IDH1/2 mutations in NSCLCs are uncommon. They occur in adenocarcinomas with high‐grade features and may be branching drivers leading to subclonal evolution. Abstract Background Selective IDH1 and IDH2 inhibitors have been approved for targeted therapy of acute myeloid leukemia. Clinical trials for solid tumors with IDH1 and IDH2 (IDH1/2) mutations are ongoing. Reports of IDH1/2‐mutated non–small cell lung cancers (NSCLCs), however, are limited. Methods We evaluated IDH1/2 mutations in...
21h
Patient reported outcomes need to become the standard in prostate cancer RCTs. There is need for consensus on the use of PRO data, which will reflect their use in the guidelines and future data collection. Abstract Background Given the growing importance of patient‐reported outcomes (PROs) as part of “big data” in improving patient care, there is a need to provide a state‐of‐the‐art picture of the added value of using PROs in prostate cancer (PCa) randomized controlled trials (RCTs). We aimed...
21h
Patients with clinically significant prostate cancer‐related anxiety should be assessed for major depression (and vice versa), as well as productivity loss. Abstract Background There are uncertainties about prostate cancer‐related anxiety's (PCRA) associations with health‐related quality of life (HRQOL) and major depression, and these could affect the quality of mental healthcare provided to prostate cancer patients. Addressing these uncertainties will provide more insight into PCRA and inform...
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Urachal carcinoma has a high recurrence rate, but only peritoneal metastasis, distant metastasis, and recurrence in pelvic lymph nodes were found to be associated with OS. Although lymphadenectomy was not an independent prognostic factor for DFS and OS, the data of this study showed a possibility that lymphadenectomy could improve surgical outcomes. Abstract Background Urachal carcinoma is a rare nonurothelial malignant tumor with high rates of local recurrence and systemic metastasis. Although...
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The study provides an innovative simulation approach using national patient‐level datasets, patient preferences based on actual hospital selections, and personal characteristics to inform health service planning. With this approach, we demonstrated for prostate cancer surgery that three different centralization scenarios would lead to similar numbers of center closures but to different increases in patient travel time, whilst all having a minimal impact on equity. Abstract Introduction There...
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This study demonstrated the promoter role of SNHG16 played in regulating autophagy in Hep3B cells with sorafenib resistance, which further contribute to a stronger sorafenib resistance in Hep3B cells. Moreover, the above process implemented through regulating the expression of miR‐23b‐3p via sponging EGR1. Abstract Objective Tumor cells could acquire drug resistance through cell autophagy. This study aimed to explore the role of SNHG16 in sorafenib‐resistant HCC cells and its mechanism with...
1d
Among French cancer survivors, 37% had a limited health literacy level. They were more likely to use GP care and social services. Raising awareness and training general practitioners and social workers on medico‐social follow‐up for patients with limited health literacy seem necessary to support these vulnerable survivors. Abstract Background Long‐term medico‐social follow‐up of cancer survivors is a challenge because of frequent subsequent troubles. In particular survivors with lower health...
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This review aims to introduce two principles of magnetic isolation and recent techniques, facilitating research in this field and providing alternatives for researchers in their study of magnetic isolation. Researchers intend to promote effective CTC isolation and analysis as well as active development of next‐generation cancer treatment. Abstract Circulating tumor cells (CTCs) largely contribute to cancer metastasis and show potential prognostic significance in cancer isolation and detection....
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Abstract Objectives This study aimed to investigate the vascular response of lesions with a layered phenotype. Background Recent studies have shown that layered plaques at culprit lesions detected by optical coherence tomography (OCT) have greater plaque burden and more inflammatory features than non‐layered plaques. Methods This is a retrospective observational study. A total of 193 target lesions from 193 patients [100 patients with acute coronary syndromes (ACS) and...
21h
Abstract Background Percutaneous coronary intervention (PCI) is increasingly utilized for treatment of coronary disease involving the unprotected left main stem (ULMS). However, no studies to date have examined the outcomes of such interventions when complicated by coronary perforation (CP). Methods Using the British Cardiovascular Intervention society (BCIS) database, data were analyzed on all ULMS‐PCI procedures complicated by CP in England and Wales between 2007 and 2014. Multivariate...
21h
Abstract Objectives The purpose of this study was to investigate 30‐day and 2‐year clinical outcomes, and predictors of 2‐year mortality in nonagenarians undergoing transcatheter aortic valve implantation (TAVI). Background TAVI has been applied to nonagenarians. However, sufficient clinical data in nonagenarians who could benefit from TAVI are limited. Methods We evaluated the data from the optimized catheter valvular intervention‐TAVI registry. Clinical outcomes were...
21h
Abstract Objectives We aimed to evaluate the early and one‐year outcomes of Impella‐supported high‐risk nonemergent percutaneous coronary intervention (PCI). Background The evidence for the use of mechanical circulatory support (MCS) devices in high‐risk nonemergent PCI is limited and nonconclusive. Methods We performed a single‐center retrospective study including all patients who underwent high‐risk nonemergent PCI supported by Impella 2.5/CP at our institution between...
