Abstract Soluble receptor for advanced glycation end-products (sRAGE), which exerts cardioprotective effect through inhibiting cardiomyocyte apoptosis and autophagy during ischemia/reperfusion (I/R) injury, is also known to enhance angiogenesis in post-ischemic reperfusion injury-critical limb ischemia (PIRI-CLI) mice. However, whether sRAGE protects the heart from myocardial I/R injury via promoting angiogenesis remains unclear. Myocardial model of I/R injury was conducted by...
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Abstract Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin lymphoma with an aggressive clinical course. To investigate the potential of immune-checkpoint therapy, we retrospectively studied the tumor microenvironment (TME) using high-plex immunohistochemistry in 22 PCNSL and compared to 7 secondary CNS lymphomas (SCNSL) and 7 “other” CNSL lymphomas with the presence of the Epstein–Barr virus and/or compromised immunity. The TME in PCNSL was predominantly...
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Abstract Combination immunotherapy targeting the PD-1 and CTLA-4 checkpoint inhibitor pathways provides substantial clinical benefit in patients with advanced-stage cancer but at the risk of dose-limiting inflammatory and autoimmune toxicity. The delicate balance that exists between unleashing tumor killing and promoting systemic autoimmune toxicity represents a major clinical challenge. We hypothesized that targeting anti-CTLA-4 so that it perfuses tumor-draining lymph nodes...
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Abstract Background The presence of liver metastasis correlates with poor therapeutic response of PD-1 blockade therapy in melanoma. A novel treatment protocol by combining cryoablation with transarterial infusion of pembrolizumab (CATAP) was proposed, and its feasibility and safety was assessed among this group of patients. Methods This registered...
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Abstract NK cells, which are composed of phenotypically and functionally heterogeneous subpopulations, play critical roles in immunity against cancer. The mechanism of generation of distinct subsets such as the effector and regulatory subtypes is unclear. Here, we show that this process comprises several steps, including generation of proliferating, highly cytotoxic cells activated by IL-15/IL-18 and differentiation into distinct cell populations induced with IL-12. Freshly prepared...
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The publisher regrets that the Table 3 of the original published version of this article is incorrect thus the table is now presented correctly. The original article has been corrected.
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Abstract Relative pollen productivity (RPP) is critical for quantitative vegetation reconstruction of past vegetation cover. The Extended R-value (ERV) model is commonly used for estimating RPP. In this study, we used modern pollen assemblages from 30 randomly selected surface sample sites, and these and vegetation data were applied to an ERV model to estimate pollen productivity of Pinus, Quercus, Corylus, Artemisia, Chenopodiaceae, Asteraceae and Caryophyllaceae relative to Poaceae....
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Telemedicine and e-Health, Ahead of Print.
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Telemedicine and e-Health, Ahead of Print.
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Telemedicine and e-Health, Ahead of Print.
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3D Printing and Additive Manufacturing, Ahead of Print.
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3D Printing and Additive Manufacturing, Ahead of Print.
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3D Printing and Additive Manufacturing, Ahead of Print.
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Abstract: We report a case of a 4-year-old Brazilian boy, who presented with an erythematous and painful nodule involving the skin of his left arm. Immunohistochemistry was performed for S100, SOX10, CD34, desmin, SMA, HMB-45, CD1a, and CD163, and fluorescence in situ hybridization for EWSR1 gene rearrangement using a break-apart probe was completed. Immunohistochemistry showed bland spindle cells with “floret-like” appearance simulating a giant cell fibroblastoma; tumor cells were positive for...
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No abstract available
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Abstract: Syphilis is a sexually transmitted disease caused by Treponema pallidum. The primary stage of the disease (the chancre) mainly involves the genital areas. Extragenital areas are involved in 5%–14% of cases, many of which occur in the oral cavity. Among the extragenital locations, the lip is the most frequent; however, despite this, published cases of the chancre of the lip are few. We present a case of a chancre presenting on the lip of a nonimmunocompromised 55-year-old male patient...
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Dtsch med WochenschrDOI: 10.1055/a-1125-1836 Hintergrund: Die chronische metabolischen Azidose (cmA) ist eine häufige Komplikation bei chronischer Niereninsuffizienz, deren Behandlung bei niereninsuffizienten Patienten mit Diabetes mellitus die Insulinresistenz verbessern kann. Um die aktuelle Therapiesituation der cmA im diabetologischen Umfeld abzubilden und mehr über die Zusammenarbeit von Diabetologen und Nephrologen zu erfahren, wurden diabetologisch tätige Haus- und Fachärzte zur...
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Gastrointestinal adenocarcinomas (GIAC) of the tubular GI tract including esophagus, stomach, colon, and rectum comprise most GI cancers and share a spectrum of genomic features. However, the unified epigenomic changes specific to GIAC are poorly characterized. Using 907 GIAC samples from The Cancer Genome Atlas, we applied mathematical algorithms to large-scale DNA methylome and transcriptome profiles to reconstruct transcription factor (TF) networks and identify a list of functionally hyperactive...
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Meredith K. Von Dohlen, Jerrilyn Jones
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Ryan Matthews, Amanda Young
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Alex Rahnema, Jerrilyn Jones
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Matthew Harrison, Amanda Young
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Laura Werline, Amanda Young
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Bethany Dalby, Jerrilyn Jones
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s):
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Publication date: February 2020Source: The Journal of Emergency Medicine, Volume 58, Issue 2Author(s): Tej Dhindsa, Martin Huecker
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ACS NanoDOI: 10.1021/acsnano.0c01993
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ACS NanoDOI: 10.1021/acsnano.0c01298
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ACS NanoDOI: 10.1021/acsnano.0c02250
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ACS NanoDOI: 10.1021/acsnano.0c02498
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ACS NanoDOI: 10.1021/acsnano.0c03262
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ACS NanoDOI: 10.1021/acsnano.0c03252
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ACS NanoDOI: 10.1021/acsnano.0c01059
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Immune checkpoint ;blockade (CPB) is increasingly used in the treatment of cancer, as it has revolutionized the treatment of advanced malignant melanoma and has recently shown efficacy in other tumour types, such as non–small-cell lung cancer. This therapy includes monoclonal antibodies targeting cytotoxic T-lymphocyte–associated protein 4 (Ipilimumab) and programmed cell death protein 1 (Nivolumab). The mechanism of action of these agents is an enhancement of the antitumour immune response by blocking...
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Abstract The psychological and psychosocial impacts of dysphagia on patients are well documented, however, caregiver perspectives have received limited attention and findings have been predominantly in the head and neck cancer population. The aim of this study was to understand the experience of supporting a person with dysphagia of varying aetiologies in the community from the caregiver perspective. Using a qualitative descriptive approach grounded in phenomenology, caregivers...
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