Cancers, Vol. 12, Pages 1053: Self-Collection for Cervical Screening Programs: From Research to Reality Cancers doi: 10.3390/cancers12041053 Authors: David Hawkes Marco H. T. Keung Yanping Huang Tracey L. McDermott Joanne Romano Marion Saville Julia M. L. Brotherton In 2018, there were an estimated 570,000 new cases of cervical cancer globally, with most of them occurring in women who either had no access to cervical screening, or had not participated in screening in...
Fri Apr 24, 2020 03:00
Cancers, Vol. 12, Pages 1051: Radiomics-Based Outcome Prediction for Pancreatic Cancer Following Stereotactic Body Radiotherapy Cancers doi: 10.3390/cancers12041051 Authors: Elsa Parr Qian Du Chi Zhang Chi Lin Ahsan Kamal Josiah McAlister Xiaoying Liang Kyle Bavitz Gerard Rux Michael Hollingsworth Michael Baine Dandan Zheng (1) Background: Radiomics use high-throughput mining of medical imaging data to extract unique information and predict tumor behavior....
Fri Apr 24, 2020 03:00
Cells, Vol. 9, Pages 1082: The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane Cells doi: 10.3390/cells9051082 Authors: Michal Stark Tomás F. D. Silva Guy Levin Miguel Machuqueiro Yehuda G. Assaraf Lipophilic weak base therapeutic agents, termed lysosomotropic drugs (LDs), undergo marked sequestration and concentration within lysosomes, hence altering lysosomal functions. This lysosomal drug entrapment...
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Cells, Vol. 9, Pages 1081: In Vitro Cytotoxicity Effects of Zinc Oxide Nanoparticles on Spermatogonia Cells Cells doi: 10.3390/cells9051081 Authors: Pinho Martins Costa Senos Silva Pereira Rebelo Zinc Oxide Nanoparticles (ZnO NPs) are a type of metal oxide nanoparticle with an extensive use in biomedicine. Several studies have focused on the biosafety of ZnO NPs, since their size and surface area favor entrance and accumulation in the body, which can induce toxic...
Sun Apr 26, 2020 03:00
Cells, Vol. 9, Pages 1076: Structure and Function of Human Matrix Metalloproteinases Cells doi: 10.3390/cells9051076 Authors: Helena Laronha Jorge Caldeira The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen,...
Sun Apr 26, 2020 03:00
Cells, Vol. 9, Pages 1075: Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease Cells doi: 10.3390/cells9051075 Authors: Franco Rivas-Santisteban Casanovas Lillo Saura Navarro (1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer’s disease (AD), is expressed in both neurons and glial cells....
Sun Apr 26, 2020 03:00
Cells, Vol. 9, Pages 1079: Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression Cells doi: 10.3390/cells9051079 Authors: Sim Lee Kim Cho Yi Park Hwang Park ANO1, a Ca2+-activated chloride channel, is highly expressed in glioblastoma cells and its surface expression is involved in their migration and invasion. However, the regulation of ANO1 surface expression in glioblastoma cells is largely unknown. In this study, we found that Ca2+/Calmodulin-dependent...
Sun Apr 26, 2020 03:00
Cells, Vol. 9, Pages 1078: Characterization of Endoplasmic Reticulum (ER) in Human Pluripotent Stem Cells Revealed Increased Susceptibility to Cell Death upon ER Stress Cells doi: 10.3390/cells9051078 Authors: Ha Jeong Shin Kim Im Song Hanna Oh Woo Han Lee Human pluripotent stem cells (hPSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have a well-orchestrated program for differentiation and self-renewal. However,...
Sun Apr 26, 2020 03:00
Cells, Vol. 9, Pages 1074: Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows Cells doi: 10.3390/cells9051074 Authors: González-Nieto Fernández-Serra Pérez-Rigueiro Panetsos Martinez-Murillo Guinea Ischemic stroke represents one of the most prevalent pathologies in humans and is a leading cause of death and disability. Anti-thrombolytic therapy with tissue plasminogen activator (t-PA) and surgical thrombectomy are the primary...