21h
Abstract Objective The purpose of this experimental bench test was to compare stent deformation, obstruction of stent struts at a jailed side branch (SB) ostium, and stent strut malapposition between SB inflation using proximal balloon edge dilation (PBED) technique and SB inflation using conventional balloon dilation in repetitive‐proximal optimizing technique (re‐POT) sequence. Background The second proximal optimizing technique (POT) procedure in the re‐POT sequence might increase...
1d
Abstract Objectives This study aimed to assess the impact of stent optimization by NC‐balloon postdilatation (PD) during primary‐PCI for STEMI with the use of coronary physiology and intracoronary imaging. Methods This was a prospective observational study (ClinicalTrials.gov:NCT02788396). Optical coherence tomography (OCT) and physiological measurements were performed immediately before and after PD with the operators blinded to all measurements. The index of microcirculatory resistance...
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Abstract Objective To summarize published case reports of aortocoronary arteriovenous fistula (ACAVF) after coronary artery bypass grafting surgery (CABG). Background Inadvertent ACAVF is a rare complication following CABG. However, the incidence continues to rise, and its management details and clinical outcomes have not been well described. Methods To identify all published cases of ACAVF following CABG, PubMed, EMBASE, and Scopus were searched through November 2019....
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Abstract Natural killer group 2 member D (NKG2D) ligands (NKG2DLs) on tumor cells engage NKG2D and mediate the killing by NKG2D+ immune cells. However, tumor cells with high NKG2DLs are still malignant and proliferate rapidly. We investigated the reason for NKG2DL‐expressing cell progression. Tumor cells in mice were assessed for their NKG2DL expression, ability to attract immune cells, tumorigenicity, mTOR and signal transducer and activator of transcription 3 (STAT3) signaling activation. The...
21h
Abstract Treatment‐free remission (TFR), wherein patients discontinue pharmacotherapy and remain in molecular remission, is an emerging treatment goal for patients with chronic myeloid leukemia (CML). Attainment of TFR requires an increased frequency of molecular monitoring, to ensure that patients maintain a deep molecular response. The objective of this analysis was to assess the economic impact of stopping nilotinib among Japanese TFR‐eligible patients. A Markov model evaluated the economic...
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Abstract Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in Southeast Asia, hence, identifying easily detectable biomarkers for NPC screening is essential for better diagnosis and prognosis. Using genome‐wide and targeted analyses based on next‐generation sequencing approaches, we previously showed that gene promoters are hypermethylated in NPC tissues. To confirm whether DNA methylation rates of genes could be used as biomarkers for NPC screening, Seventy‐nine histologically diagnosed...
1d
Abstract Invariant natural killer T (iNKT) cells are innate‐like CD1d‐restricted T cells that express the invariant T cell receptor (TCR) composed of Va24 and Vb11 in humans. iNKT cells specifically recognize glycolipid antigens such as a‐galactosylceramide (aGalCer) presented by CD1d. iNKT cells show direct cytotoxicity toward CD1d‐positive tumor cells, especially when CD1d presents glycolipid antigens. However, iNKT cell recognition of CD1d‐negative tumor cells is unknown, and direct cytotoxicity...
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Gelsolin inhibits malignant phenotype of glioblastoma and is regulated by miR‐654‐5p and miR‐450b‐5p
Abstract We have previously shown that gelsolin (GSN) levels are significantly lower in the blood of patients with glioblastoma (GBM) than in healthy controls. Here, we analyzed the function of GSN in GBM and examined its clinical significance. Furthermore, microRNAs (miRNAs) involved in GSN expression were also identified. The expression of GSN was determined using western blot analysis and found to be significantly lower in GBM samples than normal ones. GSN was mainly localized in normal astrocytes,...
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Abstract Background VTP‐50469 is a potent inhibitor of the menin‐MLL1 interaction and is implicated in signaling downstream of EWSR1‐FLI1. Procedure VTP‐50469 was evaluated against seven Ewing sarcoma (EwS) xenograft models and in vitro against EwS cell lines. Results VTP‐50469 showed limited antitumor activity, statistically significantly slowing tumor progression in four tumor models but with no evidence of tumor regression. In vitro, the IC50 concentration was 10 nM...
22h
Financial toxicity of childhood cancer and changes to parents’ employment after treatment completion
Abstract Objective Childhood cancer can have short‐ and long‐term impacts on parents’ finances and employment. It is important to understand how families adjust to the financial and employment changes caused by childhood cancer, the ongoing impacts after treatment completion, and which families need more targeted support. Qualitative research is necessary to facilitate an in‐depth understanding of the employment and financial impacts on families and to capture parents’ complex and nuanced...
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Abstract It is unclear if dosing intervals for Erwinase can be extended with intramuscular (i.m.) versus intravenous (i.v.) dosing. Children with acute lymphoblastic leukemia received Erwinase at 30 000‐42 000 IU/m2 i.v. or i.m. I.m. Erwinase (n = 22) achieved activity above 0.1 IU/mL for longer than i.v. Erwinase (n = 33) (3.4 vs 2.9 days, P = 0.0007). With 30 000 IU/m2 Monday, Wednesday, Friday, more patients achieved adequate concentrations over the weekend with i.m. vs i.v. dosing (P = 5 × 10−36)....
