Biomolecules, Vol. 10, Pages 664: Development and Characterization of a Novel Peptide-Loaded Antimicrobial Ocular Insert Biomolecules doi: 10.3390/biom10050664 Authors: Eleonora Terreni Susi Burgalassi Patrizia Chetoni Silvia Tampucci Erica Zucchetti Roberta Fais Emilia Ghelardi Antonella Lupetti Daniela Monti Infectious ocular keratitis is the leading cause of blindness worldwide. Bacterial resistance to classical pharmacological treatments raised the interest...
Sat Apr 25, 2020 03:00
Biomolecules, Vol. 10, Pages 663: Bioconversion of Biologically Active Indole Derivatives with Indole-3-Acetic Acid-Degrading Enzymes from Caballeronia glathei DSM50014 Biomolecules doi: 10.3390/biom10040663 Authors: Mikas Sadauskas Roberta Statkevičiūtė Justas Vaitekūnas Rolandas Meškys A plant auxin hormone indole-3-acetic acid (IAA) can be assimilated by bacteria as an energy and carbon source, although no degradation has been reported for indole-3-propionic acid and indole-3-butyric...
Fri Apr 24, 2020 03:00
Biomolecules, Vol. 10, Pages 657: Antikinetoplastid Activity of Indolocarbazoles from Streptomyces sanyensis Biomolecules doi: 10.3390/biom10040657 Authors: Luis Cartuche Ines Sifaoui Atteneri López-Arencibia Carlos J. Bethencourt-Estrella Desirée San Nicolás-Hernández Jacob Lorenzo-Morales José E. Piñero Ana R. Díaz-Marrero José J. Fernández Chagas disease and leishmaniasis are neglected tropical diseases caused by kinetoplastid parasites of Trypanosoma and Leishmania...
Fri Apr 24, 2020 03:00
Biomolecules, Vol. 10, Pages 662: Macrophage Cholesterol Efflux Downregulation is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression Biomolecules doi: 10.3390/biom10040662 Authors: Canyelles Tondo Lindholt Santos Fernández-Alonso Gonzalo-Calvo Blanco-Colio Escolà-Gil Martín-Ventura Blanco-Vaca Recent studies have raised the possibility of a role for lipoproteins, including high-density lipoprotein cholesterol (HDLc), in abdominal aortic...
Fri Apr 24, 2020 03:00
Biomolecules, Vol. 10, Pages 658: Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity Biomolecules doi: 10.3390/biom10040658 Authors: Alexey A. Tinkov Olga P. Ajsuvakova Tommaso Filippini Ji-Chang Zhou Xin Gen Lei Eugenia R. Gatiatulina Bernhard Michalke Margarita G. Skalnaya Marco Vinceti Michael Aschner Anatoly V. Skalny Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity...
Fri Apr 24, 2020 03:00
Biomolecules, Vol. 10, Pages 659: P1′ Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases Biomolecules doi: 10.3390/biom10040659 Authors: Michał Talma Artur Mucha Designing side chain substituents complementary to enzyme binding pockets is of great importance in the construction of potent and selective phosphinic dipeptide inhibitors of metallo-aminopeptidases. Proper structure selection makes inhibitor construction...
Fri Apr 24, 2020 03:00
Biomolecules, Vol. 10, Pages 660: Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment Biomolecules doi: 10.3390/biom10040660 Authors: Peder A. G. Lillebostad Arne Raasakka Silje J. Hjellbrekke Sudarshan Patil Trude Røstbø Hanne Hollås Siri A. Sakya Peter D. Szigetvari Anni Vedeler Petri Kursula The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins...
Fri Apr 24, 2020 03:00
Biomolecules, Vol. 10, Pages 661: Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method Biomolecules doi: 10.3390/biom10040661 Authors: Marcel Bach-Pages Felix Homma Jiorgos Kourelis Farnusch Kaschani Shabaz Mohammed Markus Kaiser Renier A. L. van der Hoorn Alfredo Castello Gail M. Preston RNA-binding proteins (RBPs) play a crucial role in regulating RNA function and fate. However, the full complement of RBPs has...
