Κυριακή 26 Απριλίου 2020

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Soluble receptor for advanced glycation end-products promotes angiogenesis through activation of STAT3 in myocardial ischemia/reperfusion injury
Abstract Soluble receptor for advanced glycation end-products (sRAGE), which exerts cardioprotective effect through inhibiting cardiomyocyte apoptosis and autophagy during ischemia/reperfusion (I/R) injury, is also known to enhance angiogenesis in post-ischemic reperfusion injury-critical limb ischemia (PIRI-CLI) mice. However, whether sRAGE protects the heart from myocardial I/R injury via promoting angiogenesis remains unclear. Myocardial model of I/R injury was conducted by...
Latest Results
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In-depth characterization of the tumor microenvironment in central nervous system lymphoma reveals implications for immune-checkpoint therapy
Abstract Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin lymphoma with an aggressive clinical course. To investigate the potential of immune-checkpoint therapy, we retrospectively studied the tumor microenvironment (TME) using high-plex immunohistochemistry in 22 PCNSL and compared to 7 secondary CNS lymphomas (SCNSL) and 7 “other” CNSL lymphomas with the presence of the Epstein–Barr virus and/or compromised immunity. The TME in PCNSL was predominantly...
Latest Results for Cancer Immunology, Immunotherapy
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Peri-tumor administration of controlled release anti-CTLA-4 synergizes with systemic anti-PD-1 to induce systemic antitumor immunity while sparing autoimmune toxicity
Abstract Combination immunotherapy targeting the PD-1 and CTLA-4 checkpoint inhibitor pathways provides substantial clinical benefit in patients with advanced-stage cancer but at the risk of dose-limiting inflammatory and autoimmune toxicity. The delicate balance that exists between unleashing tumor killing and promoting systemic autoimmune toxicity represents a major clinical challenge. We hypothesized that targeting anti-CTLA-4 so that it perfuses tumor-draining lymph nodes...
Latest Results for Cancer Immunology, Immunotherapy
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Cryoablation combined with transarterial infusion of pembrolizumab (CATAP) for liver metastases of melanoma: an ambispective, proof-of-concept cohort study
Abstract Background The presence of liver metastasis correlates with poor therapeutic response of PD-1 blockade therapy in melanoma. A novel treatment protocol by combining cryoablation with transarterial infusion of pembrolizumab (CATAP) was proposed, and its feasibility and safety was assessed among this group of patients. Methods This registered...
Latest Results for Cancer Immunology, Immunotherapy
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IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18
Abstract NK cells, which are composed of phenotypically and functionally heterogeneous subpopulations, play critical roles in immunity against cancer. The mechanism of generation of distinct subsets such as the effector and regulatory subtypes is unclear. Here, we show that this process comprises several steps, including generation of proliferating, highly cytotoxic cells activated by IL-15/IL-18 and differentiation into distinct cell populations induced with IL-12. Freshly prepared...
Latest Results for Cancer Immunology, Immunotherapy
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Correction to: Coalescence-based species delimitation using genome-wide data reveals hidden diversity in a cosmopolitan group of lichens
The publisher regrets that the Table 3 of the original published version of this article is incorrect thus the table is now presented correctly. The original article has been corrected.
Latest Results for Organisms Diversity
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Relative pollen productivity estimates of major plant taxa and relevant source area of pollen in the warm-temperate forest landscape of northern China
Abstract Relative pollen productivity (RPP) is critical for quantitative vegetation reconstruction of past vegetation cover. The Extended R-value (ERV) model is commonly used for estimating RPP. In this study, we used modern pollen assemblages from 30 randomly selected surface sample sites, and these and vegetation data were applied to an ERV model to estimate pollen productivity of Pinus, Quercus, Corylus, Artemisia, Chenopodiaceae, Asteraceae and Caryophyllaceae relative to Poaceae....
Latest Results
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Optimizing the Use Of Teleneurology During the COVID-19 Pandemic
Telemedicine and e-Health, Ahead of Print.
Telemedicine and e-Health - Table of Contents
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Telemedicine and e-Health Solutions for COVID-19: Patients' Perspective
Telemedicine and e-Health, Ahead of Print.
Telemedicine and e-Health - Table of Contents
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Role of Telehealth in the Management of COVID-19: Lessons Learned from Previous SARS, MERS, and Ebola Outbreaks
Telemedicine and e-Health, Ahead of Print.
Telemedicine and e-Health - Table of Contents
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Considerations and Cautions for Three-Dimensional-Printed Personal Protective Equipment in the COVID-19 Crisis
3D Printing and Additive Manufacturing, Ahead of Print.
