Protein cross-linking and the analysis of cross-linked peptides by mass spectrometry is currently receiving much attention. Not only is this approach applied to isolated complexes to provide information about spatial arrangements of proteins but it is also increasingly applied to entire cells and their organelles. As in quantitative proteomics, the application of isotopic labelling further makes it possible to monitor quantitative changes in the protein-protein interactions between different states...
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The vessel wall is continuously exposed to hemodynamic forces generated by blood flow. Endothelial mechanosensors perceive and translate mechanical signals via cellular signaling pathways into biological processes that control endothelial development, phenotype and function. To assess the hemodynamic effects on the endothelium on a system-wide level, we applied a quantitative mass spectrometry approach combined with cell surface chemical footprinting. SILAC-labeled endothelial cells were subjected...
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Protein cross-linking and the analysis of cross-linked peptides by mass spectrometry is currently receiving much attention. Not only is this approach applied to isolated complexes to provide information about spatial arrangements of proteins but it is also increasingly applied to entire cells and their organelles. As in quantitative proteomics, the application of isotopic labelling further makes it possible to monitor quantitative changes in the protein-protein interactions between different states...
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The vessel wall is continuously exposed to hemodynamic forces generated by blood flow. Endothelial mechanosensors perceive and translate mechanical signals via cellular signaling pathways into biological processes that control endothelial development, phenotype and function. To assess the hemodynamic effects on the endothelium on a system-wide level, we applied a quantitative mass spectrometry approach combined with cell surface chemical footprinting. SILAC-labeled endothelial cells were subjected...
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In this paper, by applying the Jacobian ellipse function method, we obtain a group of periodic traveling wave solution of coupled KdV equations. Furthermore, by the implicit function theorem, the relation between some wave velocity and the solution’s period is researched. Lastly, we show that this type of solution is orbitally stable by periodic perturbations of the same wavelength as the underlying wave.
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A multimode process monitoring method based on multiblock projection nonnegative matrix factorization (MPNMF) is proposed for traditional process monitoring methods which often adopt global model of data and ignore local information of data. Firstly, the training data set of each mode is partitioned by the complete link algorithm and the multivariate data space is divided into several subblocks. Then, the projection nonnegative matrix factorization (PNMF) algorithm is used to model each subspace...
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Publication date: Available online 25 April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Jie Yan, Shuangni Yu, Congwei Jia, Min Li, Jie Chen
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Publication date: Available online 24 April 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Amir Ajoolabady, Ayuob Aghanejad, Yagunag Bi, Yingmei Zhang, H.A. Hamid Aslkhodapasand, Alireza Abhari, Jun Ren
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Abstract In this rapid commentary, a mini-review is given of the present state-of-knowledge regarding the etiology and epidemiology of the new coronavirus 2019-nCoV and the risks for developing Acute respiratory distress syndrome (ARDS). The available knowledge on the viral genomics, molecular biology and pathogenicity of viruses of the Coronaviridae family and other Nidovirales, forms a helpful template for understanding the present pandemic outbreak. However, important questions...
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Abstract Purpose of Review Although Alzheimer’s disease (AD) was described over a century ago, there remains no cure, and with the global demographic shift to older ages, the impact is increasing rapidly. This article summarizes how the conceptualization of AD has evolved in response to research advances. Current challenges including the impact of multimorbidity are outlined, and potential targets for prevention are discussed. ...
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Publication date: Available online 24 April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Carlos Calafí, María López-Malo, Diego Velázquez, Chunyi Zhang, José Fernández-Fernández, Olga Rodríguez-Galán, Jesús de la Cruz, Joaquín Ariño, Antonio Casamayor
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Abstract Various studies have examined morphometric features of the vertebrae to understand the functional aspects of the spine. Geometric analysis of vertebral zygapophyseal facets has also been related to functional and clinical aspects of the spine, but no quantitative investigation of the costotransverse joint facet is found in the literature. The costal facet geometry may partly determine the mechanical interaction between the rib cage and spine for trunk stabilization during...
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Abstract The brachial plexus is an important nervous structure from which all major nerves to the upper limb arise. It typically originates from the anterior rami of the C5–T1 spinal nerves. As it passes laterally, the roots are successively organized into three trunks, six divisions, and three cords. The BP is susceptible to injury during the perinatal and postnatal periods, as well as in adulthood. Its structure can show considerable variation, and there is a wealth of literature...
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Publication date: Available online 24 April 2020Source: BrachytherapyAuthor(s): Gustavo Arruda Viani, Caio Viani Arruda, Alexandre Ciufi Faustino, Ligia Issa De Fendi
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Publication date: Available online 24 April 2020Source: Microbiological ResearchAuthor(s): Lucas J. Robinson, Jennifer N. Verrett, Naveen Sorout, John Stavrinides
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Abstract Background Although percutaneous coronary intervention (PCI) had become widely employed therapeutic procedure for coronary artery disease, stent restenosis limited the benefits of this revascularization and the question how to prevent such events remained unresolved. While numerous empirical observations suggested Tongguan Capsules (通冠胶囊), a patented Chinese Medicine, could decrease frequency and duration of angina pectoris...
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Publication date: Available online 25 April 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Andreas M. Bapst, Sophie L. Dahl, Thomas Knöpfel, Roland H. Wenger
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Abstract High-dose chemotherapy is increasingly evidenced to be neurotoxic and result in long-term neurocognitive sequelae. However, research investigating grey matter alterations in childhood cancer patients remains limited. As childhood sarcoma patients receive high-dose chemotherapy, we aimed to investigate cortical brain alterations in adult survivors. We analyzed high-resolution structural (T1-weighted) MRI and resting-state functional MRI (rsfMRI), to derive structural and...