Fri Apr 24, 2020 03:00
Biosensors, Vol. 10, Pages 44: Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis Biosensors doi: 10.3390/bios10050044 Authors: Timo Sorsa Joseph Bacigalupo Mauno Könönen Pirjo Pärnänen Ismo T. Räisänen Previous studies report periodontitis and peri-implantitis being able to induce systemic low-grade inflammation, which is known to be associated with increased risk for some systemic medical disease such as cardiovascular disease. In this...
Sat Apr 25, 2020 03:00
Brain Sciences, Vol. 10, Pages 251: Building, Hosting and Recruiting: A Brief Introduction to Running Behavioral Experiments Online Brain Sciences doi: 10.3390/brainsci10040251 Authors: Marian Sauter Dejan Draschkow Wolfgang Mack Researchers have ample reasons to take their experimental studies out of the lab and into the online wilderness. For some, it is out of necessity, due to an unforeseen laboratory closure or difficulties in recruiting on-site participants. Others want to...
Fri Apr 24, 2020 03:00
Brain Sciences, Vol. 10, Pages 252: Relation of Intracerebral Hemorrhage Descriptors with Clinical Factors Brain Sciences doi: 10.3390/brainsci10040252 Authors: Kornelia M. Kliś Roger M. Krzyżewski Borys M. Kwinta Krzysztof Stachura Tadeusz J. Popiela Jerzy Gąsowski Jacek Długopolski The association between intracerebral hemorrhage (ICH) shape and a poor treatment outcome has been established by few authors. We decided to analyze whether computationally assessed hemorrhage...
Fri Apr 24, 2020 03:00
Cancers, Vol. 12, Pages 1080: YM155-Adapted Cancer Cell Lines Reveal Drug-Induced Heterogeneity and Enable the Identification of Biomarker Candidates for the Acquired Resistance Setting Cancers doi: 10.3390/cancers12051080 Authors: Michaelis Wass Reddin Voges Rothweiler Hehlgans Cinatl Mernberger Nist Stiewe Rödel Cinatl Jr. Survivin is a drug target and its suppressant YM155 a drug candidate mainly investigated for high-risk neuroblastoma....
Sun Apr 26, 2020 03:00
Cancers, Vol. 12, Pages 1079: Erratum: Berndsen, R.H., et al. Colorectal Cancer Growth Retardation through Induction of Apoptosis, Using an Optimized Synergistic Cocktail of Axitinib, Erlotinib, and Dasatinib, Cancers 2019, 11, 1878 Cancers doi: 10.3390/cancers12051079 Authors: Berndsen Swier van Beijnum Nowak-Sliwinska The authors wish to make the following corrections to this paper[...]
Sun Apr 26, 2020 03:00
Cancers, Vol. 12, Pages 1076: Tumor-Infiltrating CD8 T Cells Predict Clinical Breast Cancer Outcomes in Young Women Cancers doi: 10.3390/cancers12051076 Authors: Yong Won Jin Pingzhao Hu Young women with breast cancer have disproportionately poor clinical outcomes compared to their older counterparts. The underlying biological differences behind this age-dependent disparity are still unknown and warrant investigation. Recently, the tumor immune landscape has received much attention...
Sun Apr 26, 2020 03:00
Cancers, Vol. 12, Pages 1075: Overcoming Heterogeneity of Antigen Expression for Effective CAR T Cell Targeting of Cancers Cancers doi: 10.3390/cancers12051075 Authors: Sareetha Kailayangiri Bianca Altvater Malena Wiebel Silke Jamitzky Claudia Rossig Chimeric antigen receptor (CAR) gene-modified T cells (CAR T cells) can eradicate B cell malignancies via recognition of surface-expressed B lineage antigens. Antigen escape remains a major mechanism of relapse and is a key barrier...
Sun Apr 26, 2020 03:00
Cancers, Vol. 12, Pages 1077: Cognitive Functions in Repeated Glioma Surgery Cancers doi: 10.3390/cancers12051077 Authors: Capo Skrap Guarracino Isola Battistella Ius Tomasino Low-grade gliomas (LGG) are slow-growing brain tumors infiltrating the central nervous system which tend to recur, often with malignant degeneration after primary treatment. Re-operations are not always recommended due to an assumed higher risk of neurological and cognitive deficits. However,...