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Abstract Background Rearrangements of chromosome 8q24/MYC (8q24/MYC‐r), resulting from t(8;14)(q24;q32), t(2;8)(p11;q24), or t(8;22)(q24;q11), are mainly associated with Burkitt lymphoma/leukemia (BL) and rarely observed in patients with B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). The characteristics of BCP‐ALL with 8q24/MYC‐r are poorly understood. Procedure A retrospective nationwide study of data from patients with pediatric BCP‐ALL with 8q24/MYC‐r in Japan was conducted...
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Abstract Introduction Indications for hematopoietic stem cell transplantation (HSCT) in pediatric acute myeloid leukemia (AML) are primarily dependent on risk stratification at diagnosis and relapse status. We sought to determine whether access to HSCT is influenced by regional and socioeconomic factors. Methods Children with newly diagnosed AML aged < 15 years between 2001 and 2015 were identified using the Cancer in Young People in Canada national population–based registry....
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Abstract Background We sought to develop mapping functions that use EORTC responses to approximate health utility (HU) scores for patients with head and neck cancer (HNC). Methods In total, 209 outpatients with HNC completed the EORTC QLQ‐C30 & QLQ‐H&N35 (EORTC), EQ‐5D‐5L and the HUI‐3. Results of the EORTC were mapped onto both EQ‐5D‐5L and HUI‐3 scores using ordinary least squares regression and two‐part models. Results The OLS model mapping EORTC onto the EQ‐5D‐5L...
22h
Abstract Aim The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has put health care workers at risk when exposed to aerosolized viral particles during upper airway mucosal surgery. The objective of this review was to discuss topical preparations that could be utilized preoperatively to help to decrease viral load and potentially reduce the risks of viral transmission. Methods A PubMed/MEDLINE database review of articles was performed...
22h
Abstract Multidisciplinary conferences (MDC) are an important component of head and neck oncologic care including diagnosis, treatment, and survivorship. Virtual MDC allows for improved collaboration between providers at distant sites and proper allocation of healthcare resources in a time of crisis. When approached systematically, a virtual MDC is feasible to design and implement in a large academic medical center with multiple satellite hospitals. This article is protected by copyright. All...
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Abstract Background The coronavirus infection is rapidly spreading putting a strain on healthcare services across the globe. Oral cancer patients are susceptible often immunosuppressed due to the disease and/or the treatment received. Methods We performed a simulationof the currently available data using a multi state and hazards model to provide an objective model for counseling and decision making for healthcare workers. Results Stage IV oral cancer patients that did...
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Abstract Background In the context of COVID‐19, cancer survivors represent a particularly vulnerable population that may be “doubly hit” both by costs of cancer treatment and financial strain imposed by the pandemic. Methods We performed a review of the literature pertaining to cancer, financial toxicity, and economic challenges. Results Multiple societies have put forth recommendations to modify delivery of cancer care in order to minimize patient exposure to the virus....
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Abstract Background The COVID‐19 pandemic has resulted in the implementation of rapidly changing protocols and guidelines related to the indications and perioperative precautions and protocols for tracheotomy. The purpose of this study was to evaluate current guidelines for tracheostomy during the COVID‐19 pandemic to provide a framework for health systems to prepare as the science evolves over the upcoming months and years. Methods Literature review was performed. Articles reporting...
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Abstract Background The SARS‐CoV‐2 (COVID‐19) pandemic has caused rapid changes in head and neck cancer (HNC) care. “Real‐time” methods to monitor practice patterns can optimize provider safety and patient care. Methods Head and neck surgeons from 14 institutions in the United States regularly contributed their practice patterns to a shared spreadsheet. Data from March 27th, 2020 to April fifth, 2020 was analyzed. Results All institutions had significantly restricted HNC...
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Abstract The COVID‐19 pandemic has upended head and neck cancer care delivery in ways unforeseen and unprecedented. The impact of these changes parallels other fields in oncology, but is disproportionate due to protective measures and limitations on potentially aerosolizing procedures and related interventions specific to the upper aerodigestive tract. The moral and professional dimensions of providing ethically appropriate and consistent care for our patients in the COVID‐19 crisis are considered...
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Abstract Background During the SARS‐CoV‐2 pandemic, tracheostomy may be required for COVID‐19 patients requiring long term ventilation in addition to other conditions such as airway compromise from head and neck cancer. As an aerosol generating procedure, tracheostomy increases healthcare worker exposure to COVID‐19 infection. Performing surgical tracheostomy and tracheostomy care requires a strategy that mitigates these risks and maintains the quality of patient care. Methods A...
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Abstract Background Combining photon or proton radiotherapy with targeted therapy shows promise for head and neck cancer (HNSCC). The poly (adenosine diphosphate [ADP]‐ribose) polymerase‐1/2 inhibitor niraparib targets DNA damage repair (DDR). We evaluated the effects of niraparib in combination with photons or protons, and its effects on the relative biological effectiveness (RBE) of protons, in human HNSCC cell lines. Methods Radiosensitivity was assessed and RBE was calculated...
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