IJMS, Vol. 21, Pages 3009: Human NANOS1 Represses Apoptosis by Downregulating Pro-Apoptotic Genes in the Male Germ Cell Line International Journal of Molecular Sciences doi: 10.3390/ijms21083009 Authors: Damian M. Janecki Erkut Ilaslan Maciej J. Smialek Marcin P. Sajek Maciej Kotecki Barbara Ginter-Matuszewska Patryk Krainski Jadwiga Jaruzelska Kamila Kusz-Zamelczyk While two mouse NANOS paralogues, NANOS2 and NANOS3, are crucial for maintenance of germ cells...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3004: RT-qPCR Testing of SARS-CoV-2: A Primer International Journal of Molecular Sciences doi: 10.3390/ijms21083004 Authors: Stephen A. Bustin Tania Nolan Testing for the presence of coronavirus is an essential diagnostic tool for monitoring and managing the current COVID-19 pandemic. The only reliable test in current use for testing acute infection targets the genome of SARS-CoV-2, and the most widely used method is quantitative fluorescence-based reverse transcription...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3006: Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson’s Disease in a Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21083006 Authors: Erteng Jia Ying Zhou Zhiyu Liu Liujing Wang Tinglan Ouyang Min Pan Yunfei Bai Qinyu Ge Parkinson’s disease (PD) is the second most common neurodegenerative disease and although many studies have been done on this disease, the underlying mechanisms...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3005: Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus International Journal of Molecular Sciences doi: 10.3390/ijms21083005 Authors: Michael Hudec Pavlina Dankova Roman Solc Nardjas Bettazova Marie Cerna This review aims to summarize the knowledge about the relationship between circadian rhythms and their influence on the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome. Circadian rhythms are controlled...
Fri Apr 24, 2020 03:00
IJMS, Vol. 21, Pages 3002: Naltrexone Use in Treating Hypersexuality Induced by Dopamine Replacement Therapy: Impact of OPRM1 A/G Polymorphism on Its Effectiveness International Journal of Molecular Sciences doi: 10.3390/ijms21083002 Authors: Audrey Verholleman Caroline Victorri-Vigneau Edouard Laforgue Pascal Derkinderen Celine Verstuyft Marie Grall-Bronnec Hypersexuality is a well-known adverse side effect of dopamine replacement therapy (DRT), and anti-craving drugs...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1263: Anemia and Systemic Inflammation Rather than Arterial Circulatory Dysfunction Predict Decompensation of Liver Cirrhosis Journal of Clinical Medicine doi: 10.3390/jcm9051263 Authors: Christina Bothou Sabrina Rüschenbaum Alica Kubesch Leonie Quenstedt Katharina Schwarzkopf Christoph Welsch Stefan Zeuzem Tania Mara Welzel Christian Markus Lange Background: While systemic inflammation is recognized as playing a central role in the pathogenesis...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1261: Complement Inhibition Therapy and Dialytic Strategies in Paroxysmal Nocturnal Hemoglobinuria: The Nephrologist’s Opinion Journal of Clinical Medicine doi: 10.3390/jcm9051261 Authors: Guido Gembillo Rossella Siligato Valeria Cernaro Domenico Santoro Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disease that presents an estimated incidence of 1.3 cases per million per year, with a prevalence of 15.9 cases per million. It is characterized by...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1262: Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia: A Double-Blind, Randomized, Placebo-Controlled, Multicenter Trial Journal of Clinical Medicine doi: 10.3390/jcm9051262 Authors: Sophie Dupuis-Girod Anne-Emmanuelle Fargeton Vincent Grobost Sophie Rivière Marjolaine Beaudoin Evelyne Decullier Lorraine Bernard Valentine Bréant Bettina Colombet Pierre Philouze Sabine...