Sun Apr 26, 2020 03:00
Cancers, Vol. 12, Pages 1074: Imaging Accuracy in Preoperative Staging of T3-T4 Laryngeal Cancers Cancers doi: 10.3390/cancers12051074 Authors: Marco Benazzo Fabio Sovardi Lorenzo Preda Simone Mauramati Sergio Carnevale Giulia Bertino Francesca Berton Matteo Meroni Irene Herman Giuseppe Trisolini Patrizia Morbini Background: Preoperative imaging impacts treatment planning and prognosis in laryngeal cancers. We investigated the accuracy of standard computed...
Sun Apr 26, 2020 03:00
Cancers, Vol. 12, Pages 1073: LINC00963 Promotes Cancer Stemness, Metastasis, and Drug Resistance in Head and Neck Carcinomas via ABCB5 Regulation Cancers doi: 10.3390/cancers12051073 Authors: Lee Hsieh Fang Chu Liao Yu Yu Tsai Accumulating studies have indicated that long non-coding RNAs (lncRNAs) participate in the regulation of cancer stem cells (CSCs), which are crucial in tumor initiation, metastasis, relapse, and therapy resistance. In the current study,...
Sun Apr 26, 2020 03:00
Cancers, Vol. 12, Pages 1078: Clinical Variables Associated with PSA Response to Lutetium-177-PSMA ([177Lu]-PSMA-617) Radionuclide Treatment in Men with Metastatic Castration-Resistant Prostate Cancer Cancers doi: 10.3390/cancers12051078 Authors: Moran Gadot Tima Davidson Margalit Aharon Eshetu G. Atenafu Avraham Malki Meital Levartovsky Akram Saad Liran Domachevsky Raanan Berger Raya Leibowitz Lutetium-177-PSMA ([177Lu]-PSMA-617), a radiolabeled small molecule,...
Sun Apr 26, 2020 03:00
Cancers, Vol. 12, Pages 1065: Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma Cancers doi: 10.3390/cancers12051065 Authors: Fassmannová Sedlák Sedláček Špička Grantz Šašková Proteasome inhibitors are the backbone of multiple myeloma therapy. However, disease progression or early relapse occur due to development of resistance to the therapy. One important cause of resistance to proteasome inhibition is the so-called bounce-back...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1071: Role of Calcium Signaling in Prostate Cancer Progression: Effects on Cancer Hallmarks and Bone Metastatic Mechanisms Cancers doi: 10.3390/cancers12051071 Authors: Ardura Álvarez-Carrión Gutiérrez-Rojas Alonso Advanced prostate cancers that progress to tumor metastases are often considered incurable or difficult to treat. The etiology of prostate cancers is multi-factorial. Among other factors, de-regulation of calcium signals in prostate tumor...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1067: Prognostic Value of SDF-1α Expression in Patients with Esophageal Squamous Cell Carcinoma Receiving Esophagectomy Cancers doi: 10.3390/cancers12051067 Authors: Yen-Hao Chen Shau-Hsuan Li Hung-I Lu Chien-Ming Lo Stromal cell-derived factor-1α (SDF-1α) is a chemokine that has been reported to be involved in tumor progression in several malignancies. This study aimed to evaluate the crucial role of SDF-1α in patients with...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1069: Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma Cancers doi: 10.3390/cancers12051069 Authors: Kofler Borena Dudas Innerhofer Dejaco Steinbichler Widmann von Laer Riechelmann Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct subtype of head and neck cancer. Here, we investigated how frequently brushing remained high-risk (hr)-HPV positive after...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1070: Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity Cancers doi: 10.3390/cancers12051070 Authors: Jeong Yoo Here, we developed a novel oncolytic vaccinia virus (NOV) with the dual advantages of cancer selectivity and normal vessel reconstructive activity by replacing the viral thymidine kinase (vTk) and vaccinia growth factor (VGF) genes with genes encoding TNF-related apoptosis-inducing...