IJMS, Vol. 21, Pages 3047: The Serine Protease Autotransporters TagB, TagC, and Sha from Extraintestinal Pathogenic Escherichia coli Are Internalized by Human Bladder Epithelial Cells and Cause Actin Cytoskeletal Disruption International Journal of Molecular Sciences doi: 10.3390/ijms21093047 Authors: Pokharel Díaz Bessaiah Houle Guerrero-Barrera Dozois TagB, TagC (tandem autotransporter genes B and C), and Sha (Serine-protease hemagglutinin autotransporter) are...
Sun Apr 26, 2020 03:00
IJMS, Vol. 21, Pages 3045: High Expression of miR-34a Associated with Less Aggressive Cancer Biology but Not with Survival in Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21093045 Authors: Yoshihisa Tokumaru Eriko Katsuta Masanori Oshi Judith C. Sporn Li Yan Lan Le Nobuhisa Matsuhashi Manabu Futamura Yukihiro Akao Kazuhiro Yoshida Kazuaki Takabe Most breast cancer (BC) patients succumb to metastatic disease. MiR-34a is a well-known...
Sun Apr 26, 2020 03:00
IJMS, Vol. 21, Pages 3044: Airway Microbiota as a Modulator of Lung Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21093044 Authors: Goto Recent research on cancer-associated microbial communities has elucidated the interplay between bacteria, immune cells, and tumor cells; the bacterial pathways involved in the induction of carcinogenesis; and their clinical significance. Although accumulating evidence shows that a dysbiotic condition is associated with lung carcinogenesis,...
Sun Apr 26, 2020 03:00
IJMS, Vol. 21, Pages 3043: Evaluation of Droplet Digital Polymerase Chain Reaction (ddPCR) for the Absolute Quantification of Aspergillus Species in the Human Airway International Journal of Molecular Sciences doi: 10.3390/ijms21093043 Authors: Poh Ali Chan Tiew Chotirmall Background: Prior studies illustrate the presence and clinical importance of detecting Aspergillus species in the airways of patients with chronic respiratory disease. Despite this, a low fungal biomass...
Sun Apr 26, 2020 03:00
IJMS, Vol. 21, Pages 3041: Inhibition of RNA Helicase Activity Prevents Coxsackievirus B3-Induced Myocarditis in Human iPS Cardiomyocytes International Journal of Molecular Sciences doi: 10.3390/ijms21093041 Authors: Yun Shin Ju Lee Lim Jeon Aims: Coxsackievirus B3 (CVB3) is known to be an important cause of myocarditis and dilated cardiomyopathy. Enterovirus-2C (E2C) is a viral RNA helicase. It inhibits host protein synthesis. Based on these facts, we hypothesize...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3040: Genetic Dissection of Hypertrophic Cardiomyopathy with Myocardial RNA-Seq
IJMS, Vol. 21, Pages 3040: Genetic Dissection of Hypertrophic Cardiomyopathy with Myocardial RNA-Seq International Journal of Molecular Sciences doi: 10.3390/ijms21093040 Authors: Gao Collyer Wang Sun Xu Hypertrophic cardiomyopathy (HCM) is an inherited disorder of the myocardium, and pathogenic mutations in the sarcomere genes myosin heavy chain 7 (MYH7) and myosin-binding protein C (MYBPC3) explain 60%–70% of observed clinical cases. The heterogeneity of...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3042: The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep International Journal of Molecular Sciences doi: 10.3390/ijms21093042 Authors: Dhillon Wassink Lear Davidson Holford Gunn Bennet High-dose human recombinant erythropoietin (rEPO) is a promising potential neuroprotective treatment in preterm and full-term neonates...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3038: CRISPR/Cas Derivatives as Novel Gene Modulating Tools: Possibilities and In Vivo Applications International Journal of Molecular Sciences doi: 10.3390/ijms21093038 Authors: Xu Hulshoff Tan Zeisberg Zeisberg The field of genome editing started with the discovery of meganucleases (e.g., the LAGLIDADG family of homing endonucleases) in yeast. After the discovery of transcription activator-like effector nucleases and zinc finger nucleases, the...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3037: A Comprehensive Proteomic and Phosphoproteomic Analysis of Retinal Pigment Epithelium Reveals Multiple Pathway Alterations in Response to the Inflammatory Stimuli International Journal of Molecular Sciences doi: 10.3390/ijms21093037 Authors: Song Han Lee Kim Cho Park Seok Overwhelming and persistent inflammation of retinal pigment epithelium (RPE) induces destructive changes in the retinal environment. However, the precise mechanisms...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3039: Gender Differences in Developing Biomarker-Based Major Depressive Disorder Diagnostics International Journal of Molecular Sciences doi: 10.3390/ijms21093039 Authors: Jentsch Burger Meddens Beijers van den Heuvel Meddens Schoevers The identification of biomarkers associated with major depressive disorder (MDD) holds great promise to develop an objective laboratory test. However, current biomarkers lack discriminative power due to the...