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1256: Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression Journal of Clinical Medicine doi: 10.3390/jcm9051256 Authors: Wook Jin The expression of PARK7 is upregulated in various types of cancer, suggesting its potential role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1258: Enhanced Serum Levels of sFlt1: Impact on Materno–Fetal CMV Transmission Journal of Clinical Medicine doi: 10.3390/jcm9051258 Authors: Lukas Penka Karl-Oliver Kagan Klaus Hamprecht Background: Antenatal Cytomegalovirus infection (CMV) can be associated with severe fetal symptoms and newborn outcome. The current prenatal diagnosis is based on amniocentesis (AC). No reliable biomarker for fetal infection is available. Methods: We measured Placenta-derived...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1259: COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy! Journal of Clinical Medicine doi: 10.3390/jcm9051259 Authors: Cristoforo Pomara Giovanni Li Volti Francesco Cappello The current outbreak of COVID-19 severe respiratory disease, which started in Wuhan, China, is an ongoing challenge, and a major threat to public health that requires surveillance, prompt diagnosis, and research efforts to understand this emergent pathogen and...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1255: Mathematical Model Predicts Effective Strategies to Inhibit VEGF-eNOS Signaling Journal of Clinical Medicine doi: 10.3390/jcm9051255 Authors: Qianhui Wu Stacey D. Finley The endothelial nitric oxide synthase (eNOS) signaling pathway in endothelial cells has multiple physiological significances. It produces nitric oxide (NO), an important vasodilator, and enables a long-term proliferative response, contributing to angiogenesis. This signaling pathway is mediated...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1257: Lower Activity and Function Scores Are Associated with a Higher Risk of Preoperative Deep Venous Thrombosis in Patients Undergoing Total Hip Arthroplasty Journal of Clinical Medicine doi: 10.3390/jcm9051257 Authors: Toshiyuki Kawai Koji Goto Yutaka Kuroda Shuichi Matsuda This study was performed to investigate the relationship between patients’ activity and function levels and the incidence of preoperative deep venous thrombosis (DVT) prior...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1260: Machine Learning and Virtual Reality on Body Movements’ Behaviors to Classify Children with Autism Spectrum Disorder Journal of Clinical Medicine doi: 10.3390/jcm9051260 Authors: Mariano Alcañiz Alcañiz Raya Javier Marín-Morales Maria Eleonora Minissi Gonzalo Teruel Teruel Garcia Luis Abad Irene Alice Chicchi Chicchi Giglioli Autism spectrum disorder (ASD) is mostly diagnosed according to behavioral symptoms in sensory, social, and motor domains....
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1253: New Insights into the Implication of Mitochondrial Dysfunction in Tissue, Peripheral Blood Mononuclear Cells, and Platelets during Lung Diseases Journal of Clinical Medicine doi: 10.3390/jcm9051253 Authors: Marianne Riou Abrar Alfatni Anne-Laure Charles Emmanuel Andrès Cristina Pistea Anne Charloux Bernard Geny Lung diseases such as chronic obstructive pulmonary disease, asthma, pulmonary arterial hypertension, or idiopathic pulmonary fibrosis...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1252: The Clinical Significance of PIWIL3 and PIWIL4 Expression in Pancreatic Cancer Journal of Clinical Medicine doi: 10.3390/jcm9051252 Authors: Weiyao Li Javier Martinez-Useros Nuria Garcia-Carbonero Maria J. Fernandez-Aceñero Alberto Orta Luis Ortega-Medina Sandra Garcia-Botella Elia Perez-Aguirre Luis Diez-Valladares Angel Celdran Jesús García-Foncillas P-element-induced wimpy testis (PIWI) proteins have been described in several...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1254: Bibliometric Analysis of Moxibustion Research Trends over the Past 20 Years
JCM, Vol. 9, Pages 1254: Bibliometric Analysis of Moxibustion Research Trends over the Past 20 Years Journal of Clinical Medicine doi: 10.3390/jcm9051254 Authors: Hyejin Park In-Seon Lee Hyangsook Lee Younbyoung Chae Objectives: A bibliometric approach using network analysis was applied to identify the development and research trends for moxibustion. This study also examined the network hub of moxibustion research by investigating the collaborative work of organizations and...