Sun Apr 26, 2020 03:00
Cells, Vol. 9, Pages 1080: Extracellular Vesicles Secreted by Corneal Epithelial Cells Promote Myofibroblast Differentiation Cells doi: 10.3390/cells9051080 Authors: McKay Hutcheon Zieske Ciolino The corneal epithelium mediates the initial response to injury of the ocular surface and secretes a number of profibrotic factors that promote corneal scar development within the stroma. Previous studies have shown that corneal epithelial cells also secrete small extracellular vesicles...
Sun Apr 26, 2020 03:00
Cells, Vol. 9, Pages 1072: Adenosinergic System Involvement in Ischemic Stroke Patients’ Lymphocytes
Cells, Vol. 9, Pages 1072: Adenosinergic System Involvement in Ischemic Stroke Patients’ Lymphocytes Cells doi: 10.3390/cells9051072 Authors: Pasquini Vincenzi Casetta Laudisi Merighi Gessi Borea Varani Adenosine modulates many physiological processes through the interaction with adenosine receptors (ARs) named as A1, A2A, A2B, and A3ARs. During ischemic stroke, adenosine mediates neuroprotective and anti-inflammatory effects through ARs activation. One of...
Sat Apr 25, 2020 03:00
Cells, Vol. 9, Pages 1073: Morphologic, Molecular and Clinical Features of Aggressive Variant Prostate Cancer Cells doi: 10.3390/cells9051073 Authors: Montironi Cimadamore Lopez-Beltran Scarpelli Aurilio Santoni Massari Cheng The term aggressive variant prostate cancer (AVPCa) refers to androgen receptor (AR)-independent anaplastic forms of prostate cancer (PCa), clinically characterized by a rapidly progressive disease course. This involves hormone refractoriness...
Sat Apr 25, 2020 03:00
Cells, Vol. 9, Pages 1070: Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation Cells doi: 10.3390/cells9051070 Authors: Danielle G. May Kelsey L. Scott Alexandre R. Campos Kyle J. Roux BioID is a well-established method for identifying protein–protein interactions and has been utilized within live cells and several animal models. However, the conventional labeling period requires 15–18 h for robust biotinylation which may not...
Sat Apr 25, 2020 03:00
Cells, Vol. 9, Pages 1071: PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208 Cells doi: 10.3390/cells9051071 Authors: Muñoz-Galván Rivero Peinado-Serrano Martinez-Pérez Fernández-Fernández Ortiz García-Heredia Carnero Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer is preoperative radiation alone or in combination...
Sat Apr 25, 2020 03:00
Cells, Vol. 9, Pages 1069: Cell Cycle-Dependent Dynamics of the Golgi-Centrosome Association in Motile Cells Cells doi: 10.3390/cells9051069 Authors: Keyada Frye Fioranna Renda Maria Fomicheva Xiaodong Zhu Lisa Gong Alexey Khodjakov Irina Kaverina Here, we characterize spatial distribution of the Golgi complex in human cells. In contrast to the prevailing view that the Golgi compactly surrounds the centrosome throughout interphase, we observe characteristic differences...
Sat Apr 25, 2020 03:00
Cells, Vol. 9, Pages 1068: Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms Cells doi: 10.3390/cells9051068 Authors: Kazue Hisaoka-Nakashima Honami Azuma Fumina Ishikawa Yoki Nakamura Dengli Wang Keyue Liu Hidenori Wake Masahiro Nishibori Yoshihiro Nakata Norimitsu Morioka A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release...
Sat Apr 25, 2020 03:00
Cells, Vol. 9, Pages 1067: Effects of Pyridoxine Deficiency on Hippocampal Function and Its Possible Association with V-Type Proton ATPase Subunit B2 and Heat Shock Cognate Protein 70 Cells doi: 10.3390/cells9051067 Authors: Hyo Young Jung Woosuk Kim Kyu Ri Hahn Hyun Jung Kwon Sung Min Nam Jin Young Chung Yeo Sung Yoon Dae Won Kim Dae Young Yoo In Koo Hwang Pyridoxine, one of the vitamin B6 vitamers, plays a crucial role in amino acid metabolism and synthesis...