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3036: Cracking the Monoubiquitin Code of Genetic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21093036 Authors: Sewduth Baietti Sablina Ubiquitination is a versatile and dynamic post-translational modification in which single ubiquitin molecules or polyubiquitin chains are attached to target proteins, giving rise to mono- or poly-ubiquitination, respectively. The majority of research in the ubiquitin field focused on degradative...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3035: Heterogeneity of Integrin αIIbβ3 Function in Pediatric Immune Thrombocytopenia Revealed by Continuous Flow Cytometry Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21093035 Authors: Martyanov Morozova Sorokina Filkova Fedorova Uzueva Suntsova Novichkova Zharkov Panteleev Sveshnikova Immune thrombocytopenia (ITP) is an autoimmune condition primarily induced by the loss of immune tolerance to the...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3034: Optimization of a High-Throughput 384-Well Plate-Based Screening Platform with Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 15442 Biofilms International Journal of Molecular Sciences doi: 10.3390/ijms21093034 Authors: Shella Gilbert-Girard Kirsi Savijoki Jari Yli-Kauhaluoma Adyary Fallarero In recent years, bacterial infections have become a main concern following the spread of antimicrobial resistance. In addition, bacterial biofilms...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3032: Structural Changes in Hippocampal Subfields in Patients with Continuous Remission of Drug-Naive Major Depressive Disorder International Journal of Molecular Sciences doi: 10.3390/ijms21093032 Authors: Asuka Katsuki Keita Watanabe LeHoa Nguyen Yuka Otsuka Ryohei Igata Atsuko Ikenouchi Shingo Kakeda Yukunori Korogi Reiji Yoshimura Objective: Hippocampal volume is reduced in patients with major depressive disorder (MDD) compared with healthy...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3033: The Effects of Human BDH2 on the Cell Cycle, Differentiation, and Apoptosis and Associations with Leukemia Transformation in Myelodysplastic Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms21093033 Authors: Wen-Chi Yang Sheng-Fung Lin Shu-Chen Wang Wan-Chi Tsai Chun-Chieh Wu Shih-Chi Wu Iron overload is related to leukemia transformation in myelodysplastic syndrome (MDS) patients. Siderophores help to transport iron. Type...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3030: Psychiatric Disorders and lncRNAs: A Synaptic Match International Journal of Molecular Sciences doi: 10.3390/ijms21093030 Authors: Francesco Rusconi Elena Battaglioli Marco Venturin Psychiatric disorders represent a heterogeneous class of multifactorial mental diseases whose origin entails a pathogenic integration of genetic and environmental influences. Incidence of these pathologies is dangerously high, as more than 20% of the Western population is...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3031: The Impact of Spaceflight and Simulated Microgravity on Cell Adhesion International Journal of Molecular Sciences doi: 10.3390/ijms21093031 Authors: Xiao Lin Kewen Zhang Daixu Wei Ye Tian Yongguang Gao Zhihao Chen Airong Qian Microgravity induces a number of significant physiological changes in the cardiovascular, nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell adhesion properties are one aspect affected...
Sat Apr 25, 2020 03:00
IJMS, Vol. 21, Pages 3029: Elimination of Viroids from Tobacco Pollen Involves a Decrease in Propagation Rate and an Increase of the Degradation Processes International Journal of Molecular Sciences doi: 10.3390/ijms21083029 Authors: Jaroslav Matoušek Lenka Steinbachová Lenka Záveská Drábková Tomáš Kocábek David Potěšil Ajay Kumar Mishra David Honys Gerhard Steger Some viroids—single-stranded, non-coding, circular RNA parasites of plants—are not...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3027: Increased Protein S-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON) International Journal of Molecular Sciences doi: 10.3390/ijms21083027 Authors: Lei Zhou James Chun Yip Chan Stephanie Chupin Naig Gueguen Valérie Desquiret-Dumas Siew Kwan Koh Jianguo Li Yan Gao Lu Deng Chandra Verma Roger W Beuerman Eric Chun Yong Chan Dan Milea Pascal Reynier Leber’s hereditary optic neuropathy (LHON, MIM#535000)...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3028: Promiscuous Roles of Autophagy and Proteasome in Neurodegenerative Proteinopathies International Journal of Molecular Sciences doi: 10.3390/ijms21083028 Authors: Fiona Limanaqi Francesca Biagioni Stefano Gambardella Pietro Familiari Alessandro Frati Francesco Fornai Alterations in autophagy and the ubiquitin proteasome system (UPS) are commonly implicated in protein aggregation and toxicity which manifest in a number of neurological disorders....