Sun Apr 26, 2020 03:00
JCM, Vol. 9, Pages 1251: Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease Journal of Clinical Medicine doi: 10.3390/jcm9051251 Authors: Daniel P. Zalewski Karol P. Ruszel Andrzej Stępniewski Dariusz Gałkowski Jacek Bogucki Łukasz Komsta Przemysław Kołodziej Paulina Chmiel Tomasz Zubilewicz Marcin Feldo Janusz Kocki Anna Bogucka-Kocka Chronic venous disease (CVD) is a vascular disease of lower limbs with high prevalence worldwide....
Sat Apr 25, 2020 03:00
JCM, Vol. 9, Pages 1249: Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study Journal of Clinical Medicine doi: 10.3390/jcm9051249 Authors: Enric Sánchez Chadia Mizab Ariadna Sauret Ferran Barbé Raquel Martí Carolina López-Cano Marta Hernández Liliana Gutiérrez-Carrasquilla Paola Carmona Jessica González Mireia Dalmases Cristina Hernández Rafael Simó Albert Lecube In order to compare spirometric...
Sat Apr 25, 2020 03:00
JCM, Vol. 9, Pages 1246: Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial Journal of Clinical Medicine doi: 10.3390/jcm9051246 Authors: Adrian Curran Anna Rull Jordi Navarro Judit Vidal-González Mario Martin-Castillo Joaquin Burgos Vicenç Falcó Esteban Ribera Ariadna Torrella Bibiana Planas Joaquim Peraire Manuel Crespo HIV and antiretroviral therapy...
Sat Apr 25, 2020 03:00
JCM, Vol. 9, Pages 1250: Multiparametric Modelling of Survival in Pancreatic Ductal Adenocarcinoma Using Clinical, Histomorphological, Genetic and Image-Derived Parameters Journal of Clinical Medicine doi: 10.3390/jcm9051250 Authors: Georgios A. Kaissis Friederike Jungmann Sebastian Ziegelmayer Fabian K. Lohöfer Felix N. Harder Anna Melissa Schlitter Alexander Muckenhuber Katja Steiger Rebekka Schirren Helmut Friess Roland Schmid Wilko Weichert Marcus R....
Sat Apr 25, 2020 03:00
JCM, Vol. 9, Pages 1248: Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension Journal of Clinical Medicine doi: 10.3390/jcm9051248 Authors: Cai Klein Geenen Tu Tian van den Bosch de Rijke Reiss Boersma Duncker Boomars Guignabert Merkus : Exogenous melatonin has been reported to be beneficial in the treatment of pulmonary hypertension (PH) in animal models. Multiple mechanisms are involved, with...
Sat Apr 25, 2020 03:00
JCM, Vol. 9, Pages 1247: Incidence of Anaplastic Large Cell Lymphoma and Breast-Implant-Associated Lymphoma—An Analysis of a Certified Tumor Registry over 17 Years Journal of Clinical Medicine doi: 10.3390/jcm9051247 Authors: Prantl Gerken Zeman Leitzmann Koller Klinkhammer-Schalke Evert Kuehlmann Biermann Background: Breast-implant-associated anaplastic large cell lymphoma (BI-ALCL) and primary breast ALCL are rare extranodal manifestations of non-Hodgkin...
Sat Apr 25, 2020 03:00
JCM, Vol. 9, Pages 1245: Breakpoint Mapping of Symptomatic Balanced Translocations Links the EPHA6, KLF13 and UBR3 Genes to Novel Disease Phenotype Journal of Clinical Medicine doi: 10.3390/jcm9051245 Authors: Victor Murcia Pienkowski Marzena Kucharczyk Małgorzata Rydzanicz Barbara Poszewiecka Katarzyna Pachota Marlena Młynek Piotr Stawiński Agnieszka Pollak Joanna Kosińska Katarzyna Wojciechowska Monika Lejman Agata Cieślikowska Dorota Wicher Agnieszka...