Sat Apr 25, 2020 03:00
Cells, Vol. 9, Pages 1063: The Role of Autophagy in Pancreatic Cancer: From Bench to the Dark Bedside Cells doi: 10.3390/cells9041063 Authors: Kıvanç Görgülü Kalliope N. Diakopoulos Ezgi Kaya-Aksoy Katrin J. Ciecielski Jiaoyu Ai Marina Lesina Hana Algül Pancreatic cancer is one of the deadliest cancer types urgently requiring effective therapeutic strategies. Autophagy occurs in several compartments of pancreatic cancer tissue including cancer cells, cancer associated...
Fri Apr 24, 2020 03:00
Cells, Vol. 9, Pages 1062: Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma Cells doi: 10.3390/cells9041062 Authors: Michele Minopoli Sabrina Sarno Gioconda Di Carluccio Rosa Azzaro Susan Costantini Flavio Fazioli Michele Gallo Gaetano Apice Lucia Cannella Domenica Rea Maria Patrizia Stoppelli Diana Boraschi Alfredo Budillon Katia Scotlandi Annarosaria De Chiara Maria Vincenza...
Fri Apr 24, 2020 03:00
Cells, Vol. 9, Pages 1065: Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective Cells doi: 10.3390/cells9041065 Authors: Manohar Kodavati Haibo Wang Muralidhar L. Hegde Mitochondria plays privotal role in diverse pathways that regulate cellular function and survival, and have emerged as a prime focus in aging and age-associated motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Accumulating evidence...
Fri Apr 24, 2020 03:00
Cells, Vol. 9, Pages 1064: AR/ER Ratio Correlates with Expression of Proliferation Markers and with Distinct Subset of Breast Tumors Cells doi: 10.3390/cells9041064 Authors: Nelson Rangel Milena Rondon-Lagos Laura Annaratone Andrés Felipe Aristizábal-Pachon Paola Cassoni Anna Sapino Isabella Castellano The co-expression of androgen (AR) and estrogen (ER) receptors, in terms of higher AR/ER ratio, has been recently associated with poor outcome in ER-positive (ER+) breast...
Fri Apr 24, 2020 03:00
Cells, Vol. 9, Pages 1066: Visualising Silicon in Plants: Histochemistry, Silica Sculptures and Elemental Imaging Cells doi: 10.3390/cells9041066 Authors: Gea Guerriero Ian Stokes Nathalie Valle Jean-Francois Hausman Christopher Exley Silicon is a non-essential element for plants and is available in biota as silicic acid. Its presence has been associated with a general improvement of plant vigour and response to exogenous stresses. Plants accumulate silicon in their tissues...
Fri Apr 24, 2020 03:00
Cells, Vol. 9, Pages 1061: Modification of Adenosine196 by Mettl3 Methyltransferase in the 5’-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation Cells doi: 10.3390/cells9041061 Authors: Olga Sergeeva Philipp Sergeev Pavel Melnikov Tatiana Prikazchikova Olga Dontsova Timofei Zatsepin Ribosome biogenesis is among the founding processes in the cell. During the first stages of ribosome biogenesis, polycistronic precursor of ribosomal RNA passes complex multistage...
Fri Apr 24, 2020 03:00
Children, Vol. 7, Pages 37: Psychosocial Mechanism of Adolescents’ Depression: A Dose-Response Relation with Physical Activity Children doi: 10.3390/children7040037 Authors: Man Xiang Xiangli Gu Xiaoxia Zhang Samantha Moss Chaoqun Huang Larry Paul Nelson Tao Zhang Depression has become the most prevalent mental health problem in developing countries, and especially among adolescents. Lubans and his colleagues proposed a psychosocial mechanism to understand the trajectory...