3D Printing and Additive Manufacturing - Table of Contents
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Mechanical Properties of Direct Waste Printing of Polylactic Acid with Universal Pellets Extruder: Comparison to Fused Filament Fabrication on Open-Source Desktop Three-Dimensional Printers
3D Printing and Additive Manufacturing, Ahead of Print.
3D Printing and Additive Manufacturing - Table of Contents
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Additive Manufacturing Can Assist in the Fight Against COVID-19 and Other Pandemics and Impact on the Global Supply Chain
3D Printing and Additive Manufacturing, Ahead of Print.
3D Printing and Additive Manufacturing - Table of Contents
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Clear Cell Sarcoma With Cutaneous Presentation in a 4-Year-Old Boy
Abstract: We report a case of a 4-year-old Brazilian boy, who presented with an erythematous and painful nodule involving the skin of his left arm. Immunohistochemistry was performed for S100, SOX10, CD34, desmin, SMA, HMB-45, CD1a, and CD163, and fluorescence in situ hybridization for EWSR1 gene rearrangement using a break-apart probe was completed. Immunohistochemistry showed bland spindle cells with “floret-like” appearance simulating a giant cell fibroblastoma; tumor cells were positive for...
The American Journal of Dermatopathology - Published Ahead-of-Print
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Dendritic Cell Neurofibroma With Pseudorosettes: A Variant of Neurofibroma?
No abstract available
The American Journal of Dermatopathology - Published Ahead-of-Print
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Syphilitic Chancre of the Lip
Abstract: Syphilis is a sexually transmitted disease caused by Treponema pallidum. The primary stage of the disease (the chancre) mainly involves the genital areas. Extragenital areas are involved in 5%–14% of cases, many of which occur in the oral cavity. Among the extragenital locations, the lip is the most frequent; however, despite this, published cases of the chancre of the lip are few. We present a case of a chancre presenting on the lip of a nonimmunocompromised 55-year-old male patient...
The American Journal of Dermatopathology - Published Ahead-of-Print
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Die Therapie der chronischen metabolischen Azidose im diabetologischen Umfeld
Dtsch med WochenschrDOI: 10.1055/a-1125-1836 Hintergrund: Die chronische metabolischen Azidose (cmA) ist eine häufige Komplikation bei chronischer Niereninsuffizienz, deren Behandlung bei niereninsuffizienten Patienten mit Diabetes mellitus die Insulinresistenz verbessern kann. Um die aktuelle Therapiesituation der cmA im diabetologischen Umfeld abzubilden und mehr über die Zusammenarbeit von Diabetologen und Nephrologen zu erfahren, wurden diabetologisch tätige Haus- und Fachärzte zur...
DMW - Deutsche Medizinische Wochenschrift
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Lineage-specific epigenomic and genomic activation of oncogene HNF4A promotes gastrointestinal adenocarcinomas
Gastrointestinal adenocarcinomas (GIAC) of the tubular GI tract including esophagus, stomach, colon, and rectum comprise most GI cancers and share a spectrum of genomic features. However, the unified epigenomic changes specific to GIAC are poorly characterized. Using 907 GIAC samples from The Cancer Genome Atlas, we applied mathematical algorithms to large-scale DNA methylome and transcriptome profiles to reconstruct transcription factor (TF) networks and identify a list of functionally hyperactive...