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Abstract Multiple reports for brain functional and structural alterations in patients with Crohn’s disease (CD) were published. The current study aimed to meta-analyze the existing neuroimaging data and hence produce a brain map revealing areas with functional and structural differences between patients with CD and healthy controls. Original studies published until 2019 were identified from Scopus, Web of Science and PubMed databases, and included into the analysis if they reported...
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Abstract Recent work in healthy adults suggests that white matter organization within the superior longitudinal fasciculus (SLF) may, at least partly, explain individual differences in fine motor skills. The SLF is also often implicated in the neurobiology underlying attention deficit hyperactivity disorder (ADHD) as part of the attention network connecting frontal and parietal regions. While ADHD is primarily characterized by inattention, impulsivity and/or hyperactivity, atypical...
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Publication date: Available online 25 April 2020Source: Health PolicyAuthor(s): Lara Carminati
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Publication date: Available online 24 April 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): Y.Y. Leung, A.W.K. Yeung, I.N. Ismail, N.S.M. Wong
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Publication date: Available online 25 April 2020Source: Experimental Cell ResearchAuthor(s): Masato Yoshihara, Yoshihiko Yamakita, Hiroaki Kajiyama, Takeshi Senga, Yoshihiro Koya, Mamoru Yamashita, Akihiro Nawa, Fumitaka Kikkawa
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Publication date: Available online 24 April 2020Source: Experimental Cell ResearchAuthor(s): Bo-Jie Lin, Guan-Yu Lin, Jiang-Ying Zhu, Guo-Qian Yin, Dan Huang, Yu-Yong Yan
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Publication date: Available online 24 April 2020Source: Experimental Cell ResearchAuthor(s): Xin Jing, Shan Shao, Yujiao Zhang, Anqi Luo, Lin Zhao, Lifen Zhang, Shanzhi Gu, Xinhan Zhao
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Publication date: Available online 23 April 2020Source: Experimental Cell ResearchAuthor(s): Qingling Yuan, Yuxia Fan, Zheng Liu, Xiaoming Wang, Meng Jia, Zushi Geng, Jian Zheng, Xiubo Lu
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Biosensors, Vol. 10, Pages 44: Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis Biosensors doi: 10.3390/bios10050044 Authors: Timo Sorsa Joseph Bacigalupo Mauno Könönen Pirjo Pärnänen Ismo T. Räisänen Previous studies report periodontitis and peri-implantitis being able to induce systemic low-grade inflammation, which is known to be associated with increased risk for some systemic medical disease such as cardiovascular disease....
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Publication date: Available online 24 April 2020Source: Journal of Controlled ReleaseAuthor(s): Rishi Sharma, Siva P. Kambhampati, Zhi Zhang, Anjali Sharma, Samuel Chen, Erica I. Duh, Sujatha Kannan, Mark O.M. Tso, Rangaramanujam M. Kannan
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Publication date: Available online 24 April 2020Source: Journal of Controlled ReleaseAuthor(s): Vimisha Dharamdasani, Abhirup Mandal, Qin M. Qi, Isabella Suzuki, Maria Vitória Lopes Badra Bentley, Samir Mitragotri
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Publication date: Available online 24 April 2020Source: Journal of Controlled ReleaseAuthor(s): Fang Yuan, Mengnan Sun, Huiqin Liu, Feng Qian
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Publication date: Available online 24 April 2020Source: Journal of Controlled ReleaseAuthor(s): Alpana A. Thorat, Bhushan Munjal, Todd W. Geders, Raj Suryanarayanan
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Publication date: Available online 23 April 2020Source: Journal of Controlled ReleaseAuthor(s): Chunhua Yang, Mingzhen Zhang, Sudeep Lama, Lixin Wang, Didier Merlin
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Publication date: Available online 23 April 2020Source: Journal of Controlled ReleaseAuthor(s): Tang Li, Adrian Hawley, Thomas Rades, Ben J. Boyd
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Publication date: Available online 23 April 2020Source: Journal of Controlled ReleaseAuthor(s): Young Ji Ko, Jong Won Lee, Hyosuk Kim, EunJi Cho, Yoosoo Yang, In-San Kim, Sun Hwa Kim, Ick Chan Kwon
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Publication date: Available online 24 April 2020Source: CryobiologyAuthor(s): Mohammad Hamed Shahsavari, Kele Amaral Alves, Benner Geraldo Alves, Laritza Ferreira de Lima, Diego Alberto Montano Vizcarra, Deysi Juana Dipaz Berrocal, Luciana Mascena Silva, Yago Pinto da Silva, Mary B. Zelinski, José Ricardo de Figueiredo, Gholamali Moghaddam, Ana Paula Ribeiro Rodrigues
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ABSTRACT Acral lentiginous melanoma is a histological subtype of cutaneous melanoma that occurs in the glabrous skin of the palms, soles and in the nail unit. Although in some countries, particularly in Latin America, Africa and Asia, it represents the most frequently diagnosed subtype of the disease, it only represents a small proportion of melanoma cases in European‐descent populations, which is partially why it has not been studied to the same extent as other forms of melanoma. As a result,...
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Publication date: Available online 25 April 2020Source: Journal of BiomechanicsAuthor(s): Masahiko Sugano, Shigeo Hagiwara, Junichi Nakamura, Yusuke Matsuura, Takane Suzuki, Yasushi Wako, Michiaki Miura, Yuya Kawarai, Kento Nawata, Kensuke Yoshino, Kenta Konno, Satoshi Yoh, Seiji Ohtori
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Publication date: Available online 24 April 2020Source: Journal of BiomechanicsAuthor(s): Maximilian Aurbach, Jan Spicka, Franz Süß, Sebastian Dendorfer
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