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1066: Sirtuins’ Deregulation in Bladder Cancer: SIRT7 Is Implicated in Tumor Progression through Epithelial to Mesenchymal Transition Promotion Cancers doi: 10.3390/cancers12051066 Authors: Sara Monteiro-Reis Ana Lameirinhas Vera Miranda-Gonçalves Diana Felizardo Paula C. Dias Jorge Oliveira Inês Graça Céline S. Gonçalves Bruno M. Costa Rui Henrique Carmen Jerónimo Sirtuins are emerging players in cancer biology and other age-related...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1068: Oncobiosis and Microbial Metabolite Signaling in Pancreatic Adenocarcinoma Cancers doi: 10.3390/cancers12051068 Authors: Borbála Kiss Edit Mikó Éva Sebő Judit Toth Gyula Ujlaki Judit Szabó Karen Uray Péter Bai Péter Árkosy Pancreatic adenocarcinoma is one of the most lethal cancers in both men and women, with a median five-year survival of around 5%. Therefore, pancreatic adenocarcinoma represents an unmet medical need. Neoplastic...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1064: The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights Cancers doi: 10.3390/cancers12051064 Authors: Sasaki Doukas Costa Vageli Cancers of the laryngopharynx represent the most devastating of the head and neck malignancies and additional risk factors are now epidemiologically linked to this disease. Using an in vivo model (Mus musculus C57Bl/6J), we provide novel evidence that...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1072: Solving the Time- and Frequency-Multiplexed Problem of Constrained Radiofrequency Induced Hyperthermia Cancers doi: 10.3390/cancers12051072 Authors: Kuehne Oberacker Waiczies Niendorf Targeted radiofrequency (RF) heating induced hyperthermia has a wide range of applications, ranging from adjunct anti-cancer treatment to localized release of drugs. Focal RF heating is usually approached using time-consuming nonconvex optimization procedures or...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1063: Endogenously-Activated Ultrasmall-in-Nano Therapeutics: Assessment on 3D Head and Neck Squamous Cell Carcinomas Cancers doi: 10.3390/cancers12051063 Authors: Melissa Santi Ana Katrina Mapanao Domenico Cassano Ylea Vlamidis Valentina Cappello Valerio Voliani Negative or positive HPV-associated Head and Neck Squamous Cell Carcinomas (HNSCCs) are high recurrence neoplasms usually resulting in a poor prognosis, mainly due to metastasis formation....
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1062: FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma Cancers doi: 10.3390/cancers12051062 Authors: Pauline Tétu Julie Delyon Jocelyne André Coralie Reger de Moura Malak Sabbah Ghanem E Ghanem Maxime Battistella Samia Mourah Céleste Lebbé Nicolas Dumaz KIT is a bona fide oncogene in a subset of melanoma and, ex vivo, KIT inhibitors are very efficient at killing KIT-mutant melanoma cell lines....
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1061: The Clinical Impact of Low-Volume Lymph Nodal Metastases in Early-Stage Cervical Cancer: The Senticol 1 and Senticol 2 Trials Cancers doi: 10.3390/cancers12051061 Authors: Benedetta Guani Vincent Balaya Laurent Magaud Fabrice Lecuru Patrice Mathevet Background: With the development of the sentinel node technique in early-stage cervical cancer, it is imperative to define the clinical significance of micrometastases (MICs) and isolated tumor cells...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1060: HPV Involvement in the Tumor Microenvironment and Immune Treatment in Head and Neck Squamous Cell Carcinomas Cancers doi: 10.3390/cancers12051060 Authors: Jérôme R. Lechien Géraldine Descamps Imelda Seminerio Sonia Furgiuele Didier Dequanter Francois Mouawad Cécile Badoual Fabrice Journe Sven Saussez Head and neck squamous cell carcinomas (HNSCC) are one of the most prevalent cancers worldwide. Active human papillomavirus (HPV) infection...
