Youth Entrepreneurship Education Intervention among Native American Adolescents International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072383 Authors: Tingey Larzelere Goklish Rosenstock Mayo-Wilson Pablo Goklish Grass Sprengeler Parker Ingalls Craig Barlow Background: Entrepreneurship education has demonstrated...
Tue Mar 31, 2020 03:00
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