Κυριακή 26 Απριλίου 2020

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Hookah smoking and COVID-19: call for action [Letters]
Canadian Medical Association Journal current issue
32m
Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection [Review]
Canadian Medical Association Journal current issue
32m
Calibration and discrimination of the Framingham Risk Score and the Pooled Cohort Equations [Research]
BACKGROUND:Although accurate risk prediction is essential in guiding treatment decisions in primary prevention of atherosclerotic cardiovascular disease, the accuracy of the Framingham Risk Score (recommended by a Canadian guideline) and the Pooled Cohort Equations (recommended by US guidelines) has not been assessed in a large contemporary Canadian population. Our primary objective was to assess the calibration and discrimination of the Framingham Risk Score and Pooled Cohort Equations in Ontario,...
Canadian Medical Association Journal current issue
32m
Cardiac herniation after blunt thoracic trauma [Practice]
Canadian Medical Association Journal current issue
32m
Vinyl or digital medicine? [Humanities]
Canadian Medical Association Journal current issue
32m
Chest CT imaging of an early Canadian case of COVID-19 in a 28-year-old man [Practice]
Canadian Medical Association Journal current issue
32m
Sample sizes in COVID-19-related research [Letters]
Canadian Medical Association Journal current issue
32m
Global Initiative for Asthma report: How will new recommendations affect practice in Canada? [Commentary]
Canadian Medical Association Journal current issue
32m
COVID Towers: low- and medium-intensity care for patients not in the ICU [Letters]
Canadian Medical Association Journal current issue
32m
Mitigating the psychological effects of COVID-19 on health care workers [Commentary]
Canadian Medical Association Journal current issue
32m
Parents on the front lines of COVID-19 face tough choices [News]
Canadian Medical Association Journal current issue
32m
The Role of Cardiac Opioid Receptors in the Cardioprotective Effect of Continuous Normobaric Hypoxia
We studied the role of opioid receptor subtypes in improvement of the functional state of the heart during reperfusion after adaptation to continuous normobaric hypoxia. To this end, male Wistar rats were subjected to continuous normobaric hypoxia (12% O2). Then, the hearts were isolated and exposed to total 45-min ischemia followed by 30-min reperfusion. Opioid receptor antagonists were added to the perfusion solution prior to ischemia. It was found that continuous normobaric hypoxia reduced the...
Latest Results for Bulletin of Experimental Biology and Medicine
51m
Social and Cognitive Impairments in Rat Offspring after Ultrasound-Induced Prenatal Stress
We studied the possibility of developing an autism model based on chronic prenatal psychological stress caused by variable frequency ultrasound 20-45 kHz. The offspring of female rats stressed during pregnancy demonstrated reduced time of social contacts in the social interaction test, increased anxiety in the open-field test, and memory impairment in the Morris water maze test in comparison with the control (intact) rat offspring. We also found a reducing trend in the BDNF gene expression in the...
Latest Results for Bulletin of Experimental Biology and Medicine
2d
Specific Features of Interactions between Megakaryocytic and Granulocytic Hematopoiesis Lineages and Myelofibrosis during the Acute Phase of Chronic Myeloid Leukemia, Chronic Lymphocytic Leukemia, and Multiple Myeloma
The specific features of interactions between megakaryocytic and granulocytic hematopoiesis lineages and myelofibrosis were studied in patients with active phase (before treatment) of chronic myeloid leukemia, chronic lymphocytic leukemia, and multiple myeloma. In patients with chronic myeloid leukemia, a direct correlation was found between the severity of both early and advanced myelofibrosis and the number of megakaryocytes in the bone marrow irrespectively of the type of the bone marrow tumor....
Latest Results for Bulletin of Experimental Biology and Medicine
2d
Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68
We investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid (68Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (68Ga-DTPMP) in intact Wistar rats. It was shown that 68Ga-DTPMP accumulated mainly in the bone tissue providing high femur/blood and femur/muscle ratios and had high stability in vivo. In contrast, 68Ga-HEDP was characterized by low stability and high uptake of radioactivity in blood throughout the study. So 68Ga-DTPMP can be considered as a new...
Latest Results for Bulletin of Experimental Biology and Medicine
2d
Metabolism of a New Antiaggregant, Indolinone Derivative
Cytochrome p450-mediated metabolism of GRS (indolinone antiaggregant) and its effects on activities of cytochrome p450 isoenzymes were studied. Inhibition of 6 isomers of cytochrome p450 in human liver microsomes was studied with the use of specific substrates. It was found that human liver cytochrome p450 enzymes could not induce degradation of GRS and that GRS was not an inductor or inhibitor of cytochrome p450 family members 1A2, 2C9, 2C19, 2D6, 2C8, and 3A4. Hence, clinical use of the prospective...