Sat Apr 25, 2020 03:00
JCM, Vol. 9, Pages 1244: Speckle Tracking-Derived Left Atrial Stiffness Predicts Clinical Outcome in Heart Failure Patients with Reduced to Mid-Range Ejection Fraction Journal of Clinical Medicine doi: 10.3390/jcm9051244 Authors: Ibadete Bytyçi Frank L. Dini Artan Bajraktari Nicola Riccardo Pugliese Andreina D’Agostino Gani Bajraktari Per Lindqvist Michael Y. Henein Background and Aim: Left atrial stiffness (LASt) is an important marker of cardiac function, especially...
Sat Apr 25, 2020 03:00
JCM, Vol. 9, Pages 1237: Which Child with Asthma is a Candidate for Biological Therapies? Journal of Clinical Medicine doi: 10.3390/jcm9041237 Authors: Andrew Bush In asthmatic adults, monoclonals directed against Type 2 airway inflammation have led to major improvements in quality of life, reductions in asthma attacks and less need for oral corticosteroids. The paediatric evidence base has lagged behind. All monoclonals currently available for children are anti-eosinophilic, directed...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1241: Dupilumab for the Treatment of Atopic Dermatitis in an Austrian Cohort-Real-Life Data Shows Rosacea-Like Folliculitis Journal of Clinical Medicine doi: 10.3390/jcm9041241 Authors: Tamara Quint Patrick M. Brunner Christoph Sinz Irene Steiner Robin Ristl Kornelia Vigl Susanne Kimeswenger Katharina Neubauer Detlev Pirkhammer Martin Zikeli Wolfram Hoetzenecker Norbert Reider Christine Bangert Dupilumab is the first biological treatment...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1236: Impact of Early C-Reactive Protein/Albumin Ratio on Intra-Hospital Mortality Among Patients with Spontaneous Intracerebral Hemorrhage Journal of Clinical Medicine doi: 10.3390/jcm9041236 Authors: Michael Bender Kristin Haferkorn Michaela Friedrich Eberhard Uhl Marco Stein Objective: The impact of increased C-reactive protein (CRP)/albumin ratio on intra-hospital mortality has been investigated among patients admitted to general intensive care units...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1231: Changes in Iris Perfusion Following Scleral Buckle Surgery for Rhegmatogenous Retinal Detachment: An Anterior Segment Optical Coherence Tomography Angiography (AS-OCTA) Study Journal of Clinical Medicine doi: 10.3390/jcm9041231 Authors: Rossella D’Aloisio Pasquale Viggiano Enrico Borrelli Mariacristina Parravano Aharrh-Gnama Agbèanda Federica Evangelista Giada Ferro Lisa Toto Rodolfo Mastropasqua Purpose: To investigate iris vasculature...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1233: The Usefulness of Serum Biomarkers in the Early Stages of Diabetic Retinopathy: Results of the EUROCONDOR Clinical Trial Journal of Clinical Medicine doi: 10.3390/jcm9041233 Authors: Cristina Hernández Massimo Porta Francesco Bandello Jakob Grauslund Simon P. Harding Stephen J. Aldington Catherine Egan Ulrik Frydkjaer-Olsen José García-Arumí Jonathan Gibson Gabriele E. Lang Rosangela Lattanzio Pascale Massin Edoardo Midena Berta...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1232: Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9041232 Authors: Jiwon Han Jung-Hee Ryu Bon-Wook Koo Sun Woo Nam Sang-Il Cho Ah-Young Oh The use of sugammadex can reduce post-operative residual neuromuscular blockade, which is known to increase the risk of post-operative respiratory events. However, its effect on post-operative...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1243: Prevalence and Associated Factors of Nocturnal Eating Behavior and Sleep-Related Eating Disorder-Like Behavior in Japanese Young Adults: Results of an Internet Survey Using Munich Parasomnia Screening Journal of Clinical Medicine doi: 10.3390/jcm9041243 Authors: Kentaro Matsui Yoko Komada Katsuji Nishimura Kenichi Kuriyama Yuichi Inoue Nocturnal (night) eating syndrome and sleep-related eating disorder have common characteristics, but are considered...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1242: The TAGA Study: A Study of Factors Determining Aortic Diameter in Families at High Risk of Abdominal Aortic Aneurysm Reveal Two New Candidate Genes Journal of Clinical Medicine doi: 10.3390/jcm9041242 Authors: Peypoch Paüls-Vergés Vázquez-Santiago Dilme Romero Giner Plaza Escudero Soria Camacho Sabater-Lleal A variety of disorders are known to be related with aortic geometry, among them abdominal aortic aneurysm (AAA)....
