Abstract DNA double‐strand break (DSB) is a serious type of DNA damage and is known to trigger multiple responses within cells. In the responses, novel relationships among DSB, DSB repair and transcription machineries are created. First, transcription is repressed if DSB occurs near or at the transcription site, termed DSB‐induced transcriptional repression, which contributes to DSB repair with the aid of DNA damage‐signaling pathways, ATM‐ or DNA‐PKcs‐signaling pathway. DSB‐induced transcriptional...
5h
Summary Tumor‐infiltrating immune cells play a crucial role in tumor progression and response to treatment. However, limited studies on infiltrating immune cells have shown inconsistent and even controversial results in osteosarcoma (OS). In addition, the dynamic changes of infiltrating immune cells after neoadjuvant chemotherapy are largely unknown. We downloaded the RNA expression matrix and clinical information of 80 osteosarcoma patients from the TARGET database. CIBERSORT was used to evaluate...
21h
Abstract Alternative polyadenylation (APA), which induces shortening of the 3'UTR, is emerging as an important feature in cancer development and progression. Nevertheless, the effects and mechanisms of APA‐induced 3'UTR shortening in nasopharyngeal carcinoma (NPC) remain largely unclear. Fibronectin type III domain containing 3B (FNDC3B) tended to use proximal polyadenylation site and produce shorter 3'UTR according to our previous sequencing study. Herein, we found that FNDC3B with shorter 3'UTR...
21h
Abstract Sunitinib, a muiti‐targeted receptor tyrosine kinase inhibitor including vascular endothelial growth factor, has been widely used as a first‐line treatment against metastatic renal cell carcinoma (mRCC). However, mRCC often acquires resistance to sunitinib, rendering it difficult to treat with this agent. Recently, Rapalink‐1, a drug that links rapamycin and the mTOR kinase inhibitor MLN0128, has been developed with excellent therapeutic effects against breast cancer cells carrying mTOR...
21h
Abstract Background This study mainly focus on hearing loss pattern in CSOM patients undergoing tympanoplasty surgery or tympanomastoidectomy pre-operatively and analysis of the outcome of the surgery in terms of improvement in hearing (air-bone gap) after 3 months of the surgery. Methodology All patients of age 15–65 years reporting to ENT OPD with...
6h
Earlier work in our lab identified a spontaneous mutant (likesunnsupernodulator-lss) in Medicago truncatula, resulting in increased nodulation. Molecular genetic evidence indicated the phenotype was due to an unk...
6h
Emergency laparotomy and other high-risk acute abdominal surgery procedures have a high mortality rate. The perioperative management of these patients is complex and poses several challenges. The objective of ...
6h
The rapidly expanding body of knowledge about the roles of genomics and the immune system in cancer has enabled the development of therapies targeted to specific molecular alterations or other biologic characteristics, such as those implicated in immune suppression. However, genomics has also revealed a complicated reality about malignancies that requires a major shift in the therapy paradigm: away from tumor type-centered and toward gene-directed, histology-agnostic treatment, which is individualized...
6h
Abstract Three‐dimensional (3D) printing has had an evolving role in cardiology, although has been largely reserved for planning of structural heart disease interventions. We present a case whereby multimodality imaging, including 3D printing, played a pivotal role in planning a technically feasible approach for complex percutaneous coronary intervention of a chronically occluded anomalous right coronary artery, with creation of a customized guide catheter.
6h
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
6h
Erythrosine‐11‐dUTP is synthesized, incorporated into the genomic DNA of E. coli, and proved as a label for correlative microscopy. Newly synthesized DNA in an ice‐embedded cell is visualized by Hilbert differential contrast transmission electron microscopy. Abstract The fluorescent metabolic labeling of microorganisms genome is an advanced imaging technique to observe and study the native shapes, structural changes, functions, and tracking of nucleic acids in single cells or tissues....
7h
Under intraoral conditions and with acidulated fluoride solutions, corrosion behaviour of orthodontic nickel–titanium archwires was modified. They also increased surface roughness. Abstract This study was undertaken to assess in vivo the corrosion in two commercial nickel–titanium (NiTi) orthodontic archwires removed from the oral cavity of patients using fluoride mouthwashes. Five volunteers took part in this study on the corrosion behavior of two brands of NiTi archwires (3M and AO (brand...
7h
Anatomical study of leaf xylary vessel elements of Carthamus oxycantha under lead (Pb) and nickel (Ni) stress was conducted. The deformations caused due to metals stress were detected using point‐based nonrigid image registration technique. The 3DWarpDx (an algorithm based software technique) was applied to compare microscopic images of stressed and unstressed vessels. The technique determined the soft deformable anatomical distortion in structure of the stressed vessels. We noted large deformation...