Sat Apr 25, 2020 03:00
Cancers, Vol. 12, Pages 1058: The Prognostic Value of the Detection of Microbial Translocation in the Blood of Colorectal Cancer Patients Cancers doi: 10.3390/cancers12041058 Authors: Ippokratis Messaritakis Konstantinos Vogiatzoglou Konstantina Tsantaki Agapi Ntretaki Maria Sfakianaki Asimina Koulouridi John Tsiaoussis Dimitrios Mavroudis John Souglakos Dysbiosis has been associated with various diseases and is of major health importance. Dysbiosis leads to microbial...
Fri Apr 24, 2020 03:00
Cancers, Vol. 12, Pages 1057: Unique Role of Histone Methyltransferase PRDM8 in the Tumorigenesis of Virus-negative Merkel Cell Carcinoma Cancers doi: 10.3390/cancers12041057 Authors: Elias Orouji Wiebke K. Peitsch Azadeh Orouji Roland Houben Jochen Utikal Merkel cell carcinoma (MCC) is a deadly skin cancer, and about 80% of its cases have been shown to harbor integrated Merkel polyomavirus in the tumor cell genome. Viral oncoproteins expressed in the tumor cells are considered...
Fri Apr 24, 2020 03:00
Cancers, Vol. 12, Pages 1059: Incidence of Occult Lymph Node Metastasis in Primary Larynx Squamous Cell Carcinoma, by Subsite, T Classification and Neck Level: A Systematic Review Cancers doi: 10.3390/cancers12041059 Authors: Alvaro Sanabria Jatin P. Shah Jesus E. Medina Kerry D. Olsen K. Thomas Robbins Carl E. Silver Juan P. Rodrigo Carlos Suárez Andrés Coca-Pelaz Ashok R. Shaha Antti A. Mäkitie Alessandra Rinaldo Remco de Bree Primož Strojan Marc...
Fri Apr 24, 2020 03:00
Cancers, Vol. 12, Pages 1055: Cut-Off Analysis of CTC Change under Systemic Therapy for Defining Early Therapy Response in Metastatic Breast Cancer Cancers doi: 10.3390/cancers12041055 Authors: Thomas M. Deutsch Stefan Stefanovic Manuel Feisst Chiara Fischer Fabian Riedel Carlo Fremd Christoph Domschke Klaus Pantel Andreas D. Hartkopf Marc Sutterlin Sara Y. Brucker Andreas Schneeweiss Markus Wallwiener Detection of circulating tumor cells (CTC) can...
Fri Apr 24, 2020 03:00
Cancers, Vol. 12, Pages 1054: ALK Inhibitors-Induced M Phase Delay Contributes to The Suppression of Cell Proliferation Cancers doi: 10.3390/cancers12041054 Authors: Sirajam Munira Ryuzaburo Yuki Youhei Saito Yuji Nakayama Anaplastic lymphoma kinase (ALK), a receptor-type tyrosine kinase, is involved in the pathogenesis of several cancers. ALK has been targeted with small molecule inhibitors for the treatment of different cancers, but absolute success remains elusive. In the...
Fri Apr 24, 2020 03:00
Cancers, Vol. 12, Pages 1056: Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under Parg Deficiency Cancers doi: 10.3390/cancers12041056 Authors: Yuki Sonoda Yuka Sasaki Akemi Gunji Hidenori Shirai Tomonori Araki Shoji Imamichi Takae Onodera Anna-Margareta Rydén Masatoshi Watanabe Jun Itami Takuya Honda Kazuto Ashizawa Kazuhiko Nakao Mitsuko Masutani PolyADP-ribosylation is a post-translational modification...
Fri Apr 24, 2020 03:00
Cancers, Vol. 12, Pages 1052: Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12041052 Authors: Xenia Peñate Juan Manuel Praena-Fernández Pedro Romero Pareja María del Valle Enguix-Riego Laura Payán-Bravo Begoña Vieites Lourdes Gomez-Izquierdo Javier Jaen Olasolo Eleonor Rivin del Campo Jose Carlos Reyes Sebastián Chávez Jose Luis Lopez Guerra Canonical...
Fri Apr 24, 2020 03:00
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