Fri Apr 24, 2020 03:00
Climate, Vol. 8, Pages 59: Preface: Climate Change Impact on Plant Ecology Climate doi: 10.3390/cli8050059 Authors: Vitale Collalti Climate change likely represents the major modifying agents of functional and structural processes in terrestrial and marine ecosystems [...]
Sat Apr 25, 2020 03:00
Diagnostics, Vol. 10, Pages 254: Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study Diagnostics doi: 10.3390/diagnostics10050254 Authors: Mandia Cavoretto Duca Candiani Cetin Savasi Oocyte donations (OD) represent 4.5% of all in vitro fertilization (IVF) cycles. While OD pregnancies face increased risks of obstetrical complications, especially pregnancy-induced hypertension and pre-eclampsia (PE), little is known...
Sun Apr 26, 2020 03:00
Diagnostics, Vol. 10, Pages 253: Nailfold Videocapillaroscopy is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients Diagnostics doi: 10.3390/diagnostics10050253 Authors: Sambataro Sambataro Libra Vignigni Pino Fagone Fruciano Gili Pignataro Del Papa Vancheri Nailfold videocapillaroscopy (NVC) is an easy tool used for the assessment of patients with Raynaud’s...
Sat Apr 25, 2020 03:00
Diagnostics, Vol. 10, Pages 252: A Prospective Study Comparing Three-Dimensional Rectal Water Contrast Transvaginal Ultrasonography and Computed Tomographic Colonography in the Diagnosis of Rectosigmoid Endometriosis Diagnostics doi: 10.3390/diagnostics10040252 Authors: Fabio Barra Ennio Biscaldi Carolina Scala Antonio Simone Laganà Valerio Gaetano Vellone Cesare Stabilini Fabio Ghezzi Simone Ferrero (1) Objectives: In patients with symptoms suggestive of rectosigmoid...
Fri Apr 24, 2020 03:00
Diagnostics, Vol. 10, Pages 251: Unstimulated Parotid Saliva Sampling in Juvenile Idiopathic Arthritis and Healthy Controls: A Proof-of-Concept Study on Biomarkers Diagnostics doi: 10.3390/diagnostics10040251 Authors: Alexandra Dimitrijevic Carlsson Bijar Ghafouri Carin Starkhammar Johansson Per Alstergren The aims of this proof-of-concept study were to develop a collecting method for unstimulated parotid saliva in juvenile idiopathic arthritis (JIA) patients and healthy children...
Fri Apr 24, 2020 03:00
Diversity, Vol. 12, Pages 171: Two Seas for One Great Diversity: Checklist of the Marine Heterobranchia (Mollusca; Gastropoda) from the Salento Peninsula (South-East Italy) Diversity doi: 10.3390/d12050171 Authors: Giulia Furfaro Fabio Vitale Cataldo Licchelli Paolo Mariottini The Salento peninsula is a portion of the Italian mainland separating two distinct Mediterranean basins, the Ionian and the Adriatic seas. Several authors have studied the marine Heterobranchia (Mollusca,...
Sun Apr 26, 2020 03:00
Diversity, Vol. 12, Pages 170: Loss of Mitochondrial Genetic Diversity in Overexploited Mediterranean Swordfish (Xiphias gladius, 1759) Population Diversity doi: 10.3390/d12050170 Authors: Tommaso Righi Andrea Splendiani Tatiana Fioravanti Elia Casoni Giorgia Gioacchini Oliana Carnevali Vincenzo Caputo Barucchi Intense and prolonged mortality caused by over-exploitation could drive the decay of genetic diversity which may lead to decrease species’ resilience...
Sun Apr 26, 2020 03:00
Diversity, Vol. 12, Pages 169: Final Note of Special Issue “Tardigrades Taxonomy, Biology and Ecology” Diversity doi: 10.3390/d12050169 Authors: Łukasz Kaczmarek Tardigrada (water bears) are microscopic invertebrates inhabiting aquatic (freshwater and marine) and terrestrial habitats. They are thriving in almost all Earth ecosystems from deepest oceans to highest mountains, from tropics to polar regions. Water bears are probably most famous for their cryptobiotic abilities, which allow...
