Abstract Purpose Inadequate sleep duration affects asthma and weight. The associations among sleep duration, asthma, and different weight statuses in the Chinese population need to be further determined. Methods The study included 32,776 Chinese adults from the China Health and Nutrition Survey during 2009–2015. Self-reported sleep duration was classified...
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Abstract Objective Sleep Apnea Syndrome (SAS) is frequently comorbid with Restless Legs Syndrome (RLS). Both disorders are associated with disturbed sleep. However, data about insomnia specific symptoms in patients suffering from both sleep disorders (SAS-RLS) are rare. Methods In a restrospective design, we investigated 202 patients suffering from SAS and...
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Abstract Purpose It remains inconclusive whether continuous positive airway pressure (CPAP) therapy can significantly reduce subcutaneous adipose tissue (SAT) in patients with obstructive sleep apnea (OSA). This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the impact of CPAP treatment on SAT in patients with OSA. Methods We searched...
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Since growing mouse oocytes undergo a burst of folate accumulation as they near full size, we have investigated whether oocytes transport serine, which provides one‐carbon units to the folate cycle. Substantial serine transport appeared in oocytes near the end of their growth and persisted during meiosis but ceased partway through first meiotic metaphase. Unexpectedly, exposing cumulus cell‐enclosed oocytes to the physiological mediator of meiotic arrest, natriuretic peptide precursor Type C, substantially...
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Physical and psychological stress exerts a substantial effect on gastrointestinal motility disorders. Interstitial cells of Cajal (ICCs) act as pacemakers for gallbladder motility regulation and are likely important in stress‐associated gallbladder motility disorders. This study demonstrates the impact of stress on gallbladder ICCs development and survival and further confirms the link between stress and gastrointestinal motility. Abstract Physical and psychological stress exerts a substantial...
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The present study aimed to develop a novel epigenetic signature for evaluating the relapse‐free survival of colon cancer patients. This biomarker would aid in identifying patients who require an intensive follow‐up and aggressive therapeutic intervention. Abstract Epigenetic factors play a critical role in carcinogenesis by imparting a distinct feature to the chromatin architecture. The present study aimed to develop a novel epigenetic signature for evaluating the relapse‐free survival of colon...
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Sirtuin 3 (SIRT3) depletion inhibited activation of the activated protein kinase (AMPK)‐mTOR pathway and enhanced glutathione peroxidase 4 (GPX4) level, thereby suppressing autophagy and ferroptosis. Furthermore, depletion of AMPK blocked induction of ferroptosis in trophoblasts. We concluded that upregulated SIRT3‐enhanced autophagy activation by promoting AMPK‐mTOR pathway and decreasing GPX4 level to induce ferroptosis in trophoblastic cells. SIRT3 deficiency was resistant to high glucose‐ and...
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We found that ghrelin enhanced midbrain neural stem cells proliferation, and promoted neuronal differentiation especially dopaminergic (DAergic) neuron differentiation both in vitro and ex vivo. Wnt/β‐catenin pathway was related to ghrelin enhanced DAergic neuron differentiation. Our study suggested that ghrelin may enable clinical therapies for Parkinson's disease by its neurogenesis role. Abstract Ghrelin plays a neuroprotective role in the process of dopaminergic (DAergic) neurons degeneration...
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The inactivation of nuclear factor of activated T cells (Nfatc1) and Nfatc2 in Bglap‐expressing osteoblasts causes vertebral osteopenia and a reduced number of osteoblasts. Abstract The present study defines the function of nuclear factor of activated T cells (NFAT)c1 and NFATc2 in osteoblast function in vivo and in vitro. Nfatc1 loxP/loxP , Nfatc2 loxP/loxP , and Nfatc1 loxP/loxP ;Nfatc2 loxP/loxP conditional mice were mated with BGLAP‐Cre transgenics to inactivate Nfatc1 and Nfatc2...
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The involvement of Ano6 in Ca2+ dependent regulatory volume decrease in response to hypotonic stimulus in mouse submandibular gland acinar cells Abstract The widely expressed Anoctamin 6 (Ano6) supports different Ca2+‐dependent functions, but little is known about its role in salivary glands. Mouse submandibular gland (SMG) acinar cells exhibited a robust regulatory volume decrease (RVD) following cell swelling that was reduced approximately 70% in Ano6 –/– mice. Ca2+‐free conditions nearly...
