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Early life α-tocopherol levels associated with better lung function if γ-tocopherol levels were low, suggesting the need for studies of α-tocopherol as a potential intervention in childhood asthma and lung function.
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Capsule summary: By using suction blistering, we are able to capture the atopic dermatitis disease signature at an unprecedented level of specificity and complexity, and to detect yet unrecognized putatively pathogenic players.
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Early-life wheezing with rhinovirus (RV) is associated with asthma, and infants are infected with many RV strains. RV infection of immature mice alters the immune response to subsequent heterologous infection, causing an exaggerated asthma-like phenotype.
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Eosinophils are circulating and tissue-resident leukocytes that have potent pro-inflammatory effects in a number of diseases. Recently, eosinophils have been shown to have a variety of other functions, including immunoregulation and antiviral activity. Eosinophil levels vary dramatically in a number of clinical settings, especially following eosinophil-targeted therapy, which is now available to selectively deplete these cells. There are key COVID-19–related questions concerning eosinophils whose...
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We read with interest the recent correspondence regarding the effectiveness of plastic surgery simulation for training undergraduate medical students. We are in wholehearted agreement with the statement regarding medical school curricula lacking exposure to plastic surgery and commend the authors for their efforts to pique the interest of medical students in our specialty. We wish however to point out some vagueness that, unless clarified, could be misleading to your readership.
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This investigation aimed to verify if there were any differences in autonomic nervous system function and voice parameters of teachers with and without voice complaints.
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Research studies of maximum phonation time, have questioned its validity and value as a tool to assess laryngeal competence. This study proposes a fresh look at phonation time, from a different perspective. The interrelationships of the durations between semiocclusion vs. open vocal tract (/s/-/z/ vs. /a/) and voiced vs voiceless (/z/-/a/ vs. /s/) sound are examined to determine whether this approach might provide additional clinical insight into the respiratory phonatory efficiency of patients.
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Idiopathic ulcerative laryngitis (IUL) is a rare disorder characterized by ulceration in the mid-membranous portions of the vocal folds. The etiology and optimal management of this condition are poorly understood. We aimed to survey laryngologists on their experiences with managing IUL in order to better understand the diagnosis and treatment of this unusual condition.
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The fundamental frequency and harmonic organization of voice can be quantified using cepstral measure. The two commonly studied cepstral measures are Cepstral Peak Prominence (CPP) and smoothened Cepstral peak prominence (sCPP). CPP is determined by measuring the amplitude difference from the highest peak of the cepstrum to the corresponding regression line, drawn directly below the cepstral peaks and when a smoothening factor is applied, sCPP is obtained. Cepstral analysis has been reported to be...
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Vocal fold leukoplakia is clinically defined by the presence of white mucosal lesions. Benign and malignant lesions of vocal fold leukoplakia can be distinguished clinically based on pathological biopsy. This study compared the acoustic and aerodynamic parameters of vocal cord carcinoma and dysplasia (mild to severe).
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Man Xiang, Ling Wang, Qiaojuan Yan, Zhengqiang Jiang, Shaoqing Yang
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Jinjing Li, Xin Jin, Yang Yang, Lingling Zhang, Rui Liu, Zheng Li
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Liying Ni, Lei Wang, Xiaoting Fu, Delin Duan, You-Jin Jeon, Jiachao Xu, Xin Gao
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Mengxing Li, Mark R. Wilkins
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Rabab Kamel, Nahla A. El-Wakil, AbdelFattah A. Abdelkhalek, Nermeen A. Elkasabgy
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Serdar Korpayev, Gülşah Kaygusuz, Murat Şen, Kaan Orhan, Çağdaş Oto, Ayşe Karakeçili
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Shengjun Chen, Huan Liu, Xianqing Yang, Laihao Li, Bo Qi, Xiao Hu, Haixia Ma, Chunsheng Li, Chuang Pan
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Soheyla Karimi, Hassan Namazi
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Wenhao Chen, Fei Li, Lei Chen, Yuanming Zhang, Tonghua Zhang, Tao Wang
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Publication date: 1 August 2020Source: International Journal of Biological Macromolecules, Volume 156Author(s): Boyu Du, Changzhou Chen, Yang Sun, Ming Yang, Mengtian Yu, Bingyang Liu, Xing Wang, Jinghui Zhou
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Publication date: 15 July 2020Source: International Journal of Biological Macromolecules, Volume 155Author(s): Eslam G. Al-Sakkari, Omar M. Abdeldayem, Eslam E. Genina, Lobna Amin, Nouran T. Bahgat, Eldon R. Rene, Ibrahim M. El-Sherbiny
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Abstract Introduction Patients with multiple myeloma (MM) can develop cardiac abnormalities, predisposing them to the development of heart failure, arrhythmias, or infarction with poor prognosis. The purpose of this study is to evaluate the prognostic potential of electrocardiographic (ECG) parameters in patients with MM. Methods This study retrospectively...