Sat Apr 25, 2020 03:00
Diversity, Vol. 12, Pages 168: Land-Use and Climate Impacts on Plant–Pollinator Interactions and Pollination Services Diversity doi: 10.3390/d12050168 Authors: Bo Dalsgaard Most flowering plants rely on animals for pollination and most animal pollinators rely on flowering plants for food resources. However, there is an ongoing concern that anthropogenic-induced global change threatens the mutualistic association between plants and pollinators. Two of the most important factors of global...
Sat Apr 25, 2020 03:00
Diversity, Vol. 12, Pages 167: Cave Communities: From the Surface Border to the Deep Darkness Diversity doi: 10.3390/d12050167 Authors: Enrico Lunghi Raoul Manenti The discipline of subterranean biology has provided us incredible information on the diversity, ecology and evolution of species living in different typologies of subterranean habitats. However, a general lack of information on the relationships between cave species still exists, leaving uncertainty regarding the dynamics...
Sat Apr 25, 2020 03:00
Diversity, Vol. 12, Pages 166: Attraction and Avoidance between Predators and Prey at Wildlife Crossings on Roads Diversity doi: 10.3390/d12040166 Authors: Cristina Mata Jesús Herranz Juan E. Malo Wildlife passages are currently built at roads and railway lines to re-establish connectivity. However, little is known about whether predator-prey interactions may reduce the effectiveness of the crossing structures. We evaluated the co-occurrence patterns of predator-prey species-pairs...
Fri Apr 24, 2020 03:00
Epigenomes, Vol. 4, Pages 6: An Epigenetics-Based Hypothesis of Autoantigen Development in Systemic Lupus Erythematosus Epigenomes doi: 10.3390/epigenomes4020006 Authors: Wesley Brooks Currently, we have a limited understanding of mechanisms leading to systemic lupus erythematosus, but we know that genetics, environmental factors, and epigenetics contribute to the disease. One common aspect of the various environmental triggers is that they can cause cellular stress. When extraordinary...
Thu Apr 23, 2020 03:00
Fermentation, Vol. 6, Pages 46: Selenastrum Capricornutum a New Strain of Algae for Biodiesel Production Fermentation doi: 10.3390/fermentation6020046 Authors: Pugliese Biondi Bartocci Fantozzi The increasing global demand for biofuels for energy security and to reduce the effects of climate change has created an opportunity to explore new sources of biomass, of which, microalgae is the most promising one. The Laboratory of the Biomass Research Centre (CRB, University of...
Sun Apr 26, 2020 03:00
Fermentation, Vol. 6, Pages 45: Evaluation of the Growth Kinetics of Lactobacillus Plantarum ATCC 8014 on a Medium Based on Hydrolyzed Bovine Blood Plasma at Laboratory and Bench-Scale Levels and Its Application as a Starter Culture in a Meat Product Fermentation doi: 10.3390/fermentation6020045 Authors: Barragán Sánchez Henao-Rojas Lactobacilli are used in food because of their beneficial effect on human health and their biopreservative activity in matured meat products. The...
Sun Apr 26, 2020 03:00
Fermentation, Vol. 6, Pages 44: Physicochemical, Microbiological and Functional Properties of Camelina Meal Fermented in Solid-State Using Food Grade Aspergillus Fungi Fermentation doi: 10.3390/fermentation6020044 Authors: Oladapo Oluwaseye Olukomaiya W. Chrishanthi Fernando Ram Mereddy Xiuhua Li Yasmina Sultanbawa Camelina meal (CAM) was fermented in solid-state using food grade Aspergillus fungi (A. sojae, A. ficuum and their co-cultures), and the physicochemical composition,...
Fri Apr 24, 2020 03:00
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