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1240: A Meta-Analysis on the Effect of Dexamethasone on the Sugammadex Reversal of Rocuronium-Induced Neuromuscular Block Journal of Clinical Medicine doi: 10.3390/jcm9041240 Authors: Koo Hwang Min Ryu Sugammadex reverses the rocuronium-induced neuromuscular block by trapping the cyclopentanoperhydrophenanthrene ring of rocuronium. Dexamethasone shares the same steroidal structure with rocuronium. The purpose of this study was to evaluate the influence...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1228: The Association between Serum Levels of 25[OH]D, Body Weight Changes and Body Composition Indices in Patients with Heart Failure Journal of Clinical Medicine doi: 10.3390/jcm9041228 Authors: Apolonia Stefaniak Robert Partyka Sylwia Duda Weronika Ostręga Jacek Niedziela Jolanta Nowak Jolanta Malinowska-Borowska Tomasz Rywik Przemysław Leszek Bartosz Hudzik Barbara Zubelewicz-Szkodzińska Piotr Rozentryt We try to determine the association...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1226: Detection of Platelet-Activating Antibodies Associated with Heparin-Induced Thrombocytopenia Journal of Clinical Medicine doi: 10.3390/jcm9041226 Authors: Brigitte Tardy Thomas Lecompte François Mullier Caroline Vayne Claire Pouplard Heparin-induced thrombocytopenia (HIT) is a prothrombotic immune drug reaction caused by platelet-activating antibodies that in most instances recognize platelet factor 4 (PF4)/polyanion complexes. Platelet activation...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1238: A New Method of Measuring the Volumetric Change of Alveolar Bone Around Dental Implants Using Computed Tomography Journal of Clinical Medicine doi: 10.3390/jcm9041238 Authors: Lim Lim Kim Lee This study proposes a method for measuring the volumetric change of alveolar bone after dental implant surgery using computed tomography (CT). A total of 40 implants in 20 patients (15 males and 5 females) were selected. The types of implants used were group...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1225: The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control Journal of Clinical Medicine doi: 10.3390/jcm9041225 Authors: Yosra A. Helmy Mohamed Fawzy Ahmed Elaswad Ahmed Sobieh Scott P. Kenney Awad A. Shehata A pneumonia outbreak with unknown etiology was reported in Wuhan, Hubei province, China, in December 2019, associated with the Huanan Seafood Wholesale Market. The causative agent of...
Fri Apr 24, 2020 03:00
JCM, Vol. 9, Pages 1239: Therapeutic Physical Exercise Post-Treatment in Breast Cancer: A Systematic Review of Clinical Practice Guidelines Journal of Clinical Medicine doi: 10.3390/jcm9041239 Authors: del-Rosal-Jurado Romero-Galisteo Trinidad-Fernández González-Sánchez Cuesta-Vargas Ruiz-Muñoz Advances achieved in diagnosis and improvements in treatment for breast cancer have resulted in a favourable survival rate. Therapeutic physical exercise (TPE) is presented...
Fri Apr 24, 2020 03:00
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