Latest Results for Bulletin of Experimental Biology and Medicine
2d
Graph Theory-Based Mathematical Calculation Modeling for Temperature Distribution of LED Lights’ Convective Cooled Heat Sinks under Moisture Environment
In this paper, a mathematical model based on graph theory is proposed to calculate the heat distribution of LED lights’ convective cooled heat sink. First, the heat and mass transfer process of a single fin under moisture environment is analyzed. Then, the heat transfer process is characterized by a digraph, defining fins and joints of a heat sink as edges and vertices in graph theory. Finally, the whole heat transfer process is described by two criteria achieved based on graph theory. Therefore,...
Hindawi Publishing Corporation
59m
Demand Side Management for Smart Grid Based on Smart Home Appliances with Renewable Energy Sources and an Energy Storage System
A novel energy management system to improve the efficiency of renewable energy and storage system by scheduling various types of household appliances is developed. The end users schedule appliances optimally taking into account maximum utility (a measure of the satisfaction level of user’s electricity consumption) as well as minimum user’s cost of energy as competitive objectives. A random disturbance (reflecting an uncertainty) is introduced to describe the indeterminate amount of the electricity...
Hindawi Publishing Corporation
59m
Correlation between Skip N2 Metastases and SUVmax, Long Diameter of Tumor, and Ki67 Expression in Patients with Non-Small-Cell Lung Cancer
Background. We aim at investigating the correlation between skip N2 metastases (SN2) and SUVmax, long diameter of tumor mass after 18F-FDG PET/CT, and pathological Ki67 expression in patients with non-small-cell lung cancer (NSCLC). Methods and Results. We retrospectively analyzed the factors that might affect the pathogenesis of SN2 in these patients. The clinical SN2 symptoms in patients with squamous carcinoma or adenocarcinoma were investigated. The work curve was utilized to analyze the optimal...
Hindawi Publishing Corporation
59m
The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer
Liver cancer is a devastating disease for humans with poor prognosis. Although the survival rate of patients with liver cancer has improved in the past decades, the recurrence and metastasis of liver cancer are still obstacles for us. Inositol polyphosphate-5-phosphatase K (INPP5K) belongs to the family of phosphoinositide 5-phosphatases (PI 5-phosphatases), which have been reported to be associated with cell migration, polarity, adhesion, and cell invasion, especially in cancers. However, there...
Hindawi Publishing Corporation
59m
Aptamer-Conjugated Multifunctional Polymeric Nanoparticles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems for Treatment of Castration-Resistant Prostate Cancer
Nanoscopic therapeutic systems that incorporate therapeutic agents, molecular targeting, and imaging capabilities have gained momentum and exhibited significant therapeutic potential. In this study, multifunctional polymeric nanoparticles with controlled drug delivery, cancer-targeted capability, and efficient magnetic resonance imaging (MRI) contrast characteristics were formulated and applied in the treatment of castration-resistant prostate cancer (CRPC). The “core-shell” targeted nanoparticles...
Hindawi Publishing Corporation
1h
A Novel Strategy Facilitates Reference Gene Selection by RT-qPCR Analysis in Kidney Yang Deficiency Syndrome Mice Infected with the Influenza A (H1N1) Virus
In reverse transcription-quantitative polymerase chain reaction (RT-qPCR) studies, endogenous reference genes are routinely used to normalize the expression of target gene studies. In order to precisely evaluate the relative expression of genes in the cells of mice suffering from Kidney Yang Deficiency Syndrome (KYDS) in response to influenza A virus (IAV) H1N1 using RT-qPCR, it is crucial to identify reliable reference genes. In the present study, 15 candidate reference genes (Actb, β2m, Gapdh,...
Hindawi Publishing Corporation
1h
Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation
The increased prevalence of nonalcoholic fatty liver disease (NAFLD), which develops from hepatic steatosis, represents a public health challenge. Catalpol, a natural component extracted from the roots of Radix Rehmanniae, has several pharmacological activities. The present study is aimed at examining whether catalpol prevents hepatic steatosis in cell and animal experiments and elucidating the possible mechanisms. HepG2 cells were treated with 300 μM palmitate (PA) and/or catalpol for 24 h in vitro,...
Hindawi Publishing Corporation
1h
Lower Limb Motion Recognition Method Based on Improved Wavelet Packet Transform and Unscented Kalman Neural Network
Exoskeleton robot is a typical application to assist the motion of lower limbs. To make the lower extremity exoskeleton more flexible, it is necessary to identify various motion intentions of the lower limbs of the human body. Although more sEMG sensors can be used to identify more lower limb motion intention, with the increase in the number of sensors, more and more data need to be processed. In the process of human motion, the collected sEMG signal is easy to be interfered with noise. To improve...