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We adopted odds ratios (ORs) with 95% confidence intervals (CIs), in silico tools and enzyme‐linked immunosorbent assay (ELISA) analysis to evaluate the correlation between CRP rs1205, rs2808630 variants and susceptibility of cancer. We found that CRP rs1205 C>T and rs2808630 T>C polymorphism may be associated with cancer risk, especially for Asians. Abstract The correlation between rs1205, rs2808630 variants of C‐reactive protein (CRP) gene and susceptibility of cancer has been assessed...
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Intravenous administration of human adipose‐derived mesenchymal stem cells‐extracellular vesicles (hADSC‐EVs) attenuates induced experimental autoimmune encephalomyelitis (EAE) by reducing the mean clinical score. hADSCs and hADSC‐EVs reduce myelin oligodendrocyte glycoprotein‐induced proliferation of splenocytes in EAE mice. hADSCs, but not hADSC‐EVs, increase the frequency of Treg cells in the spleen of EAE mice. hADSCs and hADSC‐EVs reduce the leukocyte infiltrations and demyelination in...
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(1) Immune‐related long noncoding RNA (lncRNA) signature had an important value for disease progression and survival prediction in hepatocellular carcinoma (HCC) (2) Immune‐related lncRNA signature may have the potential to measure the response to immune checkpoint blockade immunotherapy. (3) Our study showed immune‐related lncRNA signature provided valuable clinical applications in antitumor immunotherapy in HCC. Abstract Long noncoding RNAs (lncRNAs) show multiple functions, including...
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Schematic illustration of adipocyte differentiation, that is, affected by mechanical stimulation. The cell fate followed according to the biomechanical impact on induced lipid droplets accumulation. The proteomic analysis identified an increase of mitochondrial activity and cellular metabolism in cells subjected to static stretch stimulation that was is an accelerator of adipogenesis. Abstract Adipose tissue plays a leading role in obesity, which, in turn, can lead to Type 2 diabetes. Adipocytes...
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The mechanism of long intergenic noncoding RNA 00844 (LINC00844)/early B cell factor 1 (EBF1)/glutathione S‐transferase P1‐1 (GSTP1) axis in the development of prostate cancer (PC). LINC00844 reduced the proliferation while elevating the apoptosis of PC cells by recruiting the transcription factor EBF1 to the promoter region of the GSTP1 gene, thereby suppressing the progression of PC. Abstract Accumulating evidence have suggested the function of long noncoding RNAs as crucial players in the...
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In summary, dexamethasone (Dex) exposure downregulates transforming growth factor‐β (TGF‐β) signaling while folic acid (FA) treatment rescues it. TGF‐β signaling triggers the transcription of differentiative markers such as Runx2 and Osterix. Subsequently, the process of growth plate cartilage differentiation and osteogenic differentiation are accelerated. FA treatment rescues Dex‐induced vertebral malformation in chick embryos. Abstract Folic acid (FA) is routinely supplemented in the food of...
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The role of dietary polyphenolic phytochemicals in regulating the aggressive behavior of cancer cells has been highlighted. The role of these natural plant compounds (NPCs) as chemosensitizers as well as modulators of the metabolic properties of cancer cells has also been depicted. Therefore, the use of these NPCs alone or in combination with reduced doses of conventional chemotherapeutic drugs or with other phytochemicals can emerge as an alternative strategy for cancer treatment with lower non‐specific...
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Diabetic retinopathy (DR) is the most common ocular complication caused by diabetes mellitus (DM) and is the main cause of visual impairment in working‐age people. Reactive gliosis and pro‐inflammatory cytokine production by Müller cells contribute to the progression of DR. Melatonin inhibited Müller cell activation and pro‐inflammatory cytokine production by upregulating the long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3)/miR‐204/sirtuin 1 (SIRT1) axis. Abstract Diabetic retinopathy...
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Overexpression of cathepsin (CTS) subtypes can be associated with cancer suppression or progression. CTS can modulate the immune system by human leukocyte antigen (HLA) antigen presentation. CTS subtypes, based on the type of cancer and its stage, the type of host cells, and the probable relation with HLA, breed good or poor prognosis in patients with cancer. Abstract Cathepsins (CTSs) are multifunctional proteins that can play prominent roles in cancer progression and metastasis. In...