7h
7h
Abstract This study was conducted to examine students’ performance in paper-based and online-based tests. In the context of the study, students’ performances were considered in the General Physics course between 2014 and 2015 and 2018–2019 academic years. The participants of this study are 417 students of Engineering and Science faculties at a public university of Kyrgyz Republic. Students’ achievement scores in paper-based and online-based tests were obtained and appropriate statistical...
7h
Abstract Emergence of the use and application of Artificial Intelligence (AI) in higher education in India has opened new possibilities and challenges. Use of AI in will bring in effective change of governance in the entire internal architecture of Indian Institutes of higher education. The prospect of use of AI includes investigation of educational implications as to how teachers would enrich them, how students would learn, and how accurate and prompt decisions can be taken in...
9h
Abstract The study was aimed at identifying the potentials of and barriers to the Smart School Project (SSP). Through the use of a mixed methods design, data were garnered from 746 school teachers, principals, and information technology experts, semi-structured interviews with 21 key informants and two researcher-designed questionnaires on the potentials of and barriers to SSP. The qualitative data were analyzed using three-stage coding and quantitative data were analyzed using...
13h
Abstract Google Classroom (GC) has provided affordances for blended learning in higher education. Given this, most institutions, including Malaysian higher educational institutions, are adopting this learning management system (LMS) technology for supporting out of classroom pedagogical. Even though quantitative evidence exists to confirm the usefulness of GC usage, there is the need to also have qualitative narratives from students and instructors to obtain details on actual experiences....
21h
Deep convolutional neural network (DCNN) has shown great success in various medical image segmentation tasks, including organ-at-risk (OAR) segmentation from computed tomography (CT) images. However, most studies use the dataset from the same source(s) for training and testing so that the ability of a trained DCNN to generalize to a different dataset is not well studied, as well as the strategy to address the issue of performance drop on a different dataset. In this study we investigated...
7h
We employed an integrative strategy to present subtractive and comparative metabolic and genomic-based findings of therapeutic targets against Streptococcus parauberis. For the first time, we not only identified potential targets based on genomic and proteomic database analyses but also recommend a new antimicrobial drug for the treatment of olive flounder (Paralichthys olivaceus) infected with S. parauberis. To do that, 102 total annotated metabolic pathways of this bacterial strain were extracted...
7h
Aim. Intermittent positive pressure ventilation (IPPV) can adversely affect cardiopulmonary resuscitation outcomes by increasing the intrathoracic pressure. Continuous flow insufflation of oxygen (CFIO) has been investigated as a potential alternative, but evidence supporting its superiority over intermittent positive pressure ventilation in cases of cardiac arrest is scant. The aim of the current study was to compare the effects of continuous flow insufflation of oxygen using a one-way valve during...
7h
A 25-year-old male presented after a motor vehicle accident with tricuspid valve (TV) regurgitation, due to a flail TV secondary to papillary muscle rupture. We highlight the importance of three-dimensional echocardiographic imaging of the tricuspid valve and its utility in aiding a successful surgical repair.
7h
Objective. To explore the status of electroacupuncture (EA) among other treatments for peripheral facial paralysis (PFP). Methods. Randomized controlled trials comparing EA with other treatments that met the eligibility criteria published in databases were included. The differences were observed and quantified through the risk ratio (RR) for dichotomous outcomes and the standardized mean difference (SMD) for continuous outcomes. Then, their 95% confidence intervals (CI) were recorded. Results. Twenty-three...
7h
Atherosclerosis (AS) is a complex and chronic inflammatory disease that occurs in multiple systems of the human body. It is an important pathological basis for a variety of diseases and a serious threat to human health. So far, many theories have been formed to explain the pathogenesis of atherosclerosis, among which “inflammation theory” has gradually become a research focus. This theory presents that inflammatory response runs through the whole progress of AS, inflammatory cells play as the main...
7h
In our research, a straightforward UPLC-MS/MS method, with diazepam as the internal standard (IS), was proposed and acknowledged to determine the concentrations of enasidenib in rat plasma. When preparing the sample, we used acetonitrile for protein precipitation. The gradient elution method was used, and the mobile phase was acetonitrile and 0.1% formic acid. Diazepam was used as the IS. We used the Acquity UPLC BEH C18 column to separate enasidenib and IS. Under the positive ion electrospray ionization...
7h
Identification of nitrate sources is important for the management of rivers. In this study, stable isotopes (δ15N and δ18O) and a Bayesian model (stable isotope analysis in R, SIAR) were applied to identify nitrate sources and estimate the proportional contributions of multiple nitrate sources in the upstream of Fenhe River Reservoir that serves as a source of drinking water in Shanxi Province of North China. The results showed that the 86.4% of total nitrogen (TN) concentrations in the water samples...
7h
The application of an organically modified montmorillonite nanoreactor in the reactive extrusion process of the free radical grafting of maleic anhydride onto polypropylene (PP) can increase the MAH grafting degree on the PP. The mechanism of grafting was studied by using transmission electron microscopy and high temperature gel permeation chromatography. It was found that both the strong interactions between MAH and MMT surface and the encapsulation effect of active species confined in o-MMT improved...
7h
7h
Recent efforts have been made to develop hot-air-dried chips as a value-added product for persimmon fruit (Diospyros kaki). However, the long-term quality of this product and its dependence on processing conditions and packaging type have not yet been explored. Hence, in this work, chips were prepared from “Hachiya” persimmon fruit in 2 ways: 2 mm thickness fruit slices, hot-air-dried for 5 hours (Preparation 2–5), and 6 mm slices, dried for 10 hours (Preparation 6–10). The dried chips were then...
7h
The essential nutrients of 23 wild hazelnuts (Corylus heterophylla) grown in northeast China were analyzed in order to sieve good species and study the factors effected on nut quality. Hazelnut kernels contained 45.76–62.78% fat similar to Corylus avellana and main fatty acids were oleic acid (79.75%), linoleic acid (15.42%), palmitic acid (3.29%), and polyunsaturated fatty acids ranged between 10.37% and 25.88%. Average protein, soluble sugar, starch, and ash contents of hazelnut kernels were 25.12%,...
7h
Worldwide hypertension (HT) guidelines recommend use of home blood pressure monitoring (HBPM) in patients with persistent suboptimal blood pressure (BP) readings. It is not clear how patients with limited health literacy could perform HBPM to assist BP control. This study aimed at finding the association between HBPM and patients from lower socioeconomic classes, particularly on the effect of health literacy or educational level. Three electronic databases (MEDLINE, EMBASE, and PubMed) were searched...
7h
The locus coeruleus (LC) is closely linked with cardiovascular disease. However, whether it mediates the alleviating effect of electroacupuncture (EA) on acute myocardial ischemia (AMI) remains unclear. A rat model of myocardial ischemia was established through occlusion of the left anterior descending coronary artery. Multichannel in vivo recording and other techniques were used to assess neurons in the LC, norepinephrine (NE) and dopamine (DA) levels in central and myocardial tissue, serum levels...
7h
The old adage says, “you are what you eat.” And although it is a banality repeated by many with a grain of salt, it also has quite a bit of truth in it, as the products we eat have a considerable impact on our health. Unfortunately, humanity is eating worse from one year to another, both in terms of product quality and eating habits. At the same time, it is brought up frequently that plant products should form the basis of our diet. This issue was also reflected in the new version of the food pyramid....
7h
Eosinophilic colitis is an inflammatory condition in which the wall of the colon becomes infiltrated by eosinophils which stain densely pink on microscopy. It is an uncommon clinical entity which has a long list of differential diagnoses. We present a case of a patient whose biopsy at colonoscopy revealed eosinophilic colitis which led to a delay in the diagnosis and subsequent treatment of colon cancer. A 35-year-old male presented with a six-week history of right lower quadrant abdominal pain associated...
7h
Contrast-induced acute kidney injury (CI-AKI) is the third common cause of acute kidney injury (AKI), which is associated with poor short- and long-term outcomes. Currently, effective therapy strategy for CI-AKI remains lacking. Stanniocalcin-1 (STC1) is a conserved glycoprotein with antiapoptosis and anti-inflammatory functions, but the role of STC1 in controlling CI-AKI is unknown. Here, we demonstrated a protective role of STC1 in contrast-induced injury in cultured renal tubular epithelial cells...
7h
Context. Croton macrostachyus Hochst. ex Delile (Euphorbiaceae) has been used in traditional medicine to manage heart failure and other heart diseases in Ethiopia. Objective. To evaluate the antioxidant and cardioprotective activities of stem bark extract and solvent fractions of Croton macrostachyus on cyclophosphamide-induced cardiotoxicity in rats. Materials and Methods. DPPH free radical scavenging assay method was used to determine antioxidant activity whereas Sprague-Dawley rats were used to...
7h
Objective. To evaluate the adjuvant effects of health education of Chinese medicine (HECM) for patients with three types of common noncommunicable diseases (NCD-hypertension, diabetes, and coronary heart disease (CHD)). Methods. The protocol of this review was registered in the PROSPERO website (CRD42017058325). Six databases were searched till Sep. 30, 2019. Randomized controlled trials (RCTs) comparing HECM plus conventional therapy with conventional therapy were retrieved. Participants were diagnosed...
7h
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