Hindawi Publishing Corporation
1h
Collapse Risk Analysis of Deep Foundation Pits in Metro Stations Using a Fuzzy Bayesian Network and a Fuzzy AHP
Collapse risk analysis is of great significance for ensuring construction safety in foundation pits. This study proposes a comprehensive methodology for dynamic risk analysis of foundation pit collapse during construction based on a fuzzy Bayesian network (FBN) and a fuzzy analytical hierarchy process (FAHP). Firstly, the potential risk factors contributing to foundation pit collapse are identified based on the results of statistical analysis of foundation pit collapse cases, expert inquiry, and...
Hindawi Publishing Corporation
1h
CTLA4-Ig Abatacept Ameliorates Proteinuria by Regulating Circulating Treg/IL-17 in Adriamycin-Induced Nephropathy Rats
Objective. This study is aimed at investigating the efficacy of CTLA4-Ig abatacept in normalizing proteinuria and its possible mechanism in adriamycin-induced nephropathy (AIN) rats. Methods. A total of 32 healthy male Sprague-Dawley rats were randomly divided into a normal group, an AIN group, an abatacept group, and a prednisone group. Adriamycin (6.5 mg/kg) was injected once via the tail vein of rats to induce nephrotic syndrome. After adriamycin treatment, the abatacept group rats were given...
Hindawi Publishing Corporation
1h
Experimental Study on the Effect of Aconite and Angelica sinensis on Myocardial Ischemia Rats with Yang Deficiency and Blood Stasis
Objective. To investigate the intervention effect and mechanism of Aconite and Angelica sinensis on myocardial ischemia rats with Yang deficiency and blood stasis. Methods. SPF-class SD rats were randomly divided into low-dose and high-dose groups. Each group was divided into control group, model group, and drug-administered group (FZ, DG, FG; 1 : 0.5, 1 : 1, 1 : 2). A rat model was prepared by intraperitoneal injection of hydrocortisone and isoproterenol plus cold stimulation. Each group was given...
Hindawi Publishing Corporation
1h
Understanding and Improving 18F-Fluciclovine PET/CT Reports: A Guide for Physicians Treating Patients with Biochemical Recurrence of Prostate Cancer
The positron emission tomography (PET) tracer 18F-fluciclovine has seen increasing use to localize disease in men with biochemical recurrence of prostate cancer, i.e., elevated prostate-specific antigen (PSA) levels post-treatment. 18F-Fluciclovine PET/computed tomography (CT) imaging reports now play central roles in many physician-patient discussions. However, because no standardized grading system or templates yet exist for 18F-fluciclovine image assessment, reports vary in format, comprehensiveness,...
Hindawi Publishing Corporation
1h
Tai Chi Improves Coronary Heart Disease Risk by Inactivating MAPK/ERK Pathway through Serum miR-126
Background. Tai Chi is effective in preventing heart disease (CHD) risk, but the molecular mechanism remains unclear. Mitogen-activated protein kinase (MAPK) signaling plays a critical role in the pathogenesis of CHD and can be activated by miR-126. Tai Chi may exert its protective function through the miR-126-modulated MAPK pathway. Methods. The CHD patients after PCI were randomized into the CG group (CG) (n = 19, normal care) and Tai Chi group (TG) (Tai Chi intervention, n = 17). Epicardial adipose...
Hindawi Publishing Corporation
1h
Optimized Mahalanobis–Taguchi System for High-Dimensional Small Sample Data Classification
The Mahalanobis–Taguchi system (MTS) is a multivariate data diagnosis and prediction technology, which is widely used to optimize large sample data or unbalanced data, but it is rarely used for high-dimensional small sample data. In this paper, the optimized MTS for the classification of high-dimensional small sample data is discussed from two aspects, namely, the inverse matrix instability of the covariance matrix and the instability of feature selection. Firstly, based on regularization and smoothing...
Hindawi Publishing Corporation
13h
The Effect of Limited Proteolysis by Trypsin on the Formation of Soy Protein Isolate Nanofibrils
Nanofibril system constructed by protein self-assembly is widely used in the food industry because of purposive functional properties. Soy protein isolate nanofibrils (SPINs) were reported to form via heating at pH 2.0. In this research, the soy protein isolate (SPI) hydrolysate prepared by trypsin was used as a raw material for the formation of nanofibrils called soy protein isolate hydrolysate nanofibrils (SPIHNs). Microscopic images demonstrated the formation of two nanofibrils. Based on circular...