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To the best of our knowledge, the effects of melatonin on irradiation‐induced oxidative stress and apoptosis in the brainstem region have not been investigated so far; hence, we evaluated this issue in the current study. In this regard, malondialdehyde (MDA), nitric oxide (NO), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) levels were determined, followed by evaluating the antiapoptosis role of melatonin through caspase‐3 mediated pathways....
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Knockdown of milk fat globule EGF factor 8 protein (MFG‐E8) repressed glioma progression in vitro and in vivo by directly affecting glioma growth and TAM M2 polarization. Abstract Tumor‐associated microglial cells promote glioma growth, invasion, and chemoresistance by releasing inflammatory factors. Milk fat globule EGF factor 8 protein (MFG‐E8), a secreted glycoprotein, is closely related to tissue homeostasis and anti‐inflammation. In the present study, we investigated the role of MFG‐E8 in...
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Dental follicle stem cells (DFSCs) have become a promising stem cell source for bone regeneration and periodontal engineering, however, the mechanisms underlying DFSCs‐mediated osteogenesis remain elusive. Here we demonstrated that HOTAIRM1 and HOXA2 were highly expressed in human DFSCs (hDFSCs), and HOTAIRM1 could promote the osteogenesis of hDFSCs by epigenetically regulating HOXA2 via DNMT1. Abstract Dental follicle (DF) can develop into periodontal tissues including periodontal ligament, cementum,...
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Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of the issues that need further research. To adapt to potential clinical applications, this type of problem must be solved. Here, we briefly review EVs' biogenesis, contents, subtypes and effect of storage...
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In brief, RUNX2 cooperatively combines with EGR1 to repress Htra1 expression and promote osteogenic differentiation. Abstract Runt‐related transcription factor 2 (Runx2) has been shown to regulate osteoblast differentiation by directly or indirectly regulating numerous osteoblast‐related genes. However, our understanding of the transcriptional mechanisms of RUNX2 is mainly restricted to its transactivation, while the mechanism underlying its inhibitory effect during osteoblast differentiation...
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A novel experimental system was established, in which AFSCs were efficiently converted to multipotent progenitor stem cells using Act A and bone morphogenetic protein 4 (named as ABSCs). The ABSCs contributed to neural mesodermal progenitors and lateral plate mesoderm in postimplantation chimeras. Our study established a robust experimental system for the generation of specific multipotent progenitor stem cells that was self‐renewable and capable of contributing to embryonic and extra‐embryonic tissues....
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This review summarized the role of noncoding RNAs (ncRNAs) including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) in drug resistance in multiple myeloma (MM) and discussed the underlying molecular mechanisms, and finally provided with an overview of the potential and strategies of treating ncRNAs as therapeutic targets. Abstract Despite the administration of new effective drugs in recent years, relapse and drug resistance are still the main obstacles in multiple myeloma...
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Abstract Although much progress has been made in the diagnosis and treatment of thoracic aortic dissection (TAD), the overall morbidity and mortality rates of TAD are still high. Therefore, the molecular pathogenesis and etiology of TAD need to be elucidated. In this study, we found that histone deacetylase 1 (HDAC1) expression is dramatically higher in the aortic wall of patients with TAD (than that in a normal group) and negatively correlates with the levels of the vascular smooth muscle cell...
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Human chondrocytes in situ express G protein‐coupled receptor 30 (GPR30). Nonetheless, the receptor is partially degraded and, therefore, nonfunctional. Abstract Estrogen hormones are important for cartilage homeostasis, but nothing is known regarding the expression and role of the membrane G protein‐coupled estrogen receptor (GPER), G protein‐coupled receptor 30 (GPR30), in adult articular chondrocytes. Using immunohistochemistry of cartilage sections, quantitative real‐time polymerase chain reaction...
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we assessed the stem cell properties of human adipose‐derived stem cells (hADSCs) after transduction with a lentiviral vector containing interferon‐β and leukemia inhibitory factor. Our result showed a remarkable overexpression of the transgene in addition to the preservation of stem cell properties. Abstract Adipose‐derived stem cells (ADSCs) are a subset of mesenchymal stem cells that their therapeutic effects in various diseases make them an interesting tool in cell therapy. In the current...