Cancer Research Online First Articles
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(LEFT) Partial Contents; (RIGHT) Elsevier E-alert 1/2 pg vertical BW filler
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
ScienceDirect Publication: The Journal of Emergency Medicine
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Contents
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
ScienceDirect Publication: The Journal of Emergency Medicine
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Editorial Board
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
ScienceDirect Publication: The Journal of Emergency Medicine
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Instructions for Authors
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
ScienceDirect Publication: The Journal of Emergency Medicine
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Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients with Sepsis and Severe Acute Respiratory Failure. The CITRIS-ALI Randomized Clinical Trial: Fowler III AA, Truwit, JD, Hite RD, et al. <em>JAMA.</em> 2019;322(13):1261-1270
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Meredith K. Von Dohlen, Jerrilyn Jones
ScienceDirect Publication: The Journal of Emergency Medicine
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Optimal Timing of Coronary Intervention in Patients Resuscitated From Cardiac Arrest Without ST-Segment Elevation Myocardia Infarction (NSTEMI): A Systematic Review And Meta-Analysis: Barbarawi M, Zayed Y, Kheiri B, et al. <em>Resuscitation</em>. 2019;144:137-144
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Ryan Matthews, Amanda Young
ScienceDirect Publication: The Journal of Emergency Medicine
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Effect of a Fluid Bolus on Cardiovascular Collapse Among Critically Ill Adults Undergoing Tracheal Intubation (PrePARE): A Randomized Controlled Trial: Janz DR, Casey JD, Semler MW, et al. <em>Lancet Respir Med</em>. 2019;7(12):1039–1047
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Alex Rahnema, Jerrilyn Jones
ScienceDirect Publication: The Journal of Emergency Medicine
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Cold-stored Whole Blood: A Better Method of Trauma Resuscitation?: Hazelton JP, Cannon JW, Zatorski C, et al. <em>Journal of Trauma and Acute Care Surgery</em> 2019; 87(5):1035-1041
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Matthew Harrison, Amanda Young
ScienceDirect Publication: The Journal of Emergency Medicine
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Emergency Department to ICU Time Is Associated With Hospital Mortality: A Registry Analysis of 14,788 Patients From Six University Hospitals in The Netherlands: Groenland CNL, Termorshuizen F, Rietdijk WJR, et al. <em>Critical Care Medicine</em>. 2019;47(11):1564-1571
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Laura Werline, Amanda Young
ScienceDirect Publication: The Journal of Emergency Medicine
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Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial: Spinella PC, Tucci M, Fergusson DA, et al. <em>JAMA.</em> 2019;322(22):2179-2190
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Bethany Dalby, Jerrilyn Jones
ScienceDirect Publication: The Journal of Emergency Medicine
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AAEM_pages_Feb_2020
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
ScienceDirect Publication: The Journal of Emergency Medicine
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Dan Danzl the Paradox: Cool Dude, Warm Heart
Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Tej Dhindsa, Martin Huecker
ScienceDirect Publication: The Journal of Emergency Medicine
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[ASAP] Direct and High-Throughput Fabrication of Mie-Resonant Metasurfaces <italic toggle="yes">via</italic> Single-Pulse Laser Interference
ACS NanoDOI: 10.1021/acsnano.0c01993
ACS Nano: Latest Articles (ACS Publications)
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[ASAP] Massive Growth of Graphene Quartz Fiber as a Multifunctional Electrode
ACS NanoDOI: 10.1021/acsnano.0c01298
ACS Nano: Latest Articles (ACS Publications)
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[ASAP] Reusable and Recyclable Graphene Masks with Outstanding Superhydrophobic and Photothermal Performances
ACS NanoDOI: 10.1021/acsnano.0c02250
ACS Nano: Latest Articles (ACS Publications)
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[ASAP] Molecular Approach for Engineering Interfacial Interactions in Magnetic/Topological Insulator Heterostructures
ACS NanoDOI: 10.1021/acsnano.0c02498
ACS Nano: Latest Articles (ACS Publications)
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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020
ACS NanoDOI: 10.1021/acsnano.0c03262
ACS Nano: Latest Articles (ACS Publications)
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[ASAP] Aerosol Filtration Efficiency of Common Fabrics Used in Respiratory Cloth Masks
ACS NanoDOI: 10.1021/acsnano.0c03252
ACS Nano: Latest Articles (ACS Publications)
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[ASAP] Black Phosphorus-Loaded Separable Microneedles as Responsive Oxygen Delivery Carriers for Wound Healing
ACS NanoDOI: 10.1021/acsnano.0c01059
ACS Nano: Latest Articles (ACS Publications)
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Fatal association of fulminant myocarditis and rhabdomyolysis after immune checkpoint blockade
Immune checkpoint ;blockade (CPB) is increasingly used in the treatment of cancer, as it has revolutionized the treatment of advanced malignant melanoma and has recently shown efficacy in other tumour types, such as non–small-cell lung cancer. This therapy includes monoclonal antibodies targeting cytotoxic T-lymphocyte–associated protein 4 (Ipilimumab) and programmed cell death protein 1 (Nivolumab). The mechanism of action of these agents is an enhancement of the antitumour immune response by blocking...
European Journal of Cancer - Articles in Press
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Living with Dysphagia in the Community: Caregivers “ do whatever it takes. ”
Abstract The psychological and psychosocial impacts of dysphagia on patients are well documented, however, caregiver perspectives have received limited attention and findings have been predominantly in the head and neck cancer population. The aim of this study was to understand the experience of supporting a person with dysphagia of varying aetiologies in the community from the caregiver perspective. Using a qualitative descriptive approach grounded in phenomenology, caregivers...
Dysphagia
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