Hindawi Publishing Corporation
13h
Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion
Adhesion is a frequent complication after abdominal surgery. Although various methods have been applied to prevent and treat postoperative abdominal adhesion (PAA), few modern drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far. There is an imperative to develop some new strategies for the treatment of PAA. Traditional Chinese medicine (TCM) has been widely practiced for thousands of years and played an indispensable role in the prevention and...
Hindawi Publishing Corporation
13h
Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1
Background. Porcine parvovirus (PPV) infection-induced apoptosis was recently identified as an important pathological factor in PPV-induced placental tissue damage, resulting in reproduction failure. In the present study, we demonstrate the possible involvement of toll-like receptor (TLR) 4 and nuclear factor (NF)-κB inflammasome activation in PPV infection-induced apoptosis and the protective potential of ferulic acid (FA). PPV infection significantly activated the expression levels of TLR4, NF-κB,...
Hindawi Publishing Corporation
13h
PPARG Drives Molecular Networks as an Inhibitor for the Pathologic Development and Progression of Lung Adenocarcinoma
Previous studies showed that low PPARG expression was associated with poor prognosis of lung adenocarcinoma (LA) with limited mechanisms identified. We first conducted a large-scale literature-based data mining to identify potential molecular pathways where PPARG could exert influence on the pathological development of LA. Then a mega-analysis using 13 independent LA expression datasets and a Pathway Enrichment Analysis (PEA) was conducted to study the gene expression levels and the functionalities...
Hindawi Publishing Corporation
13h
Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFA/eNOS Signaling Pathway
Background. The testicular microcirculation was an important aspect of testicular physiology and it offered a stable environment for the transport of nutrients and secretary products in the testis. Yangjing capsule (YC), a traditional Chinese compound herbal prescription, has been proved as an effective drug to ameliorate spermatogenesis, promote testosterone synthesis in vivo, and cure spermatogenesis in clinical practice. Objective. This study was aimed at understanding the potential mechanisms...
Hindawi Publishing Corporation
1d
Combination of Fractional Exhaled Nitric Oxide (FeNO) Level and Asthma Control Test (ATC) in Detecting GINA-Defined Asthma Control in Treated Asthmatic Patients in Vietnam
Background. FeNO has been used as a marker for Th2-mediated airway inflammation in asthma. There is evidence which recommends the use of this biomarker in asthma management. Little is known about whether the FeNO test alone or in combination with the ACT score can reflect asthma control in Vietnamese patients. Materials and Methods. A cross-sectional study was conducted in asthmatic patients (≥18 years old) recruited at the University Medical Center, Ho Chi Minh City, Vietnam from March 2016 to March...
Hindawi Publishing Corporation
1d
Diagnostic Performance of PET or PET/CT with Different Radiotracers in Patients with Suspicious Lung Cancer or Pleural Tumours according to Published Meta-Analyses
Purpose. Several meta-analyses have reported data about the diagnostic performance of positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) with different radiotracers in patients with suspicious lung cancer (LC) or pleural tumours (PT). This review article aims at providing an overview on the recent evidence-based data in this setting. Methods. A comprehensive literature search of meta-analyses published in PubMed/MEDLINE and Cochrane Library database from...
Hindawi Publishing Corporation
1d
Proportion of Ophthalmic Self-Medication and Associated Factors among Adult Ophthalmic Patients Attending Borumeda Hospital, Dessie, Northeast Ethiopia
Purpose. The aim of this study was to determine the proportion of ophthalmic self-medication and associated factors among adult ophthalmic patients attending Borumeda Hospital, Northeast Ethiopia, 2019. Methods. An institution-based cross-sectional study design was conducted on 402 participants at Borumeda Hospital from April 29 to May 24, 2019. Systematic random sampling technique was used to get study participants. Data were collected with a face-to-face interview by using a semistructured questionnaire....
Hindawi Publishing Corporation
1d
Kinetic Study of the Adsorption of Polyphenols from Olive Mill Wastewater onto Natural Clay: Ghassoul
The aim of this study is based on natural clay as an adsorbent in the elimination of polyphenols from olive mill wastewater (OMW). This clay was analyzed using XRD, SEM/EDX, FTIR, surface area measurement (BET method), thermal analysis (TGA/DTA), and X-ray fluorescence (XRF) and then used in adsorption experiments. The results reveal that the best quantity of adsorption of polyphenols is 161 mg/g at the temperature of 25°C, but they decrease at 35°C and 45°C. A great agreement with pseudo-second-order...
Hindawi Publishing Corporation
1d

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