Accurate beam range prediction during clinical treatment planning is key to improve targeted dose delivery in proton and heavy ion therapy. A substantial source of beam range uncertainty is the prediction of ion stopping power ratio (SPR) relative to water from an empirical calibration based on conventional x-ray computed tomography (CT) used in clinical practice today. The aim of this study was to investigate the potential of a novel spectral CT imaging technique based on a dual-layer...
1d
Novel iterative image reconstruction methods can help reduce the required radiation dose in x-ray diagnostics such as computed tomography (CT), while maintaining sufficient image quality. Since some of the established image quality measures are not appropriate for reliably judging the quality of images derived by iterative methods, alternative approaches such as task-specific quality assessment would be highly desirable for acceptance or constancy testing. Task-based image quality...
1d
To improve respiratory-gated radiotherapy accuracy, we developed a machine learning approach for markerless tumor tracking and evaluated it using lung cancer patient data. Digitally reconstructed radiography (DRR) datasets were generated using planning 4DCT data. Tumor positions were selected on respective DRR images to place the GTV center of gravity in the center of each DRR. DRR subimages around the tumor regions were cropped so that the subimage size was defined by tumor size. Training ...
1d
Monte Carlo (MC) track structure simulation tools are commonly used for predicting radiation induced DNA damage by modeling the physical and chemical reactions at the nanometer scale. However, the outcome of these MC simulations is particularly sensitive to the adopted parameters which vary significantly across studies. In this study, a previously developed full model of nuclear DNA was used to describe the DNA geometry. The TOPAS-nBio MC toolkit was used to investigate the impact of physics...
1d
Accelerated MRI involves undersampling k-space, creating unwanted artifacts when reconstructing the data. While the strategy of incoherent k-space acquisition is proven for techniques such as compressed sensing, it may not be optimal for all techniques. This study compares the use of coherent low-resolution (coherent-LR) and incoherent undersampling phase-encoding for real-time 3D CNN image reconstruction. Data were acquired with our 3 T Philips Achieva system. A retrospective analysis...
1d
The purpose of the present development is to employ 3D printing to prototype an ion chamber array with a scalable design potentially allowing increased spatial resolution and a larger active area. An additional goal is to design and fabricate a custom size thin-panel detector array with low-Z components. As a proof of principle demonstration, a medium size detector array with 30 × 30 air-vented ion chambers was 3D-printed using PLA as frame for the electrodes. The active-area is 122 mm...
1d
Despite well-established dosimetry in clinical radiotherapy, dose measurements in pre-clinical and radiobiology studies are frequently inadequate, thus undermining the reliability and reproducibility of published findings. The lack of suitable dosimetry protocols, coupled with the increasing complexity of pre-clinical irradiation platforms, undermines confidence in preclinical studies and represents a serious obstacle in the translation to clinical practice. To accurately measure output ...
1d
The annotation of three-dimensional (3D) cephalometric landmarks in 3D computerized tomography (CT) has become an essential part of cephalometric analysis, which is used for diagnosis, surgical planning, and treatment evaluation. The automation of 3D landmarking with high-precision remains challenging due to the limited availability of training data and the high computational burden. This paper addresses these challenges by proposing a hierarchical deep-learning method consisting...
1d
Computed tomography has greatly improved over the last decade, especially through x-ray dose exposure reduction while maintaining image quality. Herein, a new concept is proposed to improve the contrast-to-noise ratio (CNR) by including the time-of-flight (TOF) information of individual photons to obtain further insight on the photon’s trajectory and to reject scatter contribution. The proof of the concept relies on both simulation and experimental measurements in a cone-beam computed tomography...
1d
In ultrasound elastography, plane-wave acquisitions and angular displacement compounding (ADC) are often used and combined to allow high frame rates and to improve accuracy of lateral displacement estimates, respectively. This study investigates the performance of displacement and strain estimation for ADC as a function of; the main-to-grating-lobe-amplitude ratio which decreases as a function of steering angle; plane-wave acquisition and Delay-and-Sum (DaS)-related parameters; and grating-lobe...
1d
In addition to playing a key role in the dynamics of ecosystems, animal diversity, especially that of wild vertebrates, is intimately linked with human evolutionary history, which has resulted in diverse inter...
1d
Cultural and religious practices of African origin have decisively influenced traditional health practices in the Americas since the African diaspora. Plants are core elements in the religions of African origi...
1d
Abstract With the proliferation of technology and the Internet, the way education is delivered has undergone a rapid change in different educational settings. Whilst a large amount of research has investigated the implementation of mobile technologies in education, there is still a paucity of research from a teaching perspective across disciplines within higher education. For this reason, this study investigated the acceptance, preparedness and adoption of mobile technologies by...
1d
Abstract The use of a computer as a means and/or a source of feedback provision has facilitated the process of teaching and learning writing. The integration of computers into writing classes enabled teachers to provide timely and reliable feedback. Taking into account these opportunities that computers bring to the classroom, the present study attempted to investigate the efficacy of using computer-mediated teacher feedback and computer-generated feedback on learners’ writing...
2d
The α2-adrenergic agonist dexmedetomidine (DEX) is a sedative and can be used as an adjunct to hypnotics. The study sought to evaluate the effects of different doses of DEX on the requirements for propofol for lo...