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Abstract Introduction Triple inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2-agonist (ICS/LAMA/LABA) combination therapy is recommended for patients with chronic obstructive pulmonary disease (COPD) who experience further exacerbations/symptoms on dual LAMA/LABA or ICS/LABA therapy. The relative efficacy of budesonide/glycopyrronium/formoterol fumarate metered dose inhaler 320/18/9.6 µg (BGF MDI) in COPD was...
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Abstract Introduction A fixed dose combination (FDC) of ibuprofen 400 mg and caffeine 100 mg has been shown to be more effective than ibuprofen 400 mg alone for the treatment of acute postoperative dental pain in a phase III randomised controlled trial. A post hoc subgroup analysis of the primary data from an active-/placebo-controlled, double-blind, single-centre, parallel-group study was conducted in patients with moderate or severe...
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Abstract Introduction Despite the well-documented benefits of prophylaxis, treatment burden is still a barrier to adherence in patients with haemophilia. An extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP) has been developed for the treatment of patients with haemophilia B and is indicated for dosing up to every 14 days. This analysis evaluated real-world outcomes in patients switching to...
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Abstract Purpose To evaluate the stability of a model Mab1 and Fab1 under in vitro vitreal conditions in the presence of various metabolites and in the presence of light at λ > 400 nM. Methods A full length IgG1 monoclonal antibody (Mab1) and a fab fragment (Fab1) were formulated with various metabolites typically found in the vitreous humor...
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Abstract The objective of this work was to investigate the capacity of mogroside V (MOG-V), a food additive, as a novel carrier to improve the bioavailability and liver distribution of silybin (SLY). Solid dispersion particles (SDPs) of SLY/MOG-V were prepared utilizing the solvent evaporation method. The physicochemical characterizations of SDPs were evaluated by using dynamic light scattering (DLS), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD)...
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Abstract This study aimed to investigate the effect of pH-mediated surface properties of bovine serum albumin (BSA) on protein aggregation and the changes of protein structure and colloidal stability at different solution pH levels. The hydrophobicity of BSA surface was characterized by endogenous fluorescence spectroscopy, fluorescence quenching of acrylamide, and fluorescence probe. The results showed that the hydrophobicity of BSA surface was similar at pH 5, 6, 7.4, followed...
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Abstract Multidrug resistance is the major problem in cancer treatment nowadays. Compounds from plants are the new targets to solve this problem. Quercetin (QCT), quercetrin (QTR), and rutin (RUT) are potential anticancer flavonoids but their poor water solubility leads to less efficacy. In this study, the polymeric micelles of benzoylated methoxy-poly (ethylene glycol)-b-oligo(ε-caprolactone) or mPEG-b-OCL-Bz loading with the flavonoids were prepared to solve these problems....
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Antibiotics, Vol. 9, Pages 210: Cinnamon (Cinnamomum zeylanicum) Oil as a Potential Alternative to Antibiotics in Poultry Antibiotics doi: 10.3390/antibiotics9050210 Authors: Mohamed E. Abd El-Hack Mahmoud Alagawany Abdel-Moneim E. Abdel-Moneim Noureldeen G. Mohammed Asmaa F. Khafaga May Bin-Jumah Sarah I. Othman Ahmed A. Allam Shaaban S. Elnesr The removal of antibiotic growth promoters (AGPs) as feed additives in poultry nutrition from the market...
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Antibiotics, Vol. 9, Pages 209: Cephalosporins’ Cross-Reactivity and the High Degree of Required Knowledge. Case Report and Review of the Literature Antibiotics doi: 10.3390/antibiotics9050209 Authors: D’Errico Frati Zanon Valentinuz Manetti Scopetti Santurro Fineschi Antibiotic cross-reactivity represents a phenomenon of considerable interest as well as antibiotic resistance. Immediate reactions to cephalosporins are reported in the literature...
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Antibiotics, Vol. 9, Pages 207: Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle Antibiotics doi: 10.3390/antibiotics9040207 Authors: Nhan Trong Le Duc Viet Ho Tuan Quoc Doan Anh Tuan Le Ain Raal Donatella Usai Giuseppina Sanna Antonio Carta Paola Rappelli Nicia Diaz Piero Cappuccinelli Stefania Zanetti Hoai Thi Nguyen Matthew Gavino Donadu The...
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Antibiotics, Vol. 9, Pages 208: Prevalence of Virulence Genes and Antimicrobial Resistances in E. coli Associated with Neonatal Diarrhea, Postweaning Diarrhea, and Edema Disease in Pigs from Austria Antibiotics doi: 10.3390/antibiotics9040208 Authors: Renzhammer Loncaric Roch Pinior Käsbohrer Spergser Ladinig Unterweger Increasing numbers of multi-resistant Escherichia (E.) coli from clinical specimens emphasize the importance of monitoring of...
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Antibiotics, Vol. 9, Pages 206: Stewardship of Antibiotics for Multidrug-Resistant Gram-Negative Bacteria Antibiotics doi: 10.3390/antibiotics9040206 Authors: Daniele Roberto Giacobbe Ilias Karaiskos Nearly one year ago, we wrote the following introductory note for authors willing to submit their paper to our Special Issue entitled “Stewardship of Antibiotics for Multidrug-Resistant Gram-Negative Bacteria” in Antibiotics: [...]
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