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3025: Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia—A Retrospective Analysis in 337 Patients International Journal of Molecular Sciences doi: 10.3390/ijms21083025 Authors: Klaus Geissler Eva Jäger Agnes Barna Michael Gurbisz Temeida Graf Elmir Graf Thomas Nösslinger Michael Pfeilstöcker Heinz Tüchler Thamer Sliwa Felix Keil Christoph Geissler...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3024: Potential Use of Extracellular Vesicles Generated by Microbubble-Assisted Ultrasound as Drug Nanocarriers for Cancer Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21083024 Authors: Yuana Balachandran Wurff-Jacobs Schiffelers Moonen Extracellular vesicles (EVs)-carrying biomolecules derived from parental cells have achieved substantial scientific interest for their potential use as drug nanocarriers. Ultrasound (US)...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3026: The Anti-Inflammatory and Antioxidant Effects of Sodium Propionate International Journal of Molecular Sciences doi: 10.3390/ijms21083026 Authors: Alessia Filippone Marika Lanza Michela Campolo Giovanna Casili Irene Paterniti Salvatore Cuzzocrea Emanuela Esposito The major end-products of dietary fiber fermentation by gut microbiota are the short-chain fatty acids (SCFAs) acetate, propionate, and butyrate, which have been shown to modulate...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3022: Role of Bone Targeting Agents in the Prevention of Bone Metastases from Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21083022 Authors: Stella D’Oronzo Erica Silvestris Angelo Paradiso Mauro Cives Marco Tucci Breast cancer (BC) is the most common malignancy in women worldwide and leads, in more than 70% of patients with advanced disease, to skeleton colonization and formation of bone metastases (BM). This condition implies...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3015: Genome-Scale Analysis of Homologous Genes among Subgenomes of Bread Wheat (Triticum aestivum L.) International Journal of Molecular Sciences doi: 10.3390/ijms21083015 Authors: Caie Zhou Zhaonian Dong Ting Zhang Jianhui Wu Shizhou Yu Qingdong Zeng Dejun Han Wei Tong Determining the distribution and correspondence of genome-scale homologous genes in wheat are effective ways to uncover chromosome rearrangement that has occurred during crop...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3018: CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets International Journal of Molecular Sciences doi: 10.3390/ijms21083018 Authors: Jordan L Kohlmeyer David J Gordon Munir R Tanas Varun Monga Rebecca D Dodd Dawn E Quelle Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology. Recent work suggests cyclin-dependent kinase (CDK)...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3023: The Dichotomic Role of Macrophage Migration Inhibitory Factor in Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21083023 Authors: Maria Sofia Basile Giuseppe Battaglia Valeria Bruno Katia Mangano Paolo Fagone Maria Cristina Petralia Ferdinando Nicoletti Eugenio Cavalli Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine expressed by different cell types and exerting multiple biological...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3021: The EDCMET Project: Metabolic Effects of Endocrine Disruptors International Journal of Molecular Sciences doi: 10.3390/ijms21083021 Authors: Jenni Küblbeck Taina Vuorio Jonna Niskanen Vittorio Fortino Albert Braeuning Khaled Abass Arja Rautio Jukka Hakkola Paavo Honkakoski Anna-Liisa Levonen Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3016: The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside International Journal of Molecular Sciences doi: 10.3390/ijms21083016 Authors: Michał Ciebiera Marta Włodarczyk Stanisław Zgliczyński Tomasz Łoziński Klaudia Walczak Artur Czekierdowski Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. Their prevalence usually is estimated at 30–40%, but may reach up...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3020: Thermogenesis in Adipose Tissue Activated by Thyroid Hormone International Journal of Molecular Sciences doi: 10.3390/ijms21083020 Authors: Winifred W. Yau Paul M. Yen Thermogenesis is the production of heat that occurs in all warm-blooded animals. During cold exposure, there is obligatory thermogenesis derived from body metabolism as well as adaptive thermogenesis through shivering and non-shivering mechanisms. The latter mainly occurs in brown adipose...