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1. p‐focal adhesion kinase (FAK) elevated dramatically in subchondral bone following anterior cruciate ligament transection in rats. 2. Specific inhibition of FAK signaling with Y15 in subchondral bone suppressed subchondral bone deterioration by mediating H‐type vessel‐induced ectopic bone formation and protected articular cartilage from degeneration. 3. Elevated p‐FAK in mesenchymal stem cells promoted angiogenesis of endothelial cells and the catabolic response of chondrocytes...
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Abstract Metabolic reprogramming of cancer cells results in a high production of acidic substances that must be extruded to maintain tumor‐cell viability. The voltage‐gated proton channel (Hv1) mediates highly selective effluxes of hydronium‐ion (H+) that prevent deleterious cytoplasmic acidification. In the work described here, we demonstrated for the first time that the amino‐terminal–truncated isoform of Hv1 is more highly expressed in tumorigenic breast‐cancer‐cell lines than in nontumorigenic...
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Cimetidine represents a very promising novel radioprotective agent that provides a significant partial intestinal and bone marrow (BM) protection via its antioxidant effect and subsequent regulation of type 2 apoptotic pathway through modulation of Bax/B‐cell lymphoma 2 (Bcl2) ratio. Our study provides the first evidence that may explain the potential differential beneficial effect of cimetidine on both cancer cells (inducing apoptosis), as previously proved through different studies, and adjacent...
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β‐Mangostin inhibits the expression of integrin aV and β3, leading to the suppression of focal adhesion kinase (FAK)/Src signaling and the subsequent inhibition of JNK/AP‐1/Snail axis, and thereby reduces the metastatic power of human cervical cancer cells. Abstract β‐Mangostin is a natural mangostin with potent anticancer activity against various cancers. In this study, we further explored the anticancer activity of β‐mangostin on cervical cancer cells. β‐Mangostin did not affect cell viability...
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1. LINC02535 and poly (rC) binding protein 2 (PCBP2) are upregulated, and LINC02535 binds with PCBP2 in CC. 2. LINC02535 and PCBP2 promote cell proliferation, migration, invasion, and inhibit apoptosis in CC. 3. LINC02535 cooperates with PCBP2 to enhance the stability of RRM1 messenger RNA. Abstract Cervical cancer (CC) is one of the commonest malignant cancers among women with high morbidity and mortality. Despite encouraging advances had been found in diagnostic and therapeutic strategies,...
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our results suggest that FGFR1 can promote myoblast proliferation and its transcription can be regulated by the methylation level of the core promoter. Our findings provide a mechanistic basis for the improvement of animal breeding. Abstract DNA methylation, which can affect the expression level of genes, is one of the most vital epigenetic modifications in mammals. Fibroblast growth factor receptor 1 (FGFR1) plays an important role in muscle development; however, DNA methylation of the FGFR1...
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We declared the involvement of miRNAs in T‐cell selection, T‐cell‐related cancers. Abstract MicroRNAs (miRNAs) characterized by small, noncoding RNAs have a fundamental role in the regulation of gene expression at the post‐transcriptional level. Additionally, miRNAs have recently been identified as potential regulators of various genes involved in the pathogenesis of the autoimmune and inflammatory disease. So far, the interaction between miRNAs and T lymphocytes in the immune response as a new...
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Abstract Our objectives were to assess the prevalence of REM sleep behaviour disorder in patients with Essential Tremor, using video‐polysomnography and to compare REM sleep behaviour disorder features in essential tremor with those of patients with alpha‐synucleinopathies. Forty‐nine patients with essential tremor were screened with the REM Sleep Behaviour Disorder Screening Questionnaire. Patients scoring positive and those with spontaneous complaints of REM sleep behaviour disorder (n = 6) underwent...
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ABSTRACT There is increasing interest regarding potential protective effects of low‐dose aspirin against various gastrointestinal cancers. We aimed to quantify the association between use of low‐dose aspirin and risk of gastric/oesophageal cancer using a population‐based primary care database in the UK. Between January 2005 and December 2015, we identified a cohort of 223 640 new users of low‐dose aspirin (75‐300 mg/day) and a matched cohort of non‐users at the start of follow‐up from The Health...
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Abstract Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-regulation of the balance between proliferation and apoptosis contributes to tumor initiation. Particularly in the colon where apoptosis is a crucial process in intestinal turnover, inhibition of apoptosis facilitates transformation and tumor progression. The BCL-2 family of proteins are key regulators of apoptosis and have been implicated in colorectal cancer (CRC) initiation, progression...
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