1d
Induction of general anesthesia increases the hemodilution resulting from infusion of crystalloid fluid, which is believed to be due to slower distribution caused by arterial hypotension. When normal distribut...
1d
INTELLiVENT-ASV® (I-ASV) is a closed-loop ventilation mode that automatically controls the ventilation settings. Although a number of studies have reported the usefulness of I-ASV, the clinical situations in whic...
1d
Spinal osteosarcoma (OS) is a rare and aggressive malignancy. Long noncoding RNA (lncRNA) BSN-AS2 has been shown to be an oncogenic gene in several cancers. However, the role and function of BSN-AS2 in spinal ...
1d
Recent studies have emphasized determining the ability of microRNAs (miRNAs) as crucial regulators in the occurrence and development of pancreatic cancer (PC), which continues to be one of the deadliest malign...
1d
Chronic rhinosinusitis (CRS) describes an inflammatory condition affecting the sinonasal mucosa. As the immune system players such as immunoglobulins play prominent roles in the development of CRS, we aimed to...
1d
The clinical efficacy of rupatadine in terms of responders has not been previously explored in perennial allergic rhinitis (PAR).
2d
As the pathological mechanisms of AD are complex, increasing evidence have demonstrated Chinese Medicine with multi-ingredients and multi-targets may be more suitable for the treatment of diseases with complex...
1d
Modified docetaxel, cisplatin, and 5-fluorouracil (mDCF) regimen has become a new standard for the treatment of metastatic or unresectable locally advanced recurrent squamous cell carcinoma of the anus (SCCA) ...
1d
The number of people living with soft-tissue and bone sarcomas is increasing due to improved individual therapy and changes in demographics. At present, there are no recommendations for psychological co-treatm...
1d
ARID1A has been described as a tumor suppressor gene, participating in chromatin re-modeling, epithelial-mesenchymal-transition and many other cellular and molecular processes. It has been cited as a contribut...
1d
The relationships among PIK3CA mutations, medication use and tumor progression remains poorly understood. Aspirin use post-diagnosis may modify components of the PI3K pathway, including AKT and mTOR, and has been...
2d
Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors. Recently, the Nodal signalling pathw...
2d
Planta MedDOI: 10.1055/a-1140-8388A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification...
1d
The echocardiography working group of the European Society of Intensive Care Medicine recognized the need to provide structured guidance for future CCE research methodology and reporting based on a systematic ...
1d
We report the results of the molecular and clinical characterization and the efficacy of afatinib in a cohort of patients with advanced NSCLC patients carrying uncommon EGFR mutations in Spanish clinical practice. In this mainly Caucasian cohort, patients with uncommon EGFR-mutant NSCLC, the most common mutations occurred on exon 18 in amino acid G719, either alone (13 of 67 patients) or in combination with another mutation (20 of 67 patients), such as S768I (11 of 67 patients). Other uncommon mutations...
1d
Abstract Myofibroma (MF) is a benign mesenchymal myofibroblast-derived tumor, which occurs most frequently in children, and rarely affects the maxilla. We reported a case of an aggressive intraosseous lesion found in the maxilla of a 9-year-old female child. Intraorally, the swelling extended from tooth 12 to 16, causing displacement of teeth 13, 14, and 15. Computed tomography revealed a large osteolytic lesion causing thinning and cortical erosion. Microscopically, the lesion...
1d
Publication date: Available online 24 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Jenna W. Briddell, Nathan D. Vandjelovic, Catherine A. Fromen, Emma L. Peterman, James S. Reilly
1d
Publication date: Available online 24 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Brian P. Kinealy, Brette C. Harding, Maryna A. Vazmitsel, Katsiaryna Laziuk, Eliav Gov-Ari
1d
Publication date: Available online 24 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): William J. Riggs, Meghan M. Hiss, Varun V. Varadarjan, Jameson K. Mattingly, Oliver F. Adunka
1d
Publication date: Available online 24 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Fabienne CARRÉ, Marion Blanchard, Sophie ACHARD, Marine PARODI, Françoise DENOYELLE, Natalie LOUNDON
2d
Publication date: Available online 23 April 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Travis Haller, Angela Shoup, Albert Park
2d
The ongoing pandemic coronavirus disease-2019 (COVID-19) infection causes severe respiratory dysfunction and has become an emergent issue for worldwide healthcare. Since COVID-19 spreads through contact and droplet infection routes, careful attention to infection control and surgical management is important to prevent cross-contamination of patients and medical staff. Tracheostomy is an effective method to treat severe respiratory dysfunction with prolonged respiratory management and should be performed...
1d
Abstract Objectives To analyze all artificial intelligence abstracts presented at the European Congress of Radiology (ECR) 2019 with regard to their topics and their adherence to the Standards for Reporting Diagnostic accuracy studies (STARD) checklist. Methods A total of 184 abstracts were analyzed with regard to adherence to the STARD criteria...
1d
Abstract Pancreatic ductal adenocarcinoma (PDAC) has continued to have a poor prognosis for the last few decades in spite of recent advances in different imaging modalities mainly due to difficulty in early diagnosis and aggressive biological behavior. Early PDAC can be missed on CT due to similar attenuation relative to the normal pancreas, small size, or hidden location in the uncinate process. Tumor resectability and its contingency on the vascular invasion most commonly assessed...
1d
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου