Τρίτη 31 Μαρτίου 2020

Cancers, Vol. 12, Pages 835: Therapy of Sporadic and NF2-Related Vestibular Schwannoma

Cancers, Vol. 12, Pages 835: Therapy of Sporadic and NF2-Related Vestibular Schwannoma:

Cancers, Vol. 12, Pages 835: Therapy of Sporadic and NF2-Related Vestibular Schwannoma

Cancers doi: 10.3390/cancers12040835

Authors:
Longping Yao
Mohammed Alahmari
Yasin Temel
Koos Hovinga


Vestibular schwannoma (VS) is a benign primary brain tumor that occurs sporadic or as part of a genetic syndrome. The most common cause is the mutation of the NF2 tumor suppressor gene that is involved in the production of the protein merlin. Merlin plays a role in cell growth and cell adhesion. In patients with NF2, the VSs arise bilaterally and coincide with other brain tumors. In sporadic VS, the tumor is typically unilateral and does not coincide in combination with other tumors. MRI is the standard imaging technique and can be used to assess the size and aspect of the tumor as well as the progression of disease. The preferred management of large VS in both VS types is surgery with or without adjuvant radiation. The management for the medium- or small-sized VS includes wait and scan, radiotherapy and/or surgery. This choice depends on the preference of the patient and institutional protocols. The outcomes of surgical and radiotherapy treatments are improving due to progress in surgical equipment/approaches, advances in radiation delivery techniques and dose optimizations protocols. The main purpose of the management of VS is preserving function as long as possible in combination with tumor control.

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