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3019: Wood Architecture and Composition Are Deeply Remodeled in Frost Sensitive Eucalyptus Overexpressing CBF/DREB1 Transcription Factors International Journal of Molecular Sciences doi: 10.3390/ijms21083019 Authors: Phi Bang Cao Raphaël Ployet Chien Nguyen Annabelle Dupas Nathalie Ladouce Yves Martinez Jacqueline Grima-Pettenati Christiane Marque Fabien Mounet Chantal Teulières Eucalypts are the most planted trees worldwide, but most of...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3017: Sweet Cherry (Prunus avium L.) PaPIP1;4 Is a Functional Aquaporin Upregulated by Pre-Harvest Calcium Treatments that Prevent Cracking International Journal of Molecular Sciences doi: 10.3390/ijms21083017 Authors: Richard Breia Andreia F. Mósca Artur Conde Sofia Correia Carlos Conde Henrique Noronha Graça Soveral Berta Gonçalves Hernâni Gerós The involvement of aquaporins in rain-induced sweet cherry (Prunus avium L.) fruit cracking is...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3007: Deubiquitinase MYSM1 in the Hematopoietic System and beyond: A Current Review International Journal of Molecular Sciences doi: 10.3390/ijms21083007 Authors: Amanda Fiore Yue Liang Yun Hsiao Lin Jacky Tung HanChen Wang David Langlais Anastasia Nijnik MYSM1 has emerged as an important regulator of hematopoietic stem cell function, blood cell production, immune response, and other aspects of mammalian physiology. It is a metalloprotease family...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3013: Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21083013 Authors: Srinivasan Chinnapaiyan Rajib Kumar Dutta Dinesh Devadoss Hitendra S Chand Irfan Rahman Hoshang Jehangir Unwalla Circadian oscillations are regulated at both central and peripheral levels to maintain physiological homeostasis. The central circadian clock consists of a central pacemaker in the suprachiasmatic...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3014: HMGA1-Regulating microRNAs Let-7a and miR-26a are Downregulated in Human Seminomas International Journal of Molecular Sciences doi: 10.3390/ijms21083014 Authors: Marco De Martino Francesco Esposito Simona Pellecchia Ricardo Cortez Cardoso Penha Gerardo Botti Alfredo Fusco Paolo Chieffi Background: Recent studies have underlined HMGA protein’s key role in the onset of testicular germ cell tumors, where HMGA1 is differently expressed...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3008: Fear Learning Enhances Prefrontal Cortical Suppression of Auditory Thalamic Inputs to the Amygdala in Adults, but Not Adolescents International Journal of Molecular Sciences doi: 10.3390/ijms21083008 Authors: Nicole C. Ferrara Eliska Mrackova Maxine K. Loh Mallika Padival J. Amiel Rosenkranz Adolescence is characterized by increased susceptibility to the development of fear- and anxiety-related disorders. Adolescents also show elevated fear responding...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3012: FGCaMP7, an Improved Version of Fungi-Based Ratiometric Calcium Indicator for In Vivo Visualization of Neuronal Activity International Journal of Molecular Sciences doi: 10.3390/ijms21083012 Authors: Barykina Sotskov Gruzdeva Wu Portugues Subach Chefanova Plusnin Ivashkina Anokhin Vlaskina Korzhenevskiy Nikolaeva Boyko Rakitina Varizhuk Pozmogova Subach Genetically encoded calcium indicators...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3011: MfPIF1 of Resurrection Plant Myrothamnus flabellifolia Plays a Positive Regulatory Role in Responding to Drought and Salinity Stresses in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21083011 Authors: Jia-Rui Qiu Xiang-Ying Xiang Jia-Tong Wang Wen-Xin Xu Jia Chen Yao Xiao Cai-Zhong Jiang Zhuo Huang Phytochrome-interacting factors (PIFs), a subfamily of basic helix-loop-helix (bHLH) transcription factors (TFs),...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3010: Novel Insights into the Pathogenesis of Spinal Sarcopenia and Related Therapeutic Approaches: A Narrative Review International Journal of Molecular Sciences doi: 10.3390/ijms21083010 Authors: Yu-Kai Kuo Yu-Ching Lin Ching-Yu Lee Chih-Yu Chen Jowy Tani Tsung-Jen Huang Hsi Chang Meng-Huang Wu Spinal sarcopenia is a complex and multifactorial disorder associated with a loss of strength, increased frailty, and increased risks of fractures and...
Fri Apr